Krister Wennerberg
Professor
Wennerberg Group
Ole Maaløes Vej 5, 2200 København N.
Member of:
- 2016
Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells
Gautam, P., Karhinen, L., Szwajda, A., Jha, S. K., Yadav, B., Aittokallio, T. & Wennerberg, Krister, 10 May 2016, In: Molecular Cancer. 15, 1, p. 34Research output: Contribution to journal › Journal article › Research › peer-review
Cancer Cell Drug Response Transcriptomes in 3D
Wennerberg, Krister, 17 Nov 2016, In: Cell Chemical Biology. 23, 11, p. 1323-1324 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
Consistency in drug response profiling
Mpindi, J. P., Yadav, B., Östling, P., Gautam, P., Malani, D., Murumägi, A., Hirasawa, A., Kangaspeska, S., Wennerberg, Krister, Kallioniemi, O. & Aittokallio, T., 30 Nov 2016, In: Nature. 540, 7631, p. E5-E6Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer
Saeed, K., Rahkama, V., Eldfors, S., Bychkov, D., Mpindi, J. P., Yadav, B., Paavolainen, L., Aittokallio, T., Heckman, C., Wennerberg, Krister, Peehl, D. M., Horvath, P., Mirtti, T., Rannikko, A., Kallioniemi, O., Östling, P. & Af Hällström, T. M., Mar 2017, In: European Urology (Italian Edition). 71, 3, p. 319-327 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells
Haltia, U., Andersson, N., Yadav, B., Färkkilä, A., Kulesskiy, E., Kankainen, M., Tang, J., Bützow, R., Riska, A., Leminen, A., Heikinheimo, M., Kallioniemi, O., Unkila-Kallio, L., Wennerberg, Krister, Aittokallio, T. & Anttonen, M., Mar 2017, In: Gynecologic Oncology. 144, 3, p. 621-630 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors
Pietarinen, P. O., Eide, C. A., Ayuda-Durán, P., Potdar, S., Kuusanmäki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, Krister, Hjorth-Hansen, H., Druker, B. J., Enserink, J. M., Tyner, J. W., Mustjoki, S. & Porkka, K., 4 Apr 2017, In: OncoTarget. 8, 14, p. 22606-22615 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
High-Throughput Dual Screening Method for Ras Activities and Inhibitors
Kopra, K., van Adrichem, A. J., Salo-Ahen, O. M. H., Peltonen, J., Wennerberg, Krister & Härmä, H., 18 Apr 2017, In: Analytical Chemistry. 89, 8, p. 4508-4516 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells
Jaiswal, A., Peddinti, G., Akimov, Y., Wennerberg, Krister, Kuznetsov, S., Tang, J. & Aittokallio, T., 1 Jun 2017, In: Genome Medicine. 9, 1, p. 51Research output: Contribution to journal › Journal article › Research › peer-review
A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury
Kohonen, P., Parkkinen, J. A., Willighagen, E. L., Ceder, R., Wennerberg, Krister, Kaski, S. & Grafström, R. C., 3 Jul 2017, In: Nature Communications. 8, p. 15932Research output: Contribution to journal › Journal article › Research › peer-review
Systematic identification of feature combinations for predicting drug response with Bayesian multi-view multi-task linear regression
Ammad-Ud-Din, M., Khan, S. A., Wennerberg, Krister & Aittokallio, T., 15 Jul 2017, In: Bioinformatics (Online). 33, 14, p. i359-i368Research output: Contribution to journal › Journal article › Research › peer-review
Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors
Cichonska, A., Ravikumar, B., Parri, E., Timonen, S., Pahikkala, T., Airola, A., Wennerberg, Krister, Rousu, J. & Aittokallio, T., Aug 2017, In: PLOS Computational Biology. 13, 8, p. e1005678Research output: Contribution to journal › Journal article › Research › peer-review
JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML
Karjalainen, R., Pemovska, T., Popa, M., Liu, M., Javarappa, K. K., Majumder, M. M., Yadav, B., Tamborero, D., Tang, J., Bychkov, D., Kontro, M., Parsons, A., Suvela, M., Mayoral Safont, M., Porkka, K., Aittokallio, T., Kallioniemi, O., McCormack, E., Gjertsen, B. T., Wennerberg, K. & 2 others, , 10 Aug 2017, In: Blood. 130, 6, p. 789-802 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling
Kuusanmäki, H., Dufva, O., Parri, E., van Adrichem, A. J., Rajala, H., Majumder, M. M., Yadav, B., Parsons, A., Chan, W. C., Wennerberg, Krister, Mustjoki, S. & Heckman, C. A., 14 Nov 2017, In: OncoTarget. 8, 57, p. 97516-97527 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines
Broad-DREAM Community, B. C., 22 Nov 2017, In: Cell Systems. 5, 5, p. 485-497.e3Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles
Tanoli, Z. R., Alam, Z., Vähä-Koskela, M., Ravikumar, B., Malyutina, A., Jaiswal, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 2018, In: Database: The Journal of Biological Databases and Curation. 2018, 2018, p. 1-13 13 p., bay083.Research output: Contribution to journal › Journal article › Research › peer-review
Drug-sensitivity screening and genomic characterization of 45 hpV-negative head and neck carcinoma cell lines for novel biomarkers of drug efficacy
Lepikhova, T., Karhemo, P. R., Louhimo, R., Yadav, B., Murumagi, A., Kulesskiy, E., Kivento, M., Sihto, H., Grenman, R., Syrjanen, S. M., Kallioniemi, O., Aittokallio, T., Wennerberg, Krister, Joensuu, H. & Monni, O., 2018, In: Molecular Cancer Therapeutics. 17, 9, p. 2060-2071 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
Vaseva, A. V., Blake, D. R., Gilbert, T. S. K., Ng, S., Hostetter, G., Azam, S. H., Ozkan-Dagliyan, I., Gautam, P., Bryant, K. L., Pearce, K. H., Herring, L. E., Han, H., Graves, L. M., Witkiewicz, A. K., Knudsen, E. S., Pecot, C. V., Rashid, N., Houghton, P. J., Wennerberg, K., Cox, A. D. & 1 others, , 2018, In: Cancer Cell. 34, 5, p. 807-822.e1-e7 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
Methods for High-throughput Drug Combination Screening and Synergy Scoring
He, L., Kulesskiy, E., Saarela, J., Turunen, L., Wennerberg, Krister, Aittokallio, T. & Tang, J., 2018, In: Methods in molecular biology (Clifton, N.J.). 1711, p. 351-398 48 p.Research output: Contribution to journal › Journal article › Research › peer-review
Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib
Dyczynski, M., Yu, Y., Otrocka, M., Parpal, S., Braga, T., Henley, A. B., Zazzi, H., Lerner, M., Wennerberg, Krister, Viklund, J., Martinsson, J., Grandér, D., De Milito, A. & Pokrovskaja Tamm, K., 2018, In: Cancer Letters. 435, p. 32-43 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Toward universal protein post-translational modification detection in high throughput format
Härmä, H., Tong-Ochoa, N., van Adrichem, A. J., Jelesarov, I., Wennerberg, Krister & Kopra, K., 2018, In: Chemical communications (Cambridge, England). 54, 23, p. 2910-2913 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions
Tang, J., Tanoli, Z-U-R., Ravikumar, B., Alam, Z., Rebane, A., Vähä-Koskela, M., Peddinti, G., van Adrichem, A. J., Wakkinen, J., Jaiswal, A., Karjalainen, E., Gautam, P., He, L., Parri, E., Khan, S., Gupta, A., Ali, M., Yetukuri, L., Gustavsson, A-L., Seashore-Ludlow, B. & 6 others, , 15 Feb 2018, In: Cell Chemical Biology. 25, 2, p. 224-229.e2Research output: Contribution to journal › Journal article › Research › peer-review
Global proteomics profiling improves drug sensitivity prediction: results from a multi-omics, pan-cancer modeling approach
Ali, M., Khan, S. A., Wennerberg, Krister & Aittokallio, T., 15 Apr 2018, In: Bioinformatics (Online). 34, 8, p. 1353-1362 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients
He, L., Tang, J., Andersson, E. I., Timonen, S., Koschmieder, S., Wennerberg, Krister, Mustjoki, S. & Aittokallio, T., 1 May 2018, In: Cancer Research. 78, 9, p. 2407-2418 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells
Kauko, O., O’Connor, C. M., Kulesskiy, E., Sangodkar, J., Aakula, A., Izadmehr, S., Yetukuri, L., Yadav, B., Padzik, A., Laajala, T. D., Haapaniemi, P., Momeny, M., Varila, T., Ohlmeyer, M., Aittokallio, T., Wennerberg, Krister, Narla, G. & Westermarck, J., 18 Jul 2018, In: Science Translational Medicine. 10, 450, p. 1-12 12 p., eaaq1093.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma
Nepal, C., O'Rourke, Colm, Oliveira, D. V., Taranta, A., Shema, S., Gautam, P., Calderaro, J., Barbour, A., Raggi, C., Wennerberg, Krister, Wang, X. W., Lautem, A., Roberts, L. R. & Andersen, Jesper Bøje, Sep 2018, In: Hepatology. 68, 3, p. 949-963 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Abstract P2-06-25: A phenotypic screening and machine learning platform efficiently identifies triple negative breast cancer-selective and readily druggable targets
Gautam, P., Jaiswal, A., Aittokallio, T., Hassan, A. & Wennerberg, Krister, 2019, In: Cancer Research. p. P2-06-25-P2-06-25Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies
Ravikumar, B., Timonen, S., Alam, Z., Parri, E., Wennerberg, Krister & Aittokallio, T., 2019, In: Cell Chemical Biology. 26, 11, p. 1608-1622Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drug screening and molecular profiling identifies INKA1 as a predictive biomarker for sensitivity to MAPK inhibition-antimitotic combination treatment in pancreatic ductal adenocarcinoma
Gautam, P., Vaha-Koskela, M., Tomlinson, M., Cox, A. D., Der, C. J., Aittokallio, T. & Wennerberg, Krister, 2019, In: Molecular Cancer Therapeutics. 18, 12, A137.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Drug sensitivity testing on patient-derived sarcoma cells predicts patient response to treatment and identifies c-Sarc inhibitors as active drugs for translocation sarcomas
Brodin, B. A., Wennerberg, Krister, Lidbrink, E., Brosjö, O., Potdar, S., Wilson, J. N., Ma, L., Moens, L. N., Hesla, A., Porovic, E., Bernhardsson, E., Papakonstantinou, A., Bauer, H., Tsagkozis, P., Von Sivers, K., Wejde, J., Östling, P., Kallioniemi, O. & Stragliotto, C. L., 2019, In: British Journal of Cancer. 120, 4, p. 435-443 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer
Tang, J., Gautam, P., Gupta, A., He, L., Timonen, S., Akimov, Y., Wang, W., Szwajda, A., Jaiswal, A., Turei, D., Yadav, B., Kankainen, M., Saarela, J., Saez-rodriguez, J., Wennerberg, Krister & Aittokallio, T., 2019, In: npj Systems Biology and Applications. 5, 1, 5.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets
Gautam, P., Jaiswal, A., Aittokallio, T., Al-ali, H. & Wennerberg, Krister, 2019, In: Cell Chemical Biology. 26, 7, p. 970-979Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Prediction of drug combination effects with a minimal set of experiments
Ianevski, A., Giri, A. K., Gautam, P., Kononov, A., Potdar, S., Saarela, J., Wennerberg, Krister & Aittokallio, T., 2019, In: Nature Machine Intelligence. 1, 12, p. 568-577Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras-Mutant Lung Cancers
Talwelkar, S. S., Nagaraj, A. S., Devlin, J. R., Hemmes, A., Potdar, S., Kiss, E. A., Saharinen, P., Salmenkivi, K., Mäyränpää, M. I., Wennerberg, Krister & Verschuren, E. W., 2019, In: Molecular Cancer Therapeutics. 18, 10, p. 1863-1874Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
A normalized drug response metric improves accuracy and consistency of anticancer drug sensitivity quantification in cell-based screening
Gupta, A., Gautam, P., Wennerberg, Krister & Aittokallio, T., 2020, In: Communications Biology. 3, 1, p. 1-12Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ALDH1A1‐related stemness in high‐grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR‐PI3K/aurora kinase inhibitors
Kaipio, K., Chen, P., Roering, P., Huhtinen, K., Mikkonen, P., Östling, P., Lehtinen, L., Mansuri, N., Korpela, T., Potdar, S., Hynninen, J., Auranen, A., Grénman, S., Wennerberg, Krister, Hautaniemi, S. & Carpén, O., 2020, In: Journal of Pathology. 250, 2, p. 159-169 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Abstract P6-10-28: Therapeutic stratification of triple negative breast cancer by integrating chemosensitivity & phospho-proteome profiles
Gautam, P., Qin, X., Vainonen, J., Nagelli, S., Lampe, J., Klefström, J., Westermarck, J., Wennerberg, Krister & Aittokallio, T., 2020.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Atypical KRASG12R mutant is impaired in PI3K signaling and macropinocytosis in pancreatic cancer
Hobbs, G. A., Baker, N. M., Miermont, A. M., Thurman, R. D., Pierobon, M., Tran, T. H., Anderson, A. O., Waters, A. M., Diehl, J. N., Papke, B., Hodge, R. G., Klomp, J. E., Goodwin, C. M., DeLiberty, J. M., Wang, J., Ng, R. W. S., Gautam, P., Bryant, K. L., Esposito, D., Campbell, S. L. & 8 others, , 2020, In: Cancer Discovery. 10, 1, p. 104-123 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Breeze: an integrated quality control and data analysis application for high-throughput drug screening
Potdar, S., Ianevski, A., Mpindi, J., Bychkov, D., Fiere, C., Ianevski, P., Yadav, B., Wennerberg, Krister, Aittokallio, T., Kallioniemi, O., Saarela, J. & Östling, P., 2020, In: Bioinformatics. 36, 11, p. 3602-3604Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human Tumor–Derived Matrix Improves the Predictability of Head and Neck Cancer Drug Testing
