Krister Wennerberg

Krister Wennerberg

Professor

Member of:

    ORCID: 0000-0002-1352-4220

    Publication year:
    All
    51 - 100 out of 122Page size: 50
    1. 2018

    2. Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients

      He, L., Tang, J., Andersson, E. I., Timonen, S., Koschmieder, S., Wennerberg, Krister, Mustjoki, S. & Aittokallio, T., 1 May 2018, In: Cancer Research. 78, 9, p. 2407-2418 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Toward universal protein post-translational modification detection in high throughput format

      Härmä, H., Tong-Ochoa, N., van Adrichem, A. J., Jelesarov, I., Wennerberg, Krister & Kopra, K., 2018, In: Chemical communications (Cambridge, England). 54, 23, p. 2910-2913 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

      Kauko, O., O’Connor, C. M., Kulesskiy, E., Sangodkar, J., Aakula, A., Izadmehr, S., Yetukuri, L., Yadav, B., Padzik, A., Laajala, T. D., Haapaniemi, P., Momeny, M., Varila, T., Ohlmeyer, M., Aittokallio, T., Wennerberg, Krister, Narla, G. & Westermarck, J., 18 Jul 2018, In: Science Translational Medicine. 10, 450, p. 1-12 12 p., eaaq1093.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Drug-sensitivity screening and genomic characterization of 45 hpV-negative head and neck carcinoma cell lines for novel biomarkers of drug efficacy

      Lepikhova, T., Karhemo, P. R., Louhimo, R., Yadav, B., Murumagi, A., Kulesskiy, E., Kivento, M., Sihto, H., Grenman, R., Syrjanen, S. M., Kallioniemi, O., Aittokallio, T., Wennerberg, Krister, Joensuu, H. & Monni, O., 2018, In: Molecular Cancer Therapeutics. 17, 9, p. 2060-2071 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma

      Nepal, C., O'Rourke, Colm, Oliveira, D. V., Taranta, A., Shema, S., Gautam, P., Calderaro, J., Barbour, A., Raggi, C., Wennerberg, Krister, Wang, X. W., Lautem, A., Roberts, L. R. & Andersen, Jesper Bøje, Sep 2018, In: Hepatology. 68, 3, p. 949-963 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions

      Tang, J., Tanoli, Z-U-R., Ravikumar, B., Alam, Z., Rebane, A., Vähä-Koskela, M., Peddinti, G., van Adrichem, A. J., Wakkinen, J., Jaiswal, A., Karjalainen, E., Gautam, P., He, L., Parri, E., Khan, S., Gupta, A., Ali, M., Yetukuri, L., Gustavsson, A-L., Seashore-Ludlow, B. & 6 others, Hersey, A., Leach, A. R., Overington, J. P., Repasky, G., Wennerberg, Krister & Aittokallio, T., 15 Feb 2018, In: Cell Chemical Biology. 25, 2, p. 224-229.e2

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles

      Tanoli, Z. R., Alam, Z., Vähä-Koskela, M., Ravikumar, B., Malyutina, A., Jaiswal, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 2018, In: Database: The Journal of Biological Databases and Curation. 2018, 2018, p. 1-13 13 p., bay083.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

      Vaseva, A. V., Blake, D. R., Gilbert, T. S. K., Ng, S., Hostetter, G., Azam, S. H., Ozkan-Dagliyan, I., Gautam, P., Bryant, K. L., Pearce, K. H., Herring, L. E., Han, H., Graves, L. M., Witkiewicz, A. K., Knudsen, E. S., Pecot, C. V., Rashid, N., Houghton, P. J., Wennerberg, K., Cox, A. D. & 1 others, Der, C. J., 2018, In: Cancer Cell. 34, 5, p. 807-822.e1-e7 23 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. 2017

    11. Systematic identification of feature combinations for predicting drug response with Bayesian multi-view multi-task linear regression

      Ammad-Ud-Din, M., Khan, S. A., Wennerberg, Krister & Aittokallio, T., 15 Jul 2017, In: Bioinformatics (Online). 33, 14, p. i359-i368

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors

      Cichonska, A., Ravikumar, B., Parri, E., Timonen, S., Pahikkala, T., Airola, A., Wennerberg, Krister, Rousu, J. & Aittokallio, T., Aug 2017, In: PLOS Computational Biology. 13, 8, p. e1005678

