Staff – University of Copenhagen

BRIC > Staff

Chromatin Repressive Complexes in Stem Cells, Development, and Cancer

Research output: Contribution to journalReviewResearchpeer-review

Documents

The chromatin environment is essential for the correct specification and preservation of cell identity through modulation and maintenance of transcription patterns. Many chromatin regulators are required for development, stem cell maintenance, and differentiation. Here, we review the roles of the polycomb repressive complexes, PRC1 and PRC2, and the HDAC1- and HDAC2-containing complexes, NuRD, Sin3, and CoREST, in stem cells, development, and cancer, as well as the ongoing efforts to develop therapies targeting these complexes in human cancer. Furthermore, we discuss the role of repressive complexes in modulating thresholds for gene activation and their importance for specification and maintenance of cell fate.

Original languageEnglish
JournalCell Stem Cell
Volume14
Issue number6
Pages (from-to)735-751
Number of pages17
ISSN1934-5909
DOIs
Publication statusPublished - 5 Jun 2014

Number of downloads are based on statistics from Google Scholar and www.ku.dk


No data available

ID: 113596937