Michael Ploug
Group leader
Ploug Group
Ole Maaløes Vej 5
2200 København N.
- Published
68Ga-labeling and in vivo evaluation of a uPAR binding DOTA- and NODAGA-conjugated peptide for PET imaging of invasive cancers
Persson, M., Madsen, J., Østergaard, S., Ploug, Michael & Kjær, Andreas, May 2012, In: Nuclear Medicine and Biology. 39, 4, p. 560-569 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GPIHBP1 Missense Mutations Often Cause Multimerization of GPIHBP1 and Thereby Prevent Lipoprotein Lipase Binding
Beigneux, A. P., Fong, L. G., Bensadoun, A., Davies, B. S., Oberer, M., Gårdsvoll, Henrik, Ploug, Michael & Young, S. G., 2015, In: Circulation Research. 116, 4, p. 624-632 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor
Hillig, T., Engelholm, Lars Henning, Ingvarsen, S., Madsen, Daniel Hargbøl, Gårdsvoll, Henrik, Larsen, J. K., Ploug, Michael, Danø, K., Kjøller, L. & Behrendt, Niels, 30 May 2008, In: Journal of Biological Chemistry. 283, 22, p. 15217-15223 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase
Kristensen, Kristian Kølby, Midtgaard, S. R., Mysling, S., Kovrov, O., Hansen, L. B., Skar-Gislinge, Nicholas, Beigneux, A. P., Kragelund, Birthe Brandt, Olivecrona, G., Young, S. G., Jørgensen, T. J. D., Fong, L. G. & Ploug, Michael, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 26, p. E6020-E6029 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A lipoprotein lipase (LPL)-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1
Allan, C. M., Larsson, M., Hu, X., He, C., Jung, R. S., Mapar, A., Voss, C., Miyashita, K., Machida, T., Murakami, M., Nakajima, K., Bensadoun, A., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., Oct 2016, In: Journal of Lipid Research. 57, 10, p. 1889-1898Research output: Contribution to journal › Journal article › Research › peer-review
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A new tagging system for production of recombinant proteins in Drosophila S2 cells using the third domain of the urokinase receptor
Gårdsvoll, Henrik, Hansen, L. V., Jørgensen, Thomas & Ploug, Michael, Apr 2007, In: Protein Expression and Purification. 52, 2, p. 384-94 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism
Young, S. G., Song, W., Yang, Y., Birrane, G., Jiang, H., Beigneux, A. P., Ploug, Michael & Fong, L. G., 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 36, 12 p., e2211136119.Research output: Contribution to journal › Journal article › Research › peer-review
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A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth
Chaurasia, P., Aguirre-Ghiso, J., Liang, O. D., Gardsvoll, H., Ploug, Michael & Ossowski, L., 26 May 2006, In: The Journal of Biological Chemistry. 281, 21, p. 14852-63 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
A soluble form of the glycolipid-anchored receptor for urokinase-type plasminogen activator is secreted from peripheral blood leukocytes from patients with paroxysmal nocturnal hemoglobinuria
Ploug, Michael, Eriksen, J., Plesner, T., Hansen, N. E. & Danø, K., 1 Sep 1992, In: European Journal of Biochemistry. 208, 2, p. 397-404 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ANGPTL4: a new mode in the regulation of intravascular lipolysis
Ploug, Michael, 2022, In: Current Opinion in Lipidology. 33, 2, p. 112-119Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ANGPTL4 inactivates lipoprotein lipase by catalyzing the irreversible unfolding of LPL's hydrolase domain
Kristensen, Kristian Kølby, Leth-Espensen, K. Z., Young, S. G. & Ploug, Michael, 2020, In: Journal of Lipid Research. 61, 9, p. 1253Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding
Winther, Anne-Marie Lund, Kumari, Anni, Young, S. G. & Ploug, Michael, 2021, In: Journal of Lipid Research. 62, 2 p., 100071.Research output: Contribution to journal › Comment/debate › Research
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Administration of Recombinant Soluble Urokinase Receptor Per Se Is Not Sufficient to Induce Podocyte Alterations and Proteinuria in Mice
Cathelin, D., Placier, S., Ploug, Michael, Verpont, M., Vandermeersch, S., Luque, Y., Hertig, A., Rondeau, E. & Mesnard, L., 2014, In: Journal of the American Society of Nephrology. 25, 8, p. 1662-1668 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Altered expression of the urokinase receptor homologue, C4.4A, in invasive areas of human esophageal squamous cell carcinoma
