Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer
Research output: Contribution to journal › Journal article › Research › peer-review
Bladder cancer is among the most prevalent malignancies, and is characterised by frequent tumour recurrences and localised inflammation, which may promote tissue invasion and metastasis. Microarray analysis was used to compare gene expression in normal bladder urothelium with that in tumours at different stages of progression. The innate immune response gene, interferon-stimulated gene 15 kDa (ISG15, GIP2), was highly expressed at all stages of bladder cancer as compared to normal urothelium. Western blotting revealed a tumour-associated expression of ISG15 protein. ISG15 exhibited a stage-associated expression, with significantly (P
| Original language | English |
|---|---|
| Journal | B J C |
| Volume | 94 |
| Issue number | 10 |
| Pages (from-to) | 1465-71 |
| Number of pages | 7 |
| ISSN | 0007-0920 |
| DOIs | |
| Publication status | Published - 22 May 2006 |
| Externally published | Yes |
- Blotting, Western, Cell Nucleus, Cytokines, Gene Expression Profiling, Humans, Muscle Neoplasms, Neoplasm Invasiveness, Neoplasm Staging, Oligonucleotide Array Sequence Analysis, Stromal Cells, Ubiquitins, Urinary Bladder Neoplasms, Urothelium
Research areas
ID: 97140502