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

      Broad-DREAM Community, B. C., 22 Nov 2017, In: Cell Systems. 5, 5, p. 485-497.e3

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells

      Haltia, U., Andersson, N., Yadav, B., Färkkilä, A., Kulesskiy, E., Kankainen, M., Tang, J., Bützow, R., Riska, A., Leminen, A., Heikinheimo, M., Kallioniemi, O., Unkila-Kallio, L., Wennerberg, Krister, Aittokallio, T. & Anttonen, M., Mar 2017, In: Gynecologic Oncology. 144, 3, p. 621-630 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells

      Jaiswal, A., Peddinti, G., Akimov, Y., Wennerberg, Krister, Kuznetsov, S., Tang, J. & Aittokallio, T., 1 Jun 2017, In: Genome Medicine. 9, 1, p. 51

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML

      Karjalainen, R., Pemovska, T., Popa, M., Liu, M., Javarappa, K. K., Majumder, M. M., Yadav, B., Tamborero, D., Tang, J., Bychkov, D., Kontro, M., Parsons, A., Suvela, M., Mayoral Safont, M., Porkka, K., Aittokallio, T., Kallioniemi, O., McCormack, E., Gjertsen, B. T., Wennerberg, K. & 2 others, Knowles, J. & Heckman, C. A., 10 Aug 2017, In: Blood. 130, 6, p. 789-802 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury

      Kohonen, P., Parkkinen, J. A., Willighagen, E. L., Ceder, R., Wennerberg, Krister, Kaski, S. & Grafström, R. C., 3 Jul 2017, In: Nature Communications. 8, p. 15932

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. High-Throughput Dual Screening Method for Ras Activities and Inhibitors

      Kopra, K., van Adrichem, A. J., Salo-Ahen, O. M. H., Peltonen, J., Wennerberg, Krister & Härmä, H., 18 Apr 2017, In: Analytical Chemistry. 89, 8, p. 4508-4516 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling

      Kuusanmäki, H., Dufva, O., Parri, E., van Adrichem, A. J., Rajala, H., Majumder, M. M., Yadav, B., Parsons, A., Chan, W. C., Wennerberg, Krister, Mustjoki, S. & Heckman, C. A., 14 Nov 2017, In: OncoTarget. 8, 57, p. 97516-97527 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

      Pietarinen, P. O., Eide, C. A., Ayuda-Durán, P., Potdar, S., Kuusanmäki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, Krister, Hjorth-Hansen, H., Druker, B. J., Enserink, J. M., Tyner, J. W., Mustjoki, S. & Porkka, K., 4 Apr 2017, In: OncoTarget. 8, 14, p. 22606-22615 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer

      Saeed, K., Rahkama, V., Eldfors, S., Bychkov, D., Mpindi, J. P., Yadav, B., Paavolainen, L., Aittokallio, T., Heckman, C., Wennerberg, Krister, Peehl, D. M., Horvath, P., Mirtti, T., Rannikko, A., Kallioniemi, O., Östling, P. & Af Hällström, T. M., Mar 2017, In: European Urology (Italian Edition). 71, 3, p. 319-327 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. 2016

    23. Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells

      Gautam, P., Karhinen, L., Szwajda, A., Jha, S. K., Yadav, B., Aittokallio, T. & Wennerberg, Krister, 10 May 2016, In: Molecular Cancer. 15, 1, p. 34

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

      Hayes, T. K., Neel, N. F., Hu, C., Gautam, P., Chenard, M., Long, B., Aziz, M., Kassner, M., Bryant, K. L., Pierobon, M., Marayati, R., Kher, S., George, S. D., Xu, M., Wang-Gillam, A., Samatar, A. A., Maitra, A., Wennerberg, K., Petricoin, E. F., Yin, H. H. & 4 others, Nelkin, B., Cox, A. D., Yeh, J. J. & Der, C. J., 11 Jan 2016, In: Cancer Cell. 29, 1, p. 75-89 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing

      Kulesskiy, E., Saarela, J., Turunen, L. & Wennerberg, Krister, Feb 2016, In: Journal of laboratory automation. 21, 1, p. 27-36 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's Disease

