Henrik Gårdsvoll

Henrik Gårdsvoll

Senior researcher

  • Behrendt Group

    Københavns Universitet, BRIC, Ole Maaløes Vej 5

    2200 København N

    Phone: +4535456038

Publication year:
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1 - 41 out of 41Page size: 100
  1. 2022
  2. Published

    The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1

    Nørregaard, Kirstine Sandal, Jürgensen, Henrik Jessen, Ingvarsen, S. Z., Heltberg, S. S., Hagensen, C. E., Gårdsvoll, Henrik, Madsen, D. H., Jensen, O. N., Engelholm, Lars Henning & Behrendt, Niels, 2022, In: Matrix Biology. 111, p. 307-328 22 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2021
  4. Published

    Osteosarcoma and metastasis associated bone degradation—a tale of osteoclast and malignant cell cooperativity

    Nørregaard, Kirstine Sandal, Jürgensen, Henrik Jessen, Gårdsvoll, Henrik, Engelholm, Lars Henning, Behrendt, Niels & Søe, K., 2021, In: International Journal of Molecular Sciences. 22, 13, 6865.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target

    Cakilkaya, Pinar, Sørensen, R. R., Jürgensen, Henrik Jessen, Krigslund, O., Gårdsvoll, Henrik, Nielsen, C. F., Santoni Rugiu, Eric, Behrendt, Niels & Engelholm, Lars Henning, 2021, In: International Journal of Molecular Sciences. 22, 21, 17 p., 11452.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2020
  7. Published

    Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/α-neurotoxin Domain

    Jiang, Y., Lin, L., Chen, S., Jiang, L., Kriegbaum, M. C., Gårdsvoll, Henrik, Hansen, L. V., Li, J., Ploug, Michael, Yuan, C. & Huang, M., 2020, In: International Journal of Biological Sciences. 16, 6, p. 981-993 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis

    Ingvarsen, S. Z., Gårdsvoll, Henrik, van Putten, Sander Maarten, Nørregaard, Kirstine Sandal, Krigslund, O., Meilstrup, Josephine Amalie, Tran, C., Jürgensen, Henrik Jessen, Melander, M. C., Nielsen, Carsten Haagen, Kjær, Andreas, Bugge, T. H., Engelholm, Lars Henning & Behrendt, Niels, 2020, In: Scientific Reports. 10, 1, p. 1-16 19138.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 2017
  10. Published

    Expression and crystallographic studies of the D1D2 domains of C4.4A, a homologous protein to the urokinase receptor

    Chen, S., Lin, L., Yuan, C., Gårdsvoll, Henrik, Kriegbaum, M. C., Ploug, Michael & Huang, M., 1 Aug 2017, In: Acta Crystallographica Section F: Structural Biology Communications. 73, 8, p. 486-490 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers

    Nielsen, C. F., van Putten, S. M., Lund, I. K., Melander, M. C., Nørregaard, Kirstine Sandal, Jürgensen, Henrik Jessen, Reckzeh, K., Christensen, K. R., Ingvarsen, S. Z., Gårdsvoll, Henrik, Jensen, K. E., Hamerlik, P., Engelholm, Lars Henning & Behrendt, Niels, 2017, In: OncoTarget. 8, 27, p. 44605-44624 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 2016
  13. Published

    The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

    Mysling, S., Kristensen, K. K., Larsson, M., Beigneux, A. P., Gårdsvoll, Henrik, Fong, L. G., Bensadouen, A., Jørgensen, T. J. D., Young, S. G. & Ploug, Michael, 2016, In: eLife. 5, 24 p., e12095.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. 2015
  15. Published

    Mapping the topographic epitope landscape on the urokinase plasminogen activator receptor (uPAR) by surface plasmon resonance and X-ray crystallography

    Zhao, B., Gandhi, S., Yuan, C., Luo, Z., Li, R., Gårdsvoll, Henrik, de Lorenzi, V., Sidenius, N., Huang, M. & Ploug, Michael, Dec 2015, In: Data in Brief. 5, p. 107-13 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Urokinase receptor cleavage correlates with tumor volume in a transgenic mouse model of breast cancer

    Thurison, T., Almholt, K., Gårdsvoll, Henrik, Ploug, Michael, Høyer-Hansen, G. & Lund, I. K., 25 Mar 2015, In: Molecular Carcinogenesis.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Stabilizing a Flexible Interdomain Hinge Region Harboring the SMB Binding Site Drives uPAR into Its Closed Conformation

    Zhao, B., Gandhi, S., Yuan, C., Luo, Z., Li, R., Gårdsvoll, Henrik, de Lorenzi, V., Sidenius, N., Huang, M. & Ploug, Michael, Mar 2015, In: Journal of Molecular Biology. 427, 6B, p. 1389-1403 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    GPIHBP1 Missense Mutations Often Cause Multimerization of GPIHBP1 and Thereby Prevent Lipoprotein Lipase Binding

