Neurodevelopmental disorders - high-resolution rethinking of disease modeling

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Neurodevelopmental disorders - high-resolution rethinking of disease modeling. / Khodosevich, Konstantin; Sellgren, Carl M.

In: Molecular Psychiatry, Vol. 28, 2023, p. 34-43.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Khodosevich, K & Sellgren, CM 2023, 'Neurodevelopmental disorders - high-resolution rethinking of disease modeling', Molecular Psychiatry, vol. 28, pp. 34-43. https://doi.org/10.1038/s41380-022-01876-1

APA

Khodosevich, K., & Sellgren, C. M. (2023). Neurodevelopmental disorders - high-resolution rethinking of disease modeling. Molecular Psychiatry, 28, 34-43. https://doi.org/10.1038/s41380-022-01876-1

Vancouver

Khodosevich K, Sellgren CM. Neurodevelopmental disorders - high-resolution rethinking of disease modeling. Molecular Psychiatry. 2023;28:34-43. https://doi.org/10.1038/s41380-022-01876-1

Author

Khodosevich, Konstantin ; Sellgren, Carl M. / Neurodevelopmental disorders - high-resolution rethinking of disease modeling. In: Molecular Psychiatry. 2023 ; Vol. 28. pp. 34-43.

Bibtex

@article{51084f0c28c044dba792e5cc272dc143,

title = "Neurodevelopmental disorders - high-resolution rethinking of disease modeling",

abstract = "Neurodevelopmental disorders arise due to various risk factors that can perturb different stages of brain development, and a combinatorial impact of these risk factors programs the phenotype in adulthood. While modeling the complete phenotype of a neurodevelopmental disorder is challenging, individual developmental perturbations can be successfully modeled in vivo in animals and in vitro in human cellular models. Nevertheless, our limited knowledge of human brain development restricts modeling strategies and has raised questions of how well a model corresponds to human in vivo brain development. Recent progress in high-resolution analysis of human tissue with single-cell and spatial omics techniques has enhanced our understanding of the complex events that govern the development of the human brain in health and disease. This new knowledge can be utilized to improve modeling of neurodevelopmental disorders and pave the way to more accurately portraying the relevant developmental perturbations in disease models.",

author = "Konstantin Khodosevich and Sellgren, {Carl M.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2023",

doi = "10.1038/s41380-022-01876-1",

language = "English",

volume = "28",

pages = "34--43",

journal = "Molecular Psychiatry",

issn = "1359-4184",

publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Neurodevelopmental disorders - high-resolution rethinking of disease modeling

AU - Khodosevich, Konstantin

AU - Sellgren, Carl M.

PY - 2023

Y1 - 2023

N2 - Neurodevelopmental disorders arise due to various risk factors that can perturb different stages of brain development, and a combinatorial impact of these risk factors programs the phenotype in adulthood. While modeling the complete phenotype of a neurodevelopmental disorder is challenging, individual developmental perturbations can be successfully modeled in vivo in animals and in vitro in human cellular models. Nevertheless, our limited knowledge of human brain development restricts modeling strategies and has raised questions of how well a model corresponds to human in vivo brain development. Recent progress in high-resolution analysis of human tissue with single-cell and spatial omics techniques has enhanced our understanding of the complex events that govern the development of the human brain in health and disease. This new knowledge can be utilized to improve modeling of neurodevelopmental disorders and pave the way to more accurately portraying the relevant developmental perturbations in disease models.

AB - Neurodevelopmental disorders arise due to various risk factors that can perturb different stages of brain development, and a combinatorial impact of these risk factors programs the phenotype in adulthood. While modeling the complete phenotype of a neurodevelopmental disorder is challenging, individual developmental perturbations can be successfully modeled in vivo in animals and in vitro in human cellular models. Nevertheless, our limited knowledge of human brain development restricts modeling strategies and has raised questions of how well a model corresponds to human in vivo brain development. Recent progress in high-resolution analysis of human tissue with single-cell and spatial omics techniques has enhanced our understanding of the complex events that govern the development of the human brain in health and disease. This new knowledge can be utilized to improve modeling of neurodevelopmental disorders and pave the way to more accurately portraying the relevant developmental perturbations in disease models.

U2 - 10.1038/s41380-022-01876-1

DO - 10.1038/s41380-022-01876-1

M3 - Journal article

C2 - 36434058

AN - SCOPUS:85142619499

VL - 28

SP - 34

EP - 43

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

ER -

ID: 327789213

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