Tuomainen, K., Al-samadi, A., Potdar, S., Turunen, L., Turunen, M., Karhemo, P., Bergman, P., Risteli, M., Åström, P., Tiikkaja, R., Grenman, R., Wennerberg, Krister, Monni, O. & Salo, T., 2020, In: Cancers. 12, 1, 92.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of novel regulators of STAT3 activity
Parri, E., Kuusanmäki, Heikki Aleksi, Van Adrichem, A. J., Kaustio, M. & Wennerberg, Krister, 2020, In: PLoS ONE. 15, 3, p. 1-18 e0230819.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improved detection of differentially represented DNA barcodes for high-throughput clonal phenomics
Akimov, Y., Bulanova, Daria, Timonen, S., Wennerberg, Krister & Aittokallio, T., 2020, In: Molecular Systems Biology. 16, 3, p. 1-18 e9195.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interactive visual analysis of drug–target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing
Tanoli, Z., Alam, Z., Ianevski, A., Wennerberg, Krister, Vähä-koskela, M. & Aittokallio, T., 2020, In: Briefings in Bioinformatics. 21, 1, p. 211-220Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KIT pathway upregulation predicts dasatinib efficacy in acute myeloid leukemia
Malani, D., Yadav, B., Kumar, A., Potdar, S., Kontro, M., Kankainen, M., Javarappa, K. K., Porkka, K., Wolf, M., Aittokallio, T., Wennerberg, Krister, Heckman, C. A., Murumägi, A. & Kallioniemi, O., 2020, In: Leukemia. 34, p. 2780-2784Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mitochondria in Their Prime Drive Venetoclax Response in Acute Myeloid Leukemia
Kriegbaum, M. C. & Wennerberg, Krister, 2020, In: Cancer Cell. 38, 6, p. 776-778 3 p.Research output: Contribution to journal › Journal article › Research
- Published
Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types
Majumder, M. M., Leppä, A., Hellesøy, M., Dowling, P., Malyutina, A., Kopperud, R., Bazou, D., Andersson, E., Parsons, A., Tang, J., Kallioniemi, O., Mustjoki, S., O’gorman, P., Wennerberg, Krister, Porkka, K., Gjertsen, B. T. & Heckman, C. A., 2020, In: Haematologica. 105, 6, p. 1527-1538Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition
Tambe, M., Karjalainen, E., Vähä-Koskela, M., Bulanova, Daria, Gjertsen, B. T., Kontro, M., Porkka, K., Heckman, C. A. & Wennerberg, Krister, 2020, In: Leukemia. 34, p. 3186-3196Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1
Kauko, O., Imanishi, S. Y., Kulesskiy, E., Yetukuri, L., Laajala, T. D., Sharma, M., Pavic, K., Aakula, A., Rupp, C., Jumppanen, M., Haapaniemi, P., Ruan, L., Yadav, B., Suni, V., Varila, T., Corthals, G. L., Reimand, J., Wennerberg, Krister, Aittokallio, T. & Westermarck, J., 2020, In: Journal of Biological Chemistry. 295, 13, p. 4194-4211Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma
Hansson, K., Radke, K., Aaltonen, K., Saarela, J., Mañas, A., Sjölund, J., Smith, E. M., Pietras, K., Påhlman, S., Wennerberg, Krister, Gisselsson, D. & Bexell, D., 2020, In: Science Translational Medicine. 12, 562, p. 1-17 eaba4434.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia
White, B. S., Khan, S. A., Mason, M. J., Ammad-ud-din, M., Potdar, S., Malani, D., Kuusanmäki, Heikki Aleksi, Druker, B. J., Heckman, C., Kallioniemi, O., Kurtz, S. E., Porkka, K., Tognon, C. E., Tyner, J. W., Aittokallio, T., Wennerberg, Krister & Guinney, J., 2021, In: n p j Precision Oncology. 5, 1, 11 p., 71.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crowdsourced mapping of unexplored target space of kinase inhibitors
Cichonska, A., Ravikumar, B., Allaway, R. J., Wan, F., Isayev, O., Li, S., Mason, M., Lamb, A., Tanoli, Z., Jeon, M., Kim, S., Popova, M., Capuzzi, S., Zeng, J., Dang, K., Koytiger, G., Kang, J., Wells, C. I., Willson, T. M., Oprea, T. I. & 6 others, , 2021, In: Nature Communications. 12, 1, 18 p., 3307.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 181406515
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147
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Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
107
downloads
Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib
Research output: Contribution to journal › Journal article › Research › peer-review
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97
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Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles
Research output: Contribution to journal › Journal article › Research › peer-review
Published