Jakob Werner Hansen
Senior Researcher
Grønbæk Group
Ole Maaløes Vej 5
2200 København N.
- 2023
- Published
Frequency and Functional Characterization of RUNX1 Germline Variants in Myeloid Neoplasms
Nitschke, N. J., Almosailleakh, M., Niu, Yiyuan, Hansen, Jakob Werner, Raaschou-Jensen, K., Jespersen, Jakob Schmidt, Severinsen, M. T., Roug, A. S., Frödin, Morten, Weischenfeldt, Joachim Lütken, Andersen, M. K. & Grønbæk, Kirsten, 2023, In: Human Mutation. 2023, 11 p., 4738660.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
LEP promoter methylation in the initiation and progression of clonal cytopenia of undetermined significance and myelodysplastic syndrome
Kaastrup, K., Gillberg, Linn, Mikkelsen, Stine Ulrik, mxz703, mxz703, Schöllkopf, C., Mortensen, B. K., Porse, Bo Torben, Hansen, Jakob Werner & Grønbæk, Kirsten, 2023, In: Clinical Epigenetics. 15, 13 p., 91.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ProGraME: A novel flow cytometry algorithm for the diagnosis of low-risk myelodysplastic syndromes in patients with cytopenia
Therkelsen, J., Træden, D. W., Schjødt, I., Andersen, M. K., Sjö, Lene Dissing, Hansen, Jakob Werner, Grønbæk, Kirsten & Dimopoulos, K., 2023, In: European Journal of Haematology. 111, 6, 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Treatment experiences with focus on IL-6R inhibition in patients with VEXAS-syndrome and a case of remission with azacytidine treatment
Johansen, Morten Munk, Fassi, Daniel El , Nielsen, Christoffer Tandrup Holst, Krintel, S. B., Graudal, N. & Hansen, Jakob Werner, 2023, (E-pub ahead of print) In: Rheumatology.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Clonal Hematopoiesis and Epigenetic Age Acceleration in Elderly Danish Twins
Sørensen, M., Tulstrup, Morten Rytter, Hansen, Jakob Werner, Weischenfeldt, Joachim Lütken, Grønbæk, Kirsten & Christensen, K., 2022, In: HemaSphere. 6, 9, 6 p., 768.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inflammatory Cytokine Profiles Do Not Differ Between Patients With Idiopathic Cytopenias of Undetermined Significance and Myelodysplastic Syndromes
Nielsen, A. B., Hansen, Jakob Werner, mxz703, mxz703, Dimopoulos, K., Salem, M., Grigorian, M., Bruunsgaard, Helle & Grønbæk, Kirsten, 2022, In: HemaSphere. 6, 5, 10 p., e0713.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Safety, Outcomes, and T-Cell Characteristics in Patients with Relapsed or Refractory MDS or CMML Treated with Atezolizumab in Combination with Guadecitabine
O'Connell, C. L., Baer, M. R., Ørskov, A. D., Saini, S. K., Duong, V. H., Kropf, P., Hansen, J. W., Tsao-Wei, D., Jang, H. S., Emadi, A., Holmberg-Thyden, S., Cowland, J., Brinker, B. T., Horwood, K., Burgos, R., Hostetter, G., Youngblood, B. A., Hadrup, S. R., Issa, J. P., Jones, P. & 3 others, , 2022, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 28, 24, p. 5306-5316 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Myelomonocytic Leukemia: Clinical and Molecular Genetic Prognostic Factors in a Nordic Population
Wedge, E., Hansen, J. W., Dybedal, I., Creignou, M., Ejerblad, E., Lorenz, F., Werlenius, O., Ungerstedt, J., Holm, M. S., Nilsson, L., Kittang, A. O., Antunovic, P., Rohon, P., Andersen, M. K., Papaemmanuil, E., Bernard, E., Jädersten, M., Hellström-Lindberg, E., Grønbæk, K., Ljungman, P. & 1 others, , 2021, In: Transplantation and Cellular Therapy. 27, 12, p. 991.e1-991.e9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutations known from B-cell lymphoid malignancies are not found in CD34+ stem cells from patients with lymphoma
