Claus Storgaard Sørensen
Associate Professor, Professor
Sørensen Group
Ole Maaløes Vej 5, 2200 København N.
Member of:
- Published
ATM/ATR-mediated phosphorylation of PALB2 promotes RAD51 function
Ahlskog, J. K., Larsen, Brian Daniel, Achanta, K. & Sørensen, Claus Storgaard, May 2016, In: E M B O Reports. 17, 5, p. 671-81 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Deregulation of the RB pathway in human testicular germ cell tumours.
Bartkova, J., Lukas, C., Sørensen, Claus Storgaard, Meyts, E. R., Skakkebaek, N. E., Lukas, J. & Bartek, J., 2003, In: Journal of Pathology. 200, 2, p. 149-56 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High-throughput siRNA screens using gammaH2AX as marker uncover key regulators of genome integrity in mammalian cells
Beck, H., Menzel, T., Syljuåsen, R. G. & Sørensen, Claus Storgaard, 2010, In: Cell Cycle. 9, 12Research output: Contribution to journal › Journal article › Research › peer-review
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Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase
Beck, H., Nähse, V., Larsen, Marie Sofie Yoo, Groth, P., Clancy, T., Lees, M., Jørgensen, M., Helleday, T., Syljuåsen, R. G. & Sørensen, Claus Storgaard, 2010, In: Journal of Cell Biology. 188, 5, p. 629-38 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption
Beck, H., Nähse-Kumpf, V., Larsen, Marie Sofie Yoo, O'Hanlon, K. A., Patzke, S., Holmberg, Christian, Mejlvang, J., Groth, Anja, Nielsen, Olaf, Syljuåsen, R. G. & Sørensen, Claus Storgaard, 2012, In: Molecular and Cellular Biology. 32, 20, p. 4226-4236 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High-throughput siRNA screens using γH2AX as marker uncover key regulators of genome integrity in mammalian cells
Beck, H., Menzel, T., Syljuåsen, R. G. & Sørensen, Claus Storgaard, 15 Jun 2010, In: Cell Cycle. 9, 12, p. 2257-2258 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
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Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low-dose treatment of high-grade serous ovarian carcinoma
Benada, Jan, Bulanova, Daria, Azzoni, Violette Iridé Liliane, Petrosius, V., Ghazanfar, S., Wennerberg, Krister & Sørensen, Claus Storgaard, 2023, In: NAR Cancer. 5, 3, 13 p., zcad029.Research output: Contribution to journal › Journal article › Research › peer-review
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Self-inflicted DNA breaks in cell differentiation and cancer
Benada, Jan, Alsowaida, D., Megeney, L. A. & Sørensen, Claus Storgaard, 2023, In: Trends in Cell Biology. 33, 10, p. 850-859Research output: Contribution to journal › Journal article › Research › peer-review
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Overcoming Treatment Toxicity through Sequential Therapy
Benada, Jan, Ejlertsen, Bent Laursen & Sørensen, Claus Storgaard, 2019, In: Cancer Cell. 35, 6, p. 821-822 2 p.Research output: Contribution to journal › Journal article › Research
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Photochemotherapy Induces Interferon Type III Expression via STING Pathway
Biskup, E., Larsen, Brian Daniel, Rib, Leonor, Folkersen, L., Niazi, O., Kamstrup, M. R. & Sørensen, Claus Storgaard, 2020, In: Cells. 9, 11, p. 1-19Research output: Contribution to journal › Journal article › Research › peer-review
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A catalog of curated breast cancer genes
Bose, M., Benada, Jan, Thatte, Jayashree Vijay, Kinalis, S., Ejlertsen, Bent Laursen, Nielsen, Finn Cilius, Sørensen, Claus Storgaard & Rossing, Caroline Maria, 2022, In: Breast Cancer Research and Treatment. 191, p. 431-441Research output: Contribution to journal › Journal article › Research › peer-review
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FBH1: a new checkpoint factor
Boyer, A. & Sørensen, Claus Storgaard, 14 Aug 2015, In: OncoTarget. 6, 23, p. 19354-19355 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
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DNA replication and cancer: From dysfunctional replication origin activities to therapeutic opportunities
