Joachim Lütken Weischenfeldt

Joachim Lütken Weischenfeldt

Group leader, Clinical Professor

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    ORCID: 0000-0002-3917-5524

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    1. Published

      Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability

      Achuthankutty, D., Thakur, R. S., Haahr, Peter Thorlund, Hoffmann, Saskia, Drainas, A. P., Bizard, A. H., Weischenfeldt, Joachim Lütken, Hickson, Ian David & Mailand, Niels, 2019, In: The Journal of Cell Biology. 218, 12, 11 p., 3943.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Epithelial specific splicing regulator proteins as emerging oncogenes in aggressive prostate cancer

      Advani, R., Luzzi, S., Scott, E., Dalgliesh, C., Weischenfeldt, Joachim Lütken, Munkley, J. & Elliott, D. J., 2023, In: Oncogene. 42, p. 3161-3168 8 p.

      Research output: Contribution to journal › Review › Research › peer-review

    3. Published

      Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

      Akdemir, K. C., Le, V. T., Chandran, S., Li, Y., Verhaak, R. G., Beroukhim, R., Campbell, P. J., Chin, L., Dixon, J. R., Futreal, P. A., Akdemir, K. C., Alvarez, E. G., Baez-Ortega, A., Beroukhim, R., Boutros, P. C., Bowtell, D. D. L., Brors, B., Burns, K. H., Campbell, P. J., Chan, K. & 32 others, Chen, K., Cortés-Ciriano, I., Dueso-Barroso, A., Dunford, A. J., Edwards, P. A., Estivill, X., Etemadmoghadam, D., Feuerbach, L., Fink, J. L., Frenkel-Morgenstern, M., Garsed, D. W., Gerstein, M., Gordenin, D. A., Haan, D., Haber, J. E., Hess, J. M., Hutter, B., Imielinski, M., Jones, D. T. W., Ju, Y. S., Kazanov, M. D., Klimczak, L. J., Koh, Y., Korbel, J. O., Kumar, K., Lee, E. A., Lee, J. J. K., Li, Y., Sidiropoulos, N., Weischenfeldt, Joachim Lütken, PCAWG Structural Variation Working Group, P. S. V. W. G. & PCAWG Consortium, P. C., 2020, In: Nature Genetics. p. 294-305

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

      Bailey, M. H., Meyerson, W. U., Dursi, L. J., Wang, L. B., Dong, G., Liang, W. W., Weerasinghe, A., Li, S., Kelso, S., Akbani, R., Anur, P., Bailey, M. H., Buchanan, A., Chiotti, K., Covington, K., Creason, A., Ding, L., Weischenfeldt, J., Brunak, S., Ding, L. & 4 others, Favero, Francesco, MC3 Working Group, M. W. G., PCAWG novel somatic mutation calling methods working group, P. N. S. M. C. M. W. G. & PCAWG Consortium, P. C., 2020, In: Nature Communications. 11, 1, 4748.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer

      Brocks, D., Assenov, Y., Minner, S., Bogatyrova, O., Simon, R., Koop, C., Oakes, C., Zucknick, M., Lipka, D. B., Weischenfeldt, J., Feuerbach, L., Cowper-Sal Lari, R., Lupien, M., Brors, B., Korbel, J., Schlomm, T., Tanay, A., Sauter, G., Gerhäuser, C., Plass, C. & 1 others, ICGC Early Onset Prostate Cancer Project, I. E. O. P. C. P., 7 Aug 2014, In: Cell Reports. 8, 3, p. 798-806 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Rare Germline Variants Are Associated with Rapid Biochemical Recurrence After Radical Prostate Cancer Treatment: A Pan Prostate Cancer Group Study

      Burns, D., Anokian, E., Saunders, E. J., Bristow, R. G., Fraser, M., Reimand, J., Schlomm, T., Sauter, G., Brors, B., Korbel, J., Weischenfeldt, J., Waszak, S. M., Corcoran, N. M., Jung, C. H., Pope, B. J., Hovens, C. M., Cancel-Tassin, G., Cussenot, O., Loda, M., Sander, C. & 16 others, Hayes, V. M., Dalsgaard Sorensen, K., Lu, Y. J., Hamdy, F. C., Foster, C. S., Gnanapragasam, V., Butler, A., Lynch, A. G., Massie, C. E., Woodcock, D. J., Cooper, C. S., Wedge, D. C., Brewer, D. S., Kote-Jarai, Z., Eeles, R. A. & CR-UK/Prostate Cancer UK, ICGC, The PPCG, C. C. U. I. T. P., 2022, In: European Urology. 82, 2, p. 201-211 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis

