Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave
Research output: Contribution to journal › Journal article › Research › peer-review
Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.
Original language | English |
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Journal | Cancer Cell |
Volume | 28 |
Issue number | 5 |
Pages (from-to) | 545-547 |
Number of pages | 3 |
ISSN | 1535-6108 |
DOIs | |
Publication status | Published - 9 Nov 2015 |
- Animals, Cell Cycle Proteins, Histones, Humans, Neoplasms, Nuclear Proteins, Nucleotides, Protein-Tyrosine Kinases, Comment, Journal Article
Research areas
ID: 165717223