Colm O'Rourke
Assistant Professor
Andersen Group
Ole Maaløes Vej 5
2200 København N.
- 2024
- Published
Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy
O'Rourke, C. J., Salati, M., Rae, C., Carpino, G., Leslie, H., Pea, A., Prete, M. G., Bonetti, L. R., Amato, F., Montal, R., Upstill-Goddard, R., Nixon, C., Sanchon-Sanchez, P., Kunderfranco, P., Sia, D., Gaudio, E., Overi, D., Cascinu, S., Hogdall, D., Pugh, S. & 15 others, , 2024, In: Gut. 73, p. 496-508Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Genetic and epigenetic analysis of hepatocellular adenomas with atypical morphological features
Haefliger, S., Hench, J., O'Rourke, Colm, Meyer-Schaller, N., Uzun, S., Saldarriaga, J., Weber, A., Mazzucchelli, L., Jermann, P., Frank, S., Andersen, Jesper Bøje, Terracciano, L., Sempoux, C. & Matter, M. S., 2023, In: Histopathology. 82, 5, p. 722–730 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Immunogenomics of cholangiocarcinoma
Gehl, Virag, O'Rourke, Colm & Andersen, Jesper Bøje, 2023, (E-pub ahead of print) In: Hepatology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis and prognostication of cholangiocarcinoma
Lapitz, A., Azkargorta, M., Milkiewicz, P., Olaizola, P., Zhuravleva, E., Grimsrud, M. M., Schramm, C., Arbelaiz, A., O'Rourke, C. J., La Casta, A., Milkiewicz, M., Pastor, T., Vesterhus, M., Jimenez-Agüero, R., Dill, M. T., Lamarca, A., Valle, J. W., Macias, R. I. R., Izquierdo-Sanchez, L., Castaño, Y. P. & 15 others, , 2023, In: Journal of Hepatology. 79, 1, p. 93-108Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells
Duwe, Lea, Munoz-Garrido, P., Lewinska, Monika, Lafuente Barquero, Juan Francisco, Satriano, L., Høgdall, Dan Taksony Solyom, Taranta, A., Nielsen, B. S., Ghazal, A., Matter, M. S., Banales, J. M., Aldana, Blanca, Gao, Y., Marquardt, J. U., Roberts, L. R., Oliveira, R. C., Koshiol, J., O'Rourke, Colm & Andersen, Jesper Bøje, 2023, In: Journal of Hepatology. 78, 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
P-123 CD73high biliary tract cancer (BTC) is a molecularly defined subtype with distinct clinical implications
Salati, M., Anna, B., O'Rourke, Colm, Piscopo, F., Evangelista, L., Pisapia, P., Riccò, B., Spallanzani, A., Gelsomino, F., Malapelle, U., Bonetti, L. R., Andersen, Jesper, Troncone, G., Dominici, M., Brunella, F. & Carotenuto, P., 2023, In: Annals of Oncology. 34, p. S58 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
miR-21-5p promotes NASH-related hepatocarcinogenesis
Rodrigues, P. M., Afonso, M. B., Simão, A. L., Islam, T., Gaspar, M. M., O'Rourke, Colm, Lewinska, Monika, Andersen, Jesper Bøje, Arretxe, E., Alonso, C., Santos-Laso, Á., Izquierdo-Sanchez, L., Jimenez-Agüero, R., Eizaguirre, E., Bujanda, L., Pareja, M. J., Prip-Buus, C., Banales, J. M., Rodrigues, C. M. P. & Castro, R. E., 2023, In: Liver International. 43, 10, p. 2256-2274 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Molecular therapeutic targets for cholangiocarcinoma: Present challenges and future possibilities
Høgdall, Dan Taksony Solyom, O'Rourke, Colm & Andersen, Jesper Bøje, 2022, Advances in Cancer Research. Academic Press, Vol. 156. p. 343-366 (Advances in Cancer Research).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Mucosal-associated invariant T-cell tumor infiltration predicts long-term survival in cholangiocarcinoma
