Michael Ploug

Michael Ploug

Group leader

ORCID: 0000-0003-2215-4265

Publication year:
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1 - 25 out of 171Page size: 25
  1. 2024
  2. Published

    CL-11 circulates in serum as functionally distinct isoforms

    Sutta, A., Leemans, N. N., Ploug, Michael, Rosbjerg, A., del Agua Villa, C., Pérez-Alós, L., Cyranka, L., Vincek, A. S., de Garay, T., Rivera, K. & Bayarri-Olmos, R., 2024, In: FASEB Journal. 38, 5, e23543.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Quantification of lipoprotein lipase in mouse plasma with a sandwich enzyme-linked immunosorbent assay

    Kimura, T., Miyashita, K., Fukamachi, I., Fukamachi, K., Ogura, K., Yokoyama, E., Tsunekawa, K., Nagasawa, T., Ploug, Michael, Yang, Y., Song, W., Young, S. G., Beigneux, A. P., Nakajima, K. & Murakami, M., 2024, In: Journal of Lipid Research. 65, 4, 7 p., 100532.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 2023
  5. Published

    Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts of lipoprotein lipase in the capillary lumen

    Yang, Y., Beigneux, A. P., Song, W., Nguyen, L. P., Jung, H., Tu, Y., Weston, T. A., Tran, C. M., Xie, K., Yu, R. G., Tran, A. P., Miyashita, K., Nakajima, K., Murakami, M., Chen, Y. Q., Zhen, E. Y., Kim, J. R., Kim, P. H., Birrane, G., Tontonoz, P. & 4 others, Ploug, Michael, Konrad, R. J., Fong, L. G. & Young, S. G., 2023, In: Journal of Clinical Investigation. 133, 23, 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures

    Song, W., Yang, Y., Heizer, P., Tu, Y., Weston, T. A., Kim, J. R., Munguia, P., Jung, H., Fong, J. L. C., Tran, C., Ploug, Michael, Beigneux, A. P., Young, S. G. & Fong, L. G., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 8, 11 p., e2219833120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase

    Kumari, Anni, Grønnemose, A. L., Kristensen, Kristian Kølby, Winther, Anne-Marie Lund, Young, S. G., Jørgensen, T. J. D. & Ploug, Michael, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 18, e2221888120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Targeted imaging of uPAR expression in vivo with cyclic AE105 variants

    Leth, Julie Maja, Newcombe, Estella Anne, Grønnemose, A. L., Jørgensen, Jesper Tranekjær, Qvist, K., Clausen, Anne Skovsbo, Knudsen, Line Bruhn Schneider, Kjær, Andreas, Kragelund, Birthe Brandt, Jørgensen, Thomas Jørgen Dyreborg & Ploug, Michael, 2023, In: Scientific Reports. 13, 17 p., 17248.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing

    Song, W., Beigneux, A. P., Weston, T. A., Chen, K., Yang, Y., Nguyen, L. P., Guagliardo, P., Jung, H., Tran, A. P., Tu, Y., Tran, C., Birrane, G., Miyashita, K., Nakajima, K., Murakami, M., Tontonoz, P., Jiang, H., Ploug, Michael, Fong, L. G. & Young, S. G., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 44, 12 p., e2313825120.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. 2022
  11. Published

    A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism

    Young, S. G., Song, W., Yang, Y., Birrane, G., Jiang, H., Beigneux, A. P., Ploug, Michael & Fong, L. G., 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 36, 12 p., e2211136119.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    ANGPTL4: a new mode in the regulation of intravascular lipolysis

    Ploug, Michael, 2022, In: Current Opinion in Lipidology. 33, 2, p. 112-119

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells

    Song, W., Beigneux, A. P., Winther, A. M. L., Kristensen, K. K., Grønnemose, A. L., Yang, Y., Tu, Y., Munguia, P., Morales, J., Jung, H., De Jong, P. J., Jung, C. J., Miyashita, K., Kimura, T., Nakajima, K., Murakami, M., Birrane, G., Jiang, H., Tontonoz, P., Ploug, M. & 2 others, Fong, L. G. & Young, S. G., 2022, In: Journal of Clinical Investigation. 132, 5, 15 p., e157500.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. 2021
  15. Published

    ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding

    Winther, Anne-Marie Lund, Kumari, Anni, Young, S. G. & Ploug, Michael, 2021, In: Journal of Lipid Research. 62, 2 p., 100071.

