The integrin-actin connection, an eternal love affair.
Research output: Contribution to journal › Journal article › Research › peer-review
Integrin receptors connect the extracellular matrix to the actin cytoskeleton. This interaction can be viewed as a cyclical liaison, which develops again and again at new adhesion sites only to cease at sites of de-adhesion. Recent work has demonstrated that multidomain proteins play crucial roles in the integrin-actin connection by providing a high degree of regulation adjusted to the needs of the cell. In this review we present several examples of this paradigm and with special emphasis on the ILK-PINCH-parvin complex, which amply demonstrates how structural and signalling functions are linked together.
Original language | English |
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Journal | EMBO Journal |
Volume | 22 |
Issue number | 10 |
Pages (from-to) | 2324-33 |
Number of pages | 9 |
ISSN | 0261-4189 |
DOIs | |
Publication status | Published - 2003 |
Bibliographical note
Keywords: Actinin; Actins; Animals; Carrier Proteins; Cell Adhesion; Cytoskeleton; DNA-Binding Proteins; Extracellular Matrix; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microfilament Proteins; Protein-Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction
ID: 5141360