Joachim Lütken Weischenfeldt
Group leader, Clinical Professor
Weischenfeldt Group
Københavns Universitet, BRIC, Ole Maaløes Vej 5
2200 København N
Member of:
- Published
Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability
Achuthankutty, D., Thakur, R. S., Haahr, Peter Thorlund, Hoffmann, Saskia, Drainas, A. P., Bizard, A. H., Weischenfeldt, Joachim Lütken, Hickson, Ian David & Mailand, Niels, 2019, In: The Journal of Cell Biology. 218, 12, 11 p., 3943.Research output: Contribution to journal › Journal article › Research › peer-review
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Epithelial specific splicing regulator proteins as emerging oncogenes in aggressive prostate cancer
Advani, R., Luzzi, S., Scott, E., Dalgliesh, C., Weischenfeldt, Joachim Lütken, Munkley, J. & Elliott, D. J., 2023, In: Oncogene. 42, p. 3161-3168 8 p.Research output: Contribution to journal › Review › Research › peer-review
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Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
Akdemir, K. C., Le, V. T., Chandran, S., Li, Y., Verhaak, R. G., Beroukhim, R., Campbell, P. J., Chin, L., Dixon, J. R., Futreal, P. A., Akdemir, K. C., Alvarez, E. G., Baez-Ortega, A., Beroukhim, R., Boutros, P. C., Bowtell, D. D. L., Brors, B., Burns, K. H., Campbell, P. J., Chan, K. & 32 others, , 2020, In: Nature Genetics. p. 294-305Research output: Contribution to journal › Journal article › Research › peer-review
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Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
Bailey, M. H., Meyerson, W. U., Dursi, L. J., Wang, L. B., Dong, G., Liang, W. W., Weerasinghe, A., Li, S., Kelso, S., Akbani, R., Anur, P., Bailey, M. H., Buchanan, A., Chiotti, K., Covington, K., Creason, A., Ding, L., Weischenfeldt, J., Brunak, S., Ding, L. & 4 others, , 2020, In: Nature Communications. 11, 1, 4748.Research output: Contribution to journal › Journal article › Research › peer-review
Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer
Brocks, D., Assenov, Y., Minner, S., Bogatyrova, O., Simon, R., Koop, C., Oakes, C., Zucknick, M., Lipka, D. B., Weischenfeldt, J., Feuerbach, L., Cowper-Sal Lari, R., Lupien, M., Brors, B., Korbel, J., Schlomm, T., Tanay, A., Sauter, G., Gerhäuser, C., Plass, C. & 1 others, , 7 Aug 2014, In: Cell Reports. 8, 3, p. 798-806 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rare Germline Variants Are Associated with Rapid Biochemical Recurrence After Radical Prostate Cancer Treatment: A Pan Prostate Cancer Group Study
Burns, D., Anokian, E., Saunders, E. J., Bristow, R. G., Fraser, M., Reimand, J., Schlomm, T., Sauter, G., Brors, B., Korbel, J., Weischenfeldt, J., Waszak, S. M., Corcoran, N. M., Jung, C. H., Pope, B. J., Hovens, C. M., Cancel-Tassin, G., Cussenot, O., Loda, M., Sander, C. & 16 others, , 2022, In: European Urology. 82, 2, p. 201-211 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
Carlevaro-Fita, J., Lanzós, A., Feuerbach, L., Hong, C., Mas-Ponte, D., Pedersen, J. S., Johnson, R., Sidiropoulos, N., Weischenfeldt, Joachim Lütken & Brunak, Søren, 2020, In: Communications Biology. 3, 1, p. 1-16 56.Research output: Contribution to journal › Journal article › Research › peer-review
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Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
Cortés-Ciriano, I., Lee, J. J. K., Xi, R., Jain, D., Jung, Y. L., Yang, L., Gordenin, D., Klimczak, L. J., Zhang, C. Z., Pellman, D. S., Akdemir, K. C., Alvarez, E. G., Baez-Ortega, A., Beroukhim, R., Boutros, P. C., Bowtell, D. D. L., Brors, B., Burns, K. H., Campbell, P. J., Chan, K. & 32 others, , 6 Feb 2020, In: Nature Genetics.Research output: Contribution to journal › Journal article › Research › peer-review
Comparative analysis of different vaccine constructs expressing defined antigens from Mycobacterium tuberculosis.
