Niels Behrendt
Clinical Professor
- 2023
- Published
Optical coherence tomography for presurgical delineation of basal cell carcinomas on the face—A comparison with histopathology
Holm, Kirsten, Nielsen, L. J., Lock-Andersen, J., Behrendt, Niels, Svensson, M. S., Themstrup, L. & Jemec, Gregor, 2023, In: Journal of Cutaneous Pathology. 50, 5, p. 441-449 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeted delivery of alcohol-containing payloads with antibody-drug conjugates
Grier, K. E., Hansen, A. H., Haxvig, C. S., Li, Xin, Krigslund, O., Behrendt, Niels, Engelholm, Lars Henning, Rossi, F., Sousa, B. C., Harradence, G. J., Camper, N. & Qvortrup, K. M., 2023, In: Chemical Communications. 59, 47, p. 7240-7242Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1
Nørregaard, Kirstine Sandal, Jürgensen, Henrik Jessen, Ingvarsen, S. Z., Heltberg, S. S., Hagensen, C. E., Gårdsvoll, Henrik, Madsen, D. H., Jensen, O. N., Engelholm, Lars Henning & Behrendt, Niels, 2022, In: Matrix Biology. 111, p. 307-328 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Uncovering mediators of collagen degradation in the tumor microenvironment
Thorseth, M. L., Carretta, M., Jensen, C., Mølgaard, K., Jürgensen, Henrik Jessen, Engelholm, Lars Henning, Behrendt, Niels, Willumsen, N. & Madsen, Daniel Hargbøl, 2022, In: Matrix Biology Plus. 13, 100101.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Osteosarcoma and metastasis associated bone degradation—a tale of osteoclast and malignant cell cooperativity
Nørregaard, Kirstine Sandal, Jürgensen, Henrik Jessen, Gårdsvoll, Henrik, Engelholm, Lars Henning, Behrendt, Niels & Søe, K., 2021, In: International Journal of Molecular Sciences. 22, 13, 6865.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target
Cakilkaya, Pinar, Sørensen, R. R., Jürgensen, Henrik Jessen, Krigslund, O., Gårdsvoll, Henrik, Nielsen, C. F., Santoni Rugiu, Eric, Behrendt, Niels & Engelholm, Lars Henning, 2021, In: International Journal of Molecular Sciences. 22, 21, 17 p., 11452.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Cellular uptake of collagens and implications for immune cell regulation in disease
Jürgensen, Henrik Jessen, van Putten, Sander Maarten, Nørregaard, Kirstine Sandal, Bugge, T. H., Engelholm, Lars Henning, Behrendt, Niels & Madsen, D. H., 2020, In: Cellular and Molecular Life Sciences. 77, 16, p. 3161-3176Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The collagen receptor uPARAP/Endo180 regulates collectins through unique structural elements in its FNII domain
Nørregaard, Kirstine Sandal, Krigslund, O., Behrendt, Niels, Engelholm, Lars Henning & Jürgensen, Henrik Jessen, 2020, In: Journal of Biological Chemistry. 295, 27, p. 9157-9170 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis
Ingvarsen, S. Z., Gårdsvoll, Henrik, van Putten, Sander Maarten, Nørregaard, Kirstine Sandal, Krigslund, O., Meilstrup, Josephine Amalie, Tran, C., Jürgensen, Henrik Jessen, Melander, M. C., Nielsen, Carsten Haagen, Kjær, Andreas, Bugge, T. H., Engelholm, Lars Henning & Behrendt, Niels, 2020, In: Scientific Reports. 10, 1, p. 1-16 19138.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins
Jürgensen, Henrik Jessen, Nørregaard, Kirstine Sandal, Sibree, M. M., Santoni Rugiu, Eric, Madsen, Daniel Hargbøl, Wassilew, K., Krustrup, D., Garred, Peter, Bugge, T. H., Engelholm, Lars Henning & Behrendt, Niels, 1 Jan 2019, In: Journal of Cell Biology. 218, 1, p. 333-349 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding
Wyseure, T., Yang, T., Zhou, J. Y., Cooke, E. J., Wanko, B., Olmer, M., Agashe, R., Morodomi, Y., Behrendt, Niels, Lotz, M., Morser, J., von Drygalski, A. & Mosnier, L. O., 1 Jan 2019, In: JCI Insight. 4, 19, p. 1-19 e128379.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets
Jürgensen, Henrik Jessen, Silva, L. M., Krigslund, O., Van Putten, S., Madsen, D. H., Behrendt, Niels, Engelholm, Lars Henning & Bugge, T. H., 2019, In: Matrix Biology Plus. 1, p. 1-20 100003.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis
