Colm O'Rourke

Colm O'Rourke

Assistant Professor


Publication year:
All
1 - 34 out of 34Page size: 100
  1. 2024
  2. Published

    Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy

    O'Rourke, C. J., Salati, M., Rae, C., Carpino, G., Leslie, H., Pea, A., Prete, M. G., Bonetti, L. R., Amato, F., Montal, R., Upstill-Goddard, R., Nixon, C., Sanchon-Sanchez, P., Kunderfranco, P., Sia, D., Gaudio, E., Overi, D., Cascinu, S., Hogdall, D., Pugh, S. & 15 others, Domingo, E., Primrose, J. N., Bridgewater, J., Spallanzani, A., Gelsomino, F., Llovet, J. M., Calvisi, D. F., Boulter, L., Caputo, F., Lleo, A., Jamieson, N. B., Luppi, G., Dominici, M., Andersen, Jesper Bøje & Braconi, C., 2024, In: Gut. 73, p. 496-508

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2023
  4. Published

    Genetic and epigenetic analysis of hepatocellular adenomas with atypical morphological features

    Haefliger, S., Hench, J., O'Rourke, Colm, Meyer-Schaller, N., Uzun, S., Saldarriaga, J., Weber, A., Mazzucchelli, L., Jermann, P., Frank, S., Andersen, Jesper Bøje, Terracciano, L., Sempoux, C. & Matter, M. S., 2023, In: Histopathology. 82, 5, p. 722–730 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. E-pub ahead of print

    Immunogenomics of cholangiocarcinoma

    Gehl, Virag, O'Rourke, Colm & Andersen, Jesper Bøje, 2023, (E-pub ahead of print) In: Hepatology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis and prognostication of cholangiocarcinoma

    Lapitz, A., Azkargorta, M., Milkiewicz, P., Olaizola, P., Zhuravleva, E., Grimsrud, M. M., Schramm, C., Arbelaiz, A., O'Rourke, C. J., La Casta, A., Milkiewicz, M., Pastor, T., Vesterhus, M., Jimenez-Agüero, R., Dill, M. T., Lamarca, A., Valle, J. W., Macias, R. I. R., Izquierdo-Sanchez, L., Castaño, Y. P. & 15 others, Caballero-Camino, F. J., Riaño, I., Krawczyk, M., Ibarra, C., Bustamante, J., Nova-Camacho, L. M., Falcon-Perez, J. M., Elortza, F., Perugorria, M. J., Andersen, Jesper Bøje, Bujanda, L., Karlsen, T. H., Folseraas, T., Rodrigues, P. M. & Banales, J. M., 2023, In: Journal of Hepatology. 79, 1, p. 93-108

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells

    Duwe, Lea, Munoz-Garrido, P., Lewinska, Monika, Lafuente Barquero, Juan Francisco, Satriano, L., Høgdall, Dan Taksony Solyom, Taranta, A., Nielsen, B. S., Ghazal, A., Matter, M. S., Banales, J. M., Aldana, Blanca, Gao, Y., Marquardt, J. U., Roberts, L. R., Oliveira, R. C., Koshiol, J., O'Rourke, Colm & Andersen, Jesper Bøje, 2023, In: Journal of Hepatology. 78, 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    P-123 CD73high biliary tract cancer (BTC) is a molecularly defined subtype with distinct clinical implications

    Salati, M., Anna, B., O'Rourke, Colm, Piscopo, F., Evangelista, L., Pisapia, P., Riccò, B., Spallanzani, A., Gelsomino, F., Malapelle, U., Bonetti, L. R., Andersen, Jesper, Troncone, G., Dominici, M., Brunella, F. & Carotenuto, P., 2023, In: Annals of Oncology. 34, p. S58 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  9. Published

    miR-21-5p promotes NASH-related hepatocarcinogenesis

    Rodrigues, P. M., Afonso, M. B., Simão, A. L., Islam, T., Gaspar, M. M., O'Rourke, Colm, Lewinska, Monika, Andersen, Jesper Bøje, Arretxe, E., Alonso, C., Santos-Laso, Á., Izquierdo-Sanchez, L., Jimenez-Agüero, R., Eizaguirre, E., Bujanda, L., Pareja, M. J., Prip-Buus, C., Banales, J. M., Rodrigues, C. M. P. & Castro, R. E., 2023, In: Liver International. 43, 10, p. 2256-2274 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. 2022
  11. Published

    Molecular therapeutic targets for cholangiocarcinoma: Present challenges and future possibilities

