Niels Behrendt
Clinical Professor
- 2023
- Published
Optical coherence tomography for presurgical delineation of basal cell carcinomas on the face—A comparison with histopathology
Holm, Kirsten, Nielsen, L. J., Lock-Andersen, J., Behrendt, Niels, Svensson, M. S., Themstrup, L. & Jemec, Gregor, 2023, In: Journal of Cutaneous Pathology. 50, 5, p. 441-449 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeted delivery of alcohol-containing payloads with antibody-drug conjugates
Grier, K. E., Hansen, A. H., Haxvig, C. S., Li, Xin, Krigslund, O., Behrendt, Niels, Engelholm, Lars Henning, Rossi, F., Sousa, B. C., Harradence, G. J., Camper, N. & Qvortrup, K. M., 2023, In: Chemical Communications. 59, 47, p. 7240-7242Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1
Nørregaard, Kirstine Sandal, Jürgensen, Henrik Jessen, Ingvarsen, S. Z., Heltberg, S. S., Hagensen, C. E., Gårdsvoll, Henrik, Madsen, D. H., Jensen, O. N., Engelholm, Lars Henning & Behrendt, Niels, 2022, In: Matrix Biology. 111, p. 307-328 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Uncovering mediators of collagen degradation in the tumor microenvironment
Thorseth, M. L., Carretta, M., Jensen, C., Mølgaard, K., Jürgensen, Henrik Jessen, Engelholm, Lars Henning, Behrendt, Niels, Willumsen, N. & Madsen, Daniel Hargbøl, 2022, In: Matrix Biology Plus. 13, 100101.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Osteosarcoma and metastasis associated bone degradation—a tale of osteoclast and malignant cell cooperativity
Nørregaard, Kirstine Sandal, Jürgensen, Henrik Jessen, Gårdsvoll, Henrik, Engelholm, Lars Henning, Behrendt, Niels & Søe, K., 2021, In: International Journal of Molecular Sciences. 22, 13, 6865.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target
Cakilkaya, Pinar, Sørensen, R. R., Jürgensen, Henrik Jessen, Krigslund, O., Gårdsvoll, Henrik, Nielsen, C. F., Santoni Rugiu, Eric, Behrendt, Niels & Engelholm, Lars Henning, 2021, In: International Journal of Molecular Sciences. 22, 21, 17 p., 11452.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Cellular uptake of collagens and implications for immune cell regulation in disease
Jürgensen, Henrik Jessen, van Putten, Sander Maarten, Nørregaard, Kirstine Sandal, Bugge, T. H., Engelholm, Lars Henning, Behrendt, Niels & Madsen, D. H., 2020, In: Cellular and Molecular Life Sciences. 77, 16, p. 3161-3176Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The collagen receptor uPARAP/Endo180 regulates collectins through unique structural elements in its FNII domain
Nørregaard, Kirstine Sandal, Krigslund, O., Behrendt, Niels, Engelholm, Lars Henning & Jürgensen, Henrik Jessen, 2020, In: Journal of Biological Chemistry. 295, 27, p. 9157-9170 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis
Ingvarsen, S. Z., Gårdsvoll, Henrik, van Putten, Sander Maarten, Nørregaard, Kirstine Sandal, Krigslund, O., Meilstrup, Josephine Amalie, Tran, C., Jürgensen, Henrik Jessen, Melander, M. C., Nielsen, Carsten Haagen, Kjær, Andreas, Bugge, T. H., Engelholm, Lars Henning & Behrendt, Niels, 2020, In: Scientific Reports. 10, 1, p. 1-16 19138.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins
Jürgensen, Henrik Jessen, Nørregaard, Kirstine Sandal, Sibree, M. M., Santoni Rugiu, Eric, Madsen, Daniel Hargbøl, Wassilew, K., Krustrup, D., Garred, Peter, Bugge, T. H., Engelholm, Lars Henning & Behrendt, Niels, 1 Jan 2019, In: Journal of Cell Biology. 218, 1, p. 333-349 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding
Wyseure, T., Yang, T., Zhou, J. Y., Cooke, E. J., Wanko, B., Olmer, M., Agashe, R., Morodomi, Y., Behrendt, Niels, Lotz, M., Morser, J., von Drygalski, A. & Mosnier, L. O., 1 Jan 2019, In: JCI Insight. 4, 19, p. 1-19 e128379.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets
Jürgensen, Henrik Jessen, Silva, L. M., Krigslund, O., Van Putten, S., Madsen, D. H., Behrendt, Niels, Engelholm, Lars Henning & Bugge, T. H., 2019, In: Matrix Biology Plus. 1, p. 1-20 100003.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis
Durré, T., Morfoisse, F., Erpicum, C., Ebroin, M., Blacher, S., García-Caballero, M., Deroanne, C., Louis, T., Balsat, C., Van de Velde, M., Kaijalainen, S., Kridelka, F., Engelholm, Lars Henning, Struman, I., Alitalo, K., Behrendt, Niels, Paupert, J. & Noel, A., 5 Dec 2018, In: Nature Communications. 9, 1, p. 1-16 5178.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Defective TAFI activation in hemophilia a mice is a major contributor to joint bleeding
Wyseure, T., Cooke, E. J., Declerck, P. J., Behrendt, Niels, Meijers, J. C. M., Von Drygalski, A. & Mosnier, L. O., 2018, In: Blood. 132, 15, p. 1593-1603 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake
Madsen, Daniel Hargbøl, Jürgensen, Henrik Jessen, Siersbæk, M. S., Kuczek, D. E., Grey Cloud, L., Liu, S., Behrendt, Niels, Grøntved, L., Weigert, R. & Bugge, T. H., 26 Dec 2017, In: Cell Reports. 21, 13, p. 3662-3671 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phagocytosis of Collagen Fibrils by Fibroblasts In Vivo is Independent of the uPARAP/Endo180 Receptor
Sprangers, S., Behrendt, Niels, Engelholm, Lars Henning, Cao, Y. & Everts, V., Jun 2017, In: Journal of Cellular Biochemistry. 118, 6, p. 1590-1595Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers
Nielsen, C. F., van Putten, S. M., Lund, I. K., Melander, M. C., Nørregaard, Kirstine Sandal, Jürgensen, Henrik Jessen, Reckzeh, K., Christensen, K. R., Ingvarsen, S. Z., Gårdsvoll, Henrik, Jensen, K. E., Hamerlik, P., Engelholm, Lars Henning & Behrendt, Niels, 2017, In: OncoTarget. 8, 27, p. 44605-44624 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding
Yuan, C., Jürgensen, Henrik Jessen, Engelholm, Lars Henning, Li, R., Liu, M., Jiang, L., Luo, Z., Behrendt, Niels & Huang, M., 1 Aug 2016, In: Biochemical Journal. 473, 15, p. 2359-68 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180
Engelholm, Lars Henning, Carlsen Melander, E. M., Hald, A., Persson, M., Madsen, D. H., Jürgensen, Henrik Jessen, Johansson, K., Nielsen, C., Nørregaard, Kirstine Sandal, Ingvarsen, S. Z., Kjær, Andreas, Trovik, C. S., Lærum, O. D., Bugge, T. H., Eide, J. & Behrendt, Niels, Jan 2016, In: Journal of Pathology. 238, 1, p. 120-33 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)
Carlsen Melander, E. M., Jürgensen, Henrik Jessen, Madsen, Daniel Hargbøl, Engelholm, Lars Henning & Behrendt, Niels, Oct 2015, In: International Journal of Oncology. 47, 4, p. 1177-88 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Advances in targeted delivery of small interfering RNA using simple bioconjugates
Nielsen, C., Kjems, J., Sørensen, K. R., Engelholm, Lars Henning & Behrendt, Niels, 2014, In: Expert Opinion on Drug Delivery. 11, 5, p. 791-822 32 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Complex Determinants in Specific Members of the Mannose Receptor Family Govern Collagen Endocytosis
Jürgensen, Henrik Jessen, Johansson, K., Madsen, D. H., Porse, A., Melander, M. C., Sørensen, K. R., Nielsen, C., Bugge, T. H., Behrendt, Niels & Engelholm, Lars Henning, 2014, In: The Journal of Biological Chemistry. 289, 11, p. 7935-7947 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells
Gaublomme, D., Buyens, T., De Groef, L., Stakenborg, M., Janssens, E., Ingvarsen, S., Porse, A., Behrendt, Niels & Moons, L., 2014, In: Journal of Neurochemistry. 129, 6, p. 966-979 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP
Shiryaev, S. A., Remacle, A. G., Golubkov, V. S., Ingvarsen, S., Porse, A., Behrendt, Niels, Cieplak, P. & Strongin, A. Y., 2 Dec 2013, In: Oncogenesis. 2, p. e80Research output: Contribution to journal › Journal article › Research › peer-review
- Published
M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway
