Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Criteria for preclinical models of cholangiocarcinoma : scientific and medical relevance. / Calvisi, Diego F.; Boulter, Luke; Vaquero, Javier; Saborowski, Anna; Fabris, Luca; Rodrigues, Pedro M.; Coulouarn, Cédric; Castro, Rui E.; Segatto, Oreste; Raggi, Chiara; van der Laan, Luc J.W.; Carpino, Guido; Goeppert, Benjamin; Roessler, Stephanie; Kendall, Timothy J.; Evert, Matthias; Gonzalez-Sanchez, Ester; Valle, Juan W.; Vogel, Arndt; Bridgewater, John; Borad, Mitesh J.; Gores, Gregory J.; Roberts, Lewis; Marin, Jose J.G.; Andersen, Jesper B.; Alvaro, Domenico; Forner, Alejandro; Banales, Jesus M.; Cardinale, Vincenzo; Macias, Rocio I.R.; Vicent, Silve; Chen, Xin; Braconi, Chiara; Verstegen, Monique M.A.; Fouassier, Laura; Roberts, Lewis; Scheiter, Alexander; Selaru, Florin M.; Evert, Katja; Utpatel, Kirsten; Broutier, Laura; Cadamuro, Massimiliano; Huch, Meritxell; Goldin, Robert; Gradilone, Sergio A.; Saito, Yoshimasa; CCA Model Consortium.

In: Nature Reviews Gastroenterology and Hepatology, Vol. 20, 2023, p. 462-480.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Calvisi, DF, Boulter, L, Vaquero, J, Saborowski, A, Fabris, L, Rodrigues, PM, Coulouarn, C, Castro, RE, Segatto, O, Raggi, C, van der Laan, LJW, Carpino, G, Goeppert, B, Roessler, S, Kendall, TJ, Evert, M, Gonzalez-Sanchez, E, Valle, JW, Vogel, A, Bridgewater, J, Borad, MJ, Gores, GJ, Roberts, L, Marin, JJG, Andersen, JB, Alvaro, D, Forner, A, Banales, JM, Cardinale, V, Macias, RIR, Vicent, S, Chen, X, Braconi, C, Verstegen, MMA, Fouassier, L, Roberts, L, Scheiter, A, Selaru, FM, Evert, K, Utpatel, K, Broutier, L, Cadamuro, M, Huch, M, Goldin, R, Gradilone, SA, Saito, Y & CCA Model Consortium 2023, 'Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance', Nature Reviews Gastroenterology and Hepatology, vol. 20, pp. 462-480. https://doi.org/10.1038/s41575-022-00739-y

APA

Calvisi, D. F., Boulter, L., Vaquero, J., Saborowski, A., Fabris, L., Rodrigues, P. M., Coulouarn, C., Castro, R. E., Segatto, O., Raggi, C., van der Laan, L. J. W., Carpino, G., Goeppert, B., Roessler, S., Kendall, T. J., Evert, M., Gonzalez-Sanchez, E., Valle, J. W., Vogel, A., ... CCA Model Consortium (2023). Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance. Nature Reviews Gastroenterology and Hepatology, 20, 462-480. https://doi.org/10.1038/s41575-022-00739-y

Vancouver

Calvisi DF, Boulter L, Vaquero J, Saborowski A, Fabris L, Rodrigues PM et al. Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance. Nature Reviews Gastroenterology and Hepatology. 2023;20:462-480. https://doi.org/10.1038/s41575-022-00739-y