    Høgdall, Dan Taksony Solyom, O'Rourke, Colm & Andersen, Jesper Bøje, 2022, Advances in Cancer Research. Academic Press, Vol. 156. p. 343-366 (Advances in Cancer Research).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  12. Published

    Mucosal-associated invariant T-cell tumor infiltration predicts long-term survival in cholangiocarcinoma

    Zimmer, C. L., Filipovic, I., Cornillet, M., O'Rourke, Colm, Berglin, L., Jansson, H., Sun, D., Strauss, O., Hertwig, L., Johansson, H., von Seth, E., Sparrelid, E., Dias, J., Glaumann, H., Melum, E., Ellis, E. C., Sandberg, J. K., Andersen, Jesper Bøje, Bergquist, A. & Björkström, N. K., 2022, In: Hepatology. 75, 5, p. 1154-1168

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Mutational signatures and processes in hepatobiliary cancers

    Zhuravleva, Ekaterina, O'Rourke, Colm & Andersen, Jesper Bøje, 2022, In: Nature Reviews. Gastroenterology & Hepatology. 19, p. 367-382

    Research output: Contribution to journal › Review › Research › peer-review

  14. Published

    Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models

    Olaizola, P., Lee-Law, P. Y., Fernandez-Barrena, M. G., Alvarez, L., Cadamuro, M., Azkargorta, M., O'Rourke, C. J., Caballero-Camino, F. J., Olaizola, I., Macias, R. I. R., Marin, J. J. G., Serrano-Maciá, M., Martinez-Chantar, M. L., Avila, M. A., Aspichueta, P., Calvisi, D. F., Evert, M., Fabris, L., Castro, R. E., Elortza, F. & 5 others, Andersen, Jesper Bøje, Bujanda, L., Rodrigues, P. M., Perugorria, M. J. & Banales, J. M., 2022, In: Journal of Hepatology. 77, 1, p. 177-190

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Whole blood microRNAs capture systemic reprogramming and have diagnostic potential in patients with biliary tract cancer

    Høgdall, Dan Taksony Solyom, O'Rourke, Colm, Larsen, F. O., Zarforoushan, S., Christensen, Troels Dreier, Ghazal, A., Boisen, M. K., Muñoz-Garrido, P., Johansen, Julia Sidenius & Andersen, Jesper Bøje, 2022, In: Journal of Hepatology. 77, p. 1047-1058 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. 2021
  17. Published

    DNA Methylation in Ovarian Tumors - a Comparison Between Fresh Tissue and FFPE Samples

    Oliveira, D. V. N. P., Hentze, J., O'Rourke, Colm, Andersen, Jesper Bøje, Høgdall, Claus Kim & Høgdall, Estrid Vilma Solyom, 2021, In: Reproductive Sciences. 28, 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    E2F1 and E2F2-mediated repression of CPT2 establishes a lipid-rich tumor-promoting environment

    Gonzalez-Romero, F., Mestre, D., Aurrekoetxea, I., O'Rourke, C. J., Andersen, J. B., Woodhoo, A., Tamayo-Caro, M., Varela-Rey, M., Palomo-Irigoyen, M., Gomez-Santos, B., de Urturi, D. S., Nuñez-García, M., García-Rodríguez, J. L., Fernandez-Ares, L., Buque, X., Iglesias-Ara, A., Bernales, I., de Juan, V. G., Delgado, T. C., Goikoetxea-Usandizaga, N. & 15 others, Lee, R., Bhanot, S., Delgado, I., Perugorria, M. J., Errazti, G., Mosteiro, L., Gaztambide, S., de la Piscina, I. M., Iruzubieta, P., Crespo, J., Banales, J. M., Martínez-Chantar, M. L., Castaño, L., Zubiaga, A. M. & Aspichueta, P., 2021, In: Cancer Research. 81, 11, p. 2874-2887 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis

    Czauderna, C., Poplawski, A., O'Rourke, Colm, Castven, D., Pérez-Aguilar, B., Becker, D., Heilmann-Heimbach, S., Odenthal, M., Amer, W., Schmiel, M., Drebber, U., Binder, H., Ridder, D. A., Schindeldecker, M., Straub, B. K., Galle, P. R., Andersen, Jesper Bøje, Thorgeirsson, S. S., Park, Y. N. & Marquardt, J. U., 2021, In: JCI insight. 6, 17, 19 p., e146196.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Longitudinal analysis of individual cfDNA methylome patterns in metastatic prostate cancer