Madsen, Daniel Hargbøl, Leonard, D., Masedunskas, A., Moyer, A., Jürgensen, Henrik Jessen, Peters, D. E., Amornphimoltham, P., Selvaraj, A., Yamada, S. S., Brenner, D. A., Burgdorf, S., Engelholm, Lars Henning, Behrendt, Niels, Holmbeck, K., Weigert, R. & Bugge, T. H., 16 Sep 2013, In: Journal of Cell Biology. 202, 6, p. 951-66 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ficolin-1-PTX3 complex formation promotes clearance of altered self-cells and modulates IL-8 production
Ma, Y. J., Doni, A., Romani, L., Jürgensen, Henrik Jessen, Behrendt, Niels, Mantovani, A. & Garred, Peter, 1 Aug 2013, In: Journal of immunology (Baltimore, Md. : 1950). 191, 3, p. 1324-33 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis
Ingvarsen, S., Porse, A., Erpicum, C., Maertens, L., Jürgensen, H. J., Madsen, Daniel Hargbøl, Melander, M. C., Gårdsvoll, Henrik, Høyer-Hansen, G., Noel, A., Holmbeck, K., Engelholm, Lars Henning & Behrendt, Niels, 12 Apr 2013, In: Journal of Biological Chemistry. 288, 15, p. 10195-204 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis
Madsen, Daniel Hargbøl, Jürgensen, Henrik Jessen, Ingvarsen, S., Melander, M. C., Albrechtsen, Reidar, Hald, A., Holmbeck, K., Bugge, T. H., Behrendt, Niels & Engelholm, Lars Henning, 2013, In: PloS one. 8, 8, p. e71261Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Matrix Proteases in Health and Disease
Behrendt, Niels, 24 Aug 2012, Wiley-VCH.Research output: Book/Report › Book › Research › peer-review
- Published
Preface: Matrix Proteases in Health and Disease
Behrendt, Niels, 24 Aug 2012, Matrix Proteases in Health and Disease. Wiley-VCH, p. xiiiResearch output: Chapter in Book/Report/Conference proceeding › Preface/postscript › Research › peer-review
- Published
Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis
Madsen, D. H., Jürgensen, H. J., Ingvarsen, S. Z., Melander, M. C., Vainer, B., Egerod, Kristoffer Lihme, Hald, A., Rønø, B., Madsen, C. A., Bugge, T. H., Engelholm, L. H. & Behrendt, Niels, 2012, In: Journal of Pathology. 227, 1, p. 94-105 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo
Lund, I. K., Rasch, M. G., Ingvarsen, S., Pass, J., Madsen, Daniel Hargbøl, Engelholm, Lars Henning, Behrendt, Niels & Høyer-Hansen, G., 2012, In: Frontiers in Pharmacology. 3, p. 122Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment
Noël, A., Gutiérrez-Fernández, A., Sounni, N. E., Behrendt, Niels, Maquoi, E., Lund, I. K., Cal, S., Hoyer-Hansen, G. & López-Otín, C., 2012, In: Frontiers in Pharmacology. 3, p. 140Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction
Gårdsvoll, Henrik, Jacobsen, B., Kriegbaum, M. C., Behrendt, Niels, Engelholm, Lars Henning, Østergaard, S. & Ploug, Michael, 23 Sep 2011, In: The Journal of Biological Chemistry. 286, 38, p. 33544-56 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The non-phagocytic route of collagen uptake: a distinct degradation pathway
Madsen, Daniel Hargbøl, Ingvarsen, S., Jürgensen, Henrik Jessen, Melander, M. C., Kjøller, L., Moyer, A., Honoré, C., Madsen, M. C., Garred, Peter, Burgdorf, S., Bugge, T. H., Behrendt, Niels & Engelholm, Lars Henning, 29 Jul 2011, In: The Journal of Biological Chemistry. 286, 30, p. 26996-7010 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uPARAP/ENDO 180
Jürgensen, Henrik Jessen, Madsen, Daniel Hargbøl, Ingvarsen, S., Melander, M. C., Gårdsvoll, Henrik, Patthy, L., Engelholm, Lars Henning & Behrendt, Niels, 2011, In: Journal of Biological Chemistry. 286, 37, p. 32736-48 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
The collagen receptor uPARAP/Endo180
Engelholm, Lars Henning, Ingvarsen, S., Jürgensen, Henrik Jessen, Hillig, T., Madsen, Daniel Hargbøl, Nielsen, B. S. & Behrendt, Niels, 1 Jan 2009, In: Frontiers in Bioscience. 14, p. 2103-14 12 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
MT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny
Szabova, L., Yamada, S. S., Wimer, H., Chrysovergis, K., Ingvarsen, S., Behrendt, Niels, Engelholm, L. H. & Holmbeck, K., 2009, In: Journal of Bone and Mineral Research. 24, 11, p. 1905-1916 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Antibody-mediated Targeting of the Urokinase-type Plasminogen Activator Proteolytic Function Neutralizes Fibrinolysis in Vivo
Lund, I. K., Jögi, A., Rono, B., Rasch, M. G., Lund, L. R., Almholt, K., Gardsvoll, H., Behrendt, Niels, Romer, J. & Hoyer-Hansen, G., 21 Nov 2008, In: Journal of Biological Chemistry. 283, 47, p. 32506-32515Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor
Hillig, T., Engelholm, Lars Henning, Ingvarsen, S., Madsen, Daniel Hargbøl, Gårdsvoll, Henrik, Larsen, J. K., Ploug, Michael, Danø, K., Kjøller, L. & Behrendt, Niels, 30 May 2008, In: Journal of Biological Chemistry. 283, 22, p. 15217-15223 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells
Ingvarsen, S. Z., Madsen, D. H., Hillig, T., Lund, L. R., Holmbeck, Kenn, Behrendt, Niels & Engelholm, L. H., 2008, In: Biological Chemistry. 389, 7, p. 943-953 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation
Madsen, Daniel Hargbøl, Engelholm, Lars Henning, Ingvarsen, S., Hillig, T., Wagenaar-Miller, R. A., Kjøller, L., Gårdsvoll, Henrik, Høyer-Hansen, G., Holmbeck, Kenn, Bugge, T. H. & Behrendt, Niels, 14 Sep 2007, In: The Journal of Biological Chemistry. 282, 37, p. 27037-45 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complementary roles of intracellular and pericellular collagen degradation pathways in vivo
Wagenaar-Miller, R. A., Engelholm, Lars Henning, Gavard, J., Yamada, S. S., Gutkind, J. S., Behrendt, Niels, Bugge, T. H. & Holmbeck, Kenn, Sep 2007, In: Molecular and Cellular Biology. 27, 18, p. 6309-22 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer
Sulek, J., Wagenaar-Miller, R. A., Shireman, J., Molinolo, A., Madsen, Daniel Hargbøl, Engelholm, Lars Henning, Behrendt, Niels & Bugge, T. H., Apr 2007, In: Journal of Histochemistry and Cytochemistry. 55, 4, p. 347-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy
Curino, A. C., Engelholm, Lars Henning, Yamada, S. S., Holmbeck, K., Lund, L. R., Molinolo, A. A., Behrendt, Niels, Nielsen, B. S. & Bugge, T. H., 2005, In: Journal of Cell Biology. 169, 6, p. 977-985 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma
Udby, L., Sørensen, O. E., Pass, J., Johnsen, A. H., Behrendt, Niels, Borregaard, N. & Kjeldsen, L., 12 Oct 2004, In: Biochemistry. 43, 40, p. 12877-86 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV
Kjøller, L., Engelholm, Lars Henning, Høyer-Hansen, M., Danø, K., Bugge, T. H. & Behrendt, Niels, 1 Feb 2004, In: Experimental Cell Research. 293, 1, p. 106-16 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling
Behrendt, Niels, Feb 2004, In: Biological Chemistry. 385, 2, p. 103-36 34 p.Research output: Contribution to journal › Review › Research › peer-review
- 2003
- Published
The pro-urokinase plasminogen-activation system in the presence of serpin-type inhibitors and the urokinase receptor: rescue of activity through reciprocal pro-enzyme activation
Behrendt, Niels, List, K., Andreasen, P. A. & Danø, K., 15 Apr 2003, In: Biochemical Journal. 371, Pt 2, p. 277-87 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion
Engelholm, Lars Henning, List, K., Netzel-Arnett, S., Cukierman, E., Mitola, D. J., Aaronson, H., Kjøller, L., Larsen, J. K., Yamada, K. M., Strickland, D. K., Holmbeck, Kenn, Danø, K., Birkedal-Hansen, H., Behrendt, Niels & Bugge, T. H., 31 Mar 2003, In: Journal of Cell Biology. 160, 7, p. 1009-15 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Urokinase-type plasminogen activator receptor
