Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice

Research output: Contribution to journal › Journal article › Research › peer-review

  • Valentina M Factor
  • Daekwan Seo
  • Tsuyoshi Ishikawa
  • Pal Kaposi-Novak
  • Jens U Marquardt
  • Andersen, Jesper Bøje
  • Elizabeth A Conner
  • Snorri S Thorgeirsson
Previous work has established that HGF/c-Met signaling plays a pivotal role in regulating the onset of S phase following partial hepatectomy (PH). In this study, we used Met(fl/fl);Alb-Cre(+/-) conditional knockout mice to determine the effects of c-Met dysfunction in hepatocytes on kinetics of liver regeneration.
Original languageEnglish
JournalPLOS ONE
Volume5
Issue number9
ISSN1932-6203
DOIs
Publication statusPublished - 2010
Externally publishedYes

    Research areas

  • Animals, Cell Division, Female, G2 Phase, Gene Expression Regulation, Hepatocytes, Liver, Liver Regeneration, MAP Kinase Signaling System, Male, Mice, Mice, Knockout, Proto-Oncogene Proteins c-met, Up-Regulation

ID: 97139742