Krister Wennerberg

Krister Wennerberg

Professor

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    ORCID: 0000-0002-1352-4220

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    1. Published

      Human Tumor–Derived Matrix Improves the Predictability of Head and Neck Cancer Drug Testing

      Tuomainen, K., Al-samadi, A., Potdar, S., Turunen, L., Turunen, M., Karhemo, P., Bergman, P., Risteli, M., Åström, P., Tiikkaja, R., Grenman, R., Wennerberg, Krister, Monni, O. & Salo, T., 2020, In: Cancers. 12, 1, 92.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Identification of novel regulators of STAT3 activity

      Parri, E., Kuusanmäki, Heikki Aleksi, Van Adrichem, A. J., Kaustio, M. & Wennerberg, Krister, 2020, In: PLoS ONE. 15, 3, p. 1-18 e0230819.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening

      Manuvakhova, M. S., Johnson, G. G., White, M. C., Ananthan, S., Sosa, M., Maddox, C., McKellip, S., Rasmussen, L., Wennerberg, Krister, Hobrath, J. V., White, E. L., Maddry, J. A. & Grimaldi, M., Jan 2011, In: Journal of Neuroscience Research. 89, 1, p. 58-72 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells

      Gautam, P., Karhinen, L., Szwajda, A., Jha, S. K., Yadav, B., Aittokallio, T. & Wennerberg, Krister, 10 May 2016, In: Molecular Cancer. 15, 1, p. 34

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis

      Khan, S. A., Virtanen, S., Kallioniemi, O. P., Wennerberg, Krister, Poso, A. & Kaski, S., 1 Sep 2014, In: Bioinformatics (Online). 30, 17, p. i497-504

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Impact of normalization methods on high-throughput screening data with high hit rates and drug testing with dose-response data

      Mpindi, J., Swapnil, P., Dmitrii, B., Jani, S., Saeed, K., Wennerberg, Krister, Aittokallio, T., Östling, P. & Kallioniemi, O., 1 Dec 2015, In: Bioinformatics (Online). 31, 23, p. 3815-21 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia

      Malani, D., Kumar, A., Brück, O., Kontro, M., Yadav, B., Hellesøy, M., Kuusanmäki, H., Dufva, O., Kankainen, M., Eldfors, S., Potdar, S., Saarela, J., Turunen, L., Parsons, A., Västrik, I., Kivinen, K., Saarela, J., Räty, R., Lehto, M., Wolf, M. & 7 others, Gjertsen, B. T., Mustjoki, S., Aittokallio, T., Wennerberg, Krister, Heckman, C. A., Kallioniemi, O. & Porkka, K., 2022, In: Cancer Discovery. 12, 2, p. 388-401 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Improved detection of differentially represented DNA barcodes for high-throughput clonal phenomics

      Akimov, Y., Bulanova, Daria, Timonen, S., Wennerberg, Krister & Aittokallio, T., 2020, In: Molecular Systems Biology. 16, 3, p. 1-18 e9195.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia

      Pemovska, T., Kontro, M., Yadav, B., Edgren, H., Eldfors, S., Szwajda, A., Almusa, H., Bespalov, M. M., Ellonen, P., Elonen, E., Gjertsen, B. T., Karjalainen, R., Kulesskiy, E., Lagström, S., Lehto, A., Lepistö, M., Lundán, T., Majumder, M. M., Marti, J. M. L., Mattila, P. & 16 others, Murumägi, A., Mustjoki, S., Palva, A., Parsons, A., Pirttinen, T., Rämet, M. E., Suvela, M., Turunen, L., Västrik, I., Wolf, M., Knowles, J., Aittokallio, T., Heckman, C. A., Porkka, K., Kallioniemi, O. & Wennerberg, Krister, Dec 2013, In: Cancer Discovery. 3, 12, p. 1416-29 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Integrative and personalized QSAR analysis in cancer by kernelized Bayesian matrix factorization

      Ammad-ud-din, M., Georgii, E., Gönen, M., Laitinen, T., Kallioniemi, O., Wennerberg, Krister, Poso, A. & Kaski, S., 25 Aug 2014, In: Journal of Chemical Information and Modeling. 54, 8, p. 2347-59 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Integrin signaling to the actin cytoskeleton

      DeMali, K. A., Wennerberg, Krister & Burridge, K., Oct 2003, In: Current Opinion in Cell Biology. 15, 5, p. 572-82 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    12. Published

      Interactive visual analysis of drug–target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing

      Tanoli, Z., Alam, Z., Ianevski, A., Wennerberg, Krister, Vähä-koskela, M. & Aittokallio, T., 2020, In: Briefings in Bioinformatics. 21, 1, p. 211-220