Boyer, A., Walter, D. & Sørensen, Claus Storgaard, Jun 2016, In: Seminars in Cancer Biology. 37-38, p. 16-25 10 p.Research output: Contribution to journal › Review › Research › peer-review
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The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis
Burkovics, P., Dome, L., Juhasz, S., Altmannova, V., Sebesta, M., Pacesa, M., Fugger, K., Sørensen, Claus Storgaard, Lee, M. Y. W. T., Haracska, L. & Krejci, L., 20 Apr 2016, In: Nucleic Acids Research. 44, 7, p. 3176-89 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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LEDGF (p75) promotes DNA-end resection and homologous recombination
Daugaard, M., Baude, A., Fugger, K., Povlsen, L. K., Beck, H., Sørensen, Claus Storgaard, Petersen, N. H. T., Sorensen, P. H. B., Lukas, Claudia, Bartek, J., Lukas, Jiri, Rohde, M. & Jaattela, Marja, Aug 2012, In: Nature Structural & Molecular Biology. 19, 8, p. 803-810 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exploiting replicative stress to treat cancer
Dobbelstein, M. & Sørensen, Claus Storgaard, Jun 2015, In: Nature Reviews. Drug Discovery. 14, 6, p. 405-23 19 p.Research output: Contribution to journal › Review › Research › peer-review
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WEE1 kinase limits CDK activities to safeguard DNA replication and mitotic entry
Elbæk, C. R., Petrosius, V. & Sørensen, Claus Storgaard, 2020, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 819-820, p. 1-6 6 p., 111694.Research output: Contribution to journal › Review › Research › peer-review
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WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
Elbæk, C. R., Petrosius, V., Benada, Jan, Erichsen, L., Damgaard, R. B. & Sørensen, Claus Storgaard, 2022, In: Cell Reports. 38, 3, 110261.Research output: Contribution to journal › Journal article › Research › peer-review
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Acute hydroxyurea-induced replication blockade results in replisome components disengagement from nascent DNA without causing fork collapse
Ercilla, A., Feu, S., Aranda, S., Llopis, A., Brynjólfsdóttir, S. H., Sørensen, Claus Storgaard, Toledo, L. I. & Agell, N., 2020, In: Cellular and molecular life sciences : CMLS. 77, p. 735–749Research output: Contribution to journal › Journal article › Research › peer-review
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FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress
Fugger, K., Chu, W. K., Haahr, P., Kousholt, A. N., Beck, H., Payne, M. J., Hanada, K., Hickson, Ian David & Sørensen, Claus Storgaard, 2013, In: Nature Communications. 4, p. 1423Research output: Contribution to journal › Journal article › Research › peer-review
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FBH1 Catalyzes Regression of Stalled Replication Forks
Fugger, K., Mistrik, M., Neelsen, K. J., Yao, Q., Zellweger, R., Kousholt, A. N., Haahr, Peter Thorlund, Chu, W. K., Bartek, J., Lopes, M., Hickson, Ian David & Sørensen, Claus Storgaard, 10 Mar 2015, In: Cell Reports.Research output: Contribution to journal › Journal article › Research › peer-review
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Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing
Galanos, P., Vougas, K., Walter, D., Polyzos, A., Maya-Mendoza, A., Haagensen, E. J., Kokkalis, A., Roumelioti, F-M., Gagos, S., Tzetis, M., Canovas, B., Igea, A., Ahuja, A. K., Zellweger, R., Havaki, S., Kanavakis, E., Kletsas, D., Roninson, I. B., Garbis, S. D., Lopes, M. & 7 others, , Jul 2016, In: Nature Cell Biology. 18, 7, p. 777-89 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability
Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N. N., Glytsou, C., Pateras, I. S., Swain, U., Souliotis, V. L., Georgakilas, A. G., Geacintov, N., Scorrano, L., Lukas, C., Lukas, J., Livneh, Z., Lygerou, Z., Chowdhury, D., Sørensen, C. S., Bartek, J. & 1 others, , 2018, In: Genome Biology (Online Edition). 19, p. 1-18 37.Research output: Contribution to journal › Journal article › Research › peer-review
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Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.
