Cell-free DNA in newly diagnosed patients with glioblastoma - a clinical prospective feasibility study
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- Cell-free DNA in newly diagnosed patients with glioblastoma – a clinical prospective feasibility study
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Background: Glioblastoma (GB) is an incurable brain cancer with limited treatment options. The aim was to test the feasibility of using cell-free DNA (cfDNA) to support evaluation of treatment response, pseudo-progression and whether progression could be found before clinical and/or radiologic progression. Results: CfDNA fluctuated during treatment with the highest levels before diagnostic surgery and at progression. An increase was seen in 3 out of 4 patients at the time of progression while no increase was seen in 3 out of 4 patients without progression. CfDNA levels could aid in 3 out of 3 questionable cases of pseudo-progression. Methods: Eight newly diagnosed GB patients were included. Blood samples were collected prior to diagnosis, before start and during oncologic treatment until progression. Seven patients received concurrent radiotherapy/Temozolomide with adjuvant Temozolomide with one of the patients included in a clinical trial with either immunotherapy or placebo as add-on. One patient received radiation alone. CfDNA concentration was determined for each blood sample. Conclusions: It was feasible to measure cfDNA concentration. Despite the limited cohort size, there was a good tendency between cfDNA and treatment course and -response, respectively with the highest levels at progression.
Original language | English |
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Journal | OncoTarget |
Volume | 10 |
Issue number | 43 |
Pages (from-to) | 4397-4406 |
Number of pages | 10 |
ISSN | 1949-2553 |
DOIs | |
Publication status | Published - 2019 |
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