Hansen, L. V., Laerum, O. D., Illemann, M., Nielsen, B. S. & Ploug, Michael, 15 Feb 2008, In: International Journal of Cancer. Supplement. 122, 4, p. 734-41 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An enzyme-linked immunosorbent assay for measuring GPIHBP1 levels in human plasma or serum
Miyashita, K., Fukamachi, I., Nagao, M., Ishida, T., Kobayashi, J., Machida, T., Nakajima, K., Murakami, M., Ploug, Michael, Beigneux, A. P., Young, S. G. & Nakajima, K., Jan 2018, In: Journal of Clinical Lipidology. 12, 1, p. 203-210 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia
Beigneux, A. P., Miyashita, K., Ploug, M., Blom, J. D., Ai, M., Linton, M. F., Khovidhunkit, W., Dufour, R., Garg, A., McMahon, M. A., Pullinger, C. R., Sandoval, N. P., Hu, X., Allan, C. M., Larsson, M., Machida, T., Murakami, M., Reue, K., Tontonoz, P., Goldberg, I. J. & 5 others, , 27 Apr 2017, In: New England Journal of Medicine. 376, 17, p. 1647-1658 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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C4.4A IS A PROGNOSTIC INDICATOR IN NON-SMALL CELL LUNG CANCER PATIENTS WITH ADENOCARCINOMAS
Jacobsen, B., Muley, T., Meister, M., Dienemann, H., Christensen, I. J., Santoni Rugiu, Eric, Laerum, O. D. & Ploug, Michael, 2011, In: Journal of Thoracic Oncology.Research output: Contribution to journal › Journal article › Research › peer-review
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C4.4A as a biomarker for poor prognosis in non-small cell lung cancer patients with adenocarcinomas
Jacobsen, B., Muley, T., Meister, M., Dienemann, H., Christensen, I. J., Santoni Rugiu, Eric, Laerum, O. D. & Ploug, Michael, 2011, In: European Journal of Cancer.Research output: Contribution to journal › Journal article › Research › peer-review
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C4.4A as a biomarker in pulmonary adenocarcinoma and squamous cell carcinoma
Jacobsen, B., Kriegbaum, M. C., Santoni Rugiu, Eric & Ploug, Michael, 10 Oct 2014, In: World Journal of Clinical Oncology. 5, 4, p. 621-32 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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C4.4A er en ny biomarkør i ikke-småcellet lungekræft
Kriegbaum, M. C., Jacobsen, B., Santoni-Rugiu, E. & Ploug, Michael, 2012, In: Best Practice Onkologie. 2, 5, p. 58-61Research output: Contribution to journal › Review › Research
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C4.4A gene ablation is compatible with normal epidermal development and causes modest overt phenotypes
Kriegbaum, M. C., Jacobsen, B., Fuchtbauer, A., Hansen, Gert Helge, Christensen, I. J., Friis, Carsten, Persson, M., Engelholm, Lars Henning, Madsen, A. N., Di Meo, I., Lund, I. K., Holst, Birgitte, Kjær, Andreas, Laerum, O. D., Fuchtbauer, E. & Ploug, Michael, 12 May 2016, In: Scientific Reports. 6, 25833.Research output: Contribution to journal › Journal article › Research › peer-review
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C4.4A som biomarkør for solid tumorvækst og dårlig prognose i patienter med lungeadenokarcinom
Jacobsen, B., Santoni-Rugiu, E. & Ploug, Michael, 2014, In: Best Practice Onkologie. 4, p. 32-35Research output: Contribution to journal › Review › Research
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CL-11 circulates in serum as functionally distinct isoforms
Sutta, A., Leemans, N. N., Ploug, Michael, Rosbjerg, A., del Agua Villa, C., Pérez-Alós, L., Cyranka, L., Vincek, A. S., de Garay, T., Rivera, K. & Bayarri-Olmos, R., 2024, In: FASEB Journal. 38, 5, e23543.Research output: Contribution to journal › Journal article › Research › peer-review
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Carbohydrate as covalent crosslink in human inter-alpha-trypsin inhibitor: a novel plasma protein structure
Jessen, T. E., Faarvang, K. L. & Ploug, Michael, 28 Mar 1988, In: FEBS Letters. 230, 1-2, p. 195-200 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptor
Rønne, Elsebeth, Behrendt, Niels, Ellis, V., Ploug, Michael, Danø, K. & Høyer-Hansen, G., 19 Aug 1991, In: FEBS Letters. 288, 1-2, p. 233-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cell-surface acceleration of urokinase-catalyzed receptor cleavage
Høyer-Hansen, G., Ploug, Michael, Behrendt, Niels, Rønne, Elsebeth & Danø, K., 15 Jan 1997, In: European Journal of Biochemistry. 243, 1-2, p. 21-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol
