Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes
Research output: Contribution to journal › Review › Research › peer-review
Standard
Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes. / Font-Cunill, Berta; Arnes, Luis; Ferrer, Jorge; Sussel, Lori; Beucher, Anthony.
In: Frontiers in Genetics, Vol. 9, 2018, p. 524.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes
AU - Font-Cunill, Berta
AU - Arnes, Luis
AU - Ferrer, Jorge
AU - Sussel, Lori
AU - Beucher, Anthony
PY - 2018
Y1 - 2018
N2 - The transcriptional programs of differentiated cells are tightly regulated by interactions between cell type-specific transcription factors and cis-regulatory elements. Long non-coding RNAs (lncRNAs) have emerged as additional regulators of gene transcription. Current evidence indicates that lncRNAs are a very heterogeneous group of molecules. For example, selected lncRNAs have been shown to regulate gene expression in cis or trans, although in most cases the precise underlying molecular mechanisms is unknown. Recent studies have uncovered a large number of lncRNAs that are selectively expressed in pancreatic islet cells, some of which were shown to regulate β cell transcriptional programs. A subset of such islet lncRNAs appears to control the expression of β cell-specific transcription factor (TF) genes by local cis-regulation. In this review, we discuss current knowledge of molecular mechanisms underlying cis-regulatory lncRNAs and discuss challenges involved in using genetic perturbations to define their function. We then discuss known examples of pancreatic islet lncRNAs that appear to exert cis-regulation of TF genes. We propose that cis-regulatory lncRNAs could represent a molecular target for modulation of diabetes-relevant genes.
AB - The transcriptional programs of differentiated cells are tightly regulated by interactions between cell type-specific transcription factors and cis-regulatory elements. Long non-coding RNAs (lncRNAs) have emerged as additional regulators of gene transcription. Current evidence indicates that lncRNAs are a very heterogeneous group of molecules. For example, selected lncRNAs have been shown to regulate gene expression in cis or trans, although in most cases the precise underlying molecular mechanisms is unknown. Recent studies have uncovered a large number of lncRNAs that are selectively expressed in pancreatic islet cells, some of which were shown to regulate β cell transcriptional programs. A subset of such islet lncRNAs appears to control the expression of β cell-specific transcription factor (TF) genes by local cis-regulation. In this review, we discuss current knowledge of molecular mechanisms underlying cis-regulatory lncRNAs and discuss challenges involved in using genetic perturbations to define their function. We then discuss known examples of pancreatic islet lncRNAs that appear to exert cis-regulation of TF genes. We propose that cis-regulatory lncRNAs could represent a molecular target for modulation of diabetes-relevant genes.
U2 - 10.3389/fgene.2018.00524
DO - 10.3389/fgene.2018.00524
M3 - Review
C2 - 30459811
VL - 9
SP - 524
JO - Frontiers in Genetics
JF - Frontiers in Genetics
SN - 1664-8021
ER -
ID: 213507046