Claus Storgaard Sørensen

Claus Storgaard Sørensen

Associate Professor, Professor

Member of:


    1. 2024
    2. Published

      PALB2-mutated human mammary cells display a broad spectrum of morphological and functional abnormalities induced by increased TGFβ signaling

      Tuppurainen, H., Laurila, N., Nätynki, M., Eshraghi, L., Tervasmäki, A., Erichsen, L., Sørensen, Claus Storgaard, Pylkäs, K., Winqvist, R. & Peltoketo, H., 2024, In: Cellular and Molecular Life Sciences. 81, 21 p., 173.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. 2023
    4. Published

      ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy

      Piotrowski, Kris, Puig Blasco, Laia, Samsøe-Petersen, Jacob, Eefsen, R. L., Illemann, M., Oria, Victor Oginga, Campos, K. I. A., Lopresti, Alexia Mélanie, Albrechtsen, Reidar, Sørensen, Claus Storgaard, Sun, X. F., Kveiborg, Marie & Gnosa, S., 2023, In: Cancer Gene Therapy. 30, p. 1369-1381 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation

      Kwon, Y., Rösner, H., Zhao, W., Selemenakis, P., He, Z., Kawale, A. S., Katz, J. N., Rogers, C. M., Neal, F. E., Badamchi Shabestari, A., Petrosius, V., Singh, A. K., Joel, M. Z., Lu, L., Holloway, S. P., Burma, S., Mukherjee, B., Hromas, R., Mazin, A., Wiese, C. & 2 others, Sørensen, Claus Storgaard & Sung, P., 2023, In: Nature Communications. 14, 18 p., 432.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

      Green, A. C., Marttila, P., Kiweler, N., Chalkiadaki, C., Wiita, E., Cookson, V., Lesur, A., Eiden, K., Bernardin, F., Vallin, K. S. A., Borhade, S., Long, M., Ghahe, E. K., Jiménez-Alonso, J. J., Jemth, A-S., Loseva, O., Mortusewicz, O., Meyers, M., Viry, E., Johansson, A. I. & 14 others, Hodek, O., Homan, E., Bonagas, N., Ramos, L., Sandberg, L., Frödin, Morten, Moussay, E., Slipicevic, A., Letellier, E., Paggetti, J., Sørensen, Claus Storgaard, Helleday, T., Henriksson, M. & Meiser, J., 2023, In: Nature Metabolism. 5, p. 642-659

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      Self-inflicted DNA breaks in cell differentiation and cancer

      Benada, Jan, Alsowaida, D., Megeney, L. A. & Sørensen, Claus Storgaard, 2023, In: Trends in Cell Biology. 33, 10, p. 850-859

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low-dose treatment of high-grade serous ovarian carcinoma

      Benada, Jan, Bulanova, Daria, Azzoni, Violette Iridé Liliane, Petrosius, V., Ghazanfar, S., Wennerberg, Krister & Sørensen, Claus Storgaard, 2023, In: NAR Cancer. 5, 3, 13 p., zcad029.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway

      Petrosius, V., Benada, Jan, Nielsen, Olaf, Schoof, E. M. & Sørensen, Claus Storgaard, 2023, In: iScience. 26, 1, 24 p., 105806.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. 2022
    11. Published

      A catalog of curated breast cancer genes

      Bose, M., Benada, Jan, Thatte, Jayashree Vijay, Kinalis, S., Ejlertsen, Bent Laursen, Nielsen, Finn Cilius, Sørensen, Claus Storgaard & Rossing, Caroline Maria, 2022, In: Breast Cancer Research and Treatment. 191, p. 431-441

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress

      Larsen, Brian Daniel, Benada, Jan, Yung, P. Y. K., Bell, R. A. V., Pappas, G., Urban, V., Ahlskog, J. K., Kuo, T. T., Janscak, P., Megeney, L. A., Elsässer, S. J., Bartek, J. & Sørensen, Claus Storgaard, 2022, In: Science. 376, 6592, p. 476-483 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. Published

      Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1 and the NAMPT-NAD+ pathway

      Maynard, S., Hall, A., Galanos, P., Rizza, S., Yamamoto, T., Gram, H. H., Munk, S. H. N., Shoaib, Muhammad, Sørensen, Claus Storgaard, Bohr, Vilhelm, Lerdrup, Mads, Maya-Mendoza, A. & Bartek, J., 2022, In: Nucleic Acids Research. 50, 17, p. 9948-9965 18 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select

      Niu, Yiyuan, Ferreira Azevedo, Catarina A, Li, Xin, Kamali, E., Nielsen, Ole Haagen, Sørensen, Claus Storgaard & Frödin, Morten, 2022, In: Nature Genetics. 54, 28 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. Published

      WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity

      Elbæk, C. R., Petrosius, V., Benada, Jan, Erichsen, L., Damgaard, R. B. & Sørensen, Claus Storgaard, 2022, In: Cell Reports. 38, 3, 110261.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. 2021
    17. Published

      Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes

      Shoaib, Muhammad, Chen, Q., Shi, X., Nair, Nidhi, Prasanna, C., Yang, R., Walter, D., Frederiksen, K. S., Einarsson, H., Svensson, J. P., Liu, C. F., Ekwall, K., Lerdrup, Mads, Nordenskiöld, L. & Sørensen, Claus Storgaard, 2021, In: Nature Communications. 12, 1, 16 p., 4800.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. 2020
    19. Published

      Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability

      Zarrizi, R., Higgs, M. R., Voßgröne, Karolin, Rossing, M., Bertelsen, B., Bose, M., Kousholt, A. N., Rösner, Heike Ilona, Network, T. C., Ejlertsen, Bent Laursen, Stewart, G. S., Nielsen, Finn Cilius & Sørensen, Claus Storgaard, 3 Aug 2020, In: The Journal of Clinical Investigation. 130, 8, p. 4069-4080 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. Published

      Acute hydroxyurea-induced replication blockade results in replisome components disengagement from nascent DNA without causing fork collapse

      Ercilla, A., Feu, S., Aranda, S., Llopis, A., Brynjólfsdóttir, S. H., Sørensen, Claus Storgaard, Toledo, L. I. & Agell, N., 2020, In: Cellular and molecular life sciences : CMLS. 77, p. 735–749

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Published

      Chromatin Landscaping At Mitotic Exit Orchestrates Genome Function

      Shoaib, Muhammad, Nair, Nidhi & Sørensen, Claus Storgaard, 2020, In: Frontiers in Genetics. 11, p. 1-9 103.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Photochemotherapy Induces Interferon Type III Expression via STING Pathway

      Biskup, E., Larsen, Brian Daniel, Rib, Leonor, Folkersen, L., Niazi, O., Kamstrup, M. R. & Sørensen, Claus Storgaard, 2020, In: Cells. 9, 11, p. 1-19

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      WEE1 kinase limits CDK activities to safeguard DNA replication and mitotic entry

      Elbæk, C. R., Petrosius, V. & Sørensen, Claus Storgaard, 2020, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 819-820, p. 1-6 6 p., 111694.

      Research output: Contribution to journalReviewResearchpeer-review

    24. 2019
    25. Published

      E2F transcription regulation: an orphan cyclin enters the stage

      Rösner, Heike Ilona & Sørensen, Claus Storgaard, 2019, In: The EMBO Journal. 38, 20, e103421.

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Published

      Overcoming Treatment Toxicity through Sequential Therapy

      Benada, Jan, Ejlertsen, Bent Laursen & Sørensen, Claus Storgaard, 2019, In: Cancer Cell. 35, 6, p. 821-822 2 p.

      Research output: Contribution to journalJournal articleResearch

    27. Published

      PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response

      Simhadri, S., Vincelli, G., Huo, Y., Misenko, S., Foo, T. K., Ahlskog, J., Sørensen, Claus Storgaard, Oakley, G. G., Ganesan, S., Bunting, S. F. & Xia, B., 2019, In: Oncogene. 38, p. 1585–1596

      Research output: Contribution to journalJournal articleResearchpeer-review

    28. Published

      Whole genome sequencing of breast cancer

      Rossing, M., Sørensen, Claus Storgaard, Ejlertsen, Bent Laursen & Nielsen, Finn Cilius, 2019, In: APMIS - Journal of Pathology, Microbiology and Immunology. 127, 5, p. 303-315 13 p.

      Research output: Contribution to journalReviewResearchpeer-review

    29. 2018
    30. Published

      Hereditary risk of breast and ovarian cancer: BRCA1 and BRCA2

      Sørensen, Claus Storgaard, 1 Jan 2018, Encyclopedia of Cancer. Elsevier, p. 214-217 4 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    31. Published

      Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

      Shoaib, Muhammad, Walter, D., Gillespie, P. J., Izard, F., Fahrenkrog, B., Lleres, D., Lerdrup, Mads, Johansen, Jens Vilstrup, Hansen, K., Julien, E., Blow, J. J. & Sørensen, Claus Storgaard, 2018, In: Nature Communications. 9, 1, p. 1-11 11 p., 3704.

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Published

      Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

      Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N. N., Glytsou, C., Pateras, I. S., Swain, U., Souliotis, V. L., Georgakilas, A. G., Geacintov, N., Scorrano, L., Lukas, C., Lukas, J., Livneh, Z., Lygerou, Z., Chowdhury, D., Sørensen, C. S., Bartek, J. & 1 others, Gorgoulis, V. G., 2018, In: Genome Biology (Online Edition). 19, p. 1-18 37.

      Research output: Contribution to journalJournal articleResearchpeer-review

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