Screening Instrumentation
Assay readout
Manufacturer: GE Healthcare Life Sciences
Capabilities: Fast, sensitive, and flexible automated cell imaging using 4x, 10x, 20x and 40x objectives and filters for imaging DAPI, FITC, Cy3, TxRed, Cy5, CFP and YFP; non-confocal but with advanced 3D deconvolution software
Applications: Broad range of high-content assays, 2D and 3D
Plate format: slide to 384-well
Assay readout
Manufacturer: Molecular Devices
Capabilities: Fast, sensitive and flexible automated cell imaging using 4x, 10x, 20x (optional water immersion) or 40x (water immersion) objectives and filters for imaging DAPI, CFP, FITC, YFP, TRITC, Cy5, Cy7 and TexasRed. 60µm pinhole confocality available and image analysis softwares, MetaXpress® and IN Carta®.
Applications: Broad range of high-content assays in 2D and 3D
Plate format: Mainly 96- and 384 well
Assay readout
Manufacturer: BioTek
Capabilities: Flexible and sensitive plate reader with monochromator based absorbance and filter based fluorescence/luminescence
Applications: 2D and 3D Broad range of absorbance or lumiscent based biological readouts; DNA measurement
Plate format: 96- and 384-well
Assay readout
Manufacturer: PerkinElmer
Capabilities: Plate reader with ultra-sensitive luminescence and filter-based absorbance technology, fluorescence well-imaging with single cell resolution as well as brightfield and digital phase-contrast imaging.
Application: 2D and 3D Broad range of absorbance or luminescent based biological readouts; DNA measurement
Plate format: 96- and 384-well
Assay readout
Manufacturer: ESSEN BIOSCIENCE
Capabilities: Real-time, non-invasive, quantitative live-cell analysis; 4x and 10x objectives, HD phase-contrast, FITC, Cy3 and TxRed
Applications: Proliferation, wound-healing, scratch assays
Plate format: Flask, dish, slides and plate formats from 24 to 384-well
Liquid Handling
Manufacturer: Hamilton
Capabilities: Liquid transfer using disposable pipet tips (Hamilton); 384well head; plate handling
Applications: HT 384well transfections/treatments; HT- QPCR; library handling
Plate format: 384-well
Transfer volume: 2-50µl
Liquid Handling
Manufacturer:Labcyte
Capabilities: Liquid transfer using ultrasonic acoustic energy (tips-free); flexible low-volume transfer for HT formats
Applications: compound screens, dose-response curves, antibody staining, library cherry-pick, low-volume qPCR
Plate format: 96- and 384-well
Transfer volume: Echo 550: 2.5nl- 2µl; Echo 525: 25nl- 5 µl
Liquid Handling
Manufacturer: BioTek
Capabilities: Liquid dispensing using random access dispense (RAD) and multi-mode dispensing
Applications: cell seeding, reagent dispensing
Plate format: 6- and 1536-well
Transfer volume: 20-30,000 µl/well
Liquid Handling
Manufacturer: BioTek
Capabilities: Microplate washing
Applications: Washing of fixed as well as live cells
Plate format: 96- and 384-well
Transfer volume: 50 µl- 3,000 µl/well