Henrik Gårdsvoll
Senior researcher
Behrendt Group
Københavns Universitet, BRIC, Ole Maaløes Vej 5
2200 København N
- 2022
- Published
The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1
Nørregaard, Kirstine Sandal, Jürgensen, Henrik Jessen, Ingvarsen, S. Z., Heltberg, S. S., Hagensen, C. E., Gårdsvoll, Henrik, Madsen, D. H., Jensen, O. N., Engelholm, Lars Henning & Behrendt, Niels, 2022, In: Matrix Biology. 111, p. 307-328 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Osteosarcoma and metastasis associated bone degradation—a tale of osteoclast and malignant cell cooperativity
Nørregaard, Kirstine Sandal, Jürgensen, Henrik Jessen, Gårdsvoll, Henrik, Engelholm, Lars Henning, Behrendt, Niels & Søe, K., 2021, In: International Journal of Molecular Sciences. 22, 13, 6865.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target
Cakilkaya, Pinar, Sørensen, R. R., Jürgensen, Henrik Jessen, Krigslund, O., Gårdsvoll, Henrik, Nielsen, C. F., Santoni Rugiu, Eric, Behrendt, Niels & Engelholm, Lars Henning, 2021, In: International Journal of Molecular Sciences. 22, 21, 17 p., 11452.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/α-neurotoxin Domain
Jiang, Y., Lin, L., Chen, S., Jiang, L., Kriegbaum, M. C., Gårdsvoll, Henrik, Hansen, L. V., Li, J., Ploug, Michael, Yuan, C. & Huang, M., 2020, In: International Journal of Biological Sciences. 16, 6, p. 981-993 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis
Ingvarsen, S. Z., Gårdsvoll, Henrik, van Putten, Sander Maarten, Nørregaard, Kirstine Sandal, Krigslund, O., Meilstrup, Josephine Amalie, Tran, C., Jürgensen, Henrik Jessen, Melander, M. C., Nielsen, Carsten Haagen, Kjær, Andreas, Bugge, T. H., Engelholm, Lars Henning & Behrendt, Niels, 2020, In: Scientific Reports. 10, 1, p. 1-16 19138.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Expression and crystallographic studies of the D1D2 domains of C4.4A, a homologous protein to the urokinase receptor
Chen, S., Lin, L., Yuan, C., Gårdsvoll, Henrik, Kriegbaum, M. C., Ploug, Michael & Huang, M., 1 Aug 2017, In: Acta Crystallographica Section F: Structural Biology Communications. 73, 8, p. 486-490 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers
Nielsen, C. F., van Putten, S. M., Lund, I. K., Melander, M. C., Nørregaard, Kirstine Sandal, Jürgensen, Henrik Jessen, Reckzeh, K., Christensen, K. R., Ingvarsen, S. Z., Gårdsvoll, Henrik, Jensen, K. E., Hamerlik, P., Engelholm, Lars Henning & Behrendt, Niels, 2017, In: OncoTarget. 8, 27, p. 44605-44624 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain
Mysling, S., Kristensen, K. K., Larsson, M., Beigneux, A. P., Gårdsvoll, Henrik, Fong, L. G., Bensadouen, A., Jørgensen, T. J. D., Young, S. G. & Ploug, Michael, 2016, In: eLife. 5, 24 p., e12095.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Mapping the topographic epitope landscape on the urokinase plasminogen activator receptor (uPAR) by surface plasmon resonance and X-ray crystallography
Zhao, B., Gandhi, S., Yuan, C., Luo, Z., Li, R., Gårdsvoll, Henrik, de Lorenzi, V., Sidenius, N., Huang, M. & Ploug, Michael, Dec 2015, In: Data in Brief. 5, p. 107-13 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Urokinase receptor cleavage correlates with tumor volume in a transgenic mouse model of breast cancer
Thurison, T., Almholt, K., Gårdsvoll, Henrik, Ploug, Michael, Høyer-Hansen, G. & Lund, I. K., 25 Mar 2015, In: Molecular Carcinogenesis.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stabilizing a Flexible Interdomain Hinge Region Harboring the SMB Binding Site Drives uPAR into Its Closed Conformation
Zhao, B., Gandhi, S., Yuan, C., Luo, Z., Li, R., Gårdsvoll, Henrik, de Lorenzi, V., Sidenius, N., Huang, M. & Ploug, Michael, Mar 2015, In: Journal of Molecular Biology. 427, 6B, p. 1389-1403 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPIHBP1 Missense Mutations Often Cause Multimerization of GPIHBP1 and Thereby Prevent Lipoprotein Lipase Binding
Beigneux, A. P., Fong, L. G., Bensadoun, A., Davies, B. S., Oberer, M., Gårdsvoll, Henrik, Ploug, Michael & Young, S. G., 2015, In: Circulation Research. 116, 4, p. 624-632 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
The urokinase receptor homolog Haldisin is a novel differentiation marker of stratum granulosum in squamous epithelia