    Beigneux, A. P., Fong, L. G., Bensadoun, A., Davies, B. S., Oberer, M., Gårdsvoll, Henrik, Ploug, Michael & Young, S. G., 2015, In: Circulation Research. 116, 4, p. 624-632 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. 2013
  20. Published

    The urokinase receptor homolog Haldisin is a novel differentiation marker of stratum granulosum in squamous epithelia

    Gårdsvoll, Henrik, Kriegbaum, M. C., Hertz, Emil Peter Thrane, Alpízar-Alpízar, W. & Ploug, Michael, Nov 2013, In: Journal of Histochemistry and Cytochemistry. 61, 11, p. 802-13 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis

    Ingvarsen, S., Porse, A., Erpicum, C., Maertens, L., Jürgensen, H. J., Madsen, Daniel Hargbøl, Melander, M. C., Gårdsvoll, Henrik, Høyer-Hansen, G., Noel, A., Holmbeck, K., Engelholm, Lars Henning & Behrendt, Niels, 12 Apr 2013, In: Journal of Biological Chemistry. 288, 15, p. 10195-204 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. 2012
  23. Published

    Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism

    Botkjaer, K. A., Deryugina, E. I., Dupont, D. M., Gårdsvoll, Henrik, Bekes, E. M., Thuesen, C. K., Chen, Z., Chen, Z., Ploug, Michael, Quigley, J. P. & Andreasen, P. A., Dec 2012, In: Molecular cancer research : MCR. 10, 12, p. 1532-43 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Erratum: Crystal structure of the urokinase receptor in a ligand-free form (Journal of Molecular Biology (2012) 416 (629-641))

    Xu, X., Gårdsvoll, Henrik, Yuan, C., Lin, L., Ploug, Michael & Huang, M., 7 Sep 2012, In: Journal of Molecular Biology. 422, 1, 1 p.

    Research output: Contribution to journal › Comment/debate › Research

  25. Published

    Crystal structure of the urokinase receptor in a ligand-free form

    Xu, X., Gårdsvoll, Henrik, Yuan, C., Lin, L., Ploug, Michael & Huang, M., 9 Mar 2012, In: Journal of Molecular Biology. 416, 5, p. 629-41 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. 2011
  27. Published

    Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut

    Ghosh, A. K., Coppens, I., Gårdsvoll, Henrik, Ploug, Michael & Jacobs-Lorena, M., 11 Oct 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17153-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction

    Gårdsvoll, Henrik, Jacobsen, B., Kriegbaum, M. C., Behrendt, Niels, Engelholm, Lars Henning, Østergaard, S. & Ploug, Michael, 23 Sep 2011, In: The Journal of Biological Chemistry. 286, 38, p. 33544-56 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uPARAP/ENDO 180

    Jürgensen, Henrik Jessen, Madsen, Daniel Hargbøl, Ingvarsen, S., Melander, M. C., Gårdsvoll, Henrik, Patthy, L., Engelholm, Lars Henning & Behrendt, Niels, 2011, In: Journal of Biological Chemistry. 286, 37, p. 32736-48 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor

    Gårdsvoll, Henrik, Kjærgaard, M., Jacobsen, B., Kriegbaum, M. C., Huang, M. & Ploug, Michael, 2011, In: Journal of Biological Chemistry. 286, 50, p. 43515-26 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. 2010
  32. Published

    Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation

    Connolly, B. M., Choi, E. Y., Gårdsvoll, Henrik, Bey, A. L., Currie, B. M., Chavakis, T., Liu, S., Molinolo, A., Ploug, Michael, Leppla, S. H. & Bugge, T. V., 2 Sep 2010, In: Blood Weekly. 116, 9, p. 1593-603 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Purification and characterization of recombinant full-length and protease domain of murine MMP-9 expressed in Drosophila S2 cells

    Rasch, M. G., Lund, I. K., Illemann, M., Høyer-Hansen, G. & Gårdsvoll, Henrik, 1 Jul 2010, In: Protein Expression and Purification. 72, 1, p. 87-94 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy

    Lin, L., Gårdsvoll, Henrik, Huai, Q., Huang, M. & Ploug, Michael, 2 Apr 2010, In: Journal of Biological Chemistry. 285, 14, p. 10982-92 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. 2009
  36. Published

    Interactions of plasminogen activator inhibitor-1 with vitronectin involve an extensive binding surface and induce mutual conformational rearrangements

    Blouse, G. E., Dupont, D. M., Schar, C. R., Jensen, J. K., Minor, K. H., Anagli, J. Y., Gårdsvoll, Henrik, Ploug, Michael, Peterson, C. B. & Andreasen, P. A., 3 Mar 2009, In: Biochemistry. 48, 8, p. 1723-35 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. 2008
  38. Published

    A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor

    Hillig, T., Engelholm, Lars Henning, Ingvarsen, S., Madsen, Daniel Hargbøl, Gårdsvoll, Henrik, Larsen, J. K., Ploug, Michael, Danø, K., Kjøller, L. & Behrendt, Niels, 30 May 2008, In: Journal of Biological Chemistry. 283, 22, p. 15217-15223 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. 2007