Dano, K., Blasi, F., Roldan, Ann, L., Cubellis, Maria, V., Masucci, Maria, T., Appella, E., Schleuning, W-D., Behrendt, N., Ronne, E., Kristensen, P., Pollanen, J., Salonen, E-M., Stephens, Ross, W., Tapiovaara, H., Vaheri, A., Moller Lisbeth, B., Ellis, V., Lund Leif, R., Ploug, M., Pyke, C. & 1 others, , 6 Feb 2003, IPC No. A61K 38/ 00 A N, Patent No. US2003027981, Priority date 8 Jan 2001, Priority No. US20010755109Research output: Patent
- 2002
- Published
Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis
List, K., Haudenschild, C. C., Szabo, R., Chen, W., Wahl, S. M., Swaim, W., Engelholm, Lars Henning, Behrendt, Niels & Bugge, T. H., 23 May 2002, In: Oncogene. 21, 23, p. 3765-79 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Urokinase receptor-associated protein (uPARAP) is expressed in connection with malignant as well as benign lesions of the human breast and occurs in specific populations of stromal cells
Schnack Nielsen, B., Rank, F., Engelholm, Lars Henning, Holm, A., Danø, K. & Behrendt, Niels, 10 Apr 2002, In: International Journal of Cancer. Supplement. 98, 5, p. 656-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis
Engelholm, Lars Henning, Nielsen, B. S., Netzel-Arnett, S., Solberg, H., Chen, X. D., Lopez Garcia, J. M., López-Otín, C., Young, M. F., Birkedal-Hansen, H., Danø, K., Lund, L. R., Behrendt, Niels & Bugge, T. H., Oct 2001, In: Laboratory Investigation. 81, 10, p. 1403-14 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor
Høyer-Hansen, G., Pessara, U., Holm, A., Pass, J., Weidle, U., Danø, K. & Behrendt, Niels, 15 Sep 2001, In: Biochemical Journal. 358, Pt 3, p. 673-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential binding of urokinase and peptide antagonists to the urokinase receptor: evidence from characterization of the receptor in four primate species
Engelholm, Lars Henning & Behrendt, Niels, Mar 2001, In: Biological Chemistry. 382, 3, p. 435-42 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The urokinase receptor associated protein (uPARAP/endo180): a novel internalization receptor connected to the plasminogen activation system
Engelholm, Lars Henning, Nielsen, B. S., Danø, K. & Behrendt, Niels, Jan 2001, In: Trends in Cardiovascular Medicine. 11, 1, p. 7-13 7 p.Research output: Contribution to journal › Review › Research › peer-review
- 2000
Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice
List, K., Jensen, O. N., Bugge, T. H., Lund, L. R., Ploug, Michael, Danø, K. & Behrendt, Niels, 25 Jan 2000, In: Biochemistry. 39, 3, p. 508-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
A urokinase receptor-associated protein with specific collagen binding properties
Behrendt, Niels, Jensen, O. N., Engelholm, Lars Henning, Mørtz, E., Mann, Matthias & Danø, K., 2000, In: The Journal of Biological Chemistry. 275, 3, p. 1993-2002 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)
Danoe, K., Blasi, F., Roldan, Ann, L., Cubellis, Maria, V., Masucci, Maria, T., Appella, E., Schleuning, W-D., Behrendt, N., Rønne, E., Kristensen, P., Pollanen, J., Salonen, E-M., Stephens, Ross, W., Tapiovaara, H., Vaheri, A., Moeller, Lisbeth, B., Ellis, V., Lund, Leif, R., Ploug, M., Pyke, C. & 1 others, , 6 Apr 1999, IPC No. A61K 38/ 00 A N, Patent No. US5891664, Priority date 6 Oct 1994, Priority No. US19940319052Research output: Patent
- Published
Different mechanisms are involved in the antibody mediated inhibition of ligand binding to the urokinase receptor: a study based on biosensor technology
List, K., Høyer-Hansen, G., Rønne, Elsebeth, Danø, K. & Behrendt, Niels, 1 Jan 1999, In: Journal of Immunological Methods. 222, 1-2, p. 125-33 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
- Published
The urokinase receptor
Behrendt, Niels & Stephens, R. W., 1 Jan 1998, In: Fibrinolysis and Proteolysis. 12, 4, p. 191-204 14 p.Research output: Contribution to journal › Review › Research › peer-review
- 1997
The intact urokinase receptor is required for efficient vitronectin binding: receptor cleavage prevents ligand interaction