      Carlevaro-Fita, J., Lanzós, A., Feuerbach, L., Hong, C., Mas-Ponte, D., Pedersen, J. S., Johnson, R., Sidiropoulos, N., Weischenfeldt, Joachim Lütken & Brunak, Søren, 2020, In: Communications Biology. 3, 1, p. 1-16 56.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

      Cortés-Ciriano, I., Lee, J. J. K., Xi, R., Jain, D., Jung, Y. L., Yang, L., Gordenin, D., Klimczak, L. J., Zhang, C. Z., Pellman, D. S., Akdemir, K. C., Alvarez, E. G., Baez-Ortega, A., Beroukhim, R., Boutros, P. C., Bowtell, D. D. L., Brors, B., Burns, K. H., Campbell, P. J., Chan, K. & 32 others, Chen, K., Cortés-Ciriano, I., Dueso-Barroso, A., Dunford, A. J., Edwards, P. A., Estivill, X., Etemadmoghadam, D., Feuerbach, L., Fink, J. L., Frenkel-Morgenstern, M., Garsed, D. W., Gerstein, M., Gordenin, D. A., Haan, D., Haber, J. E., Hess, J. M., Hutter, B., Imielinski, M., Jones, D. T. W., Ju, Y. S., Kazanov, M. D., Klimczak, L. J., Koh, Y., Korbel, J. O., Kumar, K., Lee, E. A., Lee, J. J. K., Li, Y., Sidiropoulos, N., Weischenfeldt, Joachim Lütken, PCAWG Structural Variation Working Group, P. S. V. W. G. & PCAWG Consortium, P. C., 6 Feb 2020, In: Nature Genetics.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Comparative analysis of different vaccine constructs expressing defined antigens from Mycobacterium tuberculosis.

      Doherty, T. M., Olsen, A. W., Weischenfeldt, Joachim Lütken, Huygen, K., D'Souza, S., Kondratieva, T. K., Yeremeev, V. V., Apt, A. S., Raupach, B., Grode, L., Kaufmann, S. & Andersen, P., 2004, In: Journal of Infectious Diseases. 190, 12, p. 2146-53 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Structural variations in cancer and the 3D genome

      Dubois, F., Sidiropoulos, N., Weischenfeldt, Joachim Lütken & Beroukhim, R., 2022, In: Nature Reviews Cancer. 22, p. 533-546

      Research output: Contribution to journal › Review › Research › peer-review

    11. Published

      Clonal hematopoiesis evolves from pretreatment clones and stabilizes after end of chemotherapy in patients with MCL

      Eskelund, C. W., Husby, Simon, Favero, Francesco, Klausen, T. W., Rodriguez Gonzalez, Francisco G, Kolstad, A., Pedersen, L. B., Räty, R. K., Geisler, C. H., Jerkeman, M., Weischenfeldt, Joachim Lütken & Grønbæk, Kirsten, 2020, In: Blood. 135, 22, p. 2000-2004

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    12. Published

      Implementing targeted therapies in the treatment of glioblastoma: Previous shortcomings, future promises, and a multimodal strategy recommendation

      Fougner, V., Hasselbalch, B., Lassen, Ulrik Niels, Weischenfeldt, Joachim Lütken, Poulsen, H. S. & Urup, T., 2022, In: Neuro-Oncology Advances. 4, 1, vdac157.

      Research output: Contribution to journal › Review › Research › peer-review

    13. Published

      Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories

      Gerhauser, C., Favero, F., Risch, T., Simon, R., Feuerbach, L., Assenov, Y., Heckmann, D., Sidiropoulos, N., Waszak, S. M., Hübschmann, D., Urbanucci, A., Girma, E. G., Kuryshev, V., Klimczak, L. J., Saini, N., Stütz, A. M., Weichenhan, D., Böttcher, L. M., Toth, R., Hendriksen, J. D. & 35 others, Koop, C., Lutsik, P., Matzk, S., Warnatz, H. J., Amstislavskiy, V., Feuerstein, C., Raeder, B., Bogatyrova, O., Schmitz, E. M., Hube-Magg, C., Kluth, M., Huland, H., Graefen, M., Lawerenz, C., Henry, G. H., Yamaguchi, T. N., Malewska, A., Meiners, J., Schilling, D., Reisinger, E., Eils, R., Schlesner, M., Strand, D. W., Bristow, R. G., Boutros, P. C., von Kalle, C., Gordenin, D., Sültmann, H., Brors, B., Sauter, G., Plass, C., Yaspo, M. L., Korbel, J. O., Schlomm, T. & Weischenfeldt, Joachim Lütken, 2018, In: Cancer Cell. 34, 6, p. 996-1011.e8 24 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      The landscape of genomic alterations across childhood cancers

