Kristian Helin

Kristian Helin

professor, group leader


  1. 2019
  2. Published

    Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity. / Højfeldt, Jonas Westergaard; Hedehus, Lin; Laugesen, Anne; Tatar, Tülin; Wiehle, Laura; Helin, Kristian.

    In: Molecular Cell, Vol. 76, No. 3, E3, 07.11.2019, p. 423-436.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. E-pub ahead of print

    Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders. / Poeta, Loredana; Padula, Agnese; Attianese, Benedetta; Valentino, Mariaelena; Verrillo, Lucia; Filosa, Stefania; Shoubridge, Cheryl; Barra, Adriano; Schwartz, Charles E; Christensen, Jesper; van Bokhoven, Hans; Helin, Kristian; Lioi, Maria Brigida; Collombat, Patrick; Gecz, Jozef; Altucci, Lucia; Di Schiavi, Elia; Miano, Maria Giuseppina.

    In: Human Molecular Genetics, 06.11.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia. / Radzisheuskaya, Aliaksandra; Shliaha, Pavel V; Grinev, Vasily; Lorenzini, Eugenia; Kovalchuk, Sergey; Shlyueva, Daria; Gorshkov, Vladimir; Hendrickson, Ronald C; Jensen, Ole N; Helin, Kristian.

    In: Nature Structural & Molecular Biology, Vol. 26, No. 11, 11.2019, p. 999-1012.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. E-pub ahead of print

    BTK inhibitors synergize with 5-FU to treat drug-resistant TP53-null colon cancers. / Lavitrano, Marialuisa; Ianzano, Leonarda; Bonomo, Sara; Cialdella, Annamaria; Cerrito, Maria Grazia; Pisano, Fabio; Missaglia, Carola; Giovannoni, Roberto; Romano, Gabriele; McLean, Chelsea M; Voest, Emile E; D'Amato, Filomena; Noli, Barbara; Ferri, Gian Luca; Agostini, Marco; Pucciarelli, Salvatore; Helin, Kristian; Leone, Biagio Eugenio; Canzonieri, Vincenzo; Grassilli, Emanuela.

    In: Journal of Pathology, 13.09.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2. / Garland, William; Comet, Itys; Wu, Mengjun; Radzisheuskaya, Aliaksandra; Rib, Leonor; Vitting-Seerup, Kristoffer; Lloret-Llinares, Marta; Sandelin, Albin; Helin, Kristian; Jensen, Torben Heick.

    In: Cell Reports, Vol. 29, No. 7, 2019, p. 1800-1811.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition : definition of a gene-expression model for the selection of sensitive cases. / Paroni, Gabriela; Bolis, Marco; Zanetti, Adriana; Ubezio, Paolo; Helin, Kristian; Staller, Peter; Gerlach, Lars Ole; Fratelli, Maddalena; Neve, Richard M.; Terao, Mineko; Garattini, Enrico.

    In: Oncogene, Vol. 38, 2019, p. 2675–2689.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation. / Laugesen, Anne; Højfeldt, Jonas Westergaard; Helin, Kristian.

    In: Molecular Cell, Vol. 74, No. 1, 2019, p. 8-18.

    Research output: Contribution to journalReviewResearchpeer-review

  9. Published

    PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells. / Agrawal-Singh, Shuchi; Lerdrup, Mads; Gomes, Ana-Luisa R.; van de Werken, Harmen J. G.; Johansen, Jens Vilstrup; Andersson, Robin; Sandelin, Albin; Helin, Kristian; Hansen, Klaus.

    In: eLife, Vol. 8, e40364, 2019, p. 1-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells. / Rasmussen, Kasper D; Berest, Ivan; Kessler, Sandra; Nishimura, Koutarou; Simon-Carrasco, Lucia; Vassiliou, George S; Pedersen, Marianne Terndrup; Christensen, Jesper; Zaugg, Judith; Helin, Kristian.

    In: Genome Research, Vol. 29, No. 4, 2019, p. 564-575.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance. / Agger, Karl; Nishimura, Koutarou; Miyagi, Satoru; Messling, Jan-Erik; Rasmussen, Kasper Dindler; Helin, Kristian.

    In: Blood, Vol. 134, No. 14, 2019, p. 1154-1158.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 927363