  40. Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation

    Madsen, Daniel Hargbøl, Engelholm, Lars Henning, Ingvarsen, S., Hillig, T., Wagenaar-Miller, R. A., Kjøller, L., Gårdsvoll, Henrik, Høyer-Hansen, G., Holmbeck, Kenn, Bugge, T. H. & Behrendt, Niels, 14 Sep 2007, In: The Journal of Biological Chemistry. 282, 37, p. 27037-45 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Mapping of the vitronectin-binding site on the urokinase receptor: involvement of a coherent receptor interface consisting of residues from both domain I and the flanking interdomain linker region

    Gårdsvoll, Henrik & Ploug, Michael, 4 May 2007, In: The Journal of Biological Chemistry. 282, 18, p. 13561-72 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    A new tagging system for production of recombinant proteins in Drosophila S2 cells using the third domain of the urokinase receptor

    Gårdsvoll, Henrik, Hansen, L. V., Jørgensen, Thomas & Ploug, Michael, Apr 2007, In: Protein Expression and Purification. 52, 2, p. 384-94 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. One-step affinity purification of recombinant urokinase-type plasminogen activator receptor using a synthetic peptide developed by combinatorial chemistry

    Jacobsen, B., Gårdsvoll, Henrik, Juhl Funch, G., Ostergaard, S., Barkholt, V. & Ploug, Michael, Apr 2007, In: Protein Expression and Purification. 52, 2, p. 286-96 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. 2006
  45. Published

    Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking

    Gårdsvoll, Henrik, Gilquin, B., Le Du, M. H., Ménèz, A., Jørgensen, Thomas & Ploug, Michael, 14 Jul 2006, In: The Journal of Biological Chemistry. 281, 28, p. 19260-72 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. 2005
  47. Published

    Collisional activation by MALDI tandem time-of-flight mass spectrometry induces intramolecular migration of amide hydrogens in protonated peptides

    Jørgensen, Thomas, Bache, N., Roepstorff, P., Gårdsvoll, Henrik & Ploug, Michael, Dec 2005, In: Molecular and Cellular Proteomics. 4, 12, p. 1910-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide

    Llinas, P., Le Du, M. H., Gårdsvoll, Henrik, Danø, K., Ploug, Michael, Gilquin, B., Stura, E. A. & Ménèz, A., 4 May 2005, In: E M B O Journal. 24, 9, p. 1655-63 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Intramolecular migration of amide hydrogens in protonated peptides upon collisional activation

    Jørgensen, Thomas, Gårdsvoll, Henrik, Ploug, Michael & Roepstorff, P., 2 Mar 2005, In: Journal of the American Chemical Society. 127, 8, p. 2785-93 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. 2004
  51. Published

    Dynamics of urokinase receptor interaction with Peptide antagonists studied by amide hydrogen exchange and mass spectrometry

    Jørgensen, Thomas, Gårdsvoll, Henrik, Danø, K., Roepstorff, P. & Ploug, Michael, 30 Nov 2004, In: Biochemistry. 43, 47, p. 15044-57 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Specific immunoassays for detection of intact and cleaved forms of the urokinase receptor

    Piironen, T., Laursen, B., Pass, J., List, K., Gårdsvoll, Henrik, Ploug, Michael, Danø, K. & Høyer-Hansen, G., Nov 2004, In: Clinical Chemistry. 50, 11, p. 2059-68 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor

    Hansen, L. V., Gårdsvoll, Henrik, Nielsen, B. S., Lund, L. R., Danø, K., Jensen, O. N. & Ploug, Michael, 15 Jun 2004, In: Biochemical Journal. 380, Pt 3, p. 845-57 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites

    Gårdsvoll, Henrik, Werner, F., Søndergaard, Leif, Danø, K. & Ploug, Michael, 2004, In: Protein Expression and Purification. 34, 2, p. 284-295 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. 2002

  56. Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy

    Ploug, Michael, Gårdsvoll, Henrik, Jørgensen, T. J. D., Lønborg Hansen, L. & Danø, K., Apr 2002, In: Biochemical Society Transactions. 30, 2, p. 177-183 7 p.

    Research output: Contribution to journal › Review › Research › peer-review

  57. 2001

  58. Peptide-derived antagonists of the urokinase receptor. Affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation

    Ploug, Michael, Østergaard, S., Gårdsvoll, Henrik, Kovalski, K., Holst-Hansen, C., Holm, A., Ossowski, L. & Danø, K., 9 Oct 2001, In: Biochemistry. 40, 40, p. 12157-68 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. 1999

  60. Mapping part of the functional epitope for ligand binding on the receptor for urokinase-type plasminogen activator by site-directed mutagenesis

    Gårdsvoll, Henrik, Danø, K. & Ploug, Michael, 31 Dec 1999, In: The Journal of Biological Chemistry. 274, 53, p. 37995-8003 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 33970502