Argyrophilic nucleolar organizer regions and proliferating cell nuclear antigen/cyclin in Kaposi's sarcoma. Comparison with morphology and with immunoperoxidase staining for factor VIII-related antigen.
Research output: Contribution to journal › Journal article › Research › peer-review
The proposal that Kaposi's sarcoma undergoes cellular transformation from early to late stages was studied with argyrophilic nucleolar organizer regions, proliferating cell nuclear antigen/cyclin, and immunoperoxidase staining for factor VIII-related antigen. Staining of argyrophilic nucleolar organizer regions was significantly increased in the plaque/nodular stage compared to the patch stage. The endothelial-selective marker factor VIII-related antigen stained more intensely in patch stage lesions. This was inversely correlated with staining of argyrophilic nucleolar organizer regions. Proliferating cell nuclear antigen/cyclin staining did not correlate with tumor stage or with factor VIII-related antigen. The changes in argyrophilic nucleolar organizer regions and factor VIII-related antigen staining are evidence for cellular transformation in Kaposi's sarcoma.
Original language | English |
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Journal | Archives of Pathology & Laboratory Medicine |
Volume | 119 |
Issue number | 6 |
Pages (from-to) | 538-41 |
Number of pages | 3 |
ISSN | 0003-9985 |
Publication status | Published - 1995 |
Externally published | Yes |
Bibliographical note
Keywords: Humans; Immunoenzyme Techniques; Nucleolus Organizer Region; Proliferating Cell Nuclear Antigen; Sarcoma, Kaposi; Silver Staining; von Willebrand Factor
ID: 5240671