Lars Henning Engelholm
Department of Clinical Medicine
Blegdamsvej 3
2200 2200 København N
Department of Biology
Ole Maaløes Vej 5
2200 2200 København N
- Published
Early reversal cells in adult human bone remodeling: osteoblastic nature, catabolic functions and interactions with osteoclasts
Abdelgawad, M. E., Delaissé, J., Hinge, M., Jensen, P. R., Alnaimi, R. W., Rolighed, L., Engelholm, Lars Henning, Marcussen, N. & Levin Andersen, T., 2016, In: Histochemistry and Cell Biology. 145, 6, p. 603-615 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
A urokinase receptor-associated protein with specific collagen binding properties
Behrendt, Niels, Jensen, O. N., Engelholm, Lars Henning, Mørtz, E., Mann, Matthias & Danø, K., 2000, In: The Journal of Biological Chemistry. 275, 3, p. 1993-2002 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of a novel membrane protein that interacts specifically with the upar-prourokinase complex
Behrendt, Niels, Engelholm, Lars Henning, Jensen, O. N., Mörtz, E., Ranne, E., Mann, Matthias & Dan, K., 1997, In: Fibrinolysis and Proteolysis. 11, Supl. 3, p. 10 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Personalized B cell response to the Lactobacillus rhamnosus GG probiotic in healthy human subjects: a randomized trial
Lange, Jette Bornholdt, Chen, Y., Rago, Alfredo, Sloth, S., Hendel, J., Melsæther, C., Müller, C. V., Juul Nielsen, M., Strickertsson, J., Engelholm, Lars Henning, Vitting-Seerup, K., Jensen, Kim Bak, Baker, A. & Sandelin, Albin Gustav, 9 Nov 2020, In: Gut Microbes. 12, 1, p. 1-14 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)
Carlsen Melander, E. M., Jürgensen, Henrik Jessen, Madsen, Daniel Hargbøl, Engelholm, Lars Henning & Behrendt, Niels, Oct 2015, In: International Journal of Oncology. 47, 4, p. 1177-88 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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No Effect of NGAL/lipocalin-2 on Aggressiveness of Cancer in the MMTV-PyMT/FVB/N Mouse Model for Breast Cancer
Cramer, E. P., Glenthøj, Andreas Birkedal, Häger, M., Juncker-Jensen, A., Engelholm, Lars Henning, Santoni Rugiu, Eric, Lund, L. R., Laerum, O. D., Cowland, J. B. & Borregaard, N., 2012, In: P L o S One. 7, 6, p. e39646Research output: Contribution to journal › Journal article › Research › peer-review
Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy
Curino, A. C., Engelholm, Lars Henning, Yamada, S. S., Holmbeck, K., Lund, L. R., Molinolo, A. A., Behrendt, Niels, Nielsen, B. S. & Bugge, T. H., 2005, In: Journal of Cell Biology. 169, 6, p. 977-985 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis
Durré, T., Morfoisse, F., Erpicum, C., Ebroin, M., Blacher, S., García-Caballero, M., Deroanne, C., Louis, T., Balsat, C., Van de Velde, M., Kaijalainen, S., Kridelka, F., Engelholm, Lars Henning, Struman, I., Alitalo, K., Behrendt, Niels, Paupert, J. & Noel, A., 5 Dec 2018, In: Nature Communications. 9, 1, p. 1-16 5178.Research output: Contribution to journal › Journal article › Research › peer-review
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Inflammation and uPAR-Expression in Colorectal Liver Metastases in Relation to Growth Pattern and Neo-adjuvant Therapy
Eefsen, R. L., Engelholm, Lars Henning, Alpizar-Alpizar, W., Van den Eynden, G. G. E., Vermeulen, P. B., Christensen, I. J., Laerum, O. D., Rolff, H. C., Høyer-Hansen, G., Vainer, B., Osterlind, K. & Illemann, M., Aug 2015, In: Cancer Microenvironment. 8, 2, p. 93-100 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Microvessel density and endothelial cell proliferation levels in colorectal liver metastases from patients given neo-adjuvant cytotoxic chemotherapy and bevacizumab
Eefsen, R. L., Engelholm, Lars Henning, Willemoe, G. L., Van den Eynden, G. G., Laerum, O. D., Christensen, I. J., Rolff, H. C., Høyer-Hansen, G., Osterlind, K., Vainer, B. & Illemann, M., 1 Apr 2016, In: International Journal of Cancer. 138, 7, p. 1777-84 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hypomorphic expression of parathyroid Bmal1 disrupts the internal parathyroid circadian clock and increases parathyroid cell proliferation in response to uremia
Egstrand, S., Mace, M. L., Morevati, M., Nordholm, A., Engelholm, Lars Henning, Thomsen, J. S., Brüel, A., Naveh-Many, T., Guo, Y., Ølgaard, Klaus & Lewin, E., Jun 2022, In: Kidney International. 101, 6, p. 1232-1250 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The urokinase receptor associated protein (uPARAP/endo180): a novel internalization receptor connected to the plasminogen activation system
Engelholm, Lars Henning, Nielsen, B. S., Danø, K. & Behrendt, Niels, Jan 2001, In: Trends in Cardiovascular Medicine. 11, 1, p. 7-13 7 p.Research output: Contribution to journal › Review › Research › peer-review
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The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis
Engelholm, Lars Henning, Nielsen, B. S., Netzel-Arnett, S., Solberg, H., Chen, X. D., Lopez Garcia, J. M., López-Otín, C., Young, M. F., Birkedal-Hansen, H., Danø, K., Lund, L. R., Behrendt, Niels & Bugge, T. H., Oct 2001, In: Laboratory Investigation. 81, 10, p. 1403-14 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential binding of urokinase and peptide antagonists to the urokinase receptor: evidence from characterization of the receptor in four primate species
Engelholm, Lars Henning & Behrendt, Niels, Mar 2001, In: Biological Chemistry. 382, 3, p. 435-42 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Isolation and characterization of gene expression in non-metastasizing versus metastasizing human breast cancer cells
Engelholm, Lars Henning, Kiilgaard, Jens Folke, Frandsen, T. L. & Fuqua, S., 1 Dec 1997, In: Fibrinolysis and Proteolysis. 11, SUPPL. 3, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion
Engelholm, Lars Henning, List, K., Netzel-Arnett, S., Cukierman, E., Mitola, D. J., Aaronson, H., Kjøller, L., Larsen, J. K., Yamada, K. M., Strickland, D. K., Holmbeck, Kenn, Danø, K., Birkedal-Hansen, H., Behrendt, Niels & Bugge, T. H., 31 Mar 2003, In: Journal of Cell Biology. 160, 7, p. 1009-15 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The collagen receptor uPARAP/Endo180
Engelholm, Lars Henning, Ingvarsen, S., Jürgensen, Henrik Jessen, Hillig, T., Madsen, Daniel Hargbøl, Nielsen, B. S. & Behrendt, Niels, 1 Jan 2009, In: Frontiers in Bioscience. 14, p. 2103-14 12 p.Research output: Contribution to journal › Review › Research › peer-review
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Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180
Engelholm, Lars Henning, Carlsen Melander, E. M., Hald, A., Persson, M., Madsen, D. H., Jürgensen, Henrik Jessen, Johansson, K., Nielsen, C., Nørregaard, Kirstine Sandal, Ingvarsen, S. Z., Kjær, Andreas, Trovik, C. S., Lærum, O. D., Bugge, T. H., Eide, J. & Behrendt, Niels, Jan 2016, In: Journal of Pathology. 238, 1, p. 120-33 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The collagen receptor uPARAP/Endo180
Engelholm, Lars Henning, Ingvarsen, S., Jürgensen, H. J., Hillig, T., Madsen, D. H., Nielsen, B. S. & Behrendt, N., 2009, In: Frontiers in Bioscience. 14, p. 2103-2114 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1–Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma
Engelholm, Lars Henning, Riaz, A., Serra, Denise, Dagnæs-Hansen, F., Johansen, Jens Vilstrup, Santoni Rugiu, Eric, Hansen, S. H., Niola, Francesco & Frödin, Morten, 1 Dec 2017, In: Gastroenterology. 153, 6, p. 1662-1673.e10Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment
Fjæstad, K. Y., Rømer, A. M. A., Goitea, V., Johansen, A. Z., Thorseth, M. L., Carretta, M., Engelholm, Lars Henning, Grøntved, L., Junker, N. & Madsen, Daniel Hargbøl, 2022, In: Oncogene. 41, p. 1364-1375Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasminogen activator inhibitor type 1 (PAI-1) in cancer: A potential new target for antiinvasive and antimetastatic therapy
Frandsen, T. L., Stephens, R. W., Pedersen, A. N., Engelholm, Lars Henning, Holst-Hansen, C. & Brünner, N., Aug 1998, In: Drugs of the Future. 23, 8, p. 873-883 11 p.Research output: Contribution to journal › Review › Research › peer-review
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The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion
Frank, S. R., Köllmann, C. P., van Lidth de Jeude, J. F., Thiagarajah, J. R., Engelholm, Lars Henning, Frödin, Morten & Hansen, S. H., 30 Mar 2017, In: Oncogene. 36, 13, p. 1816-1828 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Targeted delivery of alcohol-containing payloads with antibody-drug conjugates
Grier, K. E., Hansen, A. H., Haxvig, C. S., Li, Xin, Krigslund, O., Behrendt, Niels, Engelholm, Lars Henning, Rossi, F., Sousa, B. C., Harradence, G. J., Camper, N. & Qvortrup, K. M., 2023, In: Chemical Communications. 59, 47, p. 7240-7242Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction
Gårdsvoll, Henrik, Jacobsen, B., Kriegbaum, M. C., Behrendt, Niels, Engelholm, Lars Henning, Østergaard, S. & Ploug, Michael, 23 Sep 2011, In: The Journal of Biological Chemistry. 286, 38, p. 33544-56 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 9647887
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Loss of miR-10a activates Lpo and collaborates with activated Wnt signaling in inducing intestinal Neoplasia in female mice
Research output: Contribution to journal › Journal article › Research › peer-review
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The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers
Research output: Contribution to journal › Journal article › Research › peer-review
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263
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CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1–Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma
Research output: Contribution to journal › Journal article › Research › peer-review
Published