Author

Calvisi, Diego F. ; Boulter, Luke ; Vaquero, Javier ; Saborowski, Anna ; Fabris, Luca ; Rodrigues, Pedro M. ; Coulouarn, Cédric ; Castro, Rui E. ; Segatto, Oreste ; Raggi, Chiara ; van der Laan, Luc J.W. ; Carpino, Guido ; Goeppert, Benjamin ; Roessler, Stephanie ; Kendall, Timothy J. ; Evert, Matthias ; Gonzalez-Sanchez, Ester ; Valle, Juan W. ; Vogel, Arndt ; Bridgewater, John ; Borad, Mitesh J. ; Gores, Gregory J. ; Roberts, Lewis ; Marin, Jose J.G. ; Andersen, Jesper B. ; Alvaro, Domenico ; Forner, Alejandro ; Banales, Jesus M. ; Cardinale, Vincenzo ; Macias, Rocio I.R. ; Vicent, Silve ; Chen, Xin ; Braconi, Chiara ; Verstegen, Monique M.A. ; Fouassier, Laura ; Roberts, Lewis ; Scheiter, Alexander ; Selaru, Florin M. ; Evert, Katja ; Utpatel, Kirsten ; Broutier, Laura ; Cadamuro, Massimiliano ; Huch, Meritxell ; Goldin, Robert ; Gradilone, Sergio A. ; Saito, Yoshimasa ; CCA Model Consortium. / Criteria for preclinical models of cholangiocarcinoma : scientific and medical relevance. In: Nature Reviews Gastroenterology and Hepatology. 2023 ; Vol. 20. pp. 462-480.

Bibtex

@article{79a24b526f284f57817a45baf6ce55f9,
title = "Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance",
abstract = "Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary tree. CCA has a poor prognosis, its clinical management remains challenging, and effective treatments are lacking. Therefore, preclinical research is of pivotal importance and necessary to acquire a deeper understanding of CCA and improve therapeutic outcomes. Preclinical research involves developing and managing complementary experimental models, from in vitro assays using primary cells or cell lines cultured in 2D or 3D to in vivo models with engrafted material, chemically induced CCA or genetically engineered models. All are valuable tools with well-defined advantages and limitations. The choice of a preclinical model is guided by the question(s) to be addressed; ideally, results should be recapitulated in independent approaches. In this Consensus Statement, a task force of 45 experts in CCA molecular and cellular biology and clinicians, including pathologists, from ten countries provides recommendations on the minimal criteria for preclinical models to provide a uniform approach. These recommendations are based on two rounds of questionnaires completed by 35 (first round) and 45 (second round) experts to reach a consensus with 13 statements. An agreement was defined when at least 90% of the participants voting anonymously agreed with a statement. The ultimate goal was to transfer basic laboratory research to the clinics through increased disease understanding and to develop clinical biomarkers and innovative therapies for patients with CCA.",
author = "Calvisi, {Diego F.} and Luke Boulter and Javier Vaquero and Anna Saborowski and Luca Fabris and Rodrigues, {Pedro M.} and C{\'e}dric Coulouarn and Castro, {Rui E.} and Oreste Segatto and Chiara Raggi and {van der Laan}, {Luc J.W.} and Guido Carpino and Benjamin Goeppert and Stephanie Roessler and Kendall, {Timothy J.} and Matthias Evert and Ester Gonzalez-Sanchez and Valle, {Juan W.} and Arndt Vogel and John Bridgewater and Borad, {Mitesh J.} and Gores, {Gregory J.} and Lewis Roberts and Marin, {Jose J.G.} and Andersen, {Jesper B.} and Domenico Alvaro and Alejandro Forner and Banales, {Jesus M.} and Vincenzo Cardinale and Macias, {Rocio I.R.} and Silve Vicent and Xin Chen and Chiara Braconi and Verstegen, {Monique M.A.} and Laura Fouassier and Lewis Roberts and Alexander Scheiter and Selaru, {Florin M.} and Katja Evert and Kirsten Utpatel and Laura Broutier and Massimiliano Cadamuro and Meritxell Huch and Robert Goldin and Gradilone, {Sergio A.} and Yoshimasa Saito and {CCA Model Consortium}",
note = "Publisher Copyright: {\textcopyright} 2023, Springer Nature Limited.",
year = "2023",
doi = "10.1038/s41575-022-00739-y",
language = "English",
volume = "20",
pages = "462--480",
journal = "Nature Reviews. Gastroenterology & Hepatology",
issn = "1759-5045",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Criteria for preclinical models of cholangiocarcinoma

T2 - scientific and medical relevance

AU - Calvisi, Diego F.

AU - Boulter, Luke

AU - Vaquero, Javier

AU - Saborowski, Anna

AU - Fabris, Luca

AU - Rodrigues, Pedro M.

AU - Coulouarn, Cédric

AU - Castro, Rui E.

