Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair

Research output: Contribution to journal › Review › Research › peer-review

Standard

Chromatin dynamics in genome stability : Roles in suppressing endogenous DNA damage and facilitating DNA repair. / Nair, Nidhi; Shoaib, Muhammad; Sørensen, Claus Storgaard.

In: International Journal of Molecular Sciences, Vol. 18, No. 7, 1486, 10.07.2017.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Nair, N, Shoaib, M & Sørensen, CS 2017, 'Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair', International Journal of Molecular Sciences, vol. 18, no. 7, 1486. https://doi.org/10.3390/ijms18071486

APA

Nair, N., Shoaib, M., & Sørensen, C. S. (2017). Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair. International Journal of Molecular Sciences, 18(7), [1486]. https://doi.org/10.3390/ijms18071486

Vancouver

Nair N, Shoaib M, Sørensen CS. Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair. International Journal of Molecular Sciences. 2017 Jul 10;18(7). 1486. https://doi.org/10.3390/ijms18071486

Author

Nair, Nidhi ; Shoaib, Muhammad ; Sørensen, Claus Storgaard. / Chromatin dynamics in genome stability : Roles in suppressing endogenous DNA damage and facilitating DNA repair. In: International Journal of Molecular Sciences. 2017 ; Vol. 18, No. 7.

Bibtex

@article{838190fcd9f44f48a7e706be358f7eef,
title = "Chromatin dynamics in genome stability: Roles in suppressing endogenous DNA damage and facilitating DNA repair",
abstract = "Genomic DNA is compacted into chromatin through packaging with histone and non-histone proteins. Importantly, DNA accessibility is dynamically regulated to ensure genome stability. This is exemplified in the response to DNA damage where chromatin relaxation near genomic lesions serves to promote access of relevant enzymes to specific DNA regions for signaling and repair. Furthermore, recent data highlight genome maintenance roles of chromatin through the regulation of endogenous DNA-templated processes including transcription and replication. Here, we review research that shows the importance of chromatin structure regulation in maintaining genome integrity by multiple mechanisms including facilitating DNA repair and directly suppressing endogenous DNA damage.",
keywords = "Chromatin, DNA damage response, Endogenous DNA damage, Genome maintenance",
author = "Nidhi Nair and Muhammad Shoaib and S{\o}rensen, {Claus Storgaard}",
year = "2017",
month = jul,
day = "10",
doi = "10.3390/ijms18071486",
language = "English",
volume = "18",
journal = "International Journal of Molecular Sciences (CD-ROM)",
issn = "1424-6783",
publisher = "M D P I AG",
number = "7",

}

RIS

TY - JOUR

T1 - Chromatin dynamics in genome stability

T2 - Roles in suppressing endogenous DNA damage and facilitating DNA repair

AU - Nair, Nidhi

AU - Shoaib, Muhammad

AU - Sørensen, Claus Storgaard

PY - 2017/7/10

Y1 - 2017/7/10

N2 - Genomic DNA is compacted into chromatin through packaging with histone and non-histone proteins. Importantly, DNA accessibility is dynamically regulated to ensure genome stability. This is exemplified in the response to DNA damage where chromatin relaxation near genomic lesions serves to promote access of relevant enzymes to specific DNA regions for signaling and repair. Furthermore, recent data highlight genome maintenance roles of chromatin through the regulation of endogenous DNA-templated processes including transcription and replication. Here, we review research that shows the importance of chromatin structure regulation in maintaining genome integrity by multiple mechanisms including facilitating DNA repair and directly suppressing endogenous DNA damage.

AB - Genomic DNA is compacted into chromatin through packaging with histone and non-histone proteins. Importantly, DNA accessibility is dynamically regulated to ensure genome stability. This is exemplified in the response to DNA damage where chromatin relaxation near genomic lesions serves to promote access of relevant enzymes to specific DNA regions for signaling and repair. Furthermore, recent data highlight genome maintenance roles of chromatin through the regulation of endogenous DNA-templated processes including transcription and replication. Here, we review research that shows the importance of chromatin structure regulation in maintaining genome integrity by multiple mechanisms including facilitating DNA repair and directly suppressing endogenous DNA damage.

KW - Chromatin

KW - DNA damage response

KW - Endogenous DNA damage

KW - Genome maintenance

U2 - 10.3390/ijms18071486

DO - 10.3390/ijms18071486

M3 - Review

C2 - 28698521

AN - SCOPUS:85023633382

VL - 18

JO - International Journal of Molecular Sciences (CD-ROM)

JF - International Journal of Molecular Sciences (CD-ROM)

SN - 1424-6783

IS - 7

M1 - 1486

ER -

ID: 185504235