Husby, Simon, Favero, Francesco, Rodriguez Gonzalez, Francisco G, Sutton, L. A., Haastrup, E. K., mxz703, mxz703, Hansen, Jakob Werner, Arboe, B., Aslan, D., Clasen-Linde, E., Gjerdrum, Lise Mette Rahbek, Gørlev, J. S., Brown, Peter de Nully, Fischer-Nielsen, A., Rosenquist, R., Weischenfeldt, Joachim Lütken & Grønbæk, Kirsten, 2021, In: Leukemia and Lymphoma. 62, 11, p. 2808-2811Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural aberrations are associated with poor survival in patients with clonal cytopenia of undetermined significance
Mikkelsen, Stine Ulrik, Safavi, S., Dimopoulos, K., O'Rourke, Colm, Andersen, M. K., Holm, M. S., Marcher, C. W., Andersen, Jesper Bøje, Hansen, Jakob Werner & Grønbæk, Kirsten, 2021, In: Haematologica. 106, 6Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis
Tulstrup, Morten Rytter, Soerensen, M., Hansen, Jakob Werner, Gillberg, Linn, Needhamsen, M., Kaastrup, K., Helin, K., Christensen, K., Weischenfeldt, Joachim Lütken & Grønbæk, Kirsten, 2021, In: Nature Communications. 12, 1, 10 p., 6061.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Clinical impact of clonal hematopoiesis in patients with lymphoma undergoing ASCT: a national population-based cohort study
Husby, S., Favero, F., Nielsen, C., Sørensen, B. S., Bæch, J., Grell, K., Hansen, J. W., Rodriguez-Gonzalez, F. G., Haastrup, E. K., Fischer-Nielsen, A., Andersen, P., Arboe, B., Sækmose, S. G., Hansen, P. B., Christiansen, I., Clasen-Linde, E., Meldgaard, L., Ebbesen, L. H., Segel, E. K., Josefsson, P. & 6 others, , 2020, In: Leukemia. 34, p. 3256-3268 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clonal hematopoiesis in elderly twins: concordance, discordance, and mortality
Hansen, Jakob Werner, Pedersen, D. A., Larsen, L. A., Husby, Simon, Clemmensen, S. B., Hjelmborg, J., Favero, Francesco, Weischenfeldt, Joachim Lütken, Christensen, K. & Grønbæk, Kirsten, 2020, In: Blood. 135, 4, p. 261-268Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improved Outcomes after Allogenic Hematopoietic Stem Cell Transplantation with Fludarabine/Treosulfan for Patients with Myelodysplastic Syndromes
Wedge, E., Sengeløv, Henrik, Hansen, Jakob Werner, Andersen, N. S., Schjødt, I., Petersen, S. L., Kornblit, B., Grønbæk, Kirsten & Friis, L. S., 2020, In: Biology of Blood and Marrow Transplantation. 26, 6, p. 1091-1098Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The diagnostic and prognostic role of flow cytometry in idiopathic and clonal cytopenia of undetermined significance (ICUS/CCUS): A single-center analysis of 79 patients
Dimopoulos, K., Hansen, O. K., Sjö, Lene Dissing, Saft, L., Schjødt, I. M., Hansen, Jakob Werner & Grønbæk, Kirsten, 2020, In: Cytometry. Part B: Clinical Cytometry. 98, 3, p. 250-258Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The value of circulating microRNAs for early diagnosis of B-cell lymphoma: A case-control study on historical samples
Jørgensen, S., Paulsen, I. W., Hansen, Jakob Werner, Tholstrup, Dorte Maegaard, Hother, C., Sørensen, E., Petersen, M. S., Nielsen, K. R., Rostgaard, K., Larsen, M. A. H., Brown, Peter de Nully, Ralfkiær, E., Homburg, K. M., Hjalgrim, Henrik, Erikstrup, C., Ullum, H., Troelsen, J., Grønbæk, Kirsten & Pedersen, Ole Birger Vesterager, 2020, In: Scientific Reports. 10, 1, 9637.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes
Gillberg, Linn, mxz703, mxz703, Nasif, A., Ohtani, H., Madaj, Z., Hansen, Jakob Werner, Rapin, N., Mogensen, J. B., Liu, M., Dufva, I. H., Lykkesfeldt, Jens, Hajkova, P., Jones, P. A. & Grønbæk, Kirsten, 17 Oct 2019, In: Clinical Epigenetics. 11, 1, p. 143-153 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Clinical Impact of Clonal Hematopoiesis after Autologous Stem Cell Transplantation for Lymphoma: A National Population-Based Cohort Study
