Krister Wennerberg

Krister Wennerberg

Professor

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    ORCID: 0000-0002-1352-4220

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    1. Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP

      van Adrichem, A. J., Fagerholm, A., Turunen, L., Lehto, A., Saarela, J., Koskinen, A., Repasky, G. A. & Wennerberg, Krister, 2015, In: Combinatorial Chemistry & High Throughput Screening. 18, 1, p. 3-17 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. MgcRacGAP inhibition stimulates JAK-dependent STAT3 activity

      van Adrichem, A. J. & Wennerberg, Krister, 21 Dec 2015, In: FEBS Letters. 589, 24 Pt B, p. 3859-65 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. A high-throughput screen for chemical inhibitors of exocytic transport in yeast

      Zhang, L., Nebane, N. M., Wennerberg, Krister, Li, Y., Neubauer, V., Hobrath, J. V., McKellip, S., Rasmussen, L., Shindo, N., Sosa, M., Maddry, J. A., Ananthan, S., Piazza, G. A., White, E. L. & Harsay, E., 14 Jun 2010, In: ChemBioChem. 11, 9, p. 1291-301 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model

      Yadav, B., Wennerberg, Krister, Aittokallio, T. & Tang, J., 2015, In: Computational and Structural Biotechnology Journal. 13, p. 504-13 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. From drug response profiling to target addiction scoring in cancer cell models

      Yadav, B., Gopalacharyulu, P., Pemovska, T., Khan, S. A., Szwajda, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 1 Oct 2015, In: Disease models & mechanisms. 8, 10, p. 1255-64 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies

      Yadav, B., Pemovska, T., Szwajda, A., Kulesskiy, E., Kontro, M., Karjalainen, R., Majumder, M. M., Malani, D., Murumägi, A., Knowles, J., Porkka, K., Heckman, C., Kallioniemi, O., Wennerberg, Krister & Aittokallio, T., 5 Jun 2014, In: Scientific Reports. 4, p. 5193

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis

      Wolfe, L. M., Veeraraghavan, U., Idicula-Thomas, S., Schürer, S., Wennerberg, Krister, Reynolds, R., Besra, G. S. & Dobos, K. M., Jun 2013, In: Molecular and Cellular Proteomics. 12, 6, p. 1644-60 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia

      White, B. S., Khan, S. A., Mason, M. J., Ammad-ud-din, M., Potdar, S., Malani, D., Kuusanmäki, Heikki Aleksi, Druker, B. J., Heckman, C., Kallioniemi, O., Kurtz, S. E., Porkka, K., Tognon, C. E., Tyner, J. W., Aittokallio, T., Wennerberg, Krister & Guinney, J., 2021, In: n p j Precision Oncology. 5, 1, 11 p., 71.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. RhoG signals in parallel with Rac1 and Cdc42

      Wennerberg, Krister, Ellerbroek, S. M., Liu, R., Karnoub, A. E., Burridge, K. & Der, C. J., 6 Dec 2002, In: The Journal of Biological Chemistry. 277, 49, p. 47810-7 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Rnd proteins function as RhoA antagonists by activating p190 RhoGAP

      Wennerberg, Krister, Forget, M., Ellerbroek, S. M., Arthur, W. T., Burridge, K., Settleman, J., Der, C. J. & Hansen, S. H., 1 Jul 2003, In: Current biology : CB. 13, 13, p. 1106-15 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Cancer Cell Drug Response Transcriptomes in 3D

      Wennerberg, Krister, 17 Nov 2016, In: Cell Chemical Biology. 23, 11, p. 1323-1324 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Rho-family GTPases: it's not only Rac and Rho (and I like it)

      Wennerberg, Krister & Der, C. J., 15 Mar 2004, In: Journal of Cell Science. 117, Pt 8, p. 1301-12 12 p.

      Research output: Contribution to journal › Review › Research › peer-review

    13. The Ras superfamily at a glance

      Wennerberg, Krister, Rossman, K. L. & Der, C. J., 1 Mar 2005, In: Journal of Cell Science. 118, Pt 5, p. 843-6 4 p.