    Silva, R., Moran, B., Baird, A. M., O'Rourke, Colm, Finn, S. P., McDermott, R., Watson, W., Gallagher, W. M., Brennan, D. J. & Perry, A. S., 2021, In: Clinical Epigenetics. 13, 10 p., 168.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Molecular targets in cholangiocarcinoma

    O'Rourke, Colm, Munoz-Garrido, P. & Andersen, Jesper Bøje, 2021, In: Hepatology. 73, S1, p. 62-74

    Research output: Contribution to journal › Review › Research › peer-review

  22. Published

    Structural aberrations are associated with poor survival in patients with clonal cytopenia of undetermined significance

    Mikkelsen, Stine Ulrik, Safavi, S., Dimopoulos, K., O'Rourke, Colm, Andersen, M. K., Holm, M. S., Marcher, C. W., Andersen, Jesper Bøje, Hansen, Jakob Werner & Grønbæk, Kirsten, 2021, In: Haematologica. 106, 6

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  23. 2020
  24. Published

    Identification of a Pan-Gamma-Secretase Inhibitor Response Signature for Notch-Driven Cholangiocarcinoma

    O'Rourke, Colm, Matter, M. S., Nepal, C., Caetano-Oliveira, R., Ton, P. T., Factor, V. M. & Andersen, Jesper Bøje, Jan 2020, In: Hepatology. 71, 1, p. 196-213 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Integrative molecular characterization of gallbladder cancer reveals microenvironment-associated subtypes

    Nepal, C., Zhu, B., O'Rourke, C. J., Bhatt, D. K., Lee, D., Song, L., Wang, D., Van Dyke, A., Choo-Wosoba, H., Liu, Z., Hildesheim, A., Goldstein, A. M., Dean, M., LaFuente-Barquero, J., Lawrence, S., Mutreja, K., Olanich, M. E., Bermejo, J. L., Ferreccio, C., Roa, J. C. & 8 others, Rashid, A., Hsing, A. W., Gao, Y., Chanock, S. J., Araya, J. C., Andersen, Jesper Bøje, Koshiol, J. & CGR Exome Studies Group(,), C. E. S. G., 2020, In: Journal of Hepatology. 7, 5, p. 1132-1144

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis

    Lapitz, A., Arbelaiz, A., O'Rourke, C. J., Lavin, J. L., Casta, A. L., Ibarra, C., Jimeno, J. P., Santos-Laso, A., Izquierdo-Sanchez, L., Krawczyk, M., Perugorria, M. J., Jimenez-Aguero, R., Sanchez-Campos, A., Riaño, I., Gónzalez, E., Lammert, F., Marzioni, M., Macias, R. I. R., Marin, J. J. G., Karlsen, T. H. & 6 others, Bujanda, L., Falcón-Pérez, J. M., Andersen, Jesper Bøje, Aransay, A. M., Rodrigues, P. M. & Banales, J. M., 2020, In: Cells. 9, 3, p. 1-33

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers

    Høgdall, Dan Taksony Solyom, O'Rourke, Colm, Dehlendorff, C., Larsen, O. F., Jensen, L. H., Johansen, A. Z., Dang, H., Factor, V. M., Grunnet, M., Mau-Sørensen, M., Oliveira, D. V. N. P., Linnemann, D., Boisen, M. K., Wang, X. W., Johansen, Julia Sidenius & Andersen, Jesper Bøje, 2020, In: Clinical Cancer Research. 26, 21, 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms

    Esparza-Baquer, A., Labiano, I., Sharif, O., Agirre-Lizaso, A., Oakley, F., Rodrigues, P. M., Zhuravleva, E., O'Rourke, C. J., Hijona, E., Jimenez-Agüero, R., Riaño, I., Landa, A., La Casta, A., Zaki, M. Y. W., Munoz-Garrido, P., Azkargorta, M., Elortza, F., Vogel, A., Schabbauer, G., Aspichueta, P. & 6 others, Andersen, Jesper Bøje, Knapp, S., Mann, D. A., Bujanda, L., Banales, J. M. & Perugorria, M. J., 2020, In: Gut. 70, 7

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. 2019
  30. Published

    Causes of hOCT1-dependent cholangiocarcinoma resistance to sorafenib and sensitization by tumor-selective gene therapy

    Lozano, E., Macias, R. I. R., Monte, M. J., Asensio, M., Del Carmen, S., Sanchez-Vicente, L., Alonso-Peña, M., Al-Abdulla, R., Munoz-Garrido, P., Satriano, L., O'Rourke, Colm, Banales, J. M., Avila, M. A., Martinez-Chantar, M. L., Andersen, Jesper Bøje, Briz, O. & Marin, J. J. G., Oct 2019, In: Hepatology. 70, 4, p. 1246-1261 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Epigenetic events involved in organic cation transporter 1-dependent impaired response of hepatocellular carcinoma to sorafenib