      ICGC PedBrain-Seq Project, I. P. P., 2018, In: Nature. 555, 7696, p. 321-327 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Clonal hematopoiesis in elderly twins: concordance, discordance, and mortality

      Hansen, Jakob Werner, Pedersen, D. A., Larsen, L. A., Husby, Simon, Clemmensen, S. B., Hjelmborg, J., Favero, Francesco, Weischenfeldt, Joachim Lütken, Christensen, K. & Grønbæk, Kirsten, 2020, In: Blood. 135, 4, p. 261-268

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Mitochondrial mutations drive prostate cancer aggression

      Hopkins, J. F., Sabelnykova, V. Y., Weischenfeldt, J., Simon, R., Aguiar, J. A., Alkallas, R., Heisler, L. E., Zhang, J., Watson, J. D., Chua, M. L. K., Fraser, M., Favero, F., Lawerenz, C., Plass, C., Sauter, G., McPherson, J. D., Van Der Kwast, T., Korbel, J., Schlomm, T., Bristow, R. G. & 1 others, Boutros, P. C., 1 Dec 2017, In: Nature Communications. 8, 1, 8 p., 656.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Response to olaparib in a PALB2 germline mutated prostate cancer and genetic events associated with resistance

      Horak, P., Weischenfeldt, J., von Amsberg, G., Beyer, B., Schütte, A., Uhrig, S., Gieldon, L., Klink, B., Feuerbach, L., Hübschmann, D., Kreutzfeldt, S., Heining, C., Maier, S., Hutter, B., Penzel, R., Schlesner, M., Eils, R., Sauter, G., Stenzinger, A., Brors, B. & 4 others, Schröck, E., Glimm, H., Fröhling, S. & Schlomm, T., 2019, In: Cold Spring Harbor molecular case studies. 5, 2, p. 1-9 a003657.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      A polygenic two-hit hypothesis for prostate cancer

      Houlahan, K. E., Livingstone, J., Fox, N. S., Kurganovs, N., Zhu, H., Sietsma Penington, J., Jung, C-H., Yamaguchi, T. N., Heisler, L. E., Jovelin, R., Costello, A. J., Pope, B. J., Kishan, A. U., Corcoran, N. M., Bristow, R. G., Waszak, S. M., Weischenfeldt, J., He, H. H., Hung, R. J., Hovens, C. M. & 1 others, Boutros, P. C., 2023, In: Journal of the National Cancer Institute. 115, 4, p. 468-472 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Clonal hematopoiesis is associated with hematological toxicity during lenalidomide-based therapy for MCL

      Husby, Simon, Bæch-Laursen, C., Eskelund, C. W., Favero, Francesco, Jespersen, Jakob Schmidt, Hutchings, M., Pedersen, L. B., Niemann, Carsten, Weischenfeldt, Joachim Lütken, Räty, R., Larsen, T. S., Kolstad, A., Jerkeman, M. & Grønbæk, Kirsten, 2022, In: Leukemia. 36, p. 2912-2916

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Mutations known from B-cell lymphoid malignancies are not found in CD34+ stem cells from patients with lymphoma

      Husby, Simon, Favero, Francesco, Rodriguez Gonzalez, Francisco G, Sutton, L. A., Haastrup, E. K., mxz703, mxz703, Hansen, Jakob Werner, Arboe, B., Aslan, D., Clasen-Linde, E., Gjerdrum, Lise Mette Rahbek, Gørlev, J. S., Brown, Peter de Nully, Fischer-Nielsen, A., Rosenquist, R., Weischenfeldt, Joachim Lütken & Grønbæk, Kirsten, 2021, In: Leukemia and Lymphoma. 62, 11, p. 2808-2811

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Level of unique T cell clonotypes is associated with clonal hematopoiesis and survival in patients with lymphoma undergoing ASCT

