Hereditary risk of breast and ovarian cancer: BRCA1 and BRCA2
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Germline genetic abnormalities in the tumor suppressors BRCA1 and BRCA2 predispose to hereditary breast and ovarian cancer (HBOC) in an autosomal-dominant manner. BRCA1 and BRCA2 are important for DNA repair, when mutated, chromosomal DNA accumulates further mutations that fuels tumorigenesis. Clinical genetic laboratory testing of individuals at risk identifies HBOC predisposing gene variants, which is crucial to guide between several management options for the condition. Furthermore, precise information regarding pathogenic variants supports treatment choices in the event of cancer development.
Original language | English |
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Title of host publication | Encyclopedia of Cancer |
Number of pages | 4 |
Publisher | Elsevier |
Publication date | 1 Jan 2018 |
Pages | 214-217 |
ISBN (Electronic) | 9780128124857 |
DOIs | |
Publication status | Published - 1 Jan 2018 |
- BRCA1, BRCA2, Breast cancer, Genetic counseling, Genetic testing, Homologous recombination DNA repair, Ovarian cancer, PALB2, PARP inhibition, Risk assessment
Research areas
ID: 251833367