Testosterone is an endogenous regulator of BAFF and splenic B cell number

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Testosterone is an endogenous regulator of BAFF and splenic B cell number. / Wilhelmson, Anna S.; Lantero Rodriguez, Marta; Stubelius, Alexandra; Fogelstrand, Per; Johansson, Inger; Buechler, Matthew B.; Lianoglou, Steve; Kapoor, Varun N.; Johansson, Maria E.; Fagman, Johan B.; Duhlin, Amanda; Tripathi, Prabhanshu; Camponeschi, Alessandro; Porse, Bo T.; Rolink, Antonius G.; Nissbrandt, Hans; Turley, Shannon J.; Carlsten, Hans; Mårtensson, Inga-Lill; Karlsson, Mikael C. I.; Tivesten, Åsa.

In: Nature Communications, Vol. 9, 2067, 2018, p. 1-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wilhelmson, AS, Lantero Rodriguez, M, Stubelius, A, Fogelstrand, P, Johansson, I, Buechler, MB, Lianoglou, S, Kapoor, VN, Johansson, ME, Fagman, JB, Duhlin, A, Tripathi, P, Camponeschi, A, Porse, BT, Rolink, AG, Nissbrandt, H, Turley, SJ, Carlsten, H, Mårtensson, I-L, Karlsson, MCI & Tivesten, Å 2018, 'Testosterone is an endogenous regulator of BAFF and splenic B cell number', Nature Communications, vol. 9, 2067, pp. 1-13. https://doi.org/10.1038/s41467-018-04408-0

APA

Wilhelmson, A. S., Lantero Rodriguez, M., Stubelius, A., Fogelstrand, P., Johansson, I., Buechler, M. B., Lianoglou, S., Kapoor, V. N., Johansson, M. E., Fagman, J. B., Duhlin, A., Tripathi, P., Camponeschi, A., Porse, B. T., Rolink, A. G., Nissbrandt, H., Turley, S. J., Carlsten, H., Mårtensson, I-L., ... Tivesten, Å. (2018). Testosterone is an endogenous regulator of BAFF and splenic B cell number. Nature Communications, 9, 1-13. [2067]. https://doi.org/10.1038/s41467-018-04408-0

Vancouver

Wilhelmson AS, Lantero Rodriguez M, Stubelius A, Fogelstrand P, Johansson I, Buechler MB et al. Testosterone is an endogenous regulator of BAFF and splenic B cell number. Nature Communications. 2018;9:1-13. 2067. https://doi.org/10.1038/s41467-018-04408-0

Author

Wilhelmson, Anna S. ; Lantero Rodriguez, Marta ; Stubelius, Alexandra ; Fogelstrand, Per ; Johansson, Inger ; Buechler, Matthew B. ; Lianoglou, Steve ; Kapoor, Varun N. ; Johansson, Maria E. ; Fagman, Johan B. ; Duhlin, Amanda ; Tripathi, Prabhanshu ; Camponeschi, Alessandro ; Porse, Bo T. ; Rolink, Antonius G. ; Nissbrandt, Hans ; Turley, Shannon J. ; Carlsten, Hans ; Mårtensson, Inga-Lill ; Karlsson, Mikael C. I. ; Tivesten, Åsa. / Testosterone is an endogenous regulator of BAFF and splenic B cell number. In: Nature Communications. 2018 ; Vol. 9. pp. 1-13.