Gårdsvoll, Henrik, Kriegbaum, M. C., Hertz, Emil Peter Thrane, Alpízar-Alpízar, W. & Ploug, Michael, Nov 2013, In: Journal of Histochemistry and Cytochemistry. 61, 11, p. 802-13 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis
Ingvarsen, S., Porse, A., Erpicum, C., Maertens, L., Jürgensen, H. J., Madsen, Daniel Hargbøl, Melander, M. C., Gårdsvoll, Henrik, Høyer-Hansen, G., Noel, A., Holmbeck, K., Engelholm, Lars Henning & Behrendt, Niels, 12 Apr 2013, In: Journal of Biological Chemistry. 288, 15, p. 10195-204 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism
Botkjaer, K. A., Deryugina, E. I., Dupont, D. M., Gårdsvoll, Henrik, Bekes, E. M., Thuesen, C. K., Chen, Z., Chen, Z., Ploug, Michael, Quigley, J. P. & Andreasen, P. A., Dec 2012, In: Molecular cancer research : MCR. 10, 12, p. 1532-43 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erratum: Crystal structure of the urokinase receptor in a ligand-free form (Journal of Molecular Biology (2012) 416 (629-641))
Xu, X., Gårdsvoll, Henrik, Yuan, C., Lin, L., Ploug, Michael & Huang, M., 7 Sep 2012, In: Journal of Molecular Biology. 422, 1, 1 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Crystal structure of the urokinase receptor in a ligand-free form
Xu, X., Gårdsvoll, Henrik, Yuan, C., Lin, L., Ploug, Michael & Huang, M., 9 Mar 2012, In: Journal of Molecular Biology. 416, 5, p. 629-41 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut
Ghosh, A. K., Coppens, I., Gårdsvoll, Henrik, Ploug, Michael & Jacobs-Lorena, M., 11 Oct 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17153-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction
Gårdsvoll, Henrik, Jacobsen, B., Kriegbaum, M. C., Behrendt, Niels, Engelholm, Lars Henning, Østergaard, S. & Ploug, Michael, 23 Sep 2011, In: The Journal of Biological Chemistry. 286, 38, p. 33544-56 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uPARAP/ENDO 180
Jürgensen, Henrik Jessen, Madsen, Daniel Hargbøl, Ingvarsen, S., Melander, M. C., Gårdsvoll, Henrik, Patthy, L., Engelholm, Lars Henning & Behrendt, Niels, 2011, In: Journal of Biological Chemistry. 286, 37, p. 32736-48 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor
Gårdsvoll, Henrik, Kjærgaard, M., Jacobsen, B., Kriegbaum, M. C., Huang, M. & Ploug, Michael, 2011, In: Journal of Biological Chemistry. 286, 50, p. 43515-26 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation
Connolly, B. M., Choi, E. Y., Gårdsvoll, Henrik, Bey, A. L., Currie, B. M., Chavakis, T., Liu, S., Molinolo, A., Ploug, Michael, Leppla, S. H. & Bugge, T. V., 2 Sep 2010, In: Blood Weekly. 116, 9, p. 1593-603 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Purification and characterization of recombinant full-length and protease domain of murine MMP-9 expressed in Drosophila S2 cells
Rasch, M. G., Lund, I. K., Illemann, M., Høyer-Hansen, G. & Gårdsvoll, Henrik, 1 Jul 2010, In: Protein Expression and Purification. 72, 1, p. 87-94 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy
Lin, L., Gårdsvoll, Henrik, Huai, Q., Huang, M. & Ploug, Michael, 2 Apr 2010, In: Journal of Biological Chemistry. 285, 14, p. 10982-92 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Interactions of plasminogen activator inhibitor-1 with vitronectin involve an extensive binding surface and induce mutual conformational rearrangements
Blouse, G. E., Dupont, D. M., Schar, C. R., Jensen, J. K., Minor, K. H., Anagli, J. Y., Gårdsvoll, Henrik, Ploug, Michael, Peterson, C. B. & Andreasen, P. A., 3 Mar 2009, In: Biochemistry. 48, 8, p. 1723-35 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor
Hillig, T., Engelholm, Lars Henning, Ingvarsen, S., Madsen, Daniel Hargbøl, Gårdsvoll, Henrik, Larsen, J. K., Ploug, Michael, Danø, K., Kjøller, L. & Behrendt, Niels, 30 May 2008, In: Journal of Biological Chemistry. 283, 22, p. 15217-15223 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation
Madsen, Daniel Hargbøl, Engelholm, Lars Henning, Ingvarsen, S., Hillig, T., Wagenaar-Miller, R. A., Kjøller, L., Gårdsvoll, Henrik, Høyer-Hansen, G., Holmbeck, Kenn, Bugge, T. H. & Behrendt, Niels, 14 Sep 2007, In: The Journal of Biological Chemistry. 282, 37, p. 27037-45 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping of the vitronectin-binding site on the urokinase receptor: involvement of a coherent receptor interface consisting of residues from both domain I and the flanking interdomain linker region
