Michael Ploug
Group leader
Ploug Group
Ole Maaløes Vej 5
2200 København N.
- 2013
- Published
The urokinase receptor homolog Haldisin is a novel differentiation marker of stratum granulosum in squamous epithelia
Gårdsvoll, Henrik, Kriegbaum, M. C., Hertz, Emil Peter Thrane, Alpízar-Alpízar, W. & Ploug, Michael, Nov 2013, In: Journal of Histochemistry and Cytochemistry. 61, 11, p. 802-13 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting of peptide conjugated magnetic nanoparticles to urokinase plasminogen activator receptor (uPAR) expressing cells
Hansen, L., Larsen, E. K. U., Nielsen, E. H., Iversen, F. H., Liu, Z., Thomsen, K. S., Pedersen, M., Skrydstrup, T., Nielsen, N. C., Ploug, Michael & Kjems, J., 7 Sep 2013, In: Nanoscale. 5, 17, p. 8192-201 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ly6/uPAR-related protein C4.4A as a marker of solid growth pattern and poor prognosis in lung adenocarcinoma
Jacobsen, B., Muley, T., Meister, M., Dienemann, H., Christensen, I. J., Santoni Rugiu, Eric, Lærum, O. D. & Ploug, Michael, Feb 2013, In: Journal of Thoracic Oncology. 8, 2, p. 152-60 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improved PET Imaging of uPAR expression using new Cu-64-labeled cross-bridged peptide ligands: comparative in vitro and in vivo studies
Persson, M., Hosseini, M., Madsen, J., Jørgensen, T. J. D., Jensen, Knud Jørgen, Kjær, Andreas & Ploug, Michael, 2013, In: Theranostics. 3, 9, p. 618-632 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-driven design of radionuclide tracers for non-invasive imaging of uPAR and targeted radiotherapy. The tale of a synthetic peptide antagonist
Ploug, Michael, 2013, In: Theranostics. 3, 7, p. 467-76 10 p.Research output: Contribution to journal › Review › Research › peer-review
- 2012
- Published
Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism
Botkjaer, K. A., Deryugina, E. I., Dupont, D. M., Gårdsvoll, Henrik, Bekes, E. M., Thuesen, C. K., Chen, Z., Chen, Z., Ploug, Michael, Quigley, J. P. & Andreasen, P. A., Dec 2012, In: Molecular cancer research : MCR. 10, 12, p. 1532-43 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin
Trelle, M. B., Hirschberg, D., Jansson, A., Ploug, Michael, Roepstorff, P., Andreasen, P. A. & Jørgensen, Thomas, 16 Oct 2012, In: Biochemistry. 51, 41, p. 8256-66 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New peptide receptor radionuclide therapy of invasive cancer cells: in vivo studies using 177Lu-DOTA-AE105 targeting uPAR in human colorectal cancer xenografts
Persson, M., Rasmussen, P., Madsen, J., Ploug, Michael & Kjær, Andreas, Oct 2012, In: Nuclear Medicine and Biology. 39, 7, p. 962-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erratum: Crystal structure of the urokinase receptor in a ligand-free form (Journal of Molecular Biology (2012) 416 (629-641))
Xu, X., Gårdsvoll, Henrik, Yuan, C., Lin, L., Ploug, Michael & Huang, M., 7 Sep 2012, In: Journal of Molecular Biology. 422, 1, 1 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Expression of C4.4A in precursor lesions of pulmonary adenocarcinoma and squamous cell carcinoma
Jacobsen, B., Santoni Rugiu, Eric, Illemann, M., Kriegbaum, M. C., Laerum, O. D. & Ploug, Michael, 1 Jun 2012, In: International journal of cancer. Journal international du cancer. 130, 11, p. 2734-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
68Ga-labeling and in vivo evaluation of a uPAR binding DOTA- and NODAGA-conjugated peptide for PET imaging of invasive cancers
Persson, M., Madsen, J., Østergaard, S., Ploug, Michael & Kjær, Andreas, May 2012, In: Nuclear Medicine and Biology. 39, 4, p. 560-569 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crystal structure of the urokinase receptor in a ligand-free form
Xu, X., Gårdsvoll, Henrik, Yuan, C., Lin, L., Ploug, Michael & Huang, M., 9 Mar 2012, In: Journal of Molecular Biology. 416, 5, p. 629-41 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
C4.4A er en ny biomarkør i ikke-småcellet lungekræft
Kriegbaum, M. C., Jacobsen, B., Santoni-Rugiu, E. & Ploug, Michael, 2012, In: Best Practice Onkologie. 2, 5, p. 58-61Research output: Contribution to journal › Review › Research