Zimmer, C. L., Filipovic, I., Cornillet, M., O'Rourke, Colm, Berglin, L., Jansson, H., Sun, D., Strauss, O., Hertwig, L., Johansson, H., von Seth, E., Sparrelid, E., Dias, J., Glaumann, H., Melum, E., Ellis, E. C., Sandberg, J. K., Andersen, Jesper Bøje, Bergquist, A. & Björkström, N. K., 2022, In: Hepatology. 75, 5, p. 1154-1168Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutational signatures and processes in hepatobiliary cancers
Zhuravleva, Ekaterina, O'Rourke, Colm & Andersen, Jesper Bøje, 2022, In: Nature Reviews. Gastroenterology & Hepatology. 19, p. 367-382Research output: Contribution to journal › Review › Research › peer-review
- Published
Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models
Olaizola, P., Lee-Law, P. Y., Fernandez-Barrena, M. G., Alvarez, L., Cadamuro, M., Azkargorta, M., O'Rourke, C. J., Caballero-Camino, F. J., Olaizola, I., Macias, R. I. R., Marin, J. J. G., Serrano-Maciá, M., Martinez-Chantar, M. L., Avila, M. A., Aspichueta, P., Calvisi, D. F., Evert, M., Fabris, L., Castro, R. E., Elortza, F. & 5 others, , 2022, In: Journal of Hepatology. 77, 1, p. 177-190Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Whole blood microRNAs capture systemic reprogramming and have diagnostic potential in patients with biliary tract cancer
Høgdall, Dan Taksony Solyom, O'Rourke, Colm, Larsen, F. O., Zarforoushan, S., Christensen, Troels Dreier, Ghazal, A., Boisen, M. K., Muñoz-Garrido, P., Johansen, Julia Sidenius & Andersen, Jesper Bøje, 2022, In: Journal of Hepatology. 77, p. 1047-1058 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
DNA Methylation in Ovarian Tumors - a Comparison Between Fresh Tissue and FFPE Samples
Oliveira, D. V. N. P., Hentze, J., O'Rourke, Colm, Andersen, Jesper Bøje, Høgdall, Claus Kim & Høgdall, Estrid Vilma Solyom, 2021, In: Reproductive Sciences. 28, 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
E2F1 and E2F2-mediated repression of CPT2 establishes a lipid-rich tumor-promoting environment
Gonzalez-Romero, F., Mestre, D., Aurrekoetxea, I., O'Rourke, C. J., Andersen, J. B., Woodhoo, A., Tamayo-Caro, M., Varela-Rey, M., Palomo-Irigoyen, M., Gomez-Santos, B., de Urturi, D. S., Nuñez-García, M., García-Rodríguez, J. L., Fernandez-Ares, L., Buque, X., Iglesias-Ara, A., Bernales, I., de Juan, V. G., Delgado, T. C., Goikoetxea-Usandizaga, N. & 15 others, , 2021, In: Cancer Research. 81, 11, p. 2874-2887 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis
Czauderna, C., Poplawski, A., O'Rourke, Colm, Castven, D., Pérez-Aguilar, B., Becker, D., Heilmann-Heimbach, S., Odenthal, M., Amer, W., Schmiel, M., Drebber, U., Binder, H., Ridder, D. A., Schindeldecker, M., Straub, B. K., Galle, P. R., Andersen, Jesper Bøje, Thorgeirsson, S. S., Park, Y. N. & Marquardt, J. U., 2021, In: JCI insight. 6, 17, 19 p., e146196.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Longitudinal analysis of individual cfDNA methylome patterns in metastatic prostate cancer
Silva, R., Moran, B., Baird, A. M., O'Rourke, Colm, Finn, S. P., McDermott, R., Watson, W., Gallagher, W. M., Brennan, D. J. & Perry, A. S., 2021, In: Clinical Epigenetics. 13, 10 p., 168.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular targets in cholangiocarcinoma
O'Rourke, Colm, Munoz-Garrido, P. & Andersen, Jesper Bøje, 2021, In: Hepatology. 73, S1, p. 62-74Research output: Contribution to journal › Review › Research › peer-review
- Published