Ploug, Michael, Rønne, E., Behrendt, Niels, Jensen, A. L., Blasi, F. & Danø, K., 25 Jan 1991, In: The Journal of Biological Chemistry. 266, 3, p. 1926-33 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cellular receptor for urokinase-type plasminogen activator: protein structure
Behrendt, Niels, Ploug, Michael, Rønne, Elsebeth, Høyer-Hansen, G. & Danø, K., 1993, Methods of Enzymology. Vol. 223. p. 207-22 16 p. (Methods in Enzymology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites
Gårdsvoll, Henrik, Werner, F., Søndergaard, Leif, Danø, K. & Ploug, Michael, 2004, In: Protein Expression and Purification. 34, 2, p. 284-295 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking
Gårdsvoll, Henrik, Gilquin, B., Le Du, M. H., Ménèz, A., Jørgensen, Thomas & Ploug, Michael, 14 Jul 2006, In: The Journal of Biological Chemistry. 281, 28, p. 19260-72 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Chemical modification of the urokinase-type plasminogen activator and its receptor using tetranitromethane. Evidence for the involvement of specific tyrosine residues in both molecules during receptor-ligand interaction
Ploug, Michael, Rahbek-Nielsen, H., Ellis, V., Roepstorff, P. & Danø, K., 3 Oct 1995, In: Biochemistry. 34, 39, p. 12524-34 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chylomicronemia From GPIHBP1 Autoantibodies Successfully Treated With Rituximab: A Case Report
Lutz, J., Dunaj-Kazmierowska, M., Arcan, S., Kassner, U., Miyashita, K., Murakami, M., Ploug, Michael, Fong, L. G., Young, S. G., Nakajima, K. & Beigneux, A. P., 2020, In: Annals of Internal Medicine. 173, 9, p. 764-765Research output: Contribution to journal › Letter › Research › peer-review
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Chylomicronemia from GPIHBP1 autoantibodies
Miyashita, K., Lutz, J., Hudgins, L. C., Toib, D., Ashraf, A. P., Song, W., Murakami, M., Nakajima, K., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., 2020, In: Journal of Lipid Research. 61, 11, p. 1365-1376Research output: Contribution to journal › Review › Research › peer-review
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Collisional activation by MALDI tandem time-of-flight mass spectrometry induces intramolecular migration of amide hydrogens in protonated peptides
Jørgensen, Thomas, Bache, N., Roepstorff, P., Gårdsvoll, Henrik & Ploug, Michael, Dec 2005, In: Molecular and Cellular Proteomics. 4, 12, p. 1910-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction
Gårdsvoll, Henrik, Jacobsen, B., Kriegbaum, M. C., Behrendt, Niels, Engelholm, Lars Henning, Østergaard, S. & Ploug, Michael, 23 Sep 2011, In: The Journal of Biological Chemistry. 286, 38, p. 33544-56 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/α-neurotoxin Domain
Jiang, Y., Lin, L., Chen, S., Jiang, L., Kriegbaum, M. C., Gårdsvoll, Henrik, Hansen, L. V., Li, J., Ploug, Michael, Yuan, C. & Huang, M., 2020, In: International Journal of Biological Sciences. 16, 6, p. 981-993 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide
Llinas, P., Le Du, M. H., Gårdsvoll, Henrik, Danø, K., Ploug, Michael, Gilquin, B., Stura, E. A. & Ménèz, A., 4 May 2005, In: E M B O Journal. 24, 9, p. 1655-63 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit
Liu, M., Hansen, G. H., Ploug, Michael, Hanlin, L., Jiang, L., Yuan, C., Li, J. & Huang, M., 2019, In: FEBS Letters. 593, 11, p. 1236-1247 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of the urokinase receptor in a ligand-free form
Xu, X., Gårdsvoll, Henrik, Yuan, C., Lin, L., Ploug, Michael & Huang, M., 9 Mar 2012, In: Journal of Molecular Biology. 416, 5, p. 629-41 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Determination of Binding Kinetics of Intrinsically Disordered Proteins by Surface Plasmon Resonance
Leth, Julie Maja & Ploug, Michael, 2020, Intrinsically Disorded Proteins. Kragelund, B. & Skriver, K. (eds.). Springer, Vol. 2141. p. 611-627 17 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Determination of amino acid compositions and NH2-terminal sequences of peptides electroblotted onto PVDF membranes from tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis: application to peptide mapping of human complement component C3
Ploug, Michael, Jensen, Asger Lundorff & Barkholt, V., 15 Aug 1989, In: Analytical Biochemistry. 181, 1, p. 33-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Did evolution create a flexible ligand-binding cavity in the urokinase receptor through deletion of a plesiotypic disulfide bond?