Doherty, T. M., Olsen, A. W., Weischenfeldt, Joachim Lütken, Huygen, K., D'Souza, S., Kondratieva, T. K., Yeremeev, V. V., Apt, A. S., Raupach, B., Grode, L., Kaufmann, S. & Andersen, P., 2004, In: Journal of Infectious Diseases. 190, 12, p. 2146-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural variations in cancer and the 3D genome
Dubois, F., Sidiropoulos, N., Weischenfeldt, Joachim Lütken & Beroukhim, R., 2022, In: Nature Reviews Cancer. 22, p. 533-546Research output: Contribution to journal › Review › Research › peer-review
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Clonal hematopoiesis evolves from pretreatment clones and stabilizes after end of chemotherapy in patients with MCL
Eskelund, C. W., Husby, Simon, Favero, Francesco, Klausen, T. W., Rodriguez Gonzalez, Francisco G, Kolstad, A., Pedersen, L. B., Räty, R. K., Geisler, C. H., Jerkeman, M., Weischenfeldt, Joachim Lütken & Grønbæk, Kirsten, 2020, In: Blood. 135, 22, p. 2000-2004Research output: Contribution to journal › Comment/debate › Research › peer-review
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Implementing targeted therapies in the treatment of glioblastoma: Previous shortcomings, future promises, and a multimodal strategy recommendation
Fougner, V., Hasselbalch, B., Lassen, Ulrik Niels, Weischenfeldt, Joachim Lütken, Poulsen, H. S. & Urup, T., 2022, In: Neuro-Oncology Advances. 4, 1, vdac157.Research output: Contribution to journal › Review › Research › peer-review
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Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories
Gerhauser, C., Favero, F., Risch, T., Simon, R., Feuerbach, L., Assenov, Y., Heckmann, D., Sidiropoulos, N., Waszak, S. M., Hübschmann, D., Urbanucci, A., Girma, E. G., Kuryshev, V., Klimczak, L. J., Saini, N., Stütz, A. M., Weichenhan, D., Böttcher, L. M., Toth, R., Hendriksen, J. D. & 35 others, , 2018, In: Cancer Cell. 34, 6, p. 996-1011.e8 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The landscape of genomic alterations across childhood cancers
ICGC PedBrain-Seq Project, I. P. P., 2018, In: Nature. 555, 7696, p. 321-327 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Clonal hematopoiesis in elderly twins: concordance, discordance, and mortality
Hansen, Jakob Werner, Pedersen, D. A., Larsen, L. A., Husby, Simon, Clemmensen, S. B., Hjelmborg, J., Favero, Francesco, Weischenfeldt, Joachim Lütken, Christensen, K. & Grønbæk, Kirsten, 2020, In: Blood. 135, 4, p. 261-268Research output: Contribution to journal › Journal article › Research › peer-review
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Mitochondrial mutations drive prostate cancer aggression
Hopkins, J. F., Sabelnykova, V. Y., Weischenfeldt, J., Simon, R., Aguiar, J. A., Alkallas, R., Heisler, L. E., Zhang, J., Watson, J. D., Chua, M. L. K., Fraser, M., Favero, F., Lawerenz, C., Plass, C., Sauter, G., McPherson, J. D., Van Der Kwast, T., Korbel, J., Schlomm, T., Bristow, R. G. & 1 others, , 1 Dec 2017, In: Nature Communications. 8, 1, 8 p., 656.Research output: Contribution to journal › Journal article › Research › peer-review
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Response to olaparib in a PALB2 germline mutated prostate cancer and genetic events associated with resistance
Horak, P., Weischenfeldt, J., von Amsberg, G., Beyer, B., Schütte, A., Uhrig, S., Gieldon, L., Klink, B., Feuerbach, L., Hübschmann, D., Kreutzfeldt, S., Heining, C., Maier, S., Hutter, B., Penzel, R., Schlesner, M., Eils, R., Sauter, G., Stenzinger, A., Brors, B. & 4 others, , 2019, In: Cold Spring Harbor molecular case studies. 5, 2, p. 1-9 a003657.Research output: Contribution to journal › Journal article › Research › peer-review
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A polygenic two-hit hypothesis for prostate cancer
Houlahan, K. E., Livingstone, J., Fox, N. S., Kurganovs, N., Zhu, H., Sietsma Penington, J., Jung, C-H., Yamaguchi, T. N., Heisler, L. E., Jovelin, R., Costello, A. J., Pope, B. J., Kishan, A. U., Corcoran, N. M., Bristow, R. G., Waszak, S. M., Weischenfeldt, J., He, H. H., Hung, R. J., Hovens, C. M. & 1 others, , 2023, In: Journal of the National Cancer Institute. 115, 4, p. 468-472 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Clonal hematopoiesis is associated with hematological toxicity during lenalidomide-based therapy for MCL
