Reidar Albrechtsen
Emeritus
Erler Group
Ole Maaløs Vej 5
2200 København N
Member of:
- 2023
- Published
ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy
Piotrowski, Kris, Puig Blasco, Laia, Samsøe-Petersen, Jacob, Eefsen, R. L., Illemann, M., Oria, Victor Oginga, Campos, K. I. A., Lopresti, Alexia Mélanie, Albrechtsen, Reidar, Sørensen, Claus Storgaard, Sun, X. F., Kveiborg, Marie & Gnosa, S., 2023, In: Cancer Gene Therapy. 30, p. 1369-1381 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Evaluation of commercially available glucagon receptor antibodies and glucagon receptor expression
Billeschou, Anna, Johansen, C. D., Christensen, J. B., Kjeldsen, Sasha Alexandra Sampson, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Serizawa, R., Hornum, Mads, Porrini, E., Pedersen, Jens, Ørskov, Cathrine, Gluud, Lise Lotte, Sorensen, Charlotte Mehlin, Holst, Jens Juul, Albrechtsen, Reidar & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Communications Biology . 5, 1, 13 p., 1278.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents
Christiansen, Charlotte Bayer, Trammell, Sam, Albrechtsen, Nicolai Jacob Wewer, Schoonjans, K., Albrechtsen, Reidar, Gillum, M. P., Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 5, p. G574-G584 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of ADAM12 as a Novel Basigin Sheddase
Albrechtsen, Reidar, Albrechtsen, Nicolai Jacob Wewer, Gnosa, S., Schwarz, J., Dyrskjøt, L. & Kveiborg, Marie, 2019, In: International Journal of Molecular Sciences . 20, 8, 14 p., 1957 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuromedin U Does Not Act as a Decretin in Rats
Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Ghiasi, S. M., Gabe, M. B. N., Skat-Rørdam, P. A., Modvig, Ida Marie, Mandrup-Poulsen, Thomas, Albrechtsen, Reidar, Rosenkilde, Mette, Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, In: Cell Metabolism. 29, 3, p. 719-726.e1-e5 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, Olav, Jepsen, Sara Lind, Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N. & 9 others, , Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the ApcMin model of colorectal cancer
Dombernowsky, S. L., Schwarz, J., Samsøe-Petersen, Jacob, Albrechtsen, Reidar, Jensen, Kim Bak, Thomas, G. & Kveiborg, Marie, 1 Jan 2017, In: OncoTarget. 8, 65, p. 108303-108315 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma
Albrechtsen, Nicolai Jacob Wewer, Hornburg, D., Albrechtsen, Reidar, Svendsen, B., Toräng, S., Jepsen, Sara Lind, Kuhre, Rune Ehrenreich, Hansen, M., Janus, C., Floyd, A., Lund, Asger Bach, Vilsbøll, Tina, Knop, Filip Krag, drb459, drb459, Deacon, Carolyn F., Meissner, F., Mann, Matthias, Holst, Jens Juul & Hartmann, Bolette, May 2016, In: EBioMedicine. 7, p. 112-120 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomic maps of breast cancer subtypes
Tyanova, S., Albrechtsen, Reidar, Kronqvist, P., Cox, J., Mann, Matthias & Geiger, T., 4 Jan 2016, In: Nature Communications. 7, 11 p., 10259.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes
Albrechtsen, Nicolai Jacob Wewer, Albrechtsen, Reidar, Bremholm, L., Svendsen, B., Kuhre, Rune Ehrenreich, Poulsen, Steen Seier, Christiansen, Charlotte Bayer, Jensen, E. P., Janus, C., Hilsted, Linda, Deacon, Carolyn F., Hartmann, Bolette & Holst, Jens Juul, 2016, In: Cell Reports. 17, 11, p. 2845-2856 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17
Dombernowsky, S. L., Samsøe-Petersen, Jacob, Petersen, C. H., Instrell, R., Hedegaard, A. B., Thomas, L., Atkins, K. M., Auclair, S., Albrechtsen, Reidar, Mygind, Kasper Johansen, Fröhlich, C., Howell, M., Parker, P., Thomas, G. & Kveiborg, Marie, 2015, In: Nature Communications. 6, p. 1-13 13 p., 7518.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth
Albrechtsen, Reidar, Kveiborg, Marie, Hansen, D. S., Vikeså, J., Noer, Julie Boertmann, Kotzsh, A., Nielsen, Finn Cilius, Wewer, Ulla M. & Frohlich, C., 15 Oct 2013, In: Journal of Cell Science. 126, 20, p. 4707-20 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ADAM12
Kveiborg, Marie, Fröhlich, C., Albrechtsen, Reidar & Wewer, Ulla M., 29 Aug 2013, Handbook of Proteolytic Enzymes. Elsevier, Vol. 1. p. 1114-1122 9 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins
Frohlich, C., Klitgaard, M., Noer, J. B., Kotzsch, A., Nehammer, C., Kronqvist, P., Berthelsen, J., Blobel, C., Kveiborg, Marie, Albrechtsen, Reidar & Wewer, Ulla M., 15 May 2013, In: Biochemical Journal. 452, 1, p. 97-109 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis
Madsen, Daniel Hargbøl, Jürgensen, Henrik Jessen, Ingvarsen, S., Melander, M. C., Albrechtsen, Reidar, Hald, A., Holmbeck, K., Bugge, T. H., Behrendt, Niels & Engelholm, Lars Henning, 2013, In: PloS one. 8, 8, p. e71261Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Cell-surface metalloprotease ADAM12 is internalized by a clathrin- and Grb2-dependent mechanism
Hansen, D. S., Leyme, A., Grandal, M. V., Albrechtsen, Reidar, van Deurs, B., Wewer, Ulla M. & Kveiborg, Marie, 2012, In: Traffic - International Journal of Intracellular Transport. 13, 11, p. 1532-46 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression
Frohlich, C., Nehammer, C., Albrechtsen, Reidar, Kronqvist, P., Kveiborg, Marie, Sehara-Fujisawa, A., Mercurio, A. M. & Wewer, Ulla M., 29 Aug 2011, In: Molecular Cancer Research.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity
Albrechtsen, Reidar, Hansen, D. S., Sanjay, A., Kveiborg, Marie & Wewer, Ulla M., 15 Jan 2011, In: Experimental Cell Research. 317, 2, p. 195-209 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity
Stautz, D., Sanjay, A., Hansen, M. T., Albrechtsen, Reidar, Wewer, Ulla M. & Kveiborg, Marie, 2010, In: Experimental Cell Research. 316, 1, p. 55-67Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Cellular roles of ADAM12 in health and disease.
Kveiborg, Marie, Albrechtsen, Reidar, Couchman, John Robert & Wewer, Ulla M., 2008, In: International Journal of Biochemistry & Cell Biology. 40, 9, p. 1685-702 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Heparan sulfate regulates ADAM12 through a molecular switch mechanism.
Sørensen, H. P., Vives, R. R., Manetopoulos, C., Albrechtsen, Reidar, Lydolph, M. C., Jacobsen, J., Couchman, John Robert & Wewer, Ulla M., 2008, In: Journal of Biological Chemistry.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme.
Wewer, Ulla M., Mörgelin, M., Holck, P., Jacobsen, J., Lydolph, M. C., Johnsen, A. H., Kveiborg, Marie & Albrechtsen, Reidar, 2006, In: Journal of Biological Chemistry. 281, 14, p. 9418-22 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ADAM12-S stimulates bone growth in transgenic mice by modulating chondrocyte proliferation and maturation.
Kveiborg, Marie, Albrechtsen, Reidar, Rudkjaer, L., Wen, G., Damgaard-Pedersen, K. & Wewer, Ulla M., 2006, In: Journal of Bone and Mineral Research. 21, 8, p. 1288-96 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular profiling of ADAM12 in human bladder cancer.
Albrechtsen, Reidar, Dyrskjøt, L., Rudkjaer, L., Ørntoft, T. F., Frohlich, C. & Wewer, Ulla M., 2006, In: Clinical Cancer Research. 12, 24, p. 7359-68 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
A role for ADAM12 in breast tumor progression and stromal cell apoptosis.