Durré, T., Morfoisse, F., Erpicum, C., Ebroin, M., Blacher, S., García-Caballero, M., Deroanne, C., Louis, T., Balsat, C., Van de Velde, M., Kaijalainen, S., Kridelka, F., Engelholm, Lars Henning, Struman, I., Alitalo, K., Behrendt, Niels, Paupert, J. & Noel, A., 5 Dec 2018, In: Nature Communications. 9, 1, p. 1-16 5178.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Defective TAFI activation in hemophilia a mice is a major contributor to joint bleeding
Wyseure, T., Cooke, E. J., Declerck, P. J., Behrendt, Niels, Meijers, J. C. M., Von Drygalski, A. & Mosnier, L. O., 2018, In: Blood. 132, 15, p. 1593-1603 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake
Madsen, Daniel Hargbøl, Jürgensen, Henrik Jessen, Siersbæk, M. S., Kuczek, D. E., Grey Cloud, L., Liu, S., Behrendt, Niels, Grøntved, L., Weigert, R. & Bugge, T. H., 26 Dec 2017, In: Cell Reports. 21, 13, p. 3662-3671 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phagocytosis of Collagen Fibrils by Fibroblasts In Vivo is Independent of the uPARAP/Endo180 Receptor
Sprangers, S., Behrendt, Niels, Engelholm, Lars Henning, Cao, Y. & Everts, V., Jun 2017, In: Journal of Cellular Biochemistry. 118, 6, p. 1590-1595Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers
Nielsen, C. F., van Putten, S. M., Lund, I. K., Melander, M. C., Nørregaard, Kirstine Sandal, Jürgensen, Henrik Jessen, Reckzeh, K., Christensen, K. R., Ingvarsen, S. Z., Gårdsvoll, Henrik, Jensen, K. E., Hamerlik, P., Engelholm, Lars Henning & Behrendt, Niels, 2017, In: OncoTarget. 8, 27, p. 44605-44624 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding
Yuan, C., Jürgensen, Henrik Jessen, Engelholm, Lars Henning, Li, R., Liu, M., Jiang, L., Luo, Z., Behrendt, Niels & Huang, M., 1 Aug 2016, In: Biochemical Journal. 473, 15, p. 2359-68 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180
Engelholm, Lars Henning, Carlsen Melander, E. M., Hald, A., Persson, M., Madsen, D. H., Jürgensen, Henrik Jessen, Johansson, K., Nielsen, C., Nørregaard, Kirstine Sandal, Ingvarsen, S. Z., Kjær, Andreas, Trovik, C. S., Lærum, O. D., Bugge, T. H., Eide, J. & Behrendt, Niels, Jan 2016, In: Journal of Pathology. 238, 1, p. 120-33 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)
Carlsen Melander, E. M., Jürgensen, Henrik Jessen, Madsen, Daniel Hargbøl, Engelholm, Lars Henning & Behrendt, Niels, Oct 2015, In: International Journal of Oncology. 47, 4, p. 1177-88 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Advances in targeted delivery of small interfering RNA using simple bioconjugates
Nielsen, C., Kjems, J., Sørensen, K. R., Engelholm, Lars Henning & Behrendt, Niels, 2014, In: Expert Opinion on Drug Delivery. 11, 5, p. 791-822 32 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Complex Determinants in Specific Members of the Mannose Receptor Family Govern Collagen Endocytosis
Jürgensen, Henrik Jessen, Johansson, K., Madsen, D. H., Porse, A., Melander, M. C., Sørensen, K. R., Nielsen, C., Bugge, T. H., Behrendt, Niels & Engelholm, Lars Henning, 2014, In: The Journal of Biological Chemistry. 289, 11, p. 7935-7947 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells
Gaublomme, D., Buyens, T., De Groef, L., Stakenborg, M., Janssens, E., Ingvarsen, S., Porse, A., Behrendt, Niels & Moons, L., 2014, In: Journal of Neurochemistry. 129, 6, p. 966-979 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP
Shiryaev, S. A., Remacle, A. G., Golubkov, V. S., Ingvarsen, S., Porse, A., Behrendt, Niels, Cieplak, P. & Strongin, A. Y., 2 Dec 2013, In: Oncogenesis. 2, p. e80Research output: Contribution to journal › Journal article › Research › peer-review
- Published
M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway
