Michael Ploug

Michael Ploug

Group leader

ORCID: 0000-0003-2215-4265

Publication year:
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51 - 100 out of 171Page size: 50
  1. 2017
  2. Published

    Expression of C4.4A in an in Vitro Human Tissue-Engineered Skin Model

    Jacobsen, B., Larouche, D., Rochette-Drouin, O., Ploug, Michael & Germain, L., 2017, In: BioMed Research International. 2017, 9 p., 2403072.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2016
  4. Published

    The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

    Mysling, S., Kristensen, K. K., Larsson, M., Kovrov, O., Bensadouen, A., Jørgensen, T. J. D., Olivecrona, G., Young, S. G. & Ploug, Michael, 8 Dec 2016, In: eLife. 5, 18 p., e20958.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    A lipoprotein lipase (LPL)-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1

    Allan, C. M., Larsson, M., Hu, X., He, C., Jung, R. S., Mapar, A., Voss, C., Miyashita, K., Machida, T., Murakami, M., Nakajima, K., Bensadoun, A., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., Oct 2016, In: Journal of Lipid Research. 57, 10, p. 1889-1898

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Tissue Inhibitor of Metalloproteinase-1 Is Confined to Tumor-Associated Myofibroblasts and Is Increased With Progression in Gastric Adenocarcinoma

    Alpízar-Alpízar, W., Lærum, O. D., Christensen, I. J., Ovrebo, K., Skarstein, A., Høyer-Hansen, G., Ploug, Michael & Illemann, M., Aug 2016, In: Journal of Histochemistry and Cytochemistry. 64, 8, p. 483-94 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    GPIHBP1 and Plasma Triglyceride Metabolism

    Fong, L. G., Young, S. G., Beigneux, A. P., Bensadoun, A., Oberer, M., Jiang, H. & Ploug, Michael, Jul 2016, In: Trends in Endocrinology and Metabolism. 27, 7, p. 455-69 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  8. Published

    C4.4A gene ablation is compatible with normal epidermal development and causes modest overt phenotypes

    Kriegbaum, M. C., Jacobsen, B., Fuchtbauer, A., Hansen, Gert Helge, Christensen, I. J., Friis, Carsten, Persson, M., Engelholm, Lars Henning, Madsen, A. N., Di Meo, I., Lund, I. K., Holst, Birgitte, Kjær, Andreas, Laerum, O. D., Fuchtbauer, E. & Ploug, Michael, 12 May 2016, In: Scientific Reports. 6, 25833.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Peptide-Based Optical uPAR Imaging for Surgery: In Vivo Testing of ICG-Glu-Glu-AE105

    Stræde, Karina, Christensen, Anders, Persson, M., Ploug, Michael & Kjær, Andreas, 2016, In: PloS one. 11, 2, 15 p., e0147428.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

    Mysling, S., Kristensen, K. K., Larsson, M., Beigneux, A. P., Gårdsvoll, Henrik, Fong, L. G., Bensadouen, A., Jørgensen, T. J. D., Young, S. G. & Ploug, Michael, 2016, In: eLife. 5, 24 p., e12095.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. 2015
  12. Published

    Mapping the topographic epitope landscape on the urokinase plasminogen activator receptor (uPAR) by surface plasmon resonance and X-ray crystallography

    Zhao, B., Gandhi, S., Yuan, C., Luo, Z., Li, R., Gårdsvoll, Henrik, de Lorenzi, V., Sidenius, N., Huang, M. & Ploug, Michael, Dec 2015, In: Data in Brief. 5, p. 107-13 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Heterogeneity in the properties of mutant secreted lymphocyte antigen 6/urokinase receptor-related protein 1 (SLURP1) in Mal de Meleda

    Adeyo, O., Oberer, M., Ploug, Michael, Fong, L. G., Young, S. G. & Beigneux, A. P., Oct 2015, In: British Journal of Dermatology. 173, 4, p. 1066-9 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    New 177-lutetium labeled urokinase-type plasminogen activator receptor binding peptide conjugate, useful for treating cancer such as colorectal cancer, prostate cancer, neuroendocrine tumors, brain tumors, breast tumors and ovarian tumors

    Kjær, Andreas, Persson, M. & Ploug, Michael, 8 Jul 2015, IPC No. C07K 16/ 30 A I, Patent No. CN104768573, Priority date 3 May 2013, Priority No. WO2013DK50126

    Research output: Patent

  15. Published

    Urokinase receptor cleavage correlates with tumor volume in a transgenic mouse model of breast cancer

