Featured Projects

Novel high-throughput CRISPR-Select using 96-well cell culture robotics

We have helped develop a streamlined and automated pipeline for analysis of CRISPR-engineered genetic variants (mutations) found in patients in e.g. cancer predisposition genes. This approach utilizes robotics to manage drug delivery, monitor cell growth, split cell cultures at appropriate cell densities and refresh cell cultures efficiently. This innovative system not only significantly reduces the time and labor required for analysis, but also enables the investigation of thousands of variants of uncertain significance for cancer relevance with unparalleled precision. This represents a major leap forward in genetic research, offering promising opportunities for cancer prevention and treatment.

Precision Targets in Glioblastoma Therapy

This project focuses on identifying and validating new therapeutic targets for glioblastoma (GBM), particularly targeting the glioblastoma stem cells (GSCs) responsible for tumor growth and recurrence. By employing automated high-throughput CRISPR screening (by validating 1239 putative GSC-specific gene dependencies) and patient-derived neurosphere models, we aim to help our user to uncover genes critical to GSC survival and assess their viability as targets for precision medicine. This streamlined methodology facilitates the rapid discovery of genetic vulnerabilities and the efficient testing of potential therapeutic drugs, paving the way for the development of more effective, personalized GBM treatments.