Madsen, Daniel Hargbøl, Leonard, D., Masedunskas, A., Moyer, A., Jürgensen, Henrik Jessen, Peters, D. E., Amornphimoltham, P., Selvaraj, A., Yamada, S. S., Brenner, D. A., Burgdorf, S., Engelholm, Lars Henning, Behrendt, Niels, Holmbeck, K., Weigert, R. & Bugge, T. H., 16 Sep 2013, In: Journal of Cell Biology. 202, 6, p. 951-66 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ficolin-1-PTX3 complex formation promotes clearance of altered self-cells and modulates IL-8 production
Ma, Y. J., Doni, A., Romani, L., Jürgensen, Henrik Jessen, Behrendt, Niels, Mantovani, A. & Garred, Peter, 1 Aug 2013, In: Journal of immunology (Baltimore, Md. : 1950). 191, 3, p. 1324-33 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis
Ingvarsen, S., Porse, A., Erpicum, C., Maertens, L., Jürgensen, H. J., Madsen, Daniel Hargbøl, Melander, M. C., Gårdsvoll, Henrik, Høyer-Hansen, G., Noel, A., Holmbeck, K., Engelholm, Lars Henning & Behrendt, Niels, 12 Apr 2013, In: Journal of Biological Chemistry. 288, 15, p. 10195-204 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis
Madsen, Daniel Hargbøl, Jürgensen, Henrik Jessen, Ingvarsen, S., Melander, M. C., Albrechtsen, Reidar, Hald, A., Holmbeck, K., Bugge, T. H., Behrendt, Niels & Engelholm, Lars Henning, 2013, In: PloS one. 8, 8, p. e71261Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Matrix Proteases in Health and Disease
Behrendt, Niels, 24 Aug 2012, Wiley-VCH.Research output: Book/Report › Book › Research › peer-review
- Published
Preface: Matrix Proteases in Health and Disease
Behrendt, Niels, 24 Aug 2012, Matrix Proteases in Health and Disease. Wiley-VCH, p. xiiiResearch output: Chapter in Book/Report/Conference proceeding › Preface/postscript › Research › peer-review
- Published
Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis
Madsen, D. H., Jürgensen, H. J., Ingvarsen, S. Z., Melander, M. C., Vainer, B., Egerod, Kristoffer Lihme, Hald, A., Rønø, B., Madsen, C. A., Bugge, T. H., Engelholm, L. H. & Behrendt, Niels, 2012, In: Journal of Pathology. 227, 1, p. 94-105 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo
Lund, I. K., Rasch, M. G., Ingvarsen, S., Pass, J., Madsen, Daniel Hargbøl, Engelholm, Lars Henning, Behrendt, Niels & Høyer-Hansen, G., 2012, In: Frontiers in Pharmacology. 3, p. 122Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment
Noël, A., Gutiérrez-Fernández, A., Sounni, N. E., Behrendt, Niels, Maquoi, E., Lund, I. K., Cal, S., Hoyer-Hansen, G. & López-Otín, C., 2012, In: Frontiers in Pharmacology. 3, p. 140Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction
Gårdsvoll, Henrik, Jacobsen, B., Kriegbaum, M. C., Behrendt, Niels, Engelholm, Lars Henning, Østergaard, S. & Ploug, Michael, 23 Sep 2011, In: The Journal of Biological Chemistry. 286, 38, p. 33544-56 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The non-phagocytic route of collagen uptake: a distinct degradation pathway
Madsen, Daniel Hargbøl, Ingvarsen, S., Jürgensen, Henrik Jessen, Melander, M. C., Kjøller, L., Moyer, A., Honoré, C., Madsen, M. C., Garred, Peter, Burgdorf, S., Bugge, T. H., Behrendt, Niels & Engelholm, Lars Henning, 29 Jul 2011, In: The Journal of Biological Chemistry. 286, 30, p. 26996-7010 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uPARAP/ENDO 180
Jürgensen, Henrik Jessen, Madsen, Daniel Hargbøl, Ingvarsen, S., Melander, M. C., Gårdsvoll, Henrik, Patthy, L., Engelholm, Lars Henning & Behrendt, Niels, 2011, In: Journal of Biological Chemistry. 286, 37, p. 32736-48 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
The collagen receptor uPARAP/Endo180
Engelholm, Lars Henning, Ingvarsen, S., Jürgensen, Henrik Jessen, Hillig, T., Madsen, Daniel Hargbøl, Nielsen, B. S. & Behrendt, Niels, 1 Jan 2009, In: Frontiers in Bioscience. 14, p. 2103-14 12 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
MT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny
Szabova, L., Yamada, S. S., Wimer, H., Chrysovergis, K., Ingvarsen, S., Behrendt, Niels, Engelholm, L. H. & Holmbeck, K., 2009, In: Journal of Bone and Mineral Research. 24, 11, p. 1905-1916 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Antibody-mediated Targeting of the Urokinase-type Plasminogen Activator Proteolytic Function Neutralizes Fibrinolysis in Vivo
