Interplay between LOX enzymes and integrins in the tumor microenvironment

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Interplay between LOX enzymes and integrins in the tumor microenvironment. / Amendola, Pier Giorgio; Reuten, Raphael; Erler, Janine Terra.

In: Cancers, Vol. 11, No. 5, 729, 05.2019.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Amendola, PG, Reuten, R & Erler, JT 2019, 'Interplay between LOX enzymes and integrins in the tumor microenvironment', Cancers, vol. 11, no. 5, 729. https://doi.org/10.3390/cancers11050729

APA

Amendola, P. G., Reuten, R., & Erler, J. T. (2019). Interplay between LOX enzymes and integrins in the tumor microenvironment. Cancers, 11(5), [729]. https://doi.org/10.3390/cancers11050729

Vancouver

Amendola PG, Reuten R, Erler JT. Interplay between LOX enzymes and integrins in the tumor microenvironment. Cancers. 2019 May;11(5). 729. https://doi.org/10.3390/cancers11050729

Author

Amendola, Pier Giorgio ; Reuten, Raphael ; Erler, Janine Terra. / Interplay between LOX enzymes and integrins in the tumor microenvironment. In: Cancers. 2019 ; Vol. 11, No. 5.

Bibtex

@article{3bc9467943bb42239af5e3c0934a81fb,
title = "Interplay between LOX enzymes and integrins in the tumor microenvironment",
abstract = "Members of the lysyl oxidase (LOX) family are secreted copper-dependent amine oxidases that catalyze the covalent crosslinking of collagens and elastin in the extracellular matrix (ECM), an essential process for the structural integrity of all tissues. LOX enzymes can also remodel the tumor microenvironment and have been implicated in all stages of tumor initiation and progression of many cancer types. Changes in the ECM can influence several cancer cell phenotypes. Integrin adhesion complexes (IACs) physically connect cells with their microenvironment. This review article summarizes the main findings on the role of LOX proteins in modulating the tumor microenvironment, with a particular focus on how ECM changes are integrated by IACs to modulate cells behavior. Finally, we discuss how the development of selective LOX inhibitors may lead to novel and effective therapies in cancer treatment.",
keywords = "Adhesion complexes, Cancer, Extracellular matrix, Integrins, Lysyl oxidase",
author = "Amendola, {Pier Giorgio} and Raphael Reuten and Erler, {Janine Terra}",
year = "2019",
month = may,
doi = "10.3390/cancers11050729",
language = "English",
volume = "11",
journal = "Cancers",
issn = "2072-6694",
publisher = "M D P I AG",
number = "5",

}

RIS

TY - JOUR

T1 - Interplay between LOX enzymes and integrins in the tumor microenvironment

AU - Amendola, Pier Giorgio

AU - Reuten, Raphael

AU - Erler, Janine Terra

PY - 2019/5

Y1 - 2019/5

N2 - Members of the lysyl oxidase (LOX) family are secreted copper-dependent amine oxidases that catalyze the covalent crosslinking of collagens and elastin in the extracellular matrix (ECM), an essential process for the structural integrity of all tissues. LOX enzymes can also remodel the tumor microenvironment and have been implicated in all stages of tumor initiation and progression of many cancer types. Changes in the ECM can influence several cancer cell phenotypes. Integrin adhesion complexes (IACs) physically connect cells with their microenvironment. This review article summarizes the main findings on the role of LOX proteins in modulating the tumor microenvironment, with a particular focus on how ECM changes are integrated by IACs to modulate cells behavior. Finally, we discuss how the development of selective LOX inhibitors may lead to novel and effective therapies in cancer treatment.

AB - Members of the lysyl oxidase (LOX) family are secreted copper-dependent amine oxidases that catalyze the covalent crosslinking of collagens and elastin in the extracellular matrix (ECM), an essential process for the structural integrity of all tissues. LOX enzymes can also remodel the tumor microenvironment and have been implicated in all stages of tumor initiation and progression of many cancer types. Changes in the ECM can influence several cancer cell phenotypes. Integrin adhesion complexes (IACs) physically connect cells with their microenvironment. This review article summarizes the main findings on the role of LOX proteins in modulating the tumor microenvironment, with a particular focus on how ECM changes are integrated by IACs to modulate cells behavior. Finally, we discuss how the development of selective LOX inhibitors may lead to novel and effective therapies in cancer treatment.

KW - Adhesion complexes

KW - Cancer

KW - Extracellular matrix

KW - Integrins

KW - Lysyl oxidase

U2 - 10.3390/cancers11050729

DO - 10.3390/cancers11050729

M3 - Review

C2 - 31130685

AN - SCOPUS:85067246546

VL - 11

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 5

M1 - 729

ER -

ID: 234658945