High-Content CRISPR Screens (HCCS)

BRIC’s Core Facility for High-Content CRISPR Screens (HCCS) offers cutting-edge assay automation and cell-based screening services. Our open-access, flexible, state-of-the-art screening platform unlocks a wide array of possibilities for automated assays, including:

• Arrayed CRISPR-Cas9 Screens
• Compound Screens
• 2D and 3D Cell Culture Assays
• Automated and miniaturized multi-well plate assays

For all these assays and more, we offer readouts in

• High-Throughput Confocal Microscopy
• High-Throughput Live Cell Imaging
• High-Throughput Flow Cytometry
• Luminescence, fluorescence and absorbance measurements

We are excited to announce that our human sgRNA library (consisting of 18847 genes) is available for either a genome-wide screen or for cherry-picking! Our team is dedicated to supporting you at every step of your research journey, offering assistance with:

• Initial assay setup
• Automation of assays
• Screen performance
• Data and statistical analysis
• Candidate validation

Explore the full potential of your research with our comprehensive support and advanced technologies. Join us and take advantage of our resources to drive your discoveries forward!

External Funding

Novo Nordisk Foundation Infrastructure grant number NNF20OC0061734