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML

      Karjalainen, R., Pemovska, T., Popa, M., Liu, M., Javarappa, K. K., Majumder, M. M., Yadav, B., Tamborero, D., Tang, J., Bychkov, D., Kontro, M., Parsons, A., Suvela, M., Mayoral Safont, M., Porkka, K., Aittokallio, T., Kallioniemi, O., McCormack, E., Gjertsen, B. T., Wennerberg, K. & 2 others, Knowles, J. & Heckman, C. A., 10 Aug 2017, In: Blood. 130, 6, p. 789-802 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. KIFC1 is a novel potential therapeutic target for breast cancer

      Li, Y., Lu, W., Chen, D., Boohaker, R. J., Zhai, L., Padmalayam, I., Wennerberg, Krister, Xu, B. & Zhang, W., 2015, In: Cancer Biology & Therapy. 16, 9, p. 1316-22 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      KIT pathway upregulation predicts dasatinib efficacy in acute myeloid leukemia

      Malani, D., Yadav, B., Kumar, A., Potdar, S., Kontro, M., Kankainen, M., Javarappa, K. K., Porkka, K., Wolf, M., Aittokallio, T., Wennerberg, Krister, Heckman, C. A., Murumägi, A. & Kallioniemi, O., 2020, In: Leukemia. 34, p. 2780-2784

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

      Vaseva, A. V., Blake, D. R., Gilbert, T. S. K., Ng, S., Hostetter, G., Azam, S. H., Ozkan-Dagliyan, I., Gautam, P., Bryant, K. L., Pearce, K. H., Herring, L. E., Han, H., Graves, L. M., Witkiewicz, A. K., Knudsen, E. S., Pecot, C. V., Rashid, N., Houghton, P. J., Wennerberg, K., Cox, A. D. & 1 others, Der, C. J., 2018, In: Cancer Cell. 34, 5, p. 807-822.e1-e7 23 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

      Hayes, T. K., Neel, N. F., Hu, C., Gautam, P., Chenard, M., Long, B., Aziz, M., Kassner, M., Bryant, K. L., Pierobon, M., Marayati, R., Kher, S., George, S. D., Xu, M., Wang-Gillam, A., Samatar, A. A., Maitra, A., Wennerberg, K., Petricoin, E. F., Yin, H. H. & 4 others, Nelkin, B., Cox, A. D., Yeh, J. J. & Der, C. J., 11 Jan 2016, In: Cancer Cell. 29, 1, p. 75-89 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF

      Swenson-Fields, K. I., Sandquist, J. C., Rossol-Allison, J., Blat, I. C., Wennerberg, Krister, Burridge, K. & Means, A. R., 10 Oct 2008, In: Molecular Cell. 32, 1, p. 43-56 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis

      Tang, J., Szwajda, A., Shakyawar, S., Xu, T., Hintsanen, P., Wennerberg, Krister & Aittokallio, T., 24 Mar 2014, In: Journal of Chemical Information and Modeling. 54, 3, p. 735-43 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Methods for High-throughput Drug Combination Screening and Synergy Scoring

      He, L., Kulesskiy, E., Saarela, J., Turunen, L., Wennerberg, Krister, Aittokallio, T. & Tang, J., 2018, In: Methods in molecular biology (Clifton, N.J.). 1711, p. 351-398 48 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. MgcRacGAP inhibition stimulates JAK-dependent STAT3 activity

      van Adrichem, A. J. & Wennerberg, Krister, 21 Dec 2015, In: FEBS Letters. 589, 24 Pt B, p. 3859-65 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Minimal information for chemosensitivity assays (MICHA): a next-generation pipeline to enable the FAIRification of drug screening experiments

      Tanoli, Z., Aldahdooh, J., Alam, F., Wang, Y., Seemab, U., Fratelli, M., Pavlis, P., Hajduch, M., Bietrix, F., Gribbon, P., Zaliani, A., Hall, M. D., Shen, M., Brimacombe, K., Kulesskiy, E., Saarela, J., Wennerberg, Krister, Vähä-Koskela, M. & Tang, J., 2022, In: Briefings in Bioinformatics. 23, 1, 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Mitochondria in Their Prime Drive Venetoclax Response in Acute Myeloid Leukemia

      Kriegbaum, M. C. & Wennerberg, Krister, 2020, In: Cancer Cell. 38, 6, p. 776-778 3 p.