    Research output: Contribution to journal › Comment/debate › Research

  16. Published

    Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry

    Staby, L., Kemplen, K. R., Stein, Amelie, Ploug, Michael, Clarke, J., Skriver, Karen, Heidarsson, P. O. & Kragelund, Birthe Brandt, 2021, In: Cellular and molecular life sciences : CMLS. 78, p. 2263-2278 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Expression and one-step purification of active LPL contemplated by biophysical considerations

    Winther, Anne-Marie Lund, Kristensen, Kristian Kølby, Kumari, Anni & Ploug, Michael, 2021, In: Journal of Lipid Research. 62, 13 p., 100149.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity

    Kristensen, Kristian Kølby, Leth-Espensen, K. Z., Kumari, Anni, Grønnemose, A. L., Winther, Anne-Marie Lund, Young, S. G. & Ploug, Michael, 2021, In: Frontiers in Cell and Developmental Biology. 9, 20 p., 702508.

    Research output: Contribution to journal › Review › Research › peer-review

  19. Published

    IRDye800CW labeled uPAR-targeting peptide for fluorescence-guided glioblastoma surgery: Preclinical studies in orthotopic xenografts

    Kurbegovic, Sorel, Stræde, Karina, Sørensen, K. K., Leth, Julie Maja, Willemoe, G. L., Christensen, Anders, Adams, Yvonne, Jensen, Anja Ramstedt, von Buchwald, Christian, Skjøth-rasmussen, J., Ploug, Michael, Jensen, Knud Jørgen & Kjær, Andreas, 2021, In: Theranostics. 11, 15, p. 7159-7174 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Optimization and Evaluation of Al18F Labeling Using a NOTA—or RESCA1-Conjugated AE105 Peptide Antagonist of uPAR

    Jeppesen, T. E., Simón, M., Torp, J., Knudsen, Line Bruhn Schneider, Leth, Julie Maja, Crestey, F., Ploug, Michael, Jørgensen, Jesper Tranekjær, Madsen, J., Herth, Matthias Manfred & Kjær, Andreas, 2021, In: Frontiers in Nuclear Medicine. 1, 9 p., 799533.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Targeting the Urokinase-Type Plasminogen Activator Receptor (uPAR) in Human Diseases With a View to Non-invasive Imaging and Therapeutic Intervention

    Leth, Julie Maja & Ploug, Michael, 2021, In: Frontiers in Cell and Developmental Biology. 9, 20 p., 732015.

    Research output: Contribution to journal › Review › Research › peer-review

  22. Published

    The Importance of Lipoprotein Lipase Regulation in Atherosclerosis

    Kumari, Anni, Kristensen, Kristian Kølby, Ploug, Michael & Winther, Anne-Marie Lund, 2021, In: Biomedicines. 9, 7, 24 p., 782.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The Urokinase Receptor (uPAR) as a “Trojan Horse” in Targeted Cancer Therapy: Challenges and Opportunities

    Metrangolo, Virginia, Ploug, Michael & Engelholm, Lars Henning, 2021, In: Cancers. 13, 21, 45 p., 5376.

    Research output: Contribution to journal › Review › Research › peer-review

  24. Published

    The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding

    Leth-Espensen, K. Z., Kristensen, Kristian Kølby, Kumari, Anni, Winther, Anne-Marie Lund, Young, S. G., Jørgensen, T. J. D. & Ploug, Michael, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 12, e2026650118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. 2020
  26. Published

    ANGPTL4 inactivates lipoprotein lipase by catalyzing the irreversible unfolding of LPL's hydrolase domain

    Kristensen, Kristian Kølby, Leth-Espensen, K. Z., Young, S. G. & Ploug, Michael, 2020, In: Journal of Lipid Research. 61, 9, p. 1253

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Chylomicronemia From GPIHBP1 Autoantibodies Successfully Treated With Rituximab: A Case Report

    Lutz, J., Dunaj-Kazmierowska, M., Arcan, S., Kassner, U., Miyashita, K., Murakami, M., Ploug, Michael, Fong, L. G., Young, S. G., Nakajima, K. & Beigneux, A. P., 2020, In: Annals of Internal Medicine. 173, 9, p. 764-765

    Research output: Contribution to journal › Letter › Research › peer-review

  28. Published

    Chylomicronemia from GPIHBP1 autoantibodies

    Miyashita, K., Lutz, J., Hudgins, L. C., Toib, D., Ashraf, A. P., Song, W., Murakami, M., Nakajima, K., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., 2020, In: Journal of Lipid Research. 61, 11, p. 1365-1376

    Research output: Contribution to journal › Review › Research › peer-review

  29. Published

    Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/α-neurotoxin Domain

    Jiang, Y., Lin, L., Chen, S., Jiang, L., Kriegbaum, M. C., Gårdsvoll, Henrik, Hansen, L. V., Li, J., Ploug, Michael, Yuan, C. & Huang, M., 2020, In: International Journal of Biological Sciences. 16, 6, p. 981-993 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Determination of Binding Kinetics of Intrinsically Disordered Proteins by Surface Plasmon Resonance

    Leth, Julie Maja & Ploug, Michael, 2020, Intrinsically Disorded Proteins. Kragelund, B. & Skriver, K. (eds.). Springer, Vol. 2141. p. 611-627 17 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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ID: 33978213