Michael Ploug

Michael Ploug

Group leader


  1. 2023
  2. Published

    Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts of lipoprotein lipase in the capillary lumen

    Yang, Y., Beigneux, A. P., Song, W., Nguyen, L. P., Jung, H., Tu, Y., Weston, T. A., Tran, C. M., Xie, K., Yu, R. G., Tran, A. P., Miyashita, K., Nakajima, K., Murakami, M., Chen, Y. Q., Zhen, E. Y., Kim, J. R., Kim, P. H., Birrane, G., Tontonoz, P. & 4 others, Ploug, Michael, Konrad, R. J., Fong, L. G. & Young, S. G., 2023, In: Journal of Clinical Investigation. 133, 23, 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures

    Song, W., Yang, Y., Heizer, P., Tu, Y., Weston, T. A., Kim, J. R., Munguia, P., Jung, H., Fong, J. L. C., Tran, C., Ploug, Michael, Beigneux, A. P., Young, S. G. & Fong, L. G., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 8, 11 p., e2219833120.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase

    Kumari, Anni, Grønnemose, A. L., Kristensen, Kristian Kølby, Winther, Anne-Marie Lund, Young, S. G., Jørgensen, T. J. D. & Ploug, Michael, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 18, e2221888120.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published
  6. Published

    The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing

    Song, W., Beigneux, A. P., Weston, T. A., Chen, K., Yang, Y., Nguyen, L. P., Guagliardo, P., Jung, H., Tran, A. P., Tu, Y., Tran, C., Birrane, G., Miyashita, K., Nakajima, K., Murakami, M., Tontonoz, P., Jiang, H., Ploug, Michael, Fong, L. G. & Young, S. G., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 44, 12 p., e2313825120.

    Research output: Contribution to journalJournal articlepeer-review

  7. 2022
  8. Published

    ANGPTL4: a new mode in the regulation of intravascular lipolysis

    Ploug, Michael, 2022, In: Current Opinion in Lipidology. 33, 2, p. 112-119

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells

    Song, W., Beigneux, A. P., Winther, A. M. L., Kristensen, K. K., Grønnemose, A. L., Yang, Y., Tu, Y., Munguia, P., Morales, J., Jung, H., De Jong, P. J., Jung, C. J., Miyashita, K., Kimura, T., Nakajima, K., Murakami, M., Birrane, G., Jiang, H., Tontonoz, P., Ploug, M. & 2 others, Fong, L. G. & Young, S. G., 2022, In: Journal of Clinical Investigation. 132, 5, 15 p., e157500.

    Research output: Contribution to journalJournal articlepeer-review

  10. 2021
  11. Published

    ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding

    Winther, Anne-Marie Lund, Kumari, Anni, Young, S. G. & Ploug, Michael, 2021, In: Journal of Lipid Research. 62, 2 p., 100071.

    Research output: Contribution to journalComment/debate

  12. Published

    Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry

    Staby, L., Kemplen, K. R., Stein, Amelie, Ploug, Michael, Clarke, J., Skriver, Karen, Heidarsson, P. O. & Kragelund, Birthe Brandt, 2021, In: Cellular and molecular life sciences : CMLS. 78, p. 2263-2278 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Expression and one-step purification of active LPL contemplated by biophysical considerations

    Winther, Anne-Marie Lund, Kristensen, Kristian Kølby, Kumari, Anni & Ploug, Michael, 2021, In: Journal of Lipid Research. 62, 13 p., 100149.

    Research output: Contribution to journalJournal articlepeer-review

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ID: 33978213