Kristian Helin

Kristian Helin

professor, group leader


  1. 2021
  2. Published

    Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis

    Radzisheuskaya, A., Shliaha, P. V., Grinev, V. V., Shlyueva, Daria, Damhofer, H., Koche, R., Gorshkov, V., Kovalchuk, S., Zhan, Y., Rodriguez, K. L., Johnstone, A. L., Keogh, M. C., Hendrickson, R. C., Jensen, O. N. & Helin, Kristian, 2021, In: Molecular Cell. 81, 8, p. 1749-1765.e8

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published
  4. 2020
  5. Published

    PR-DUB maintains expression of critical genes through FOXK1/2 and ASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination

    Kolovos, P., Nishimura, K., Sankar, Aditya, Sidoli, S., Cloos, Paul, Helin, Kristian & Christensen, J., Aug 2020, In: Genome Research. 30, 8, p. 1119-1130

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. BTK inhibitors synergize with 5-FU to treat drug-resistant TP53-null colon cancers

    Lavitrano, M., Ianzano, L., Bonomo, S., Cialdella, A., Cerrito, M. G., Pisano, F., Missaglia, C., Giovannoni, R., Romano, G., McLean, C. M., Voest, E. E., D'Amato, F., Noli, B., Ferri, G. L., Agostini, M., Pucciarelli, S., Helin, Kristian, Leone, B. E., Canzonieri, V. & Grassilli, E., Feb 2020, In: Journal of Pathology. 250, 2, p. 134-147 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary

    Kim, S. H., Da Cruz Paula, A., Basili, T., Dopeso, H., Bi, R., Pareja, F., da Silva, E. M., Gularte-Mérida, R., Sun, Z., Fujisawa, S., Smith, C. G., Ferrando, L., Martins Sebastião, A. P., Bykov, Y., Li, A., Silveira, C., Ashley, C. W., Stylianou, A., Selenica, P., Samore, W. R., Jungbluth, A. A., Zamarin, D., Abu-Rustum, N. R., Helin, Kristian, Soslow, R. A., Reis-Filho, J. S., Oliva, E. & Weigelt, B., 2 Jan 2020, In: Nature Communications. 11, 1, p. 44

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes

    Sankar, Aditya, Lerdrup, Mads, Manaf, A., Johansen, Jens Vilstrup, Martin Gonzalez, Javier, Borup, R., Blanshard, R., Klungland, A., Hansen, Klaus, tcg964, tcg964, Dahl, J. A., Helin, Kristian & Hoffmann, Eva, 2020, In: Nature Cell Biology. 22, 4, p. 380-388 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Mutant FOXL2C134W highjacks SMAD4 and SMAD2/3 to drive adult granulosa cell tumors

    Weis-Banke, Stine Emilie, Lerdrup, Mads, Kleine-Kohlbrecher, D., Mohammad, F., Sidoli, S., Jensen, O. N., Yanase, T., Nakamura, T., Iwase, A., Stylianou, A., Abu-Rustum, N. R., Aghajanian, C., Soslow, R., Da Cruz Paula, A., Koche, R. P., Weigelt, B., Christensen, J., Helin, Kristian & Cloos, Paul, 2020, In: Cancer Research. 80, 17, p. 3466-3479

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    PRMT5 inhibition modulates E2F1 methylation and gene regulatory networks leading to therapeutic efficacy in JAK2V617F mutant MPN

    Pastore, F., Bhagwat, N., Pastore, A., Radzisheuskaya, A., Karzai, A., Krishnan, A., Li, B., Bowman, R. L., Xiao, W., Viny, A. D., Zouak, A., Park, Y. C., Cordner, K. B., Braunstein, S., Maag, J. L. V., Grego, A., Mehta, J., Wang, M., Lin, H., Durham, B. H., Koche, R. P., Rampal, R. K., Helin, Kristian, Scherle, P., Vaddi, K. & Levine, R. L., 2020, In: Cancer Discovery. 10, 11, p. 1742-1757

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2019
  12. Published

    Quantification of Differential Transcription Factor Activity and Multiomics-Based Classification into Activators and Repressors: diffTF

    Berest, I., Arnold, C., Reyes-Palomares, A., Palla, G., Rasmussen, K. D., Giles, H., Bruch, P., Huber, W., Dietrich, S., Helin, Kristian & Zaugg, J. B., 3 Dec 2019, In: Cell Reports. 29, 10, p. 3147-3159.e12 25 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity

    Højfeldt, J. W., Hedehus, Lin, Laugesen, Anne, Tatar, T., Wiehle, L. & Helin, Kristian, 7 Nov 2019, In: Molecular Cell. 76, 3, p. 423-436 12 p., E3.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 927363