      Research output: Contribution to journal › Journal article › Research

    24. Published

      Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor

      Jaiswal, A., Gautam, P., Pietilä, E. A., Timonen, S., Nordström, N., Akimov, Y., Sipari, N., Tanoli, Z., Fleischer, T., Lehti, K., Wennerberg, Krister & Aittokallio, T., 2021, In: Molecular Systems Biology. 17, 3, p. 1-25 e9526.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types

      Majumder, M. M., Leppä, A., Hellesøy, M., Dowling, P., Malyutina, A., Kopperud, R., Bazou, D., Andersson, E., Parsons, A., Tang, J., Kallioniemi, O., Mustjoki, S., O’gorman, P., Wennerberg, Krister, Porkka, K., Gjertsen, B. T. & Heckman, C. A., 2020, In: Haematologica. 105, 6, p. 1527-1538

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

      Kibble, M., Saarinen, N., Tang, J., Wennerberg, Krister, Mäkelä, S. & Aittokallio, T., Aug 2015, In: Natural Product Reports. 32, 8, p. 1249-66 18 p.

      Research output: Contribution to journal › Review › Research › peer-review

    27. Published

      Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer

      Tang, J., Gautam, P., Gupta, A., He, L., Timonen, S., Akimov, Y., Wang, W., Szwajda, A., Jaiswal, A., Turei, D., Yadav, B., Kankainen, M., Saarela, J., Saez-rodriguez, J., Wennerberg, Krister & Aittokallio, T., 2019, In: npj Systems Biology and Applications. 5, 1, 5.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Network-guided identification of cancer-selective combinatorial therapies in ovarian cancer

      He, L., Bulanova, Daria, Oikkonen, J., Häkkinen, A., Zhang, K., Zheng, S., Wang, W., Erkan, E. P., Carpén, O., Joutsiniemi, T., Hietanen, S., Hynninen, J., Huhtinen, K., Hautaniemi, S., Vähärautio, A., Tang, J., Wennerberg, Krister & Aittokallio, T., 2021, In: Briefings in Bioinformatics. 22, 6, 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      PI3Kβ inhibition enhances ALK-inhibitor sensitivity in ALK-rearranged lung cancer

      Talwelkar, S. S., Mayranpaa, M. I., Schuler, J., Linnavirta, N., Hemmes, A., Adinolfi, S., Kankainen, M., Sommergruber, W., Levonen, A., Rasanen, J., Knuuttila, A., Verschuren, E. W. & Wennerberg, Krister, 2023, In: Molecular Oncology. 17, 5, p. 747-764 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

      Kauko, O., O’Connor, C. M., Kulesskiy, E., Sangodkar, J., Aakula, A., Izadmehr, S., Yetukuri, L., Yadav, B., Padzik, A., Laajala, T. D., Haapaniemi, P., Momeny, M., Varila, T., Ohlmeyer, M., Aittokallio, T., Wennerberg, Krister, Narla, G. & Westermarck, J., 18 Jul 2018, In: Science Translational Medicine. 10, 450, p. 1-12 12 p., eaaq1093.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      PP2A-based triple-strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells

      Denisova, O. V., Merisaari, J., Huhtaniemi, R., Qiao, X., Yetukuri, L., Jumppanen, M., Kaur, A., Pääkkönen, M., von Schantz-Fant, С., Ohlmeyer, M., Wennerberg, Krister, Kauko, O., Koch, R., Aittokallio, T., Taipale, M. & Westermarck, J., 2023, In: Molecular Oncology. 17, 9, p. 1803-1820 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition

      Tambe, M., Karjalainen, E., Vähä-Koskela, M., Bulanova, Daria, Gjertsen, B. T., Kontro, M., Porkka, K., Heckman, C. A. & Wennerberg, Krister, 2020, In: Leukemia. 34, p. 3186-3196

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients

      He, L., Tang, J., Andersson, E. I., Timonen, S., Koschmieder, S., Wennerberg, Krister, Mustjoki, S. & Aittokallio, T., 1 May 2018, In: Cancer Research. 78, 9, p. 2407-2418 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Patient-tailored design for selective co-inhibition of leukemic cell subpopulations

      Ianevski, A., Lahtela, J., Javarappa, K. K., Sergeev, P., Ghimire, B. R., Gautam, P., Vähä-Koskela, M., Turunen, L., Linnavirta, N., Kuusanmäki, Heikki Aleksi, Kontro, M., Porkka, K., Heckman, C. A., Mattila, P., Wennerberg, Krister, Giri, A. K. & Aittokallio, T., 2021, In: Science Advances. 7, 8, eabe4038.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets

      Gautam, P., Jaiswal, A., Aittokallio, T., Al-ali, H. & Wennerberg, Krister, 2019, In: Cell Chemical Biology. 26, 7, p. 970-979