      Husby, Simon, Jørgensen, G. Ø., Favero, Francesco, Jespersen, Jakob Schmidt, Rodriguez Gonzalez, Francisco G, Nielsen, C., Sorensen, B., Ebbesen, L. H., Bæch, J., Haastrup, E. K., Josefsson, P., Thorsgaard, M., Brown, Peter de Nully, El-Galaly, T. C., Larsen, T. S., Weischenfeldt, Joachim Lütken & Grønbæk, Kirsten, 2022, In: Bone Marrow Transplantation. 57, p. 674-677

      Research output: Contribution to journal › Letter › Research › peer-review

    22. Published

      Clinical impact of clonal hematopoiesis in patients with lymphoma undergoing ASCT: a national population-based cohort study

      Husby, S., Favero, F., Nielsen, C., Sørensen, B. S., Bæch, J., Grell, K., Hansen, J. W., Rodriguez-Gonzalez, F. G., Haastrup, E. K., Fischer-Nielsen, A., Andersen, P., Arboe, B., Sækmose, S. G., Hansen, P. B., Christiansen, I., Clasen-Linde, E., Meldgaard, L., Ebbesen, L. H., Segel, E. K., Josefsson, P. & 6 others, Thorsgaard, M., El-Galaly, T. C., Brown, Peter de Nully, Weischenfeldt, Joachim Lütken, Larsen, T. S. & Grønbæk, Kirsten, 2020, In: Leukemia. 34, p. 3256-3268 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Identification of unique and shared mitochondrial DNA mutations in neurodegeneration and cancer by single-cell mitochondrial DNA structural variation sequencing (MitoSV-seq)

      Jaberi, E., Tresse-Gommeaux, Emilie, Grønbæk, Kirsten, Weischenfeldt, Joachim Lütken & Issazadeh-Navikas, Shohreh, 2020, In: EBioMedicine. 57, p. 1-17 102868.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Dissecting the genomic complexity underlying medulloblastoma

      Jones, D. T. W., Jäger, N., Kool, M., Zichner, T., Hutter, B., Sultan, M., Cho, Y-J., Pugh, T. J., Hovestadt, V., Stütz, A. M., Rausch, T., Warnatz, H-J., Ryzhova, M., Bender, S., Sturm, D., Pleier, S., Cin, H., Pfaff, E., Sieber, L., Wittmann, A. & 70 others, Remke, M., Witt, H., Hutter, S., Tzaridis, T., Weischenfeldt, Joachim Lütken, Raeder, B., Avci, M., Amstislavskiy, V., Zapatka, M., Weber, U. D., Wang, Q., Lasitschka, B., Bartholomae, C. C., Schmidt, M., von Kalle, C., Ast, V., Lawerenz, C., Eils, J., Kabbe, R., Benes, V., van Sluis, P., Koster, J., Volckmann, R., Shih, D., Betts, M. J., Russell, R. B., Coco, S., Tonini, G. P., Schüller, U., Hans, V., Graf, N., Kim, Y., Monoranu, C., Roggendorf, W., Unterberg, A., Herold-Mende, C., Milde, T., Kulozik, A. E., von Deimling, A., Witt, O., Maass, E., Rössler, J., Ebinger, M., Schuhmann, M. U., Frühwald, M. C., Hasselblatt, M., Jabado, N., Rutkowski, S., von Bueren, A. O., Williamson, D., Clifford, S. C., McCabe, M. G., Collins, V. P., Wolf, S., Wiemann, S., Lehrach, H., Brors, B., Scheurlen, W., Felsberg, J., Reifenberger, G., Northcott, P. A., Taylor, M. D., Meyerson, M., Pomeroy, S. L., Yaspo, M., Korbel, J. O., Korshunov, A., Eils, R., Pfister, S. M. & Lichter, P., 2 Aug 2012, In: Nature. 488, 7409, p. 100-5 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Loss of Upk1a and Upk1b expression is linked to stage progression in urothelial carcinoma of the bladder

      Kaczmarek, K., Plage, H., Furlano, K., Hofbauer, S., Weinberger, S., Ralla, B., Franz, A., Fendler, A., de Martino, M., Roßner, F., Schallenberg, S., Elezkurtaj, S., Kluth, M., Lennartz, M., Blessin, N. C., Marx, A. H., Samtleben, H., Fisch, M., Rink, M., Slojewski, M. & 12 others, Ecke, T., Hallmann, S., Koch, S., Adamini, N., Minner, S., Simon, R., Sauter, G., Weischenfeldt, Joachim Lütken, Klatte, T., Schlomm, T., Horst, D. & Zecha, H., 2024, In: International Urology and Nephrology. 56, p. 499-508 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 3997200