Michael Ploug
Group leader
Ploug Group
Ole Maaløes Vej 5
2200 København N.
- 2020
- Published
Efficient refolding and reconstitution of tissue factor into nanodiscs facilitates structural investigation of a multicomponent system on a lipid bilayer
Tidemand, Frederik Grønbæk, Østergaard, H., Ploug, Michael, Kragelund, Birthe Brandt & Arleth, Lise, 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 10 p., 183214.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Helicobacter pylori Colonization Drives Urokinase Receptor (uPAR) Expression in Murine Gastric Epithelium During Early Pathogenesis
Alpízar-Alpízar, W., Skindersoe, M. E., Rasmussen, L., Kriegbaum, M. C., Christensen, I. J., Lund, I. K., Illemann, M., Laerum, O. D., Krogfelt, K. A., Andersen, L. P. & Ploug, Michael, 2020, In: Microorganisms. 8, 7, 1019.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intermittent chylomicronemia caused by intermittent GPIHBP1 autoantibodies
Ashraf, A. P., Miyashita, K., Nakajima, K., Murakami, M., Hegele, R. A., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., 2020, In: Journal of Clinical Lipidology. 14, 2, p. 197-200Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Small-Molecule Inhibition of the uPAR uPA Interaction by Conformational Selection
Xu, D., Bum-Erdene, K., Leth, Julie Maja, Ghozayel, M. K., Ploug, Michael & Meroueh, S. O., 2020, In: ChemMedChem. 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase
Luz, J., Beigneux, A. P., Asamoto, D. K., He, C., Song, W., Allan, C. M., Morales, J. E., Tu, Y., Kwok, A., Cottle, T., Meiyappan, M., Fong, L. G., Kim, J., Ploug, Michael, Young, S. G. & Birrane, G., 2020, In: Journal of Lipid Research. 61, 10, p. 1347-1359Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism
Kristensen, Kristian Kølby, Leth-Espensen, K. Z., Mertens, H. D. T., Birrane, G., Meiyappan, M., Olivecrona, G., Jørgensen, T. J. D., Young, S. G. & Ploug, Michael, 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 8, p. 4337-4346Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit
Liu, M., Hansen, G. H., Ploug, Michael, Hanlin, L., Jiang, L., Yuan, C., Li, J. & Huang, M., 2019, In: FEBS Letters. 593, 11, p. 1236-1247 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Did evolution create a flexible ligand-binding cavity in the urokinase receptor through deletion of a plesiotypic disulfide bond?
Leth, Julie Maja, Mertens, H. D. T., Leth-Espensen, K. Z., Jørgensen, T. J. D. & Ploug, Michael, 2019, In: The Journal of Biological Chemistry. 294, 18, p. 7403-7418 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evolution and Medical Significance of LU Domain-Containing Proteins
Leth, Julie Maja, Leth-Espensen, K. Z., Kristensen, Kristian Kølby, Kumari, Anni, Winther, Anne-Marie Lund, Young, S. G. & Ploug, Michael, 2019, In: International Journal of Molecular Sciences. 20, 11, p. 1-20 20 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism
Young, S. G., Fong, L. G., Beigneux, A. P., Allan, C. M., He, C., Jiang, H., Nakajima, K., Meiyappan, M., Birrane, G. & Ploug, Michael, 2019, In: Cell Metabolism. 30, 1, p. 51-65 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
GPIHBP1 autoantibody syndrome during interferon β1a treatment
Eguchi, J., Miyashita, K., Fukamachi, I., Nakajima, K., Murakami, M., Kawahara, Y., Yamashita, T., Ohta, Y., Abe, K., Nakatsuka, A., Mino, M., Takase, S., Okazaki, H., Hegele, R. A., Ploug, Michael, Hu, X., Wada, J., Young, S. G. & Beigneux, A. P., 2019, In: Journal of Clinical Lipidology. 13, 1, p. 62-69 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipoprotein lipase is active as a monomer
Beigneux, A. P., Allan, C. M., Sandoval, N. P., Cho, G. W., Heizer, P. J., Jung, R. S., Stanhope, K. L., Havel, P. J., Birrane, G., Meiyappan, M., Gill, J. E., Murakami, M., Miyashita, K., Nakajima, K., Ploug, Michael, Fong, L. G. & Young, S. G., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 13, p. 6319-6328 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity
Kovrov, O., Kristensen, Kristian Kølby, Larsson, E., Ploug, Michael & Olivecrona, G., 2019, In: Journal of Lipid Research. 60, 4, p. 783-793 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Origin and diversification of the plasminogen activation system among chordates
Chana-Muñoz, A., Jendroszek, A., Sønnichsen, M., Wang, T., Ploug, Michael, Jensen, J. K., Andreasen, P. A., Bendixen, C. & Panitz, F., 2019, In: BMC Evolutionary Biology. 19, 1, p. 1-17 17 p., 27.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peptide disc mediated control of membrane protein orientation in supported lipid bilayers for surface-sensitive investigations