Husby, Simon, Bæch-Laursen, C., Eskelund, C. W., Favero, Francesco, Jespersen, Jakob Schmidt, Hutchings, M., Pedersen, L. B., Niemann, Carsten, Weischenfeldt, Joachim Lütken, Räty, R., Larsen, T. S., Kolstad, A., Jerkeman, M. & Grønbæk, Kirsten, 2022, In: Leukemia. 36, p. 2912-2916Research output: Contribution to journal › Journal article › Research › peer-review
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Mutations known from B-cell lymphoid malignancies are not found in CD34+ stem cells from patients with lymphoma
Husby, Simon, Favero, Francesco, Rodriguez Gonzalez, Francisco G, Sutton, L. A., Haastrup, E. K., mxz703, mxz703, Hansen, Jakob Werner, Arboe, B., Aslan, D., Clasen-Linde, E., Gjerdrum, Lise Mette Rahbek, Gørlev, J. S., Brown, Peter de Nully, Fischer-Nielsen, A., Rosenquist, R., Weischenfeldt, Joachim Lütken & Grønbæk, Kirsten, 2021, In: Leukemia and Lymphoma. 62, 11, p. 2808-2811Research output: Contribution to journal › Journal article › Research › peer-review
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Level of unique T cell clonotypes is associated with clonal hematopoiesis and survival in patients with lymphoma undergoing ASCT
Husby, Simon, Jørgensen, G. Ø., Favero, Francesco, Jespersen, Jakob Schmidt, Rodriguez Gonzalez, Francisco G, Nielsen, C., Sorensen, B., Ebbesen, L. H., Bæch, J., Haastrup, E. K., Josefsson, P., Thorsgaard, M., Brown, Peter de Nully, El-Galaly, T. C., Larsen, T. S., Weischenfeldt, Joachim Lütken & Grønbæk, Kirsten, 2022, In: Bone Marrow Transplantation. 57, p. 674-677Research output: Contribution to journal › Letter › Research › peer-review
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Clinical impact of clonal hematopoiesis in patients with lymphoma undergoing ASCT: a national population-based cohort study
Husby, S., Favero, F., Nielsen, C., Sørensen, B. S., Bæch, J., Grell, K., Hansen, J. W., Rodriguez-Gonzalez, F. G., Haastrup, E. K., Fischer-Nielsen, A., Andersen, P., Arboe, B., Sækmose, S. G., Hansen, P. B., Christiansen, I., Clasen-Linde, E., Meldgaard, L., Ebbesen, L. H., Segel, E. K., Josefsson, P. & 6 others, , 2020, In: Leukemia. 34, p. 3256-3268 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of unique and shared mitochondrial DNA mutations in neurodegeneration and cancer by single-cell mitochondrial DNA structural variation sequencing (MitoSV-seq)
Jaberi, E., Tresse-Gommeaux, Emilie, Grønbæk, Kirsten, Weischenfeldt, Joachim Lütken & Issazadeh-Navikas, Shohreh, 2020, In: EBioMedicine. 57, p. 1-17 102868.Research output: Contribution to journal › Journal article › Research › peer-review
Dissecting the genomic complexity underlying medulloblastoma
Jones, D. T. W., Jäger, N., Kool, M., Zichner, T., Hutter, B., Sultan, M., Cho, Y-J., Pugh, T. J., Hovestadt, V., Stütz, A. M., Rausch, T., Warnatz, H-J., Ryzhova, M., Bender, S., Sturm, D., Pleier, S., Cin, H., Pfaff, E., Sieber, L., Wittmann, A. & 70 others, , 2 Aug 2012, In: Nature. 488, 7409, p. 100-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss of Upk1a and Upk1b expression is linked to stage progression in urothelial carcinoma of the bladder
Kaczmarek, K., Plage, H., Furlano, K., Hofbauer, S., Weinberger, S., Ralla, B., Franz, A., Fendler, A., de Martino, M., Roßner, F., Schallenberg, S., Elezkurtaj, S., Kluth, M., Lennartz, M., Blessin, N. C., Marx, A. H., Samtleben, H., Fisch, M., Rink, M., Slojewski, M. & 12 others, , 2024, In: International Urology and Nephrology. 56, p. 499-508 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 3997200
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Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns
Research output: Contribution to journal › Journal article › Research › peer-review
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415
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The landscape of genomic alterations across childhood cancers
Research output: Contribution to journal › Journal article › Research › peer-review
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The whole-genome landscape of medulloblastoma subtypes
Research output: Contribution to journal › Journal article › Research › peer-review
Published