    Thurison, T., Almholt, K., Gårdsvoll, Henrik, Ploug, Michael, Høyer-Hansen, G. & Lund, I. K., 25 Mar 2015, In: Molecular Carcinogenesis.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Stabilizing a Flexible Interdomain Hinge Region Harboring the SMB Binding Site Drives uPAR into Its Closed Conformation

    Zhao, B., Gandhi, S., Yuan, C., Luo, Z., Li, R., Gårdsvoll, Henrik, de Lorenzi, V., Sidenius, N., Huang, M. & Ploug, Michael, Mar 2015, In: Journal of Molecular Biology. 427, 6B, p. 1389-1403 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    GPIHBP1 Missense Mutations Often Cause Multimerization of GPIHBP1 and Thereby Prevent Lipoprotein Lipase Binding

    Beigneux, A. P., Fong, L. G., Bensadoun, A., Davies, B. S., Oberer, M., Gårdsvoll, Henrik, Ploug, Michael & Young, S. G., 2015, In: Circulation Research. 116, 4, p. 624-632 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    First-in-human uPAR PET: Imaging of Cancer Aggressiveness

    Persson, M., Skovgaard, D., Brandt-Larsen, M., Christensen, C., Madsen, J., Nielsen, Carsten Haagen, Røndbjerg, T. T., Klausen, Thomas Levin, Holm, S., Loft, A., Berthelsen, A. K., Ploug, Michael, Pappot, H., Brasso, K., Kroman, Niels Thorndahl, Højgaard, Liselotte & Kjær, Andreas, 2015, In: Theranostics. 5, 12, p. 1303-16 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites

    Dupont, D. M., Thuesen, C. K., Bøtkjær, K. A., Behrens, M. A., Dam, K., Sørensen, H. P., Pedersen, J., Ploug, Michael, Jensen, J. K. & Andreasen, P. A., 2015, In: PLOS ONE. 10, 4, 22 p., e0119207.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Stepping up the tension in uPAR-mediated signaling by integrins

    Ploug, Michael, 2015

    Research output: Other contribution › Net publication - Internet publication › Research

  21. 2014
  22. Published

    C4.4A as a biomarker in pulmonary adenocarcinoma and squamous cell carcinoma

    Jacobsen, B., Kriegbaum, M. C., Santoni Rugiu, Eric & Ploug, Michael, 10 Oct 2014, In: World Journal of Clinical Oncology. 5, 4, p. 621-32 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    uPAR Targeted Radionuclide Therapy with 177Lu-DOTA-AE105 Inhibits Dissemination of Metastatic Prostate Cancer

    Persson, M., Stræde, Karina, Rasmussen, P., Brandt-Larsen, M., Madsen, J., Ploug, Michael & Kjær, Andreas, 4 Aug 2014, In: Molecular Pharmaceutics. 11, 8, p. 2796–2806 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Multimerization of GPIHBP1 and Familial Chylomicronemia from a Serine-to-Cysteine Substitution in GPIHBP1's Ly6 Domain

    Plengpanich, W., Young, S. G., Khovidhunkit, W., Bensadoun, A., Karnman, H., Ploug, Michael, Gardsvoll, H., Leung, C. S., Adeyo, O., Larsson, M., Muanpetch, S., Charoen, S., Fong, L. G., Niramitmahapanya, S. & Beigneux, A. P., 11 Jul 2014, In: The Journal of Biological Chemistry. 289, p. 19491-19499

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Electrochemical reduction of disulfide-containing proteins for hydrogen/deuterium exchange monitored by mass spectrometry

    Mysling, S., Salbo, R., Ploug, Michael & Jørgensen, T. J. D., 7 Jan 2014, In: Analytical Chemistry. 86, 1, p. 340-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Administration of Recombinant Soluble Urokinase Receptor Per Se Is Not Sufficient to Induce Podocyte Alterations and Proteinuria in Mice

    Cathelin, D., Placier, S., Ploug, Michael, Verpont, M., Vandermeersch, S., Luque, Y., Hertig, A., Rondeau, E. & Mesnard, L., 2014, In: Journal of the American Society of Nephrology. 25, 8, p. 1662-1668 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    C4.4A som biomarkør for solid tumorvækst og dårlig prognose i patienter med lungeadenokarcinom

    Jacobsen, B., Santoni-Rugiu, E. & Ploug, Michael, 2014, In: Best Practice Onkologie. 4, p. 32-35

    Research output: Contribution to journal › Review › Research

  28. Published

    Expression of the Ly6/uPAR-domain proteins C4.4A and Haldisin in non-invasive and invasive skin lesions

    Kriegbaum, M. C., Clausen, O. P. F., Lærum, O. D. & Ploug, Michael, 2014, In: Journal of Histochemistry and Cytochemistry. 63, 2, p. 142-154 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication

