Impact of Microenvironment and Stem-Like Plasticity in Cholangiocarcinoma: Molecular Networks and Biological Concepts

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Impact of Microenvironment and Stem-Like Plasticity in Cholangiocarcinoma : Molecular Networks and Biological Concepts. / Raggi, Chiara; Invernizzi, Pietro; Andersen, Jesper Bøje.

In: Journal of Hepatology, 11.09.2014.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Raggi, C, Invernizzi, P & Andersen, JB 2014, 'Impact of Microenvironment and Stem-Like Plasticity in Cholangiocarcinoma: Molecular Networks and Biological Concepts', Journal of Hepatology. https://doi.org/10.1016/j.jhep.2014.09.007

APA

Raggi, C., Invernizzi, P., & Andersen, J. B. (2014). Impact of Microenvironment and Stem-Like Plasticity in Cholangiocarcinoma: Molecular Networks and Biological Concepts. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2014.09.007

Vancouver

Raggi C, Invernizzi P, Andersen JB. Impact of Microenvironment and Stem-Like Plasticity in Cholangiocarcinoma: Molecular Networks and Biological Concepts. Journal of Hepatology. 2014 Sep 11. https://doi.org/10.1016/j.jhep.2014.09.007

Author

Raggi, Chiara ; Invernizzi, Pietro ; Andersen, Jesper Bøje. / Impact of Microenvironment and Stem-Like Plasticity in Cholangiocarcinoma : Molecular Networks and Biological Concepts. In: Journal of Hepatology. 2014.

Bibtex

@article{87948be2729f4777a0fad9c2bf3fe159,
title = "Impact of Microenvironment and Stem-Like Plasticity in Cholangiocarcinoma: Molecular Networks and Biological Concepts",
abstract = "Clinical complexity, anatomic diversity and molecular heterogeneity of cholangiocarcinoma (CCA) represent a major challenge in the assessment of effective targeted therapies. Molecular and cellular mechanisms underlying diversity of CCA growth patterns remain a key issue and a clinical concern. Crucial questions comprise the nature of the CCA-origin, the initial target for cellular transformation as well as the relationship with the cancer stem cells (CSC) concept. Additionally, since CCA often develops in the context of an inflammatory milieu (cirrhosis and cholangitis), the stromal compartment or tumor microenvironment (TME) likely promotes initiation and progression of this malignancy contributing to its heterogeneity. This review will emphasize the dynamic interplay between stem-like intrinsic and TME-extrinsic pathways, which may represent novel options for multi-targeted therapies in CCA.",
author = "Chiara Raggi and Pietro Invernizzi and Andersen, {Jesper B{\o}je}",
note = "Copyright {\textcopyright} 2014. Published by Elsevier B.V.",
year = "2014",
month = sep,
day = "11",
doi = "10.1016/j.jhep.2014.09.007",
language = "English",
journal = "Journal of Hepatology, Supplement",
issn = "0169-5185",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Impact of Microenvironment and Stem-Like Plasticity in Cholangiocarcinoma

T2 - Molecular Networks and Biological Concepts

AU - Raggi, Chiara

AU - Invernizzi, Pietro

AU - Andersen, Jesper Bøje

N1 - Copyright © 2014. Published by Elsevier B.V.

PY - 2014/9/11

Y1 - 2014/9/11

N2 - Clinical complexity, anatomic diversity and molecular heterogeneity of cholangiocarcinoma (CCA) represent a major challenge in the assessment of effective targeted therapies. Molecular and cellular mechanisms underlying diversity of CCA growth patterns remain a key issue and a clinical concern. Crucial questions comprise the nature of the CCA-origin, the initial target for cellular transformation as well as the relationship with the cancer stem cells (CSC) concept. Additionally, since CCA often develops in the context of an inflammatory milieu (cirrhosis and cholangitis), the stromal compartment or tumor microenvironment (TME) likely promotes initiation and progression of this malignancy contributing to its heterogeneity. This review will emphasize the dynamic interplay between stem-like intrinsic and TME-extrinsic pathways, which may represent novel options for multi-targeted therapies in CCA.

AB - Clinical complexity, anatomic diversity and molecular heterogeneity of cholangiocarcinoma (CCA) represent a major challenge in the assessment of effective targeted therapies. Molecular and cellular mechanisms underlying diversity of CCA growth patterns remain a key issue and a clinical concern. Crucial questions comprise the nature of the CCA-origin, the initial target for cellular transformation as well as the relationship with the cancer stem cells (CSC) concept. Additionally, since CCA often develops in the context of an inflammatory milieu (cirrhosis and cholangitis), the stromal compartment or tumor microenvironment (TME) likely promotes initiation and progression of this malignancy contributing to its heterogeneity. This review will emphasize the dynamic interplay between stem-like intrinsic and TME-extrinsic pathways, which may represent novel options for multi-targeted therapies in CCA.

U2 - 10.1016/j.jhep.2014.09.007

DO - 10.1016/j.jhep.2014.09.007

M3 - Journal article

C2 - 25220250

JO - Journal of Hepatology, Supplement

JF - Journal of Hepatology, Supplement

SN - 0169-5185

ER -

ID: 124507524