Joachim Lütken Weischenfeldt
Group leader, Clinical Professor
Weischenfeldt Group
Københavns Universitet, BRIC, Ole Maaløes Vej 5
2200 København N
Member of:
- 2024
- Accepted/In press
CEA (CEACAM5) expression is common in muscle-invasive urothelial carcinoma of the bladder but unrelated to the disease course
Plage, H., Furlano, K., Neymeyer, J., Weinberger, S., Gerdes, B., Hubatsch, M., Ralla, B., Franz, A., Fendler, A., de Martino, M., Roßner, F., Schallenberg, S., Elezkurtaj, S., Kluth, M., Lennartz, M., Blessin, N. C., Marx, A. H., Samtleben, H., Fisch, M., Rink, M. & 14 others, , 2024, (Accepted/In press) In: BJUI Compass.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss of Upk1a and Upk1b expression is linked to stage progression in urothelial carcinoma of the bladder
Kaczmarek, K., Plage, H., Furlano, K., Hofbauer, S., Weinberger, S., Ralla, B., Franz, A., Fendler, A., de Martino, M., Roßner, F., Schallenberg, S., Elezkurtaj, S., Kluth, M., Lennartz, M., Blessin, N. C., Marx, A. H., Samtleben, H., Fisch, M., Rink, M., Slojewski, M. & 12 others, , 2024, In: International Urology and Nephrology. 56, p. 499-508 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
A polygenic two-hit hypothesis for prostate cancer
Houlahan, K. E., Livingstone, J., Fox, N. S., Kurganovs, N., Zhu, H., Sietsma Penington, J., Jung, C-H., Yamaguchi, T. N., Heisler, L. E., Jovelin, R., Costello, A. J., Pope, B. J., Kishan, A. U., Corcoran, N. M., Bristow, R. G., Waszak, S. M., Weischenfeldt, J., He, H. H., Hung, R. J., Hovens, C. M. & 1 others, , 2023, In: Journal of the National Cancer Institute. 115, 4, p. 468-472 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epithelial specific splicing regulator proteins as emerging oncogenes in aggressive prostate cancer
Advani, R., Luzzi, S., Scott, E., Dalgliesh, C., Weischenfeldt, Joachim Lütken, Munkley, J. & Elliott, D. J., 2023, In: Oncogene. 42, p. 3161-3168 8 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Frequency and Functional Characterization of RUNX1 Germline Variants in Myeloid Neoplasms
Nitschke, N. J., Almosailleakh, M., Niu, Yiyuan, Hansen, Jakob Werner, Raaschou-Jensen, K., Jespersen, Jakob Schmidt, Severinsen, M. T., Roug, A. S., Frödin, Morten, Weischenfeldt, Joachim Lütken, Andersen, M. K. & Grønbæk, Kirsten, 2023, In: Human Mutation. 2023, 11 p., 4738660.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hunting for the elusive target antigen in gestational alloimmune liver disease (GALD)
Rieneck, K., Rasmussen, K. K., Schoof, E. M., Clausen, F. B., Holze, H., Bergholt, Thomas, Jørgensen, M. H., Christensen, Vibeke Brix, Almaas, R., Jordal, P. L., Locard-Paulet, Marie, Runager, K., Nielsen, L. K., Schlotmann, Balthasar Clemens, Weischenfeldt, Joachim Lütken, Jensen, Lars Juhl & Dziegiel, Morten Hanefeld, 2023, In: PLoS ONE. 18, 10, 25 p., e0286432.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Neurogenome study: Comprehensive molecular profiling to optimize treatment for Danish glioblastoma patients
Nørøxe, D. S., Maarup, S., Fougner, Vincent Nicolay, Muhic, A., Møller, Søren, Urup, T., Lü, Maya Jeje Schuang, Weischenfeldt, Joachim Lütken, Hansen, Adam Espe, Skovgaard Poulsen, H., Lassen, Ulrik Niels & Hasselbalch, B., 2023, In: Neuro-Oncology Advances. 5, 1, 8 p., vdad137.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
When 3D genome changes cause disease: the impact of structural variations in congenital disease and cancer
Weischenfeldt, Joachim Lütken & Ibrahim, D. M., 2023, In: Current Opinion in Genetics and Development. 80, 102048.Research output: Contribution to journal › Review › Research › peer-review
- 2022
- Published
Clonal Hematopoiesis and Epigenetic Age Acceleration in Elderly Danish Twins
Sørensen, M., Tulstrup, Morten Rytter, Hansen, Jakob Werner, Weischenfeldt, Joachim Lütken, Grønbæk, Kirsten & Christensen, K., 2022, In: HemaSphere. 6, 9, 6 p., 768.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clonal hematopoiesis is associated with hematological toxicity during lenalidomide-based therapy for MCL
Husby, Simon, Bæch-Laursen, C., Eskelund, C. W., Favero, Francesco, Jespersen, Jakob Schmidt, Hutchings, M., Pedersen, L. B., Niemann, Carsten, Weischenfeldt, Joachim Lütken, Räty, R., Larsen, T. S., Kolstad, A., Jerkeman, M. & Grønbæk, Kirsten, 2022, In: Leukemia. 36, p. 2912-2916