Kveiborg, Marie, Frohlich, C., Albrechtsen, Reidar, Tischler, V., Dietrich, N., Holck, P., Kronqvist, P., Rank, F., Mercurio, A. M. & Wewer, Ulla M., 2005, In: Cancer Research. 65, 11, p. 4754-61 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.
Thodeti, C. K., Frohlich, C., Nielsen, C. K., Takada, Y., Fässler, R., Albrechtsen, Reidar & Wewer, Ulla M., 2005, In: FEBS Letters. 579, 25, p. 5589-95 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hierarchy of ADAM12 binding to integrins in tumor cells.
Thodeti, C. K., Fröhlich, C., Nielsen, C. K., Holck, P., Sundberg, C., Kveiborg, Marie, Mahalingam, Y., Albrechtsen, Reidar, Couchman, John Robert & Wewer, Ulla M., 2005, In: Experimental Cell Research. 309, 2, p. 438-50 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Regulation of ADAM12 cell-surface expression by protein kinase C epsilon.
Sundberg, C., Thodeti, C. K., Kveiborg, Marie, Larsson, C., Parker, P., Albrechtsen, Reidar & Wewer, Ulla M., 2004, In: Journal of Biological Chemistry. 279, 49, p. 51601-11 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins
Moghadaszadeh, B., Albrechtsen, Reidar, Guo, L. T., Zaik, M., Kawaguchi, N., Borup, R. H., Kronqvist, P., Schroder, H. D., Davies, K. E., Voit, T., Nielsen, Finn Cilius, Engvall, E. & Wewer, Ulla M., 1 Oct 2003, In: Human Molecular Genetics. 12, 19, p. 2467-79 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function.
Kawaguchi, N., Sundberg, C., Kveiborg, Marie, Moghadaszadeh, B., Asmar, M., Dietrich, N., Thodeti, C. K., Nielsen, F. C., Möller, P., Mercurio, A. M., Albrechtsen, Reidar & Wewer, Ulla M., 2003, In: Journal of Cell Science. 116, Pt 19, p. 3893-904 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ADAM12: a novel first-trimester maternal serum marker for Down syndrome.
Laigaard, J., Sørensen, T., Fröhlich, C., Pedersen, B. N., Christiansen, M., Schiøtt, K., Uldbjerg, N., Albrechtsen, Reidar, Clausen, H. V., Ottesen, B. & Wewer, Ulla M., 2003, In: Prenatal Diagnosis. 23, 13, p. 1086-91 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alfa7 integrin, utrophin, and associated glycoproteins.
Moghadas Zadeh, S. B., Albrechtsen, Reidar, Guo, L. T., Zaik, M., Kawaguchi, N., Borup, R. H., Kronqvist, P. E., Schröder, H. D., Davies, K. E., Voit, T., Nielsen, F. C., Engvall, E. & Wewer, Ulla M., 2003, In: Human Molecular Genetics. 12, p. 2467-2479Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice
Kronqvist, P., Kawaguchi, N., Albrechtsen, Reidar, Xu, X., Schrøder, H. D., Moghadaszadeh, B., Nielsen, Finn Cilius, Frohlich, C., Engvall, E. & Wewer, Ulla M., 1 Nov 2002, In: American Journal of Pathology. 161, 5, p. 1535-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ADAM 12 alleviates the skeletal muscle 0pathology in mdx dystrophic mice
Kronqvist, P. E., Kawaguchi, N., Albrechtsen, Reidar, Xu, X., Schrøder, H. D., Moghadas Zadeh, S. B., Nielsen, F. C., Frohlich, L. C., Engvall, E. & Wewer, Ulla M., 2002, In: American Journal of Pathology. 161, p. 1535-1540Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ADAM 12 protease induces adipogenesis in transgenic mice.