Gatei, M., Sloper, K., Sørensen, Claus Storgaard, Syljuäsen, R., Falck, J., Hobson, K., Savage, K., Lukas, J., Zhou, B., Bartek, J. & Khanna, K. K., 2003, In: Journal of Biological Chemistry. 278, 17, p. 14806-11 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
Green, A. C., Marttila, P., Kiweler, N., Chalkiadaki, C., Wiita, E., Cookson, V., Lesur, A., Eiden, K., Bernardin, F., Vallin, K. S. A., Borhade, S., Long, M., Ghahe, E. K., Jiménez-Alonso, J. J., Jemth, A-S., Loseva, O., Mortusewicz, O., Meyers, M., Viry, E., Johansson, A. I. & 14 others, , 2023, In: Nature Metabolism. 5, p. 642-659Research output: Contribution to journal › Journal article › Research › peer-review
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DNA repair rate and etoposide (VP16) resistance of tumor cell subpopulations derived from a single human small cell lung cancer.
Hansen, L. T., Lundin, C., Helleday, T., Poulsen, H. S., Sørensen, Claus Storgaard, Petersen, L. N. & Spang-Thomsen, M., 2003, In: Lung Cancer. 40, 2, p. 157-64 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1).
Hsu, J. Y., Reimann, J. D. R., Sørensen, Claus Storgaard, Lukas, J. & Jackson, P. K., 2002, In: Nature Cell Biology. 4, 5, p. 358-66 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP
Hühn, D., Kousholt, A. N., Sørensen, Claus Storgaard & Sartori, A. A., 2015, In: Oncogene. 0, p. 3977-3984 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Topokaryotyping demonstrates single cell variability and stress dependent variations in nuclear envelope associated domains
Jurisic, A., Robin, C., Tarlykov, P., Siggens, L., Schoell, B., Jauch, A., Ekwall, K., Sørensen, Claus Storgaard, Lipinski, M., Shoaib, Muhammad & Ogryzko, V., 2018, In: Nucleic Acids Research. 46, 22, p. 1-16 16 p., e135.Research output: Contribution to journal › Journal article › Research › peer-review
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SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
Jørgensen, S., Eskildsen, M., Fugger, K., Hansen, L., Larsen, Marie Sofie Yoo, Kousholt, A. N., Syljuåsen, R. G., Trelle, M. B., Jensen, O. N., Helin, K. & Sørensen, Claus Storgaard, 10 Jan 2011, In: Journal of Cell Biology. 192, 1, p. 43-54 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity
Jørgensen, S., Schotta, G. & Sørensen, Claus Storgaard, 1 Mar 2013, In: Nucleic Acids Research. 41, 5, p. 2797-806 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The histone methyltransferase SET8 is required for S-phase progression.
Jørgensen, S., Elvers, I., Trelle, M. B., Menzel, T., Eskildsen, M., Jensen, O. N., Helleday, T., Helin, K. & Sørensen, Claus Storgaard, 2008, In: Journal of Cell Biology. 179, 7, p. 1337-45 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control
Klein, D. K., Hoffmann, Saskia, Ahlskog, J. K., O'Hanlon, K., Quaas, M., Larsen, Brian Daniel, Rolland, B., Rösner, Heike Ilona, Walter, D., Kousholt, A. N., Menzel, T., Lees, M., Johansen, Jens Vilstrup, Rappsilber, J., Engeland, K. & Sørensen, Claus Storgaard, 2015, In: Nature Communications. 6, p. 5800Research output: Contribution to journal › Journal article › Research › peer-review
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CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation
Kousholt, A. N., Fugger, K., Hoffmann, S., Larsen, Brian Daniel, Menzel, T., Sartori, A. A. & Sørensen, Claus Storgaard, 2012, In: Journal of Cell Biology. 197, 7, p. 869-76 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pathways for genome integrity in G2 phase of the cell cycle
Kousholt, A. N., Menzel, T. & Sørensen, Claus Storgaard, 1 Jan 2012, In: Biomolecules. 2, 4, p. 579-607 29 p.Research output: Contribution to journal › Review › Research › peer-review
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DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation
Kwon, Y., Rösner, H., Zhao, W., Selemenakis, P., He, Z., Kawale, A. S., Katz, J. N., Rogers, C. M., Neal, F. E., Badamchi Shabestari, A., Petrosius, V., Singh, A. K., Joel, M. Z., Lu, L., Holloway, S. P., Burma, S., Mukherjee, B., Hromas, R., Mazin, A., Wiese, C. & 2 others, , 2023, In: Nature Communications. 14, 18 p., 432.Research output: Contribution to journal › Journal article › Research › peer-review
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Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity
Köpper, F., Bierwirth, C., Schön, M., Kunze, M., Elvers, I., Kranz, D., Saini, P., Menon, M. B., Walter, D., Sørensen, Claus Storgaard, Gaestel, M., Helleday, T., Schön, M. P. & Dobbelstein, M., 15 Oct 2013, In: PNAS Early Edition. 110, 42, p. 16856-61 6 p.Research output: Contribution to journal › Journal article › Research
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Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress
Larsen, Brian Daniel, Benada, Jan, Yung, P. Y. K., Bell, R. A. V., Pappas, G., Urban, V., Ahlskog, J. K., Kuo, T. T., Janscak, P., Megeney, L. A., Elsässer, S. J., Bartek, J. & Sørensen, Claus Storgaard, 2022, In: Science. 376, 6592, p. 476-483 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The caspase-activated DNase: apoptosis and beyond
Larsen, Brian Daniel & Sørensen, Claus Storgaard, Apr 2017, In: F E B S Journal. 284, 8, p. 1160-1170 11 p.Research output: Contribution to journal › Review › Research › peer-review
Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex.