Lund, I. K., Jögi, A., Rono, B., Rasch, M. G., Lund, L. R., Almholt, K., Gardsvoll, H., Behrendt, Niels, Romer, J. & Hoyer-Hansen, G., 21 Nov 2008, In: Journal of Biological Chemistry. 283, 47, p. 32506-32515Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor
Hillig, T., Engelholm, Lars Henning, Ingvarsen, S., Madsen, Daniel Hargbøl, Gårdsvoll, Henrik, Larsen, J. K., Ploug, Michael, Danø, K., Kjøller, L. & Behrendt, Niels, 30 May 2008, In: Journal of Biological Chemistry. 283, 22, p. 15217-15223 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells
Ingvarsen, S. Z., Madsen, D. H., Hillig, T., Lund, L. R., Holmbeck, Kenn, Behrendt, Niels & Engelholm, L. H., 2008, In: Biological Chemistry. 389, 7, p. 943-953 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation
Madsen, Daniel Hargbøl, Engelholm, Lars Henning, Ingvarsen, S., Hillig, T., Wagenaar-Miller, R. A., Kjøller, L., Gårdsvoll, Henrik, Høyer-Hansen, G., Holmbeck, Kenn, Bugge, T. H. & Behrendt, Niels, 14 Sep 2007, In: The Journal of Biological Chemistry. 282, 37, p. 27037-45 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complementary roles of intracellular and pericellular collagen degradation pathways in vivo
Wagenaar-Miller, R. A., Engelholm, Lars Henning, Gavard, J., Yamada, S. S., Gutkind, J. S., Behrendt, Niels, Bugge, T. H. & Holmbeck, Kenn, Sep 2007, In: Molecular and Cellular Biology. 27, 18, p. 6309-22 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer
Sulek, J., Wagenaar-Miller, R. A., Shireman, J., Molinolo, A., Madsen, Daniel Hargbøl, Engelholm, Lars Henning, Behrendt, Niels & Bugge, T. H., Apr 2007, In: Journal of Histochemistry and Cytochemistry. 55, 4, p. 347-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy
Curino, A. C., Engelholm, Lars Henning, Yamada, S. S., Holmbeck, K., Lund, L. R., Molinolo, A. A., Behrendt, Niels, Nielsen, B. S. & Bugge, T. H., 2005, In: Journal of Cell Biology. 169, 6, p. 977-985 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma
Udby, L., Sørensen, O. E., Pass, J., Johnsen, A. H., Behrendt, Niels, Borregaard, N. & Kjeldsen, L., 12 Oct 2004, In: Biochemistry. 43, 40, p. 12877-86 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV
Kjøller, L., Engelholm, Lars Henning, Høyer-Hansen, M., Danø, K., Bugge, T. H. & Behrendt, Niels, 1 Feb 2004, In: Experimental Cell Research. 293, 1, p. 106-16 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling
Behrendt, Niels, Feb 2004, In: Biological Chemistry. 385, 2, p. 103-36 34 p.Research output: Contribution to journal › Review › Research › peer-review
- 2003
- Published
The pro-urokinase plasminogen-activation system in the presence of serpin-type inhibitors and the urokinase receptor: rescue of activity through reciprocal pro-enzyme activation
Behrendt, Niels, List, K., Andreasen, P. A. & Danø, K., 15 Apr 2003, In: Biochemical Journal. 371, Pt 2, p. 277-87 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion
Engelholm, Lars Henning, List, K., Netzel-Arnett, S., Cukierman, E., Mitola, D. J., Aaronson, H., Kjøller, L., Larsen, J. K., Yamada, K. M., Strickland, D. K., Holmbeck, Kenn, Danø, K., Birkedal-Hansen, H., Behrendt, Niels & Bugge, T. H., 31 Mar 2003, In: Journal of Cell Biology. 160, 7, p. 1009-15 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 33867134
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The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
156
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Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake
Research output: Contribution to journal › Journal article › Research › peer-review
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Defective TAFI activation in hemophilia a mice is a major contributor to joint bleeding
Research output: Contribution to journal › Journal article › Research › peer-review
Published