Luchini, A., Tidemand, Frederik Grønbæk, Johansen, Nicolai Tidemand, Campana, M., Sotres, J., Ploug, Michael, Cárdenas, M. & Arleth, Lise, 2019, In: Analytical Chemistry. 92, 1, p. 1081-1088Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis
Birrane, G., Beigneux, A. P., Dwyer, B., Strack-Logue, B., Kristensen, Kristian Kølby, Francone, O. L., Fong, L. G., Mertens, H. D. T., Pan, C. Q., Ploug, Michael, Young, S. G. & Meiyappan, M., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1723-1732 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The PCNA interaction motifs revisited: thinking outside the PIP-box
Prestel, Andreas, Wichmann, N., Martins, J. M., Marabini, R., Kassem, N., Broendum, S. S., Otterlei, M., Nielsen, Olaf, Willemoës, Martin, Ploug, Michael, Boomsma, Wouter & Kragelund, Birthe Brandt, 2019, In: Cellular and Molecular Life Sciences. 76, 24, p. 4923-4943Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes
He, C., Weston, T. A., Jung, R. S., Heizer, P., Larsson, M., Hu, X., Allan, C. M., Tontonoz, P., Reue, K., Beigneux, A. P., Ploug, Michael, Holme, A., Kilburn, M., Guagliardo, P., Ford, D. A., Fong, L. G., Young, S. G. & Jiang, H., 1 May 2018, In: Cell Metabolism. 27, 5, p. 1055-1066.e3 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An enzyme-linked immunosorbent assay for measuring GPIHBP1 levels in human plasma or serum
Miyashita, K., Fukamachi, I., Nagao, M., Ishida, T., Kobayashi, J., Machida, T., Nakajima, K., Murakami, M., Ploug, Michael, Beigneux, A. P., Young, S. G. & Nakajima, K., Jan 2018, In: Journal of Clinical Lipidology. 12, 1, p. 203-210 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase
Kristensen, Kristian Kølby, Midtgaard, S. R., Mysling, S., Kovrov, O., Hansen, L. B., Skar-Gislinge, Nicholas, Beigneux, A. P., Kragelund, Birthe Brandt, Olivecrona, G., Young, S. G., Jørgensen, T. J. D., Fong, L. G. & Ploug, Michael, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 26, p. E6020-E6029 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Expression and crystallographic studies of the D1D2 domains of C4.4A, a homologous protein to the urokinase receptor
Chen, S., Lin, L., Yuan, C., Gårdsvoll, Henrik, Kriegbaum, M. C., Ploug, Michael & Huang, M., 1 Aug 2017, In: Acta Crystallographica Section F: Structural Biology Communications. 73, 8, p. 486-490 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia
Hu, X., Dallinga-Thie, G. M., Hovingh, G. K., Chang, S. Y., Sandoval, N. P., Dang, T. L. P., Fukamachi, I., Miyashita, K., Nakajima, K., Murakami, M., Fong, L. G., Ploug, Michael, Young, S. G. & Beigneux, A. P., 1 Jul 2017, In: Journal of Clinical Lipidology. 11, 4, p. 964-971 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia
Beigneux, A. P., Miyashita, K., Ploug, M., Blom, J. D., Ai, M., Linton, M. F., Khovidhunkit, W., Dufour, R., Garg, A., McMahon, M. A., Pullinger, C. R., Sandoval, N. P., Hu, X., Allan, C. M., Larsson, M., Machida, T., Murakami, M., Reue, K., Tontonoz, P., Goldberg, I. J. & 5 others, , 27 Apr 2017, In: New England Journal of Medicine. 376, 17, p. 1647-1658 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mobility of “HSPG-bound” LPL explains how LPL is able to reach GPIHBP1 on capillaries
Allan, C. M., Larsson, M., Jung, R. S., Ploug, Michael, Bensadoun, A., Beigneux, A. P., Fong, L. G. & Young, S. G., Jan 2017, In: Journal of Lipid Research. 58, 1, p. 216-225Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Monoclonal Antibodies That Bind to the Ly6 Domain of GPIHBP1 Abolish the Binding of LPL
Hu, X., Sleeman, M. W., Miyashita, K., Linton, M. F., Allan, C. M., He, C., Larsson, M., Tu, Y., Sandoval, N. P., Jung, R. S., Mapar, A., Machida, T., Murakami, M., Nakajima, K., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., Jan 2017, In: Journal of Lipid Research. 58, p. 208-215 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 33978213
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Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites
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Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis
Research output: Contribution to journal › Journal article › Research › peer-review
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IRDye800CW labeled uPAR-targeting peptide for fluorescence-guided glioblastoma surgery: Preclinical studies in orthotopic xenografts
Research output: Contribution to journal › Journal article › Research › peer-review
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