Høyer-Hansen, G., Behrendt, Niels, Ploug, Michael, Danø, K. & Preissner, K. T., 22 Dec 1997, In: FEBS Letters. 420, 1, p. 79-85 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Different mechanisms are involved in the antibody mediated inhibition of the interaction between the urokjnasetype plasminogen activator and its receptor
List, K., Høyer-Hansen, G., Rønne, E., Danø, K. & Behrendt, Niels, 1 Dec 1997, In: Fibrinolysis and Proteolysis. 11, SUPPL. 3, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Establishment of murine monoclonal antibodies against murine urokinase receptor raised in urokinase receptor knock-out mice
Ranne, E., Hansen, G. H., Behrendt, Niels, Solberg, H., Larsen, J. K. & Danø, K., 1 Dec 1997, In: Fibrinolysis and Proteolysis. 11, SUPPL. 3, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Establishment of murine monoclonal antibodies against murine urokinase receptor raised in urokinase receptor knock-out mice
Ranne, E., Hansen, G. H., Behrendt, Niels, Solberg, H., Larsen, J. K. & Danø, K., 1 Dec 1997, In: Fibrinolysis and Proteolysis. 11, SUPPL. 3, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The rntact urokinase receptor is required for high affinity vitronectin binding: receptor cleavage prevents ligand interaction
GunillaHaver-Hansjan, Behrendt, Niels, Ploug, Michael, Dana, K. & Preissner, K. T., 1 Dec 1997, In: Fibrinolysis and Proteolysis. 11, SUPPL. 3, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
ELISA for complexes between urokinase-type plasminogen activator and its receptor in lung cancer tissue extracts
de Witte, H., Pappot, Helle, Brünner, N., Grøndahl-Hansen, J., Hoyer-Hansen, G., Behrendt, Niels, Guldhammer-Skov, B., Sweep, F., Benraad, T. & Danø, K., 29 Jul 1997, In: International Journal of Cancer. Supplement. 72, 3, p. 416-23 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Reply to comment on 'Effect of purified, soluble urokinase receptor on the plasminogen-prourokinase activation system' (A. A-R. Higazi)
Behrendt, Niels & Danø, K., 3 Feb 1997, In: FEBS Letters. 402, 2-3, p. 293-4 2 p.Research output: Contribution to journal › Journal article › Research
Cell-surface acceleration of urokinase-catalyzed receptor cleavage
Høyer-Hansen, G., Ploug, Michael, Behrendt, Niels, Rønne, Elsebeth & Danø, K., 15 Jan 1997, In: European Journal of Biochemistry. 243, 1-2, p. 21-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of a novel membrane protein that interacts specifically with the upar-prourokinase complex
Behrendt, Niels, Engelholm, Lars Henning, Jensen, O. N., Mörtz, E., Ranne, E., Mann, Matthias & Dan, K., 1997, In: Fibrinolysis and Proteolysis. 11, Supl. 3, p. 10 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
Structure, function and expression on blood and bone marrow cells of the urokinase-type plasminogen activator receptor, uPAR
Plesner, T., Behrendt, Niels & Ploug, Michael, 1997, In: Stem Cells. 15, 6, p. 398-408 11 p.Research output: Contribution to journal › Review › Research › peer-review
- 1996
Domain interplay in the urokinase receptor. Requirement for the third domain in high affinity ligand binding and demonstration of ligand contact sites in distinct receptor domains
Behrendt, Niels, Ronne, E. & Dano, K., 13 Sep 1996, In: The Journal of Biological Chemistry. 271, 37, p. 22885-94 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Effect of purified, soluble urokinase receptor on the plasminogen-prourokinase activation system
Behrendt, Niels & Danø, K., 9 Sep 1996, In: FEBS Letters. 393, 1, p. 31-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1995
The structure and function of the urokinase receptor, a membrane protein governing plasminogen activation on the cell surface
Behrendt, Niels, Rønne, E. & Danø, K., May 1995, In: Biological Chemistry Hoppe-Seyler. 376, 5, p. 269-79 11 p.Research output: Contribution to journal › Review › Research › peer-review