- Published
Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion
Persson, M., Madsen, J., Østergaard, S., Wessel, Mette Munk, Jørgensen, Jesper Tranekjær, Stræde, Karina, Lehmann, C., Ploug, Michael & Kjær, Andreas, 2012, In: Journal of Nuclear Medicine. 53, 1, p. 138-45 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Urokinase-type plasminogen activator-like proteases in teleosts lack genuine receptor-binding epidermal growth factor-like domains
Bager, R., Kristensen, T. K., Jensen, J., Szczur, A., Christensen, A., Andersen, L., Johansen, J. S., Larsen, N., Baatrup, E., Huang, M., Ploug, Michael & Andreasen, P. A., 2012, In: The Journal of Biological Chemistry. 287, 33, p. 27526-27536 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Rational targeting of the urokinase receptor (uPAR): development of antagonists and non-invasive imaging probes
Kriegbaum, M. C., Persson, M., Haldager, L., Alpizar, W. E. A., Jacobsen, B., Gårdsvoll, H., Kjær, Andreas & Ploug, Michael, Nov 2011, In: Current Drug Targets. 12, 12, p. 1711-1728 18 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut
Ghosh, A. K., Coppens, I., Gårdsvoll, Henrik, Ploug, Michael & Jacobs-Lorena, M., 11 Oct 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17153-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction
Gårdsvoll, Henrik, Jacobsen, B., Kriegbaum, M. C., Behrendt, Niels, Engelholm, Lars Henning, Østergaard, S. & Ploug, Michael, 23 Sep 2011, In: The Journal of Biological Chemistry. 286, 38, p. 33544-56 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of C4.4A, a structural uPAR homolog, reflects squamous epithelial differentiation in the adult mouse and during embryogenesis
Kriegbaum, M. C., Jacobsen, B., Hald, A. & Ploug, Michael, 1 Feb 2011, In: Journal of Histochemistry and Cytochemistry. 59, 2, p. 188-201 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
C4.4A IS A PROGNOSTIC INDICATOR IN NON-SMALL CELL LUNG CANCER PATIENTS WITH ADENOCARCINOMAS
Jacobsen, B., Muley, T., Meister, M., Dienemann, H., Christensen, I. J., Santoni Rugiu, Eric, Laerum, O. D. & Ploug, Michael, 2011, In: Journal of Thoracic Oncology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
C4.4A as a biomarker for poor prognosis in non-small cell lung cancer patients with adenocarcinomas
Jacobsen, B., Muley, T., Meister, M., Dienemann, H., Christensen, I. J., Santoni Rugiu, Eric, Laerum, O. D. & Ploug, Michael, 2011, In: European Journal of Cancer.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor
Gårdsvoll, Henrik, Kjærgaard, M., Jacobsen, B., Kriegbaum, M. C., Huang, M. & Ploug, Michael, 2011, In: Journal of Biological Chemistry. 286, 50, p. 43515-26 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteasernes veje og vildveje
Andreasen, P., Kjaer, A., Persson, M. & Ploug, Michael, 2011, In: Aktuel Naturvidenskab. 6, p. 24-27Research output: Contribution to journal › Review › Research
- 2010
- Published
INDUCTION AND/OR MAINTENANCE OF TUMOR DORMANCY BY DISRUPTION OF UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR-INTEGRIN INTERACTION
Ossowski, L., Chaurasia, P., Aguirre-Ghiso Julio, A., Zhou, M. & Ploug, Michael, 30 Sep 2010, IPC No. G06G 7/ 60 A I, Patent No. US2010249184, Priority date 17 Mar 2008, Priority No. US20080531502Research output: Patent
- Published
Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation
Connolly, B. M., Choi, E. Y., Gårdsvoll, Henrik, Bey, A. L., Currie, B. M., Chavakis, T., Liu, S., Molinolo, A., Ploug, Michael, Leppla, S. H. & Bugge, T. V., 2 Sep 2010, In: Blood Weekly. 116, 9, p. 1593-603 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 33978213
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Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites
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Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis
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IRDye800CW labeled uPAR-targeting peptide for fluorescence-guided glioblastoma surgery: Preclinical studies in orthotopic xenografts
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