Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing
Research output: Contribution to journal › Journal article › Research › peer-review
Documents
- s41467-019-13687-0
Final published version, 2.38 MB, PDF document
Variations in transcription start site (TSS) selection reflect diversity of preinitiation complexes and can impact on post-transcriptional RNA fates. Most metazoan polymerase II-transcribed genes carry canonical initiation with pyrimidine/purine (YR) dinucleotide, while translation machinery-associated genes carry polypyrimidine initiator (5’-TOP or TCT). By addressing the developmental regulation of TSS selection in zebrafish we uncovered a class of dual-initiation promoters in thousands of genes, including snoRNA host genes. 5’-TOP/TCT initiation is intertwined with canonical initiation and used divergently in hundreds of dual-initiation promoters during maternal to zygotic transition. Dual-initiation in snoRNA host genes selectively generates host and snoRNA with often different spatio-temporal expression. Dual-initiation promoters are pervasive in human and fruit fly, reflecting evolutionary conservation. We propose that dual-initiation on shared promoters represents a composite promoter architecture, which can function both coordinately and divergently to diversify RNAs.
Original language | English |
---|---|
Article number | 168 |
Journal | Nature Communications |
Volume | 11 |
Issue number | 1 |
Pages (from-to) | 1-16 |
ISSN | 2041-1723 |
DOIs | |
Publication status | Published - 2020 |
Number of downloads are based on statistics from Google Scholar and www.ku.dk
ID: 236327650