      Lindholm, D., Pham, D. D., Cascone, A., Eriksson, O., Wennerberg, Krister & Saarma, M., 2016, In: Frontiers in Aging Neuroscience. 8, p. 254

      Research output: Contribution to journal › Review › Research › peer-review

    27. Consistency in drug response profiling

      Mpindi, J. P., Yadav, B., Östling, P., Gautam, P., Malani, D., Murumägi, A., Hirasawa, A., Kangaspeska, S., Wennerberg, Krister, Kallioniemi, O. & Aittokallio, T., 30 Nov 2016, In: Nature. 540, 7631, p. E5-E6

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses

      Varghese, F. S., Kaukinen, P., Gläsker, S., Bespalov, M., Hanski, L., Wennerberg, Krister, Kümmerer, B. M. & Ahola, T., Feb 2016, In: Antiviral Research. 126, p. 117-24 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Cancer Cell Drug Response Transcriptomes in 3D

      Wennerberg, Krister, 17 Nov 2016, In: Cell Chemical Biology. 23, 11, p. 1323-1324 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. 2015

    31. Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth

      Al-Ali, H., Lee, D., Danzi, M. C., Nassif, H., Gautam, P., Wennerberg, Krister, Zuercher, B., Drewry, D. H., Lee, J. K., Lemmon, V. P. & Bixby, J. L., 21 Aug 2015, In: ACS chemical biology. 10, 8, p. 1939-51 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Bioluminescent, Nonlytic, Real-Time Cell Viability Assay and Use in Inhibitor Screening

      Duellman, S. J., Zhou, W., Meisenheimer, P., Vidugiris, G., Cali, J. J., Gautam, P., Wennerberg, Krister & Vidugiriene, J., Oct 2015, In: ASSAY and Drug Development Technologies. 13, 8, p. 456-65 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. TIMMA-R: an R package for predicting synergistic multi-targeted drug combinations in cancer cell lines or patient-derived samples

      He, L., Wennerberg, Krister, Aittokallio, T. & Tang, J., 1 Jun 2015, In: Bioinformatics (Online). 31, 11, p. 1866-8 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

      Kibble, M., Saarinen, N., Tang, J., Wennerberg, Krister, Mäkelä, S. & Aittokallio, T., Aug 2015, In: Natural Product Reports. 32, 8, p. 1249-66 18 p.

      Research output: Contribution to journal › Review › Research › peer-review

    35. KIFC1 is a novel potential therapeutic target for breast cancer

      Li, Y., Lu, W., Chen, D., Boohaker, R. J., Zhai, L., Padmalayam, I., Wennerberg, Krister, Xu, B. & Zhang, W., 2015, In: Cancer Biology & Therapy. 16, 9, p. 1316-22 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Impact of normalization methods on high-throughput screening data with high hit rates and drug testing with dose-response data

      Mpindi, J., Swapnil, P., Dmitrii, B., Jani, S., Saeed, K., Wennerberg, Krister, Aittokallio, T., Östling, P. & Kallioniemi, O., 1 Dec 2015, In: Bioinformatics (Online). 31, 23, p. 3815-21 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

      Pemovska, T., Johnson, E., Kontro, M., Repasky, G. A., Chen, J., Wells, P., Cronin, C. N., McTigue, M., Kallioniemi, O., Porkka, K., Murray, B. W. & Wennerberg, Krister, 5 Mar 2015, In: Nature. 519, 7541, p. 102-5 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data

      Pokharel, Y. R., Saarela, J., Szwajda, A., Rupp, C., Rokka, A., Lal Kumar Karna, S., Teittinen, K., Corthals, G., Kallioniemi, O., Wennerberg, Krister, Aittokallio, T. & Westermarck, J., Dec 2015, In: Molecular and Cellular Proteomics. 14, 12, p. 3274-83 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles

      Szwajda, A., Gautam, P., Karhinen, L., Jha, S. K., Saarela, J., Shakyawar, S., Turunen, L., Yadav, B., Tang, J., Wennerberg, Krister & Aittokallio, T., 20 Aug 2015, In: Chemistry & Biology. 22, 8, p. 1144-55 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. What is synergy? The Saariselkä agreement revisited

      Tang, J., Wennerberg, Krister & Aittokallio, T., 2015, In: Frontiers in Pharmacology. 6, p. 181