- 1994
- Published
Quantitation of the receptor for urokinase plasminogen activator by enzyme-linked immunosorbent assay
Rønne, Elsebeth, Behrendt, Niels, Ploug, Michael, Nielsen, H. J., Wöllisch, E., Weidle, U., Danø, K. & Høyer-Hansen, G., 3 Jan 1994, In: Journal of Immunological Methods. 167, 1-2, p. 91-101 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
The urokinase receptor. Protein structure and role in plasminogen activation and cancer invasion
Danø, K., Behrendt, Niels, Brünner, N., Ellis, V., Ploug, Michael & Oyke, C., 1994, In: Fibrinolysis. 8, Supplement 1, p. 189-203Research output: Contribution to journal › Review › Research › peer-review
- 1993
A novel, specific pro-urokinase complex on monocyte-like cells, detected by transglutaminase-catalyzed cross-linking
Behrendt, Niels, Rønne, E. & Danø, K., 28 Dec 1993, In: FEBS Letters. 336, 3, p. 394-6 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
Binding of the urokinase-type plasminogen activator to its cell surface receptor is inhibited by low doses of suramin
Behrendt, Niels, Rønne, E. & Danø, K., 15 Mar 1993, In: The Journal of Biological Chemistry. 268, 8, p. 5985-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cellular receptor for urokinase-type plasminogen activator: function in cell-surface proteolysis
Ellis, V., Behrendt, Niels & Danø, K., 1993, Methods in Enzymology. Vol. 223. p. 223-33 11 p. (Methods in Enzymology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Cellular receptor for urokinase-type plasminogen activator: protein structure
Behrendt, Niels, Ploug, Michael, Rønne, Elsebeth, Høyer-Hansen, G. & Danø, K., 1993, Methods of Enzymology. Vol. 223. p. 207-22 16 p. (Methods in Enzymology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 1992
Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain
Høyer-Hansen, G., Rønne, E., Solberg, H., Behrendt, Niels, Ploug, Michael, Lund, L. R., Ellis, V. & Danø, K., 5 Sep 1992, In: The Journal of Biological Chemistry. 267, 25, p. 18224-18229 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification and characterization of the murine cell surface receptor for the urokinase-type plasminogen activator
Solberg, H., Løber, D., Eriksen, J., Ploug, Michael, Rønne, E., Behrendt, Niels, Danø, K. & Høyer-Hansen, G., 15 Apr 1992, In: European Journal of Biochemistry. 205, 2, p. 451-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1991
- Published
Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptor
Rønne, Elsebeth, Behrendt, Niels, Ellis, V., Ploug, Michael, Danø, K. & Høyer-Hansen, G., 19 Aug 1991, In: FEBS Letters. 288, 1-2, p. 233-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor
Ellis, V., Behrendt, Niels & Danø, K., 5 Jul 1991, In: The Journal of Biological Chemistry. 266, 19, p. 12752-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Protein structure and membrane anchorage of the cellular receptor for urokinase-type plasminogen activator
Ploug, Michael, Behrendt, Niels, Løber, D. & Danø, K., Jul 1991, In: Seminars in Thrombosis and Hemostasis. 17, 3, p. 183-93 11 p.Research output: Contribution to journal › Review › Research › peer-review
Urokinase receptor mRNA level and gene transcription are strongly and rapidly increased by phorbol myristate acetate in human monocyte-like U937 cells
Lund, L. R., Rønne, E., Roldan, A. L., Behrendt, Niels, Rømer, J., Blasi, F. & Danø, K., 15 Mar 1991, In: The Journal of Biological Chemistry. 266, 8, p. 5177-81 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
IDENTIFICATION AND LOCALIZATION OF A SOLUBLE-ANTIGEN, AG2, OF 136-KDA FROM PLASMODIUM-FALCIPARUM INVITRO CULTURES
Jakobsen, P. H., Grellier, P., THEANDER, T., Behrendt, Niels, Torii, M., Aikawa, M., Schrevel, J. & JEPSEN, S., Feb 1991, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 99, 2, p. 155-162Research output: Contribution to journal › Journal article › Research › peer-review
Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol
Ploug, Michael, Rønne, E., Behrendt, Niels, Jensen, A. L., Blasi, F. & Danø, K., 25 Jan 1991, In: The Journal of Biological Chemistry. 266, 3, p. 1926-33 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1990
Characterization of human endothelial cell urokinase-type plasminogen activator receptor protein and messenger RNA
Barnathan, E. S., Kuo, A., Kariko, K., Rosenfeld, L., Murray, C. S., Behrendt, Niels, Rønne, Elsebeth, Weiner, D. M., Henkin, J. & Cines, D. B., 1 Nov 1990, In: Blood. 76, 9, p. 1795-806 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Inhibition of receptor-bound urokinase by plasminogen-activator inhibitors
Ellis, V., Wun, T., Behrendt, Niels, Rønne, Elsebeth & Danø, K., 15 Jun 1990, In: The Journal of Biological Chemistry. 265, 17, p. 9904-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants
Behrendt, Niels, Rønne, Elsebeth, Ploug, Michael, Petri, T., Løber, D., Nielsen, L. S., Schleuning, W. D., Blasi, F., Appella, E. & Danø, K., 15 Apr 1990, In: The Journal of Biological Chemistry. 265, 11, p. 6453-60 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
The urokinase receptor and regulation of cell surface plasminogen activation
Blasi, F., Cubellis, M. V., Masucci, M. T., Møller, L. B., Olson, D. P., Pedersen, N., Behrendt, Niels, Ellis, V., Ploug, Michael, Rønne, E. & Danø, K., 1990, In: Cell Differentation and Development. 32, 3, p. 247-54Research output: Contribution to journal › Journal article › Research
- 1989
Activation of pro-urokinase and plasminogen on human sarcoma cells: a proteolytic system with surface-bound reactants
Stephens, R. W., Pöllänen, J., Tapiovaara, H., Leung, K. C., Sim, P. S., Salonen, E., Rønne, Elsebeth, Behrendt, Niels, Danø, K. & Vaheri, A., May 1989, In: Journal of Cell Biology. 108, 5, p. 1987-95 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Regulation of urokinase receptors in monocytelike U937 cells by phorbol ester phorbol myristate acetate
Picone, R., Kajtaniak, E. L., Nielsen, L. S., Behrendt, Niels, Mastronicola, M. R., Cubellis, M. V., Stoppelli, M. P., Pedersen, S., Danø, K. & Blasi, F., Feb 1989, In: Journal of Cell Biology. 108, 2, p. 693-702 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1988
A 55,000-60,000 Mr receptor protein for urokinase-type plasminogen activator. Identification in human tumor cell lines and partial purification
Nielsen, L. S., Kellerman, G. M., Behrendt, Niels, Picone, R., Danø, K. & Blasi, F., 15 Feb 1988, In: The Journal of Biological Chemistry. 263, 5, p. 2358-63 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1987
- Published
Localization and functional significance of a polymorphic determinant in the third component of human complement
Behrendt, Niels, Hansen, Ole, Ploug, Michael, Barkholt, V. & Koch, C., Oct 1987, In: Molecular Immunology. 24, 10, p. 1097-103 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1986
A novel polymorphism of human complement component C3 detected by means of a monoclonal antibody
Koch, C. & Behrendt, Niels, 1986, In: Immunogenetics. 23, 5, p. 322-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1985
Human complement component C3: characterization of active C3 S and C3 F, the two common genetic variants
Behrendt, Niels, Aug 1985, In: Molecular Immunology. 22, 8, p. 1005-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 33867134
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The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers
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Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake
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Defective TAFI activation in hemophilia a mice is a major contributor to joint bleeding
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