Gårdsvoll, Henrik & Ploug, Michael, 4 May 2007, In: The Journal of Biological Chemistry. 282, 18, p. 13561-72 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A new tagging system for production of recombinant proteins in Drosophila S2 cells using the third domain of the urokinase receptor
Gårdsvoll, Henrik, Hansen, L. V., Jørgensen, Thomas & Ploug, Michael, Apr 2007, In: Protein Expression and Purification. 52, 2, p. 384-94 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
One-step affinity purification of recombinant urokinase-type plasminogen activator receptor using a synthetic peptide developed by combinatorial chemistry
Jacobsen, B., Gårdsvoll, Henrik, Juhl Funch, G., Ostergaard, S., Barkholt, V. & Ploug, Michael, Apr 2007, In: Protein Expression and Purification. 52, 2, p. 286-96 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking
Gårdsvoll, Henrik, Gilquin, B., Le Du, M. H., Ménèz, A., Jørgensen, Thomas & Ploug, Michael, 14 Jul 2006, In: The Journal of Biological Chemistry. 281, 28, p. 19260-72 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Collisional activation by MALDI tandem time-of-flight mass spectrometry induces intramolecular migration of amide hydrogens in protonated peptides
Jørgensen, Thomas, Bache, N., Roepstorff, P., Gårdsvoll, Henrik & Ploug, Michael, Dec 2005, In: Molecular and Cellular Proteomics. 4, 12, p. 1910-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide
Llinas, P., Le Du, M. H., Gårdsvoll, Henrik, Danø, K., Ploug, Michael, Gilquin, B., Stura, E. A. & Ménèz, A., 4 May 2005, In: E M B O Journal. 24, 9, p. 1655-63 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intramolecular migration of amide hydrogens in protonated peptides upon collisional activation
Jørgensen, Thomas, Gårdsvoll, Henrik, Ploug, Michael & Roepstorff, P., 2 Mar 2005, In: Journal of the American Chemical Society. 127, 8, p. 2785-93 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Dynamics of urokinase receptor interaction with Peptide antagonists studied by amide hydrogen exchange and mass spectrometry
Jørgensen, Thomas, Gårdsvoll, Henrik, Danø, K., Roepstorff, P. & Ploug, Michael, 30 Nov 2004, In: Biochemistry. 43, 47, p. 15044-57 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Specific immunoassays for detection of intact and cleaved forms of the urokinase receptor
Piironen, T., Laursen, B., Pass, J., List, K., Gårdsvoll, Henrik, Ploug, Michael, Danø, K. & Høyer-Hansen, G., Nov 2004, In: Clinical Chemistry. 50, 11, p. 2059-68 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor
Hansen, L. V., Gårdsvoll, Henrik, Nielsen, B. S., Lund, L. R., Danø, K., Jensen, O. N. & Ploug, Michael, 15 Jun 2004, In: Biochemical Journal. 380, Pt 3, p. 845-57 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites
Gårdsvoll, Henrik, Werner, F., Søndergaard, Leif, Danø, K. & Ploug, Michael, 2004, In: Protein Expression and Purification. 34, 2, p. 284-295 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy
Ploug, Michael, Gårdsvoll, Henrik, Jørgensen, T. J. D., Lønborg Hansen, L. & Danø, K., Apr 2002, In: Biochemical Society Transactions. 30, 2, p. 177-183 7 p.Research output: Contribution to journal › Review › Research › peer-review
- 2001
Peptide-derived antagonists of the urokinase receptor. Affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation
Ploug, Michael, Østergaard, S., Gårdsvoll, Henrik, Kovalski, K., Holst-Hansen, C., Holm, A., Ossowski, L. & Danø, K., 9 Oct 2001, In: Biochemistry. 40, 40, p. 12157-68 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
Mapping part of the functional epitope for ligand binding on the receptor for urokinase-type plasminogen activator by site-directed mutagenesis
Gårdsvoll, Henrik, Danø, K. & Ploug, Michael, 31 Dec 1999, In: The Journal of Biological Chemistry. 274, 53, p. 37995-8003 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 33970502
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The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
67
downloads
Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/α-neurotoxin Domain
Research output: Contribution to journal › Journal article › Research › peer-review
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Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis
Research output: Contribution to journal › Journal article › Research › peer-review
Published