    Kamalyukova, I. M., Young, C., Strømme, C. B., Ménard, Patrice, Jasencakova, Zuzana, Mejlvang, J., Ask, K., Ploug, Michael, Nielsen, Michael Lund, Jensen, O. N. & Groth, Anja, 2014, In: Nature Communications. 5, p. 3394

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. 2013
  31. Published

    The urokinase receptor homolog Haldisin is a novel differentiation marker of stratum granulosum in squamous epithelia

    Gårdsvoll, Henrik, Kriegbaum, M. C., Hertz, Emil Peter Thrane, Alpízar-Alpízar, W. & Ploug, Michael, Nov 2013, In: Journal of Histochemistry and Cytochemistry. 61, 11, p. 802-13 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Targeting of peptide conjugated magnetic nanoparticles to urokinase plasminogen activator receptor (uPAR) expressing cells

    Hansen, L., Larsen, E. K. U., Nielsen, E. H., Iversen, F. H., Liu, Z., Thomsen, K. S., Pedersen, M., Skrydstrup, T., Nielsen, N. C., Ploug, Michael & Kjems, J., 7 Sep 2013, In: Nanoscale. 5, 17, p. 8192-201 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Ly6/uPAR-related protein C4.4A as a marker of solid growth pattern and poor prognosis in lung adenocarcinoma

    Jacobsen, B., Muley, T., Meister, M., Dienemann, H., Christensen, I. J., Santoni Rugiu, Eric, Lærum, O. D. & Ploug, Michael, Feb 2013, In: Journal of Thoracic Oncology. 8, 2, p. 152-60 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Improved PET Imaging of uPAR expression using new Cu-64-labeled cross-bridged peptide ligands: comparative in vitro and in vivo studies

    Persson, M., Hosseini, M., Madsen, J., Jørgensen, T. J. D., Jensen, Knud Jørgen, Kjær, Andreas & Ploug, Michael, 2013, In: Theranostics. 3, 9, p. 618-632 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Structure-driven design of radionuclide tracers for non-invasive imaging of uPAR and targeted radiotherapy. The tale of a synthetic peptide antagonist

    Ploug, Michael, 2013, In: Theranostics. 3, 7, p. 467-76 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  36. 2012
  37. Published

    Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism

    Botkjaer, K. A., Deryugina, E. I., Dupont, D. M., Gårdsvoll, Henrik, Bekes, E. M., Thuesen, C. K., Chen, Z., Chen, Z., Ploug, Michael, Quigley, J. P. & Andreasen, P. A., Dec 2012, In: Molecular cancer research : MCR. 10, 12, p. 1532-43 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin

    Trelle, M. B., Hirschberg, D., Jansson, A., Ploug, Michael, Roepstorff, P., Andreasen, P. A. & Jørgensen, Thomas, 16 Oct 2012, In: Biochemistry. 51, 41, p. 8256-66 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    New peptide receptor radionuclide therapy of invasive cancer cells: in vivo studies using 177Lu-DOTA-AE105 targeting uPAR in human colorectal cancer xenografts

    Persson, M., Rasmussen, P., Madsen, J., Ploug, Michael & Kjær, Andreas, Oct 2012, In: Nuclear Medicine and Biology. 39, 7, p. 962-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Erratum: Crystal structure of the urokinase receptor in a ligand-free form (Journal of Molecular Biology (2012) 416 (629-641))

    Xu, X., Gårdsvoll, Henrik, Yuan, C., Lin, L., Ploug, Michael & Huang, M., 7 Sep 2012, In: Journal of Molecular Biology. 422, 1, 1 p.

    Research output: Contribution to journal › Comment/debate › Research

  41. Published

    Expression of C4.4A in precursor lesions of pulmonary adenocarcinoma and squamous cell carcinoma

    Jacobsen, B., Santoni Rugiu, Eric, Illemann, M., Kriegbaum, M. C., Laerum, O. D. & Ploug, Michael, 1 Jun 2012, In: International journal of cancer. Journal international du cancer. 130, 11, p. 2734-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    68Ga-labeling and in vivo evaluation of a uPAR binding DOTA- and NODAGA-conjugated peptide for PET imaging of invasive cancers

    Persson, M., Madsen, J., Østergaard, S., Ploug, Michael & Kjær, Andreas, May 2012, In: Nuclear Medicine and Biology. 39, 4, p. 560-569 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Crystal structure of the urokinase receptor in a ligand-free form