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1

      Kauko, O., Imanishi, S. Y., Kulesskiy, E., Yetukuri, L., Laajala, T. D., Sharma, M., Pavic, K., Aakula, A., Rupp, C., Jumppanen, M., Haapaniemi, P., Ruan, L., Yadav, B., Suni, V., Varila, T., Corthals, G. L., Reimand, J., Wennerberg, Krister, Aittokallio, T. & Westermarck, J., 2020, In: Journal of Biological Chemistry. 295, 13, p. 4194-4211

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1

      Velling, T., Risteli, J., Wennerberg, Krister, Mosher, D. F. & Johansson, S., 4 Oct 2002, In: The Journal of Biological Chemistry. 277, 40, p. 37377-81 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing

      Kulesskiy, E., Saarela, J., Turunen, L. & Wennerberg, Krister, Feb 2016, In: Journal of laboratory automation. 21, 1, p. 27-36 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Prediction of drug combination effects with a minimal set of experiments

      Ianevski, A., Giri, A. K., Gautam, P., Kononov, A., Potdar, S., Saarela, J., Wennerberg, Krister & Aittokallio, T., 2019, In: Nature Machine Intelligence. 1, 12, p. 568-577

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Protocol to utilize fresh uncultured human lung tumor cells for personalized functional diagnostics

      Talwelkar, S. S., Lähdeniemi, I. A. K., Mäyränpää, M. I., Hemmes, A., Linnavirta, N., Räsänen, J., Knuuttila, A., Wennerberg, Krister & Verschuren, E. W., 2022, In: STAR Protocols. 3, 4, 19 p., 101720.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies

      Yadav, B., Pemovska, T., Szwajda, A., Kulesskiy, E., Kontro, M., Karjalainen, R., Majumder, M. M., Malani, D., Murumägi, A., Knowles, J., Porkka, K., Heckman, C., Kallioniemi, O., Wennerberg, Krister & Aittokallio, T., 5 Jun 2014, In: Scientific Reports. 4, p. 5193

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth

      Al-Ali, H., Lee, D., Danzi, M. C., Nassif, H., Gautam, P., Wennerberg, Krister, Zuercher, B., Drewry, D. H., Lee, J. K., Lemmon, V. P. & Bixby, J. L., 21 Aug 2015, In: ACS chemical biology. 10, 8, p. 1939-51 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras-Mutant Lung Cancers

      Talwelkar, S. S., Nagaraj, A. S., Devlin, J. R., Hemmes, A., Potdar, S., Kiss, E. A., Saharinen, P., Salmenkivi, K., Mäyränpää, M. I., Wennerberg, Krister & Verschuren, E. W., 2019, In: Molecular Cancer Therapeutics. 18, 10, p. 1863-1874

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data

      Pokharel, Y. R., Saarela, J., Szwajda, A., Rupp, C., Rokka, A., Lal Kumar Karna, S., Teittinen, K., Corthals, G., Kallioniemi, O., Wennerberg, Krister, Aittokallio, T. & Westermarck, J., Dec 2015, In: Molecular and Cellular Proteomics. 14, 12, p. 3274-83 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Rho and Rac take center stage

      Burridge, K. & Wennerberg, Krister, 23 Jan 2004, In: Cell. 116, 2, p. 167-79 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    46. Rho-family GTPases: it's not only Rac and Rho (and I like it)

      Wennerberg, Krister & Der, C. J., 15 Mar 2004, In: Journal of Cell Science. 117, Pt 8, p. 1301-12 12 p.

      Research output: Contribution to journal › Review › Research › peer-review

    47. RhoG signals in parallel with Rac1 and Cdc42

      Wennerberg, Krister, Ellerbroek, S. M., Liu, R., Karnoub, A. E., Burridge, K. & Der, C. J., 6 Dec 2002, In: The Journal of Biological Chemistry. 277, 49, p. 47810-7 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Rnd proteins function as RhoA antagonists by activating p190 RhoGAP

      Wennerberg, Krister, Forget, M., Ellerbroek, S. M., Arthur, W. T., Burridge, K., Settleman, J., Der, C. J. & Hansen, S. H., 1 Jul 2003, In: Current biology : CB. 13, 13, p. 1106-15 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Robust scoring of selective drug responses for patient-tailored therapy selection

      Chen, Y., He, L., Ianevski, A., Ayuda-Durán, P., Potdar, S., Saarela, J., Miettinen, J. J., Kytölä, S., Miettinen, S., Manninen, M., Heckman, C. A., Enserink, J. M., Wennerberg, Krister & Aittokallio, T., 2024, In: Nature Protocols. 19, p. 60-82

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis

      Ellerbroek, S. M., Wennerberg, Krister, Arthur, W. T., Dunty, J. M., Bowman, D. R., DeMali, K. A., Der, C. & Burridge, K., Jul 2004, In: Molecular Biology of the Cell. 15, 7, p. 3309-19 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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