Husby, S., Francesco, F., Nielsen, C., Sorensen, B., Baech, J., Hansen, J. W., Gonzalez, G. G. R., Arboe, B., Andersen, L. P., Hastrup, E. K., Fischer-Nielsen, A., Saekmose, S. G., Hansen, P. B., Christiansen, I., Clasen-Linde, E., Knudsen, L. M., Grell, K., Segel, E. K., Ebbesen, L. H., Thorsgaard, M. & 6 others, , 2018, In: Blood. 132, Suppl 1, p. 607 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Long-term clinical outcomes of patients with hematologically unexplained cytopenia after routine assessment: A single center study
Johansen, M. M., Andersen, M. A., Grønbæk, Kirsten & Hansen, Jakob Werner, 2018, In: European Journal of Haematology. 101, 5, p. 595–603 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Treatment strategies, outcomes and prognostic factors in 291 patients with secondary CNS involvement by diffuse large B-cell lymphoma
El-Galaly, T. C., Cheah, C. Y., Bendtsen, M. D., Nowakowski, G. S., Kansara, R., Savage, K. J., Connors, J. M., Sehn, L. H., Goldschmidt, N., Shaulov, A., Farooq, U., Link, B. K., Ferreri, A. J. M., Calimeri, T., Cecchetti, C., Dann, E. J., Thompson, C. A., Inbar, T., Maurer, M. J., Gade, I. L. & 14 others, , 2018, In: European Journal of Cancer. 93, p. 57-68 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Anemia is present years before myelodysplastic syndrome diagnosis: Results from the pre-diagnostic period
Hansen, Jakob Werner, Sandholdt, H., Siersma, Volkert Dirk, mxz703, mxz703, Holmberg, S., Bjerrum, O. W., Hasselbalch, Hans Carl, Olivarius, Niels de Fine, Grønbæk, Kirsten & Andersen, Christen Bertel L, Jul 2017, In: American Journal of Hematology. 92, 7, p. E130-E132 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Global hypomethylation is an independent prognostic factor in diffuse large B cell lymphoma
Wedge, E., Hansen, Jakob Werner, Garde, C., Asmar, F., Tholstrup, Dorte Maegaard, Kristensen, S. S., Munch-Petersen, H. D., Ralfkiaer, E., Brown, Peter de Nully, Grønbæk, Kirsten & Kristensen, L. S., Jul 2017, In: American Journal of Hematology. 92, 7, p. 689-694 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TP53 mutations identify younger mantle cell lymphoma patients who do not benefit from intensive chemoimmunotherapy
Eskelund, C. W., Dahl, C., Hansen, Jakob Werner, Westman, M., Kolstad, A., Pedersen, L. B., Montano-Almendras, C. P., Husby, Simon, Freiburghaus, C., Ek, S., Vestergaard, Anja Holm, Niemann, Carsten, Raty, R., Brown, Peter de Nully, Geisler, C. H., Andersen, M. K., Guldberg, P., Jerkeman, M. & Grønbæk, Kirsten, 2017, In: Blood. 130, 17, p. 1903-1910 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Mutations in idiopathic cytopenia of undetermined significance assist diagnostics and correlate to dysplastic changes
Hansen, Jakob Werner, Westman, M. K., Sjö, Lene Dissing, Saft, L., Sommer Kristensen, L., mxz703, mxz703, Treppendahl, M., Andersen, M. K. & Grønbæk, Kirsten, Dec 2016, In: American Journal of Hematology. 91, 12, p. 1234-1238 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Uterine, but not ovarian, female reproductive organ involvement at presentation by diffuse large B-cell lymphoma is associated with poor outcomes and a high frequency of secondary CNS involvement
El-Galaly, T. C., Cheah, C. Y., Hutchings, M., Mikhaeel, N. G., Savage, K. J., Sehn, L. H., Barrington, S. F., Hansen, J. W., Poulsen, M. Ø., Smith, D. L., Rady, K., Mylam, K. J., Larsen, T. S., Holmberg, S., Juul, M. B., Cordua, S., Clausen, M. R., Jensen, K. B., Boegsted, M., Johnsen, H. E. & 4 others, , Dec 2016, In: British Journal of Haematology. 175, 5, p. 876-883 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Immune Mechanisms in Myelodysplastic Syndrome