      Research output: Contribution to journal › Review › Research › peer-review

    14. Bioluminescent cell-based NAD(P)/NAD(P)H assays for rapid dinucleotide measurement and inhibitor screening

      Vidugiriene, J., Leippe, D., Sobol, M., Vidugiris, G., Zhou, W., Meisenheimer, P., Gautam, P., Wennerberg, Krister & Cali, J. J., 17 Dec 2014, In: ASSAY and Drug Development Technologies. 12, 9-10, p. 514-26 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1

      Velling, T., Risteli, J., Wennerberg, Krister, Mosher, D. F. & Johansson, S., 4 Oct 2002, In: The Journal of Biological Chemistry. 277, 40, p. 37377-81 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

      Vaseva, A. V., Blake, D. R., Gilbert, T. S. K., Ng, S., Hostetter, G., Azam, S. H., Ozkan-Dagliyan, I., Gautam, P., Bryant, K. L., Pearce, K. H., Herring, L. E., Han, H., Graves, L. M., Witkiewicz, A. K., Knudsen, E. S., Pecot, C. V., Rashid, N., Houghton, P. J., Wennerberg, K., Cox, A. D. & 1 others, Der, C. J., 2018, In: Cancer Cell. 34, 5, p. 807-822.e1-e7 23 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses

      Varghese, F. S., Kaukinen, P., Gläsker, S., Bespalov, M., Hanski, L., Wennerberg, Krister, Kümmerer, B. M. & Ahola, T., Feb 2016, In: Antiviral Research. 126, p. 117-24 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Human Tumor–Derived Matrix Improves the Predictability of Head and Neck Cancer Drug Testing

      Tuomainen, K., Al-samadi, A., Potdar, S., Turunen, L., Turunen, M., Karhemo, P., Bergman, P., Risteli, M., Åström, P., Tiikkaja, R., Grenman, R., Wennerberg, Krister, Monni, O. & Salo, T., 2020, In: Cancers. 12, 1, 92.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Interactive visual analysis of drug–target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing

      Tanoli, Z., Alam, Z., Ianevski, A., Wennerberg, Krister, Vähä-koskela, M. & Aittokallio, T., 2020, In: Briefings in Bioinformatics. 21, 1, p. 211-220

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Minimal information for chemosensitivity assays (MICHA): a next-generation pipeline to enable the FAIRification of drug screening experiments

      Tanoli, Z., Aldahdooh, J., Alam, F., Wang, Y., Seemab, U., Fratelli, M., Pavlis, P., Hajduch, M., Bietrix, F., Gribbon, P., Zaliani, A., Hall, M. D., Shen, M., Brimacombe, K., Kulesskiy, E., Saarela, J., Wennerberg, Krister, Vähä-Koskela, M. & Tang, J., 2022, In: Briefings in Bioinformatics. 23, 1, 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Exploration of databases and methods supporting drug repurposing: A comprehensive survey

      Tanoli, Z., Seemab, U., Scherer, A., Wennerberg, Krister, Tang, J. & Vähä-Koskela, M., 2021, In: Briefings in Bioinformatics. 22, 2, p. 1656-1678 23 p.

      Research output: Contribution to journal › Review › Research › peer-review

    22. Published

      Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles

      Tanoli, Z. R., Alam, Z., Vähä-Koskela, M., Ravikumar, B., Malyutina, A., Jaiswal, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 2018, In: Database: The Journal of Biological Databases and Curation. 2018, 2018, p. 1-13 13 p., bay083.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer

      Tang, J., Gautam, P., Gupta, A., He, L., Timonen, S., Akimov, Y., Wang, W., Szwajda, A., Jaiswal, A., Turei, D., Yadav, B., Kankainen, M., Saarela, J., Saez-rodriguez, J., Wennerberg, Krister & Aittokallio, T., 2019, In: npj Systems Biology and Applications. 5, 1, 5.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. What is synergy? The Saariselkä agreement revisited

      Tang, J., Wennerberg, Krister & Aittokallio, T., 2015, In: Frontiers in Pharmacology. 6, p. 181

      Research output: Contribution to journal › Review › Research › peer-review

    25. Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions

      Tang, J., Tanoli, Z-U-R., Ravikumar, B., Alam, Z., Rebane, A., Vähä-Koskela, M., Peddinti, G., van Adrichem, A. J., Wakkinen, J., Jaiswal, A., Karjalainen, E., Gautam, P., He, L., Parri, E., Khan, S., Gupta, A., Ali, M., Yetukuri, L., Gustavsson, A-L., Seashore-Ludlow, B. & 6 others, Hersey, A., Leach, A. R., Overington, J. P., Repasky, G., Wennerberg, Krister & Aittokallio, T., 15 Feb 2018, In: Cell Chemical Biology. 25, 2, p. 224-229.e2

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways

      Tang, J., Karhinen, L., Xu, T., Szwajda, A., Yadav, B., Wennerberg, Krister & Aittokallio, T., 2013, In: PLOS Computational Biology. 9, 9, p. e1003226

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis

      Tang, J., Szwajda, A., Shakyawar, S., Xu, T., Hintsanen, P., Wennerberg, Krister & Aittokallio, T., 24 Mar 2014, In: Journal of Chemical Information and Modeling. 54, 3, p. 735-43 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition

