Phosphorylation of Serine 248 of C/EBPa Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Phosphorylation of Serine 248 of C/EBPa Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency. / Hasemann, Marie S; Schuster, Mikkel B; Frank, Anne-Katrine; Theilgaard-Mönch, Kim; Pedersen, Thomas Å; Nerlov, Claus; Porse, Bo T.

In: P L o S One, Vol. 7, No. 6, 2012, p. e38841.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hasemann, MS, Schuster, MB, Frank, A-K, Theilgaard-Mönch, K, Pedersen, TÅ, Nerlov, C & Porse, BT 2012, 'Phosphorylation of Serine 248 of C/EBPa Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency', P L o S One, vol. 7, no. 6, pp. e38841. https://doi.org/10.1371/journal.pone.0038841

APA

Hasemann, M. S., Schuster, M. B., Frank, A-K., Theilgaard-Mönch, K., Pedersen, T. Å., Nerlov, C., & Porse, B. T. (2012). Phosphorylation of Serine 248 of C/EBPa Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency. P L o S One, 7(6), e38841. https://doi.org/10.1371/journal.pone.0038841

Vancouver

Hasemann MS, Schuster MB, Frank A-K, Theilgaard-Mönch K, Pedersen TÅ, Nerlov C et al. Phosphorylation of Serine 248 of C/EBPa Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency. P L o S One. 2012;7(6):e38841. https://doi.org/10.1371/journal.pone.0038841

Author

Hasemann, Marie S ; Schuster, Mikkel B ; Frank, Anne-Katrine ; Theilgaard-Mönch, Kim ; Pedersen, Thomas Å ; Nerlov, Claus ; Porse, Bo T. / Phosphorylation of Serine 248 of C/EBPa Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency. In: P L o S One. 2012 ; Vol. 7, No. 6. pp. e38841.

Bibtex

@article{84d2dfac78fc4211b81c6089b0427155,
title = "Phosphorylation of Serine 248 of C/EBPa Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency",
abstract = "Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory proteins that are simultanously recruited and activated to ensure timely gene expression. The transcription factor CCAAT/enhancer binding protein a (C/EBPa) is such a factor and is essential for the development of granulocytic/monocytic cells. The activity of C/EBPa is regulated on several levels including gene expression, alternative translation, protein interactions and posttranslational modifications, such as phosphorylation. In particular, the phosphorylation of serine 248 of the transactivation domain has been shown to be of crucial importance for granulocytic differentiation of 32Dcl3 cells in vitro.",
author = "Hasemann, {Marie S} and Schuster, {Mikkel B} and Anne-Katrine Frank and Kim Theilgaard-M{\"o}nch and Pedersen, {Thomas {\AA}} and Claus Nerlov and Porse, {Bo T}",
year = "2012",
doi = "10.1371/journal.pone.0038841",
language = "English",
volume = "7",
pages = "e38841",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",

}

RIS

TY - JOUR

T1 - Phosphorylation of Serine 248 of C/EBPa Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency

AU - Hasemann, Marie S

AU - Schuster, Mikkel B

AU - Frank, Anne-Katrine

AU - Theilgaard-Mönch, Kim

AU - Pedersen, Thomas Å

AU - Nerlov, Claus

AU - Porse, Bo T

PY - 2012

Y1 - 2012

N2 - Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory proteins that are simultanously recruited and activated to ensure timely gene expression. The transcription factor CCAAT/enhancer binding protein a (C/EBPa) is such a factor and is essential for the development of granulocytic/monocytic cells. The activity of C/EBPa is regulated on several levels including gene expression, alternative translation, protein interactions and posttranslational modifications, such as phosphorylation. In particular, the phosphorylation of serine 248 of the transactivation domain has been shown to be of crucial importance for granulocytic differentiation of 32Dcl3 cells in vitro.

AB - Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory proteins that are simultanously recruited and activated to ensure timely gene expression. The transcription factor CCAAT/enhancer binding protein a (C/EBPa) is such a factor and is essential for the development of granulocytic/monocytic cells. The activity of C/EBPa is regulated on several levels including gene expression, alternative translation, protein interactions and posttranslational modifications, such as phosphorylation. In particular, the phosphorylation of serine 248 of the transactivation domain has been shown to be of crucial importance for granulocytic differentiation of 32Dcl3 cells in vitro.

U2 - 10.1371/journal.pone.0038841

DO - 10.1371/journal.pone.0038841

M3 - Journal article

C2 - 22715416

VL - 7

SP - e38841

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 6

ER -

ID: 38429708