    Al-Abdulla, R., Lozano, E., Macias, R. I. R., Monte, M. J., Briz, O., O'Rourke, Colm, Serrano, M. A., Banales, J. M., Avila, M. A., Martinez-Chantar, M. L., Geier, A., Andersen, Jesper Bøje & Marin, J. J. G., 2019, In: British Journal of Pharmacology. 176, 6, p. 787-800

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Epigenome Remodeling in Cholangiocarcinoma

    O'Rourke, Colm, Lafuente Barquero, Juan Francisco & Andersen, Jesper Bøje, 2019, In: Trends in Cancer. 5, 6, p. 335-350 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  33. Published

    Identification of a pan-gamma-secretase inhibitor response signature for notch-driven cholangiocarcinoma

    O'Rourke, Colm, Matter, M., Nepal, C., Ton, P., Factor, V. & Andersen, Jesper Bøje, 2019, In: Journal of Hepatology. 70, 1, p. e28

    Research output: Contribution to journal › Conference abstract in journal › Research

  34. Published

    Therapeutic Potential of Pharmacoepigenetics in Cholangiocarcinoma

    O'Rourke, Colm, Satriano, L., Oliveira, D. V. N. P., Munoz-Garrido, P. & Andersen, Jesper Bøje, 2019, Pharmacoepigenetics. Academic Press, p. 551-562 12 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  35. 2018
  36. Published

    Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma

    Nepal, C., O'Rourke, Colm, Oliveira, D. V., Taranta, A., Shema, S., Gautam, P., Calderaro, J., Barbour, A., Raggi, C., Wennerberg, Krister, Wang, X. W., Lautem, A., Roberts, L. R. & Andersen, Jesper Bøje, Sep 2018, In: Hepatology. 68, 3, p. 949-963 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression

    Erice, O., Labiano, I., Arbelaiz, A., Santos-Laso, A., Munoz-Garrido, P., Jimenez-Agüero, R., Olaizola, P., Caro-Maldonado, A., Martín-Martín, N., Carracedo, A., Lozano, E., Marin, J. J., O'Rourke, C. J., Andersen, J. B., Llop, J., Gómez-Vallejo, V., Padro, D., Martin, A., Marzioni, M., Adorini, L. & 4 others, Trauner, M., Bujanda, L., Perugorria, M. J. & Banales, J. M., Apr 2018, In: B B A - Reviews on Cancer. 1864, 4, Part B, p. 1335-1344

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

    Cancer Genome Atlas Research Network, C. G. A. R. N., 2018, In: Cell Systems. 7, 4, p. 422-437.e1-e7 23 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Epigenome dysregulation in cholangiocarcinoma

    O'Rourke, Colm, Munoz-Garrido, P., Aguayo, E. L. & Andersen, Jesper Bøje, 2018, In: BBA Molecular Basis of Disease. 1864, 4, Part B, p. 1423-1434 12 p.

    Research output: Contribution to journal › Review › Research › peer-review

  40. 2017
  41. Published

    SOX17 Regulates Cholangiocyte Differentiation and Acts as a Tumor Suppressor in Cholangiocarcinoma

    Merino-Azpitarte, M., Lozano, E., Perugorria, M. J., Esparza-Baquer, A., Erice, O., Santos-Laso, A., O'Rourke, C., Andersen, J. B., Jiménez-Agüero, R., Lacasta, A., D'Amato, M., Briz, O., Jalan-Sakrikar, N., Huebert, R. C., Thelen, K. M., Gradilone, S. A., Aransay, A. M., Lavín, J. L., Fernández-Barrena, M. G., Matheu, A. & 5 others, Marzioni, M., Gores, G. J., Bujanda, L., Marin, J. J. G. & Banales, J. M., 22 Feb 2017, In: Journal of Hepatology. 67, 1, p. 72-83 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. 2016
  43. Published

    Molecular Pathogenesis and Current Therapy in Intrahepatic Cholangiocarcinoma

    Høgdall, Dan Taksony Solyom, O'Rourke, Colm, Taranta, A., NP Oliveira, D. & Andersen, Jesper Bøje, 2016, In: Digestive Diseases. 34, 4, p. 440-51 12 p.

    Research output: Contribution to journal › Review › Research › peer-review

ID: 130666470