Bibtex

@article{a9a00ea848d7467c85092915ecd48b85,
title = "Testosterone is an endogenous regulator of BAFF and splenic B cell number",
abstract = "Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor for B cells. Male mice lacking the androgen receptor have increased splenic B cell numbers, serum BAFF levels and splenic Baff mRNA. Testosterone deficiency by castration causes expansion of BAFF-producing fibroblastic reticular cells (FRCs) in spleen, which may be coupled to lower splenic noradrenaline levels in castrated males, as an α-adrenergic agonist decreases splenic FRC number in vitro. Antibody-mediated blockade of the BAFF receptor or treatment with the neurotoxin 6-hydroxydopamine revert the increased splenic B cell numbers induced by castration. Among healthy men, serum BAFF levels are higher in men with low testosterone. Our study uncovers a previously unrecognized regulation of BAFF by testosterone and raises important questions about BAFF in testosterone-mediated protection against autoimmunity.",
author = "Wilhelmson, {Anna S.} and {Lantero Rodriguez}, Marta and Alexandra Stubelius and Per Fogelstrand and Inger Johansson and Buechler, {Matthew B.} and Steve Lianoglou and Kapoor, {Varun N.} and Johansson, {Maria E.} and Fagman, {Johan B.} and Amanda Duhlin and Prabhanshu Tripathi and Alessandro Camponeschi and Porse, {Bo T.} and Rolink, {Antonius G.} and Hans Nissbrandt and Turley, {Shannon J.} and Hans Carlsten and Inga-Lill M{\aa}rtensson and Karlsson, {Mikael C. I.} and {\AA}sa Tivesten",
year = "2018",
doi = "10.1038/s41467-018-04408-0",
language = "English",
volume = "9",
pages = "1--13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Testosterone is an endogenous regulator of BAFF and splenic B cell number

AU - Wilhelmson, Anna S.

AU - Lantero Rodriguez, Marta

AU - Stubelius, Alexandra

AU - Fogelstrand, Per

AU - Johansson, Inger

AU - Buechler, Matthew B.

AU - Lianoglou, Steve

AU - Kapoor, Varun N.

AU - Johansson, Maria E.

AU - Fagman, Johan B.

AU - Duhlin, Amanda

AU - Tripathi, Prabhanshu

AU - Camponeschi, Alessandro

AU - Porse, Bo T.

AU - Rolink, Antonius G.

AU - Nissbrandt, Hans

AU - Turley, Shannon J.

AU - Carlsten, Hans

AU - Mårtensson, Inga-Lill

AU - Karlsson, Mikael C. I.

AU - Tivesten, Åsa

PY - 2018

Y1 - 2018

N2 - Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor for B cells. Male mice lacking the androgen receptor have increased splenic B cell numbers, serum BAFF levels and splenic Baff mRNA. Testosterone deficiency by castration causes expansion of BAFF-producing fibroblastic reticular cells (FRCs) in spleen, which may be coupled to lower splenic noradrenaline levels in castrated males, as an α-adrenergic agonist decreases splenic FRC number in vitro. Antibody-mediated blockade of the BAFF receptor or treatment with the neurotoxin 6-hydroxydopamine revert the increased splenic B cell numbers induced by castration. Among healthy men, serum BAFF levels are higher in men with low testosterone. Our study uncovers a previously unrecognized regulation of BAFF by testosterone and raises important questions about BAFF in testosterone-mediated protection against autoimmunity.

AB - Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor for B cells. Male mice lacking the androgen receptor have increased splenic B cell numbers, serum BAFF levels and splenic Baff mRNA. Testosterone deficiency by castration causes expansion of BAFF-producing fibroblastic reticular cells (FRCs) in spleen, which may be coupled to lower splenic noradrenaline levels in castrated males, as an α-adrenergic agonist decreases splenic FRC number in vitro. Antibody-mediated blockade of the BAFF receptor or treatment with the neurotoxin 6-hydroxydopamine revert the increased splenic B cell numbers induced by castration. Among healthy men, serum BAFF levels are higher in men with low testosterone. Our study uncovers a previously unrecognized regulation of BAFF by testosterone and raises important questions about BAFF in testosterone-mediated protection against autoimmunity.

U2 - 10.1038/s41467-018-04408-0

DO - 10.1038/s41467-018-04408-0

M3 - Journal article

C2 - 29802242

VL - 9

SP - 1

EP - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2067

ER -

ID: 199464842