      Research output: Contribution to journal › Review › Research › peer-review

    41. From drug response profiling to target addiction scoring in cancer cell models

      Yadav, B., Gopalacharyulu, P., Pemovska, T., Khan, S. A., Szwajda, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 1 Oct 2015, In: Disease models & mechanisms. 8, 10, p. 1255-64 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model

      Yadav, B., Wennerberg, Krister, Aittokallio, T. & Tang, J., 2015, In: Computational and Structural Biotechnology Journal. 13, p. 504-13 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP

      van Adrichem, A. J., Fagerholm, A., Turunen, L., Lehto, A., Saarela, J., Koskinen, A., Repasky, G. A. & Wennerberg, Krister, 2015, In: Combinatorial Chemistry & High Throughput Screening. 18, 1, p. 3-17 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. MgcRacGAP inhibition stimulates JAK-dependent STAT3 activity

      van Adrichem, A. J. & Wennerberg, Krister, 21 Dec 2015, In: FEBS Letters. 589, 24 Pt B, p. 3859-65 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. 2014

    46. Integrative and personalized QSAR analysis in cancer by kernelized Bayesian matrix factorization

      Ammad-ud-din, M., Georgii, E., Gönen, M., Laitinen, T., Kallioniemi, O., Wennerberg, Krister, Poso, A. & Kaski, S., 25 Aug 2014, In: Journal of Chemical Information and Modeling. 54, 8, p. 2347-59 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells

      Antila, H., Autio, H., Turunen, L., Harju, K., Tammela, P., Wennerberg, Krister, Yli-Kauhaluoma, J., Huttunen, H. J., Castrén, E. & Rantamäki, T., 30 Jan 2014, In: Journal of Neuroscience Methods. 222, p. 142-6 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza

      Atkins, C., Evans, C. W., Nordin, B., Patricelli, M. P., Reynolds, R., Wennerberg, Krister & Noah, J. W., Jul 2014, In: Journal of Biomolecular Screening. 19, 6, p. 936-46 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. A community effort to assess and improve drug sensitivity prediction algorithms

      NCI DREAM Community, N. D. C., Dec 2014, In: Nature Biotechnology. 32, 12, p. 1202-12 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis

      Khan, S. A., Virtanen, S., Kallioniemi, O. P., Wennerberg, Krister, Poso, A. & Kaski, S., 1 Sep 2014, In: Bioinformatics (Online). 30, 17, p. i497-504

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. The high throughput biomedicine unit at the institute for molecular medicine Finland: high throughput screening meets precision medicine

      Pietiainen, V., Saarela, J., von Schantz, C., Turunen, L., Ostling, P. & Wennerberg, Krister, May 2014, In: Combinatorial Chemistry & High Throughput Screening. 17, 4, p. 377-86 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Antifungal application of nonantifungal drugs

      Stylianou, M., Kulesskiy, E., Lopes, J. P., Granlund, M., Wennerberg, Krister & Urban, C. F., 2014, In: Antimicrobial Agents and Chemotherapy. 58, 2, p. 1055-62 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis

      Tang, J., Szwajda, A., Shakyawar, S., Xu, T., Hintsanen, P., Wennerberg, Krister & Aittokallio, T., 24 Mar 2014, In: Journal of Chemical Information and Modeling. 54, 3, p. 735-43 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Bioluminescent cell-based NAD(P)/NAD(P)H assays for rapid dinucleotide measurement and inhibitor screening

      Vidugiriene, J., Leippe, D., Sobol, M., Vidugiris, G., Zhou, W., Meisenheimer, P., Gautam, P., Wennerberg, Krister & Cali, J. J., 17 Dec 2014, In: ASSAY and Drug Development Technologies. 12, 9-10, p. 514-26 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies

      Yadav, B., Pemovska, T., Szwajda, A., Kulesskiy, E., Kontro, M., Karjalainen, R., Majumder, M. M., Malani, D., Murumägi, A., Knowles, J., Porkka, K., Heckman, C., Kallioniemi, O., Wennerberg, Krister & Aittokallio, T., 5 Jun 2014, In: Scientific Reports. 4, p. 5193

      Research output: Contribution to journal › Journal article › Research › peer-review

    Previous 1 2 3 Next

    ID: 181406515