Leth, Julie Maja, Mertens, H. D. T., Leth-Espensen, K. Z., Jørgensen, T. J. D. & Ploug, Michael, 2019, In: The Journal of Biological Chemistry. 294, 18, p. 7403-7418 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry
Staby, L., Kemplen, K. R., Stein, Amelie, Ploug, Michael, Clarke, J., Skriver, Karen, Heidarsson, P. O. & Kragelund, Birthe Brandt, 2021, In: Cellular and molecular life sciences : CMLS. 78, p. 2263-2278 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamics of urokinase receptor interaction with Peptide antagonists studied by amide hydrogen exchange and mass spectrometry
Jørgensen, Thomas, Gårdsvoll, Henrik, Danø, K., Roepstorff, P. & Ploug, Michael, 30 Nov 2004, In: Biochemistry. 43, 47, p. 15044-57 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficient refolding and reconstitution of tissue factor into nanodiscs facilitates structural investigation of a multicomponent system on a lipid bilayer
Tidemand, Frederik Grønbæk, Østergaard, H., Ploug, Michael, Kragelund, Birthe Brandt & Arleth, Lise, 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 10 p., 183214.Research output: Contribution to journal › Journal article › Research › peer-review
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Electrochemical reduction of disulfide-containing proteins for hydrogen/deuterium exchange monitored by mass spectrometry
Mysling, S., Salbo, R., Ploug, Michael & Jørgensen, T. J. D., 7 Jan 2014, In: Analytical Chemistry. 86, 1, p. 340-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells
Song, W., Beigneux, A. P., Winther, A. M. L., Kristensen, K. K., Grønnemose, A. L., Yang, Y., Tu, Y., Munguia, P., Morales, J., Jung, H., De Jong, P. J., Jung, C. J., Miyashita, K., Kimura, T., Nakajima, K., Murakami, M., Birrane, G., Jiang, H., Tontonoz, P., Ploug, M. & 2 others, , 2022, In: Journal of Clinical Investigation. 132, 5, 15 p., e157500.Research output: Contribution to journal › Journal article › Research › peer-review
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Erratum: Crystal structure of the urokinase receptor in a ligand-free form (Journal of Molecular Biology (2012) 416 (629-641))
Xu, X., Gårdsvoll, Henrik, Yuan, C., Lin, L., Ploug, Michael & Huang, M., 7 Sep 2012, In: Journal of Molecular Biology. 422, 1, 1 p.Research output: Contribution to journal › Comment/debate › Research
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Evolution and Medical Significance of LU Domain-Containing Proteins
Leth, Julie Maja, Leth-Espensen, K. Z., Kristensen, Kristian Kølby, Kumari, Anni, Winther, Anne-Marie Lund, Young, S. G. & Ploug, Michael, 2019, In: International Journal of Molecular Sciences. 20, 11, p. 1-20 20 p.Research output: Contribution to journal › Review › Research › peer-review
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Expression and crystallographic studies of the D1D2 domains of C4.4A, a homologous protein to the urokinase receptor
Chen, S., Lin, L., Yuan, C., Gårdsvoll, Henrik, Kriegbaum, M. C., Ploug, Michael & Huang, M., 1 Aug 2017, In: Acta Crystallographica Section F: Structural Biology Communications. 73, 8, p. 486-490 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 33978213
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Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites
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Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis
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IRDye800CW labeled uPAR-targeting peptide for fluorescence-guided glioblastoma surgery: Preclinical studies in orthotopic xenografts
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