Lars Henning Engelholm
Department of Clinical Medicine
Blegdamsvej 3
2200 2200 København N
Department of Biology
Ole Maaløes Vej 5
2200 2200 København N
- 1997
- Published
Differential gene expression in human mammary carcinoma cells: Identification of a new member of a receptor family
Schiemann, S., Rückels, M., Engelholm, Lars Henning, Schwirzke, M., Brünner, N. & Weidle, U. H., 1997, In: Anticancer Research. 17, 1 A, p. 13-20 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of a novel membrane protein that interacts specifically with the upar-prourokinase complex
Behrendt, Niels, Engelholm, Lars Henning, Jensen, O. N., Mörtz, E., Ranne, E., Mann, Matthias & Dan, K., 1997, In: Fibrinolysis and Proteolysis. 11, Supl. 3, p. 10 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Isolation and characterization of gene expression in non-metastasizing versus metastasizing human breast cancer cells
Engelholm, Lars Henning, Kiilgaard, Jens Folke, Frandsen, T. L. & Fuqua, S., 1 Dec 1997, In: Fibrinolysis and Proteolysis. 11, SUPPL. 3, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
- Published
Plasminogen activator inhibitor type 1 (PAI-1) in cancer: A potential new target for antiinvasive and antimetastatic therapy
Frandsen, T. L., Stephens, R. W., Pedersen, A. N., Engelholm, Lars Henning, Holst-Hansen, C. & Brünner, N., Aug 1998, In: Drugs of the Future. 23, 8, p. 873-883 11 p.Research output: Contribution to journal › Review › Research › peer-review
- 2000
A urokinase receptor-associated protein with specific collagen binding properties
Behrendt, Niels, Jensen, O. N., Engelholm, Lars Henning, Mørtz, E., Mann, Matthias & Danø, K., 2000, In: The Journal of Biological Chemistry. 275, 3, p. 1993-2002 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
The urokinase receptor associated protein (uPARAP/endo180): a novel internalization receptor connected to the plasminogen activation system
Engelholm, Lars Henning, Nielsen, B. S., Danø, K. & Behrendt, Niels, Jan 2001, In: Trends in Cardiovascular Medicine. 11, 1, p. 7-13 7 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Differential binding of urokinase and peptide antagonists to the urokinase receptor: evidence from characterization of the receptor in four primate species
Engelholm, Lars Henning & Behrendt, Niels, Mar 2001, In: Biological Chemistry. 382, 3, p. 435-42 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of two estrogen regulated genes associated with growth regulation of human breast cancer
Ohlsson, H., Brünner, N., Engelholm, Lars Henning, Lundholt, B. K., Weidle, U., Briand, P. & Lykkesfeldt, A. E., 20 Aug 2001, In: Molecular and Cellular Endocrinology. 182, 1, p. 1-11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis
Engelholm, Lars Henning, Nielsen, B. S., Netzel-Arnett, S., Solberg, H., Chen, X. D., Lopez Garcia, J. M., López-Otín, C., Young, M. F., Birkedal-Hansen, H., Danø, K., Lund, L. R., Behrendt, Niels & Bugge, T. H., Oct 2001, In: Laboratory Investigation. 81, 10, p. 1403-14 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Urokinase receptor-associated protein (uPARAP) is expressed in connection with malignant as well as benign lesions of the human breast and occurs in specific populations of stromal cells
Schnack Nielsen, B., Rank, F., Engelholm, Lars Henning, Holm, A., Danø, K. & Behrendt, Niels, 10 Apr 2002, In: International Journal of Cancer. Supplement. 98, 5, p. 656-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis
List, K., Haudenschild, C. C., Szabo, R., Chen, W., Wahl, S. M., Swaim, W., Engelholm, Lars Henning, Behrendt, Niels & Bugge, T. H., 23 May 2002, In: Oncogene. 21, 23, p. 3765-79 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion
Engelholm, Lars Henning, List, K., Netzel-Arnett, S., Cukierman, E., Mitola, D. J., Aaronson, H., Kjøller, L., Larsen, J. K., Yamada, K. M., Strickland, D. K., Holmbeck, Kenn, Danø, K., Birkedal-Hansen, H., Behrendt, Niels & Bugge, T. H., 31 Mar 2003, In: Journal of Cell Biology. 160, 7, p. 1009-15 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV
Kjøller, L., Engelholm, Lars Henning, Høyer-Hansen, M., Danø, K., Bugge, T. H. & Behrendt, Niels, 1 Feb 2004, In: Experimental Cell Research. 293, 1, p. 106-16 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy
Curino, A. C., Engelholm, Lars Henning, Yamada, S. S., Holmbeck, K., Lund, L. R., Molinolo, A. A., Behrendt, Niels, Nielsen, B. S. & Bugge, T. H., 2005, In: Journal of Cell Biology. 169, 6, p. 977-985 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer
Sulek, J., Wagenaar-Miller, R. A., Shireman, J., Molinolo, A., Madsen, Daniel Hargbøl, Engelholm, Lars Henning, Behrendt, Niels & Bugge, T. H., Apr 2007, In: Journal of Histochemistry and Cytochemistry. 55, 4, p. 347-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complementary roles of intracellular and pericellular collagen degradation pathways in vivo
Wagenaar-Miller, R. A., Engelholm, Lars Henning, Gavard, J., Yamada, S. S., Gutkind, J. S., Behrendt, Niels, Bugge, T. H. & Holmbeck, Kenn, Sep 2007, In: Molecular and Cellular Biology. 27, 18, p. 6309-22 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation
Madsen, Daniel Hargbøl, Engelholm, Lars Henning, Ingvarsen, S., Hillig, T., Wagenaar-Miller, R. A., Kjøller, L., Gårdsvoll, Henrik, Høyer-Hansen, G., Holmbeck, Kenn, Bugge, T. H. & Behrendt, Niels, 14 Sep 2007, In: The Journal of Biological Chemistry. 282, 37, p. 27037-45 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor
Hillig, T., Engelholm, Lars Henning, Ingvarsen, S., Madsen, Daniel Hargbøl, Gårdsvoll, Henrik, Larsen, J. K., Ploug, Michael, Danø, K., Kjøller, L. & Behrendt, Niels, 30 May 2008, In: Journal of Biological Chemistry. 283, 22, p. 15217-15223 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
The collagen receptor uPARAP/Endo180
Engelholm, Lars Henning, Ingvarsen, S., Jürgensen, H. J., Hillig, T., Madsen, D. H., Nielsen, B. S. & Behrendt, N., 2009, In: Frontiers in Bioscience. 14, p. 2103-2114 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The collagen receptor uPARAP/Endo180
Engelholm, Lars Henning, Ingvarsen, S., Jürgensen, Henrik Jessen, Hillig, T., Madsen, Daniel Hargbøl, Nielsen, B. S. & Behrendt, Niels, 1 Jan 2009, In: Frontiers in Bioscience. 14, p. 2103-14 12 p.Research output: Contribution to journal › Review › Research › peer-review
- 2010
Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation
Sugiyama, N., Varjosalo, M., Meller, P., Lohi, J., Hyytiäinen, M., Kilpinen, S., Kallioniemi, O., Ingvarsen, S., Engelholm, Lars Henning, Taipale, J., Alitalo, K., Keski-Oja, J. & Lehti, K., 15 Oct 2010, In: Accomplishments in Cancer Research. 70, 20, p. 7851-61 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uPARAP/ENDO 180
Jürgensen, Henrik Jessen, Madsen, Daniel Hargbøl, Ingvarsen, S., Melander, M. C., Gårdsvoll, Henrik, Patthy, L., Engelholm, Lars Henning & Behrendt, Niels, 2011, In: Journal of Biological Chemistry. 286, 37, p. 32736-48 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The non-phagocytic route of collagen uptake: a distinct degradation pathway
Madsen, Daniel Hargbøl, Ingvarsen, S., Jürgensen, Henrik Jessen, Melander, M. C., Kjøller, L., Moyer, A., Honoré, C., Madsen, M. C., Garred, Peter, Burgdorf, S., Bugge, T. H., Behrendt, Niels & Engelholm, Lars Henning, 29 Jul 2011, In: The Journal of Biological Chemistry. 286, 30, p. 26996-7010 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction
Gårdsvoll, Henrik, Jacobsen, B., Kriegbaum, M. C., Behrendt, Niels, Engelholm, Lars Henning, Østergaard, S. & Ploug, Michael, 23 Sep 2011, In: The Journal of Biological Chemistry. 286, 38, p. 33544-56 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo
Lund, I. K., Rasch, M. G., Ingvarsen, S., Pass, J., Madsen, Daniel Hargbøl, Engelholm, Lars Henning, Behrendt, Niels & Høyer-Hansen, G., 2012, In: Frontiers in Pharmacology. 3, p. 122Research output: Contribution to journal › Journal article › Research › peer-review
ID: 9647887
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Loss of miR-10a activates Lpo and collaborates with activated Wnt signaling in inducing intestinal Neoplasia in female mice
Research output: Contribution to journal › Journal article › Research › peer-review
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The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers
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CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1–Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma
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