Structural aberrations are associated with poor survival in patients with clonal cytopenia of undetermined significance
Mikkelsen, Stine Ulrik, Safavi, S., Dimopoulos, K., O'Rourke, Colm, Andersen, M. K., Holm, M. S., Marcher, C. W., Andersen, Jesper Bøje, Hansen, Jakob Werner & Grønbæk, Kirsten, 2021, In: Haematologica. 106, 6Research output: Contribution to journal › Comment/debate › Research › peer-review
- 2020
- Published
Identification of a Pan-Gamma-Secretase Inhibitor Response Signature for Notch-Driven Cholangiocarcinoma
O'Rourke, Colm, Matter, M. S., Nepal, C., Caetano-Oliveira, R., Ton, P. T., Factor, V. M. & Andersen, Jesper Bøje, Jan 2020, In: Hepatology. 71, 1, p. 196-213 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrative molecular characterization of gallbladder cancer reveals microenvironment-associated subtypes
Nepal, C., Zhu, B., O'Rourke, C. J., Bhatt, D. K., Lee, D., Song, L., Wang, D., Van Dyke, A., Choo-Wosoba, H., Liu, Z., Hildesheim, A., Goldstein, A. M., Dean, M., LaFuente-Barquero, J., Lawrence, S., Mutreja, K., Olanich, M. E., Bermejo, J. L., Ferreccio, C., Roa, J. C. & 8 others, , 2020, In: Journal of Hepatology. 7, 5, p. 1132-1144Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis
Lapitz, A., Arbelaiz, A., O'Rourke, C. J., Lavin, J. L., Casta, A. L., Ibarra, C., Jimeno, J. P., Santos-Laso, A., Izquierdo-Sanchez, L., Krawczyk, M., Perugorria, M. J., Jimenez-Aguero, R., Sanchez-Campos, A., Riaño, I., Gónzalez, E., Lammert, F., Marzioni, M., Macias, R. I. R., Marin, J. J. G., Karlsen, T. H. & 6 others, , 2020, In: Cells. 9, 3, p. 1-33Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers
Høgdall, Dan Taksony Solyom, O'Rourke, Colm, Dehlendorff, C., Larsen, O. F., Jensen, L. H., Johansen, A. Z., Dang, H., Factor, V. M., Grunnet, M., Mau-Sørensen, M., Oliveira, D. V. N. P., Linnemann, D., Boisen, M. K., Wang, X. W., Johansen, Julia Sidenius & Andersen, Jesper Bøje, 2020, In: Clinical Cancer Research. 26, 21, 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms
Esparza-Baquer, A., Labiano, I., Sharif, O., Agirre-Lizaso, A., Oakley, F., Rodrigues, P. M., Zhuravleva, E., O'Rourke, C. J., Hijona, E., Jimenez-Agüero, R., Riaño, I., Landa, A., La Casta, A., Zaki, M. Y. W., Munoz-Garrido, P., Azkargorta, M., Elortza, F., Vogel, A., Schabbauer, G., Aspichueta, P. & 6 others, , 2020, In: Gut. 70, 7Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Causes of hOCT1-dependent cholangiocarcinoma resistance to sorafenib and sensitization by tumor-selective gene therapy
Lozano, E., Macias, R. I. R., Monte, M. J., Asensio, M., Del Carmen, S., Sanchez-Vicente, L., Alonso-Peña, M., Al-Abdulla, R., Munoz-Garrido, P., Satriano, L., O'Rourke, Colm, Banales, J. M., Avila, M. A., Martinez-Chantar, M. L., Andersen, Jesper Bøje, Briz, O. & Marin, J. J. G., Oct 2019, In: Hepatology. 70, 4, p. 1246-1261 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epigenetic events involved in organic cation transporter 1-dependent impaired response of hepatocellular carcinoma to sorafenib
Al-Abdulla, R., Lozano, E., Macias, R. I. R., Monte, M. J., Briz, O., O'Rourke, Colm, Serrano, M. A., Banales, J. M., Avila, M. A., Martinez-Chantar, M. L., Geier, A., Andersen, Jesper Bøje & Marin, J. J. G., 2019, In: British Journal of Pharmacology. 176, 6, p. 787-800Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epigenome Remodeling in Cholangiocarcinoma