      Tambe, M., Karjalainen, E., Vähä-Koskela, M., Bulanova, Daria, Gjertsen, B. T., Kontro, M., Porkka, K., Heckman, C. A. & Wennerberg, Krister, 2020, In: Leukemia. 34, p. 3186-3196

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras-Mutant Lung Cancers

      Talwelkar, S. S., Nagaraj, A. S., Devlin, J. R., Hemmes, A., Potdar, S., Kiss, E. A., Saharinen, P., Salmenkivi, K., Mäyränpää, M. I., Wennerberg, Krister & Verschuren, E. W., 2019, In: Molecular Cancer Therapeutics. 18, 10, p. 1863-1874

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      PI3Kβ inhibition enhances ALK-inhibitor sensitivity in ALK-rearranged lung cancer

      Talwelkar, S. S., Mayranpaa, M. I., Schuler, J., Linnavirta, N., Hemmes, A., Adinolfi, S., Kankainen, M., Sommergruber, W., Levonen, A., Rasanen, J., Knuuttila, A., Verschuren, E. W. & Wennerberg, Krister, 2023, In: Molecular Oncology. 17, 5, p. 747-764 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

      Talwelkar, S. S., Mäyränpää, M. I., Søraas, L., Potdar, S., Bao, J., Hemmes, A., Linnavirta, N., Lømo, J., Räsänen, J., Knuuttila, A., Wennerberg, Krister & Verschuren, E. W., 2021, In: Cell Reports Medicine. 2, 8, 21 p., 100373.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Protocol to utilize fresh uncultured human lung tumor cells for personalized functional diagnostics

      Talwelkar, S. S., Lähdeniemi, I. A. K., Mäyränpää, M. I., Hemmes, A., Linnavirta, N., Räsänen, J., Knuuttila, A., Wennerberg, Krister & Verschuren, E. W., 2022, In: STAR Protocols. 3, 4, 19 p., 101720.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles

      Szwajda, A., Gautam, P., Karhinen, L., Jha, S. K., Saarela, J., Shakyawar, S., Turunen, L., Yadav, B., Tang, J., Wennerberg, Krister & Aittokallio, T., 20 Aug 2015, In: Chemistry & Biology. 22, 8, p. 1144-55 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF

      Swenson-Fields, K. I., Sandquist, J. C., Rossol-Allison, J., Blat, I. C., Wennerberg, Krister, Burridge, K. & Means, A. R., 10 Oct 2008, In: Molecular Cell. 32, 1, p. 43-56 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Antifungal application of nonantifungal drugs

      Stylianou, M., Kulesskiy, E., Lopes, J. P., Granlund, M., Wennerberg, Krister & Urban, C. F., 2014, In: Antimicrobial Agents and Chemotherapy. 58, 2, p. 1055-62 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors

      Stalnecker, C. A., Grover, K. R., Edwards, A. C., Coleman, M. F., Yang, R., DeLiberty, J. M., Papke, B., Goodwin, C. M., Pierobon, M., Petricoin, E. F., Gautam, P., Wennerberg, Krister, Cox, A. D., Der, C. J., Hursting, S. D. & Bryant, K. L., 2022, In: Cancer Research. 82, 4, p. 586-598 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids

      Senkowski, W., Gall-Mas, L., Falco, M. M., Li, Y., Lavikka, K., Kriegbaum, M. C., Oikkonen, J., Bulanova, D., Pietras, E. J., Voßgröne, K., Chen, Y. J., Erkan, E. P., Dai, J., Lundgren, A., Grønning Høg, M. K., Larsen, I. M., Lamminen, T., Kaipio, K., Huvila, J., Virtanen, A. & 9 others, Engelholm, Lars Henning, Christiansen, P., Santoni Rugiu, Eric, Huhtinen, K., Carpén, O., Hynninen, J., Hautaniemi, S., Vähärautio, A. & Wennerberg, Krister, 2023, In: Developmental Cell. 58, 12, p. 1106-1121.e7 24 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer

      Saeed, K., Rahkama, V., Eldfors, S., Bychkov, D., Mpindi, J. P., Yadav, B., Paavolainen, L., Aittokallio, T., Heckman, C., Wennerberg, Krister, Peehl, D. M., Horvath, P., Mirtti, T., Rannikko, A., Kallioniemi, O., Östling, P. & Af Hällström, T. M., Mar 2017, In: European Urology (Italian Edition). 71, 3, p. 319-327 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status