AU - Segatto, Oreste

AU - Raggi, Chiara

AU - van der Laan, Luc J.W.

AU - Carpino, Guido

AU - Goeppert, Benjamin

AU - Roessler, Stephanie

AU - Kendall, Timothy J.

AU - Evert, Matthias

AU - Gonzalez-Sanchez, Ester

AU - Valle, Juan W.

AU - Vogel, Arndt

AU - Bridgewater, John

AU - Borad, Mitesh J.

AU - Gores, Gregory J.

AU - Roberts, Lewis

AU - Marin, Jose J.G.

AU - Andersen, Jesper B.

AU - Alvaro, Domenico

AU - Forner, Alejandro

AU - Banales, Jesus M.

AU - Cardinale, Vincenzo

AU - Macias, Rocio I.R.

AU - Vicent, Silve

AU - Chen, Xin

AU - Braconi, Chiara

AU - Verstegen, Monique M.A.

AU - Fouassier, Laura

AU - Roberts, Lewis

AU - Scheiter, Alexander

AU - Selaru, Florin M.

AU - Evert, Katja

AU - Utpatel, Kirsten

AU - Broutier, Laura

AU - Cadamuro, Massimiliano

AU - Huch, Meritxell

AU - Goldin, Robert

AU - Gradilone, Sergio A.

AU - Saito, Yoshimasa

AU - CCA Model Consortium

N1 - Publisher Copyright: © 2023, Springer Nature Limited.

PY - 2023

Y1 - 2023

N2 - Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary tree. CCA has a poor prognosis, its clinical management remains challenging, and effective treatments are lacking. Therefore, preclinical research is of pivotal importance and necessary to acquire a deeper understanding of CCA and improve therapeutic outcomes. Preclinical research involves developing and managing complementary experimental models, from in vitro assays using primary cells or cell lines cultured in 2D or 3D to in vivo models with engrafted material, chemically induced CCA or genetically engineered models. All are valuable tools with well-defined advantages and limitations. The choice of a preclinical model is guided by the question(s) to be addressed; ideally, results should be recapitulated in independent approaches. In this Consensus Statement, a task force of 45 experts in CCA molecular and cellular biology and clinicians, including pathologists, from ten countries provides recommendations on the minimal criteria for preclinical models to provide a uniform approach. These recommendations are based on two rounds of questionnaires completed by 35 (first round) and 45 (second round) experts to reach a consensus with 13 statements. An agreement was defined when at least 90% of the participants voting anonymously agreed with a statement. The ultimate goal was to transfer basic laboratory research to the clinics through increased disease understanding and to develop clinical biomarkers and innovative therapies for patients with CCA.

AB - Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary tree. CCA has a poor prognosis, its clinical management remains challenging, and effective treatments are lacking. Therefore, preclinical research is of pivotal importance and necessary to acquire a deeper understanding of CCA and improve therapeutic outcomes. Preclinical research involves developing and managing complementary experimental models, from in vitro assays using primary cells or cell lines cultured in 2D or 3D to in vivo models with engrafted material, chemically induced CCA or genetically engineered models. All are valuable tools with well-defined advantages and limitations. The choice of a preclinical model is guided by the question(s) to be addressed; ideally, results should be recapitulated in independent approaches. In this Consensus Statement, a task force of 45 experts in CCA molecular and cellular biology and clinicians, including pathologists, from ten countries provides recommendations on the minimal criteria for preclinical models to provide a uniform approach. These recommendations are based on two rounds of questionnaires completed by 35 (first round) and 45 (second round) experts to reach a consensus with 13 statements. An agreement was defined when at least 90% of the participants voting anonymously agreed with a statement. The ultimate goal was to transfer basic laboratory research to the clinics through increased disease understanding and to develop clinical biomarkers and innovative therapies for patients with CCA.

U2 - 10.1038/s41575-022-00739-y

DO - 10.1038/s41575-022-00739-y

M3 - Journal article

C2 - 36755084

AN - SCOPUS:85147649578

VL - 20

SP - 462

EP - 480

JO - Nature Reviews. Gastroenterology & Hepatology

JF - Nature Reviews. Gastroenterology & Hepatology

SN - 1759-5045

ER -

ID: 336601613