    Xu, X., Gårdsvoll, Henrik, Yuan, C., Lin, L., Ploug, Michael & Huang, M., 9 Mar 2012, In: Journal of Molecular Biology. 416, 5, p. 629-41 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    C4.4A er en ny biomarkør i ikke-småcellet lungekræft

    Kriegbaum, M. C., Jacobsen, B., Santoni-Rugiu, E. & Ploug, Michael, 2012, In: Best Practice Onkologie. 2, 5, p. 58-61

    Research output: Contribution to journal › Review › Research

  45. Published

    Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion

    Persson, M., Madsen, J., Østergaard, S., Wessel, Mette Munk, Jørgensen, Jesper Tranekjær, Stræde, Karina, Lehmann, C., Ploug, Michael & Kjær, Andreas, 2012, In: Journal of Nuclear Medicine. 53, 1, p. 138-45 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Urokinase-type plasminogen activator-like proteases in teleosts lack genuine receptor-binding epidermal growth factor-like domains

    Bager, R., Kristensen, T. K., Jensen, J., Szczur, A., Christensen, A., Andersen, L., Johansen, J. S., Larsen, N., Baatrup, E., Huang, M., Ploug, Michael & Andreasen, P. A., 2012, In: The Journal of Biological Chemistry. 287, 33, p. 27526-27536 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. 2011
  48. Published

    Rational targeting of the urokinase receptor (uPAR): development of antagonists and non-invasive imaging probes

    Kriegbaum, M. C., Persson, M., Haldager, L., Alpizar, W. E. A., Jacobsen, B., Gårdsvoll, H., Kjær, Andreas & Ploug, Michael, Nov 2011, In: Current Drug Targets. 12, 12, p. 1711-1728 18 p.

    Research output: Contribution to journal › Review › Research › peer-review

  49. Published

    Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut

    Ghosh, A. K., Coppens, I., Gårdsvoll, Henrik, Ploug, Michael & Jacobs-Lorena, M., 11 Oct 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17153-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction

    Gårdsvoll, Henrik, Jacobsen, B., Kriegbaum, M. C., Behrendt, Niels, Engelholm, Lars Henning, Østergaard, S. & Ploug, Michael, 23 Sep 2011, In: The Journal of Biological Chemistry. 286, 38, p. 33544-56 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Expression of C4.4A, a structural uPAR homolog, reflects squamous epithelial differentiation in the adult mouse and during embryogenesis

    Kriegbaum, M. C., Jacobsen, B., Hald, A. & Ploug, Michael, 1 Feb 2011, In: Journal of Histochemistry and Cytochemistry. 59, 2, p. 188-201 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    C4.4A IS A PROGNOSTIC INDICATOR IN NON-SMALL CELL LUNG CANCER PATIENTS WITH ADENOCARCINOMAS

    Jacobsen, B., Muley, T., Meister, M., Dienemann, H., Christensen, I. J., Santoni Rugiu, Eric, Laerum, O. D. & Ploug, Michael, 2011, In: Journal of Thoracic Oncology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    C4.4A as a biomarker for poor prognosis in non-small cell lung cancer patients with adenocarcinomas

    Jacobsen, B., Muley, T., Meister, M., Dienemann, H., Christensen, I. J., Santoni Rugiu, Eric, Laerum, O. D. & Ploug, Michael, 2011, In: European Journal of Cancer.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor

    Gårdsvoll, Henrik, Kjærgaard, M., Jacobsen, B., Kriegbaum, M. C., Huang, M. & Ploug, Michael, 2011, In: Journal of Biological Chemistry. 286, 50, p. 43515-26 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Proteasernes veje og vildveje

    Andreasen, P., Kjaer, A., Persson, M. & Ploug, Michael, 2011, In: Aktuel Naturvidenskab. 6, p. 24-27

    Research output: Contribution to journal › Review › Research

  56. 2010
  57. Published

    INDUCTION AND/OR MAINTENANCE OF TUMOR DORMANCY BY DISRUPTION OF UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR-INTEGRIN INTERACTION

    Ossowski, L., Chaurasia, P., Aguirre-Ghiso Julio, A., Zhou, M. & Ploug, Michael, 30 Sep 2010, IPC No. G06G 7/ 60 A I, Patent No. US2010249184, Priority date 17 Mar 2008, Priority No. US20080531502

    Research output: Patent

  58. Published

    Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation

    Connolly, B. M., Choi, E. Y., Gårdsvoll, Henrik, Bey, A. L., Currie, B. M., Chavakis, T., Liu, S., Molinolo, A., Ploug, Michael, Leppla, S. H. & Bugge, T. V., 2 Sep 2010, In: Blood Weekly. 116, 9, p. 1593-603 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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