Krister Wennerberg

Krister Wennerberg

Professor

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    ORCID: 0000-0002-1352-4220

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    1. Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

      Pemovska, T., Johnson, E., Kontro, M., Repasky, G. A., Chen, J., Wells, P., Cronin, C. N., McTigue, M., Kallioniemi, O., Porkka, K., Murray, B. W. & Wennerberg, Krister, 5 Mar 2015, In: Nature. 519, 7541, p. 102-5 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

      Pietarinen, P. O., Eide, C. A., Ayuda-Durán, P., Potdar, S., Kuusanmäki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, Krister, Hjorth-Hansen, H., Druker, B. J., Enserink, J. M., Tyner, J. W., Mustjoki, S. & Porkka, K., 4 Apr 2017, In: OncoTarget. 8, 14, p. 22606-22615 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. The high throughput biomedicine unit at the institute for molecular medicine Finland: high throughput screening meets precision medicine

      Pietiainen, V., Saarela, J., von Schantz, C., Turunen, L., Ostling, P. & Wennerberg, Krister, May 2014, In: Combinatorial Chemistry & High Throughput Screening. 17, 4, p. 377-86 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data

      Pokharel, Y. R., Saarela, J., Szwajda, A., Rupp, C., Rokka, A., Lal Kumar Karna, S., Teittinen, K., Corthals, G., Kallioniemi, O., Wennerberg, Krister, Aittokallio, T. & Westermarck, J., Dec 2015, In: Molecular and Cellular Proteomics. 14, 12, p. 3274-83 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Breeze: an integrated quality control and data analysis application for high-throughput drug screening

      Potdar, S., Ianevski, A., Mpindi, J., Bychkov, D., Fiere, C., Ianevski, P., Yadav, B., Wennerberg, Krister, Aittokallio, T., Kallioniemi, O., Saarela, J. & Östling, P., 2020, In: Bioinformatics. 36, 11, p. 3602-3604

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Breeze 2.0: an interactive web-tool for visual analysis and comparison of drug response data

      Potdar, S., Ianevski, F., Ianevski, A., Tanoli, Ziaurrehman, Wennerberg, Krister, Seashore-Ludlow, B., Kallioniemi, O., Ostling, P., Aittokallio, T. & Saarela, J., 2023, In: Nucleic Acids Research. 51, W1, p. W57-W61 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

      Rajala, H. L. M., Eldfors, S., Kuusanmäki, H., van Adrichem, A. J., Olson, T., Lagström, S., Andersson, E. I., Jerez, A., Clemente, M. J., Yan, Y., Zhang, D., Awwad, A., Ellonen, P., Kallioniemi, O., Wennerberg, Krister, Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. & Mustjoki, S., 30 May 2013, In: Blood. 121, 22, p. 4541-50 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies

      Ravikumar, B., Timonen, S., Alam, Z., Parri, E., Wennerberg, Krister & Aittokallio, T., 2019, In: Cell Chemical Biology. 26, 11, p. 1608-1622

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status

      Roering, P., Siddiqui, A., Heuser, V. D., Potdar, S., Mikkonen, P., Oikkonen, J., Li, Y., Pikkusaari, S., Wennerberg, Krister, Hynninen, J., Grenman, S., Huhtinen, K., Auranen, A., Carpén, O. & Kaipio, K., 2022, In: Frontiers in Oncology. 12, 14 p., 954430.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer

      Saeed, K., Rahkama, V., Eldfors, S., Bychkov, D., Mpindi, J. P., Yadav, B., Paavolainen, L., Aittokallio, T., Heckman, C., Wennerberg, Krister, Peehl, D. M., Horvath, P., Mirtti, T., Rannikko, A., Kallioniemi, O., Östling, P. & Af Hällström, T. M., Mar 2017, In: European Urology (Italian Edition). 71, 3, p. 319-327 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids

      Senkowski, W., Gall-Mas, L., Falco, M. M., Li, Y., Lavikka, K., Kriegbaum, M. C., Oikkonen, J., Bulanova, D., Pietras, E. J., Voßgröne, K., Chen, Y. J., Erkan, E. P., Dai, J., Lundgren, A., Grønning Høg, M. K., Larsen, I. M., Lamminen, T., Kaipio, K., Huvila, J., Virtanen, A. & 9 others, Engelholm, Lars Henning, Christiansen, P., Santoni Rugiu, Eric, Huhtinen, K., Carpén, O., Hynninen, J., Hautaniemi, S., Vähärautio, A. & Wennerberg, Krister, 2023, In: Developmental Cell. 58, 12, p. 1106-1121.e7 24 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors

      Stalnecker, C. A., Grover, K. R., Edwards, A. C., Coleman, M. F., Yang, R., DeLiberty, J. M., Papke, B., Goodwin, C. M., Pierobon, M., Petricoin, E. F., Gautam, P., Wennerberg, Krister, Cox, A. D., Der, C. J., Hursting, S. D. & Bryant, K. L., 2022, In: Cancer Research. 82, 4, p. 586-598 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Antifungal application of nonantifungal drugs

      Stylianou, M., Kulesskiy, E., Lopes, J. P., Granlund, M., Wennerberg, Krister & Urban, C. F., 2014, In: Antimicrobial Agents and Chemotherapy. 58, 2, p. 1055-62 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF

      Swenson-Fields, K. I., Sandquist, J. C., Rossol-Allison, J., Blat, I. C., Wennerberg, Krister, Burridge, K. & Means, A. R., 10 Oct 2008, In: Molecular Cell. 32, 1, p. 43-56 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles

      Szwajda, A., Gautam, P., Karhinen, L., Jha, S. K., Saarela, J., Shakyawar, S., Turunen, L., Yadav, B., Tang, J., Wennerberg, Krister & Aittokallio, T., 20 Aug 2015, In: Chemistry & Biology. 22, 8, p. 1144-55 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras-Mutant Lung Cancers

      Talwelkar, S. S., Nagaraj, A. S., Devlin, J. R., Hemmes, A., Potdar, S., Kiss, E. A., Saharinen, P., Salmenkivi, K., Mäyränpää, M. I., Wennerberg, Krister & Verschuren, E. W., 2019, In: Molecular Cancer Therapeutics. 18, 10, p. 1863-1874

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      PI3Kβ inhibition enhances ALK-inhibitor sensitivity in ALK-rearranged lung cancer

      Talwelkar, S. S., Mayranpaa, M. I., Schuler, J., Linnavirta, N., Hemmes, A., Adinolfi, S., Kankainen, M., Sommergruber, W., Levonen, A., Rasanen, J., Knuuttila, A., Verschuren, E. W. & Wennerberg, Krister, 2023, In: Molecular Oncology. 17, 5, p. 747-764 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

      Talwelkar, S. S., Mäyränpää, M. I., Søraas, L., Potdar, S., Bao, J., Hemmes, A., Linnavirta, N., Lømo, J., Räsänen, J., Knuuttila, A., Wennerberg, Krister & Verschuren, E. W., 2021, In: Cell Reports Medicine. 2, 8, 21 p., 100373.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Protocol to utilize fresh uncultured human lung tumor cells for personalized functional diagnostics

      Talwelkar, S. S., Lähdeniemi, I. A. K., Mäyränpää, M. I., Hemmes, A., Linnavirta, N., Räsänen, J., Knuuttila, A., Wennerberg, Krister & Verschuren, E. W., 2022, In: STAR Protocols. 3, 4, 19 p., 101720.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition

      Tambe, M., Karjalainen, E., Vähä-Koskela, M., Bulanova, Daria, Gjertsen, B. T., Kontro, M., Porkka, K., Heckman, C. A. & Wennerberg, Krister, 2020, In: Leukemia. 34, p. 3186-3196

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer

      Tang, J., Gautam, P., Gupta, A., He, L., Timonen, S., Akimov, Y., Wang, W., Szwajda, A., Jaiswal, A., Turei, D., Yadav, B., Kankainen, M., Saarela, J., Saez-rodriguez, J., Wennerberg, Krister & Aittokallio, T., 2019, In: npj Systems Biology and Applications. 5, 1, 5.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. What is synergy? The Saariselkä agreement revisited

      Tang, J., Wennerberg, Krister & Aittokallio, T., 2015, In: Frontiers in Pharmacology. 6, p. 181

      Research output: Contribution to journal › Review › Research › peer-review

    23. Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions

      Tang, J., Tanoli, Z-U-R., Ravikumar, B., Alam, Z., Rebane, A., Vähä-Koskela, M., Peddinti, G., van Adrichem, A. J., Wakkinen, J., Jaiswal, A., Karjalainen, E., Gautam, P., He, L., Parri, E., Khan, S., Gupta, A., Ali, M., Yetukuri, L., Gustavsson, A-L., Seashore-Ludlow, B. & 6 others, Hersey, A., Leach, A. R., Overington, J. P., Repasky, G., Wennerberg, Krister & Aittokallio, T., 15 Feb 2018, In: Cell Chemical Biology. 25, 2, p. 224-229.e2

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways

      Tang, J., Karhinen, L., Xu, T., Szwajda, A., Yadav, B., Wennerberg, Krister & Aittokallio, T., 2013, In: PLOS Computational Biology. 9, 9, p. e1003226

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis

      Tang, J., Szwajda, A., Shakyawar, S., Xu, T., Hintsanen, P., Wennerberg, Krister & Aittokallio, T., 24 Mar 2014, In: Journal of Chemical Information and Modeling. 54, 3, p. 735-43 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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