      Roering, P., Siddiqui, A., Heuser, V. D., Potdar, S., Mikkonen, P., Oikkonen, J., Li, Y., Pikkusaari, S., Wennerberg, Krister, Hynninen, J., Grenman, S., Huhtinen, K., Auranen, A., Carpén, O. & Kaipio, K., 2022, In: Frontiers in Oncology. 12, 14 p., 954430.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies

      Ravikumar, B., Timonen, S., Alam, Z., Parri, E., Wennerberg, Krister & Aittokallio, T., 2019, In: Cell Chemical Biology. 26, 11, p. 1608-1622

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

      Rajala, H. L. M., Eldfors, S., Kuusanmäki, H., van Adrichem, A. J., Olson, T., Lagström, S., Andersson, E. I., Jerez, A., Clemente, M. J., Yan, Y., Zhang, D., Awwad, A., Ellonen, P., Kallioniemi, O., Wennerberg, Krister, Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. & Mustjoki, S., 30 May 2013, In: Blood. 121, 22, p. 4541-50 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Breeze: an integrated quality control and data analysis application for high-throughput drug screening

      Potdar, S., Ianevski, A., Mpindi, J., Bychkov, D., Fiere, C., Ianevski, P., Yadav, B., Wennerberg, Krister, Aittokallio, T., Kallioniemi, O., Saarela, J. & Östling, P., 2020, In: Bioinformatics. 36, 11, p. 3602-3604

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Breeze 2.0: an interactive web-tool for visual analysis and comparison of drug response data

      Potdar, S., Ianevski, F., Ianevski, A., Tanoli, Ziaurrehman, Wennerberg, Krister, Seashore-Ludlow, B., Kallioniemi, O., Ostling, P., Aittokallio, T. & Saarela, J., 2023, In: Nucleic Acids Research. 51, W1, p. W57-W61 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data

      Pokharel, Y. R., Saarela, J., Szwajda, A., Rupp, C., Rokka, A., Lal Kumar Karna, S., Teittinen, K., Corthals, G., Kallioniemi, O., Wennerberg, Krister, Aittokallio, T. & Westermarck, J., Dec 2015, In: Molecular and Cellular Proteomics. 14, 12, p. 3274-83 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. The high throughput biomedicine unit at the institute for molecular medicine Finland: high throughput screening meets precision medicine

      Pietiainen, V., Saarela, J., von Schantz, C., Turunen, L., Ostling, P. & Wennerberg, Krister, May 2014, In: Combinatorial Chemistry & High Throughput Screening. 17, 4, p. 377-86 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

      Pietarinen, P. O., Eide, C. A., Ayuda-Durán, P., Potdar, S., Kuusanmäki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, Krister, Hjorth-Hansen, H., Druker, B. J., Enserink, J. M., Tyner, J. W., Mustjoki, S. & Porkka, K., 4 Apr 2017, In: OncoTarget. 8, 14, p. 22606-22615 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia

      Pemovska, T., Kontro, M., Yadav, B., Edgren, H., Eldfors, S., Szwajda, A., Almusa, H., Bespalov, M. M., Ellonen, P., Elonen, E., Gjertsen, B. T., Karjalainen, R., Kulesskiy, E., Lagström, S., Lehto, A., Lepistö, M., Lundán, T., Majumder, M. M., Marti, J. M. L., Mattila, P. & 16 others, Murumägi, A., Mustjoki, S., Palva, A., Parsons, A., Pirttinen, T., Rämet, M. E., Suvela, M., Turunen, L., Västrik, I., Wolf, M., Knowles, J., Aittokallio, T., Heckman, C. A., Porkka, K., Kallioniemi, O. & Wennerberg, Krister, Dec 2013, In: Cancer Discovery. 3, 12, p. 1416-29 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

      Pemovska, T., Johnson, E., Kontro, M., Repasky, G. A., Chen, J., Wells, P., Cronin, C. N., McTigue, M., Kallioniemi, O., Porkka, K., Murray, B. W. & Wennerberg, Krister, 5 Mar 2015, In: Nature. 519, 7541, p. 102-5 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Identification of novel regulators of STAT3 activity

      Parri, E., Kuusanmäki, Heikki Aleksi, Van Adrichem, A. J., Kaustio, M. & Wennerberg, Krister, 2020, In: PLoS ONE. 15, 3, p. 1-18 e0230819.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Selective drug combination vulnerabilities in STAT3- And TP53-mutant malignant NK cells

      Parri, E., Kuusanmäki, Heikki Aleksi, Bulanova, Daria, Mustjoki, S. & Wennerberg, Krister, 2021, In: Blood advances. 5, 7, p. 1862-1875

      Research output: Contribution to journal › Journal article › Research › peer-review

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