Kawaguchi, N., Xu, X., Tajima, R., Kronqvist, P., Sundberg, C., Loechel, F., Albrechtsen, Reidar & Wewer, Ulla M., 2002, In: American Journal of Pathology. 160, 5, p. 1895-903 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
Thodeti, C. K., Albrechtsen, Reidar, Grauslund, M., Asmar, M., Larsson, C., Takada, Y., Mercurio, A. M., Couchman, John Robert & Wewer, Ulla M., 2002, In: Journal of Biological Chemistry. 278, 11, p. 9576-84 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tetranectin
Wewer, Ulla M. & Albrechtsen, Reidar, 2002, In: Wiley Encyclopedia of Molecular Medicine. 5, p. 3117-3118Research output: Contribution to journal › Journal article › Research
- 2001
- Published
Mice with a targeted deletion of the tetranectin gene exhibit a spinal deformity.
Iba, K., Durkin, M. E., Johnsen, L., Hunziker, E., Damgaard-Pedersen, K., Zhang, H., Engvall, E., Albrechtsen, Reidar & Wewer, Ulla M., 2001, In: Molecular and Cellular Biology. 21, 22, p. 7817-25 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of laminin beta2 chain gene expression in human cancer cell lines.
Durkin, M. E., Nielsen, F. C., Loechel, F., Albrechtsen, Reidar & Wewer, Ulla M., 2001, In: European Journal of Biochemistry. 268, 13, p. 3797-806 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tetranectin in slow intra- and extrafusal chicken muscle fibers.
Xu, X., Gilpin, B., Iba, K., Maier, A., Engvall, E., Albrechtsen, Reidar & Wewer, Ulla M., 2001, In: Journal of Muscle Research and Cell Motility. 22, 2, p. 121-32 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3.
Loechel, F., Fox, J. W., Murphy, G., Albrechtsen, Reidar & Wewer, Ulla M., 2000, In: Biochemical and Biophysical Research Communications. 278, 3, p. 511-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading.
Iba, K., Albrechtsen, Reidar, Gilpin, B., Frohlich, C., Loechel, F., Zolkiewska, A., Ishiguro, K., Kojima, T., Liu, W., Langford, J. K., Sanderson, R. D., Brakebusch, Cord Herbert, Fässler, R. & Wewer, Ulla M., 2000, In: Journal of Cell Biology. 149, 5, p. 1143-56 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trafficking of human ADAM 12-L: retention in the trans-Golgi network.
Hougaard, S., Loechel, F., Xu, X., Tajima, R., Albrechtsen, Reidar & Wewer, Ulla M., 2000, In: Biochemical and Biophysical Research Communications. 275, 2, p. 261-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
Characterization of the human laminin beta2 chain locus (LAMB2): linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS).
Durkin, M. E., Jäger, A. C., Khurana, T. S., Nielsen, F. C., Albrechtsen, Reidar & Wewer, Ulla M., 1999, In: Cytogenetic and Genome Research. 84, 3-4, p. 173-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion.
Iba, K., Albrechtsen, Reidar, Gilpin, B. J., Loechel, F. & Wewer, Ulla M., 1999, In: American Journal of Pathology. 154, 5, p. 1489-501 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of human ADAM 12 protease by the prodomain. Evidence for a functional cysteine switch.
Loechel, F., Overgaard, M. T., Oxvig, C., Albrechtsen, Reidar & Wewer, Ulla M., 1999, In: Journal of Biological Chemistry. 274, 19, p. 13427-33 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
- Published
A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo.
Gilpin, B. J., Loechel, F., Mattei, M. G., Engvall, E., Albrechtsen, Reidar & Wewer, Ulla M., 1998, In: Journal of Biological Chemistry. 273, 1, p. 157-66 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of Lama5 as a candidate for the mouse ragged (Ra) mutation.
Durkin, M. E., Albrechtsen, Reidar, Chambers, D. M., Abbott, C. M. & Wewer, Ulla M., 1998, In: Biochemical and Biophysical Research Communications. 250, 1, p. 125-30 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human ADAM 12 (meltrin alpha) is an active metalloprotease.
Loechel, F., Gilpin, B. J., Engvall, E., Albrechtsen, Reidar & Wewer, Ulla M., 1998, In: Journal of Biological Chemistry. 273, 27, p. 16993-7 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5394
Most downloads
-
390
downloads
Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
303
downloads
Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
259
downloads
Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the ApcMin model of colorectal cancer
Research output: Contribution to journal › Journal article › Research › peer-review
Published