Lukas, C., Sørensen, Claus Storgaard, Kramer, E., Santoni Rugiu, Eric, Lindeneg, C., Peters, J. M., Bartek, J. & Lukas, J., 1999, In: Nature. 401, 6755, p. 815-8 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression.
Lukas, C., Kramer, E. R., Peters, J. M., Bartek, J., Lukas, J. & Sørensen, Claus Storgaard, 2001, In: Molecular and Cellular Biology. 21, 11, p. 3692-703 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis.
Lukas, C., Kramer, E. R., Peters, J. M., Bartek, J., Lukas, J. & Sørensen, Claus Storgaard, 2000, In: Molecular and Cellular Biology. 20, 20, p. 7613-23 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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p16INK4a, but not constitutively active pRb, can impose a sustained G1 arrest: molecular mechanisms and implications for oncogenesis.
Lukas, J., Sørensen, Claus Storgaard, Lukas, C., Santoni Rugiu, Eric & Bartek, J., 1999, In: Oncogene. 18, 27, p. 3930-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Echocardiography in the initial assessment of patients with small cell lung cancer
Mackintosh, J. F., Hawson, G. A. T. & Sørensen, Claus Storgaard, 1 Jan 1990, In: Cancer Journal. 3, 5, p. 248-251 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1 and the NAMPT-NAD+ pathway
Maynard, S., Hall, A., Galanos, P., Rizza, S., Yamamoto, T., Gram, H. H., Munk, S. H. N., Shoaib, Muhammad, Sørensen, Claus Storgaard, Bohr, Vilhelm, Lerdrup, Mads, Maya-Mendoza, A. & Bartek, J., 2022, In: Nucleic Acids Research. 50, 17, p. 9948-9965 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
Melixetian, M., Helin, K., Klein, D. K. & Sørensen, Claus Storgaard, 1 Jan 2009, In: Nature Cell Biology. 11, 10, p. 1247-1253 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance
Menzel, T., Nähse-Kumpf, V., Kousholt, A. N., Klein, D. K., Lund-Andersen, C., Lees, M., Johansen, Jens Vilstrup, Syljuåsen, R. G. & Sørensen, Claus Storgaard, 1 Jan 2011, In: E M B O Reports. 12, 7, p. 705-12 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair
Nair, Nidhi, Shoaib, Muhammad & Sørensen, Claus Storgaard, 10 Jul 2017, In: International Journal of Molecular Sciences. 18, 7, 21 p., 1486.Research output: Contribution to journal › Review › Research › peer-review
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Hereditary breast and ovarian cancer: new genes in confined pathways
Nielsen, Finn Cilius, Hansen, T. V. O. & Sørensen, Claus Storgaard, Sep 2016, In: Nature Reviews. Cancer. 16, 9, p. 599-612 14 p.Research output: Contribution to journal › Review › Research › peer-review
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Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select
Niu, Yiyuan, Ferreira Azevedo, Catarina A, Li, Xin, Kamali, E., Nielsen, Ole Haagen, Sørensen, Claus Storgaard & Frödin, Morten, 2022, In: Nature Genetics. 54, 28 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 10867
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Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair
Research output: Contribution to journal › Review › Research › peer-review
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244
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Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing
Research output: Contribution to journal › Journal article › Research › peer-review
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175
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Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability
Research output: Contribution to journal › Journal article › Research › peer-review
Published