Glenthøj, A., mxz703, mxz703, Hansen, Jakob Werner, Hadrup, S. R., O'Connell, C. & Grønbæk, Kirsten, 15 Jun 2016, In: International Journal of Molecular Sciences (Online). 17, 6, 13 p., 944.Research output: Contribution to journal › Review › Research › peer-review
- Published
The value of routine bone marrow biopsy in patients with diffuse large B-cell lymphoma staged with PET/CT: a Danish-Canadian study
Alzahrani, M., El-Galaly, T. C., Hutchings, M., Hansen, Jakob Werner, Loft, A., Johnsen, H. E., Iyer, V., Wilson, D., Sehn, L. H., Savage, K. J., Connors, J. M., Gascoyne, R. D., Johansen, P., Clasen-Linde, E., Brown, P. & Villa, D., Jun 2016, In: Annals of Oncology. 27, 6, p. 1095-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aberrant methylation of cell-free circulating DNA in plasma predicts poor outcome in diffuse large B cell lymphoma
Sommer Kristensen, L., Hansen, Jakob Werner, Kristensen, S. S., Tholstrup, D., Harsløf, L. B. S., Pedersen, Ole Birger Vesterager, Brown, Peter de Nully & Grønbæk, Kirsten, 2016, In: Clinical Epigenetics. 8, 11 p., 95.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations
Aslan, D., Garde, C., Nygaard, M. K., Helbo, A. S., Dimopoulos, K., Hansen, Jakob Werner, Severinsen, M. T., Treppendahl, M. B., Sjö, Lene Dissing, Grønbæk, Kirsten & Sommer Kristensen, L., 2016, In: OncoTarget. 7, 9, p. 9951-63 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Outcome prediction by extranodal involvement, IPI, and R-IPI in the PET/CT and rituximab era: A Danish-Canadian study of 443 patients with diffuse-large B-cell lymphoma
El-Galaly, T. C., Villa, D., Alzahrani, M., Hansen, Jakob Werner, Sehn, L. H., Wilson, D., de Nully Brown, P., Loft, A., Iyer, V., Johnsen, H. E., Savage, K. J., Connors, J. M. & Hutchings, M., Nov 2015, In: American Journal of Hematology. 90, 11, p. 1041–1046Research output: Contribution to journal › Journal article › Research › peer-review
- Published
YKL-40 and genetic status of CHI3L1 in a large group of asthmatics
Hansen, Jakob Werner, Thomsen, Simon Francis, Porsbjerg, Celeste Michala, Rasmussen, L. M., Harmsen, L., Johansen, Julia Sidenius & Backer, Vibeke, 2015, In: European Clinical Respiratory Journal. 2, p. 1-8 8 p., 25117.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Hypermethylation of DAPK1 is an independent prognostic factor predicting survival in diffuse large B-cell lymphoma
Kristensen, L. S., Asmar, F., Dimopoulos, K., Nygaard, M. K., Aslan, D., Hansen, Jakob Werner, Ralfkiaer, E. & Grønbæk, Kirsten, 2014, In: OncoTarget. 5, 20, p. 9798-810 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Rhinitis: a complication to asthma
Hansen, Jakob Werner, Thomsen, Simon Francis, Nolte, H. & Backer, Vibeke, Jul 2010, In: Allergy. 65, 7, p. 883-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
Gudbjartsson, D. F., Bjornsdottir, U. S., Halapi, E., Helgadottir, A., Sulem, P., Jonsdottir, G. M., Thorleifsson, G., Helgadottir, H., Steinthorsdottir, V., Stefansson, H., Williams, C., Hui, J., Beilby, J., Warrington, N. M., James, A., Palmer, L. J., Koppelman, G. H., Heinzmann, A., Krueger, M., Boezen, H. M. & 53 others, , Mar 2009, In: Nature Genetics. 41, 3, p. 342-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 129470785
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321
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Aberrant methylation of cell-free circulating DNA in plasma predicts poor outcome in diffuse large B cell lymphoma
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
201
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Tumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
29
downloads
Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes
Research output: Contribution to journal › Journal article › Research › peer-review
Published