PhD defence: Development of CRISPR-based Technologies to Define Disease Predisposition and Drug Response of Hereditary Cancer Genes and Variants

Casper Carstens Lund

CRISPR-based functional assays provide a powerful means to define the cellular roles of variants and genes with applications in VUS classification, drug development, and basic research. However, current functional assays are non-accurate, non-flexible, low throughput, ignores the genomic background, or a combination.

We developed functional assays that eliminate shortcomings of existing methods and retain important strengths. Our assays allow accurate, flexible, high-throughput variant and gene analysis for VUS classification, drug development, and basic research.

Assessment Committee

Professor Cord Herbert Brakebusch (chair), Biotech Research and Innovation Centre (BRIC), University of Copenhagen.

Professor Yonglun Luo, Aarhus University.

Associate professor Samuel Gebre-Medhin, Lund University.

Supervisors

Associate Professor Morten Frödin, Biotech Research and Innovation Centre (BRIC), University of Copenhagen.

Lene Juel Rasmussen.

Graduate Programme

Molecular Mechanisms of Disease

Place

Building: Bygning 20, stuen, Room: Victor Haderup auditorium, Hovedindgang fra Blegdamsvej 3B, DK-2200 København N.

Copy of the thesis

Email address to gain access to the thesis: casper.lund@bric.ku.dk.

You will either receive a copy of the thesis or be informed where you can read a physical copy.

Recipients of copies of the thesis are not allowed to share or distribute it due to copyright compliance.