O'Rourke, Colm, Lafuente Barquero, Juan Francisco & Andersen, Jesper Bøje, 2019, In: Trends in Cancer. 5, 6, p. 335-350 16 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Identification of a pan-gamma-secretase inhibitor response signature for notch-driven cholangiocarcinoma
O'Rourke, Colm, Matter, M., Nepal, C., Ton, P., Factor, V. & Andersen, Jesper Bøje, 2019, In: Journal of Hepatology. 70, 1, p. e28Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Therapeutic Potential of Pharmacoepigenetics in Cholangiocarcinoma
O'Rourke, Colm, Satriano, L., Oliveira, D. V. N. P., Munoz-Garrido, P. & Andersen, Jesper Bøje, 2019, Pharmacoepigenetics. Academic Press, p. 551-562 12 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2018
- Published
Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma
Nepal, C., O'Rourke, Colm, Oliveira, D. V., Taranta, A., Shema, S., Gautam, P., Calderaro, J., Barbour, A., Raggi, C., Wennerberg, Krister, Wang, X. W., Lautem, A., Roberts, L. R. & Andersen, Jesper Bøje, Sep 2018, In: Hepatology. 68, 3, p. 949-963 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression
Erice, O., Labiano, I., Arbelaiz, A., Santos-Laso, A., Munoz-Garrido, P., Jimenez-Agüero, R., Olaizola, P., Caro-Maldonado, A., Martín-Martín, N., Carracedo, A., Lozano, E., Marin, J. J., O'Rourke, C. J., Andersen, J. B., Llop, J., Gómez-Vallejo, V., Padro, D., Martin, A., Marzioni, M., Adorini, L. & 4 others, , Apr 2018, In: B B A - Reviews on Cancer. 1864, 4, Part B, p. 1335-1344Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily
Cancer Genome Atlas Research Network, C. G. A. R. N., 2018, In: Cell Systems. 7, 4, p. 422-437.e1-e7 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epigenome dysregulation in cholangiocarcinoma
O'Rourke, Colm, Munoz-Garrido, P., Aguayo, E. L. & Andersen, Jesper Bøje, 2018, In: BBA Molecular Basis of Disease. 1864, 4, Part B, p. 1423-1434 12 p.Research output: Contribution to journal › Review › Research › peer-review
- 2017
- Published
SOX17 Regulates Cholangiocyte Differentiation and Acts as a Tumor Suppressor in Cholangiocarcinoma
Merino-Azpitarte, M., Lozano, E., Perugorria, M. J., Esparza-Baquer, A., Erice, O., Santos-Laso, A., O'Rourke, C., Andersen, J. B., Jiménez-Agüero, R., Lacasta, A., D'Amato, M., Briz, O., Jalan-Sakrikar, N., Huebert, R. C., Thelen, K. M., Gradilone, S. A., Aransay, A. M., Lavín, J. L., Fernández-Barrena, M. G., Matheu, A. & 5 others, , 22 Feb 2017, In: Journal of Hepatology. 67, 1, p. 72-83 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Molecular Pathogenesis and Current Therapy in Intrahepatic Cholangiocarcinoma
Høgdall, Dan Taksony Solyom, O'Rourke, Colm, Taranta, A., NP Oliveira, D. & Andersen, Jesper Bøje, 2016, In: Digestive Diseases. 34, 4, p. 440-51 12 p.Research output: Contribution to journal › Review › Research › peer-review
ID: 130666470
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A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily
Research output: Contribution to journal › Journal article › Research › peer-review
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Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma
Research output: Contribution to journal › Journal article › Research › peer-review
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Epigenome dysregulation in cholangiocarcinoma
Research output: Contribution to journal › Review › Research › peer-review
Published