Self-inflicted DNA breaks in cell differentiation and cancer

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Self-inflicted DNA breaks in cell differentiation and cancer. / Benada, Jan; Alsowaida, Dalal; Megeney, Lynn A.; Sørensen, Claus S.

In: Trends in Cell Biology, Vol. 33, No. 10, 2023, p. 850-859.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Benada, J, Alsowaida, D, Megeney, LA & Sørensen, CS 2023, 'Self-inflicted DNA breaks in cell differentiation and cancer', Trends in Cell Biology, vol. 33, no. 10, pp. 850-859. https://doi.org/10.1016/j.tcb.2023.03.002

APA

Benada, J., Alsowaida, D., Megeney, L. A., & Sørensen, C. S. (2023). Self-inflicted DNA breaks in cell differentiation and cancer. Trends in Cell Biology, 33(10), 850-859. https://doi.org/10.1016/j.tcb.2023.03.002

Vancouver

Benada J, Alsowaida D, Megeney LA, Sørensen CS. Self-inflicted DNA breaks in cell differentiation and cancer. Trends in Cell Biology. 2023;33(10):850-859. https://doi.org/10.1016/j.tcb.2023.03.002

Author

Benada, Jan ; Alsowaida, Dalal ; Megeney, Lynn A. ; Sørensen, Claus S. / Self-inflicted DNA breaks in cell differentiation and cancer. In: Trends in Cell Biology. 2023 ; Vol. 33, No. 10. pp. 850-859.

Bibtex

@article{c1a76c0522ec4301a47adcc63514e62a,
title = "Self-inflicted DNA breaks in cell differentiation and cancer",
abstract = "Self-inflicted DNA strand breaks are canonically linked with cell death pathways and the establishment of genetic diversity in immune and germline cells. Moreover, this form of DNA damage is an established source of genome instability in cancer development. However, recent studies indicate that nonlethal self-inflicted DNA strand breaks play an indispensable but underappreciated role in a variety of cell processes, including differentiation and cancer therapy responses. Mechanistically, these physiological DNA breaks originate from the activation of nucleases, which are best characterized for inducing DNA fragmentation in apoptotic cell death. In this review, we outline the emerging biology of one critical nuclease, caspase-activated DNase (CAD), and how directed activation or deployment of this enzyme can lead to divergent cell fate outcomes.",
author = "Jan Benada and Dalal Alsowaida and Megeney, {Lynn A.} and S{\o}rensen, {Claus S.}",
year = "2023",
doi = "10.1016/j.tcb.2023.03.002",
language = "English",
volume = "33",
pages = "850--859",
journal = "Trends in Cell Biology",
issn = "0962-8924",
publisher = "Elsevier Ltd. * Trends Journals",
number = "10",

}

RIS

TY - JOUR

T1 - Self-inflicted DNA breaks in cell differentiation and cancer

AU - Benada, Jan

AU - Alsowaida, Dalal

AU - Megeney, Lynn A.

AU - Sørensen, Claus S.

PY - 2023

Y1 - 2023

N2 - Self-inflicted DNA strand breaks are canonically linked with cell death pathways and the establishment of genetic diversity in immune and germline cells. Moreover, this form of DNA damage is an established source of genome instability in cancer development. However, recent studies indicate that nonlethal self-inflicted DNA strand breaks play an indispensable but underappreciated role in a variety of cell processes, including differentiation and cancer therapy responses. Mechanistically, these physiological DNA breaks originate from the activation of nucleases, which are best characterized for inducing DNA fragmentation in apoptotic cell death. In this review, we outline the emerging biology of one critical nuclease, caspase-activated DNase (CAD), and how directed activation or deployment of this enzyme can lead to divergent cell fate outcomes.

AB - Self-inflicted DNA strand breaks are canonically linked with cell death pathways and the establishment of genetic diversity in immune and germline cells. Moreover, this form of DNA damage is an established source of genome instability in cancer development. However, recent studies indicate that nonlethal self-inflicted DNA strand breaks play an indispensable but underappreciated role in a variety of cell processes, including differentiation and cancer therapy responses. Mechanistically, these physiological DNA breaks originate from the activation of nucleases, which are best characterized for inducing DNA fragmentation in apoptotic cell death. In this review, we outline the emerging biology of one critical nuclease, caspase-activated DNase (CAD), and how directed activation or deployment of this enzyme can lead to divergent cell fate outcomes.

U2 - 10.1016/j.tcb.2023.03.002

DO - 10.1016/j.tcb.2023.03.002

M3 - Journal article

C2 - 36997393

VL - 33

SP - 850

EP - 859

JO - Trends in Cell Biology

JF - Trends in Cell Biology

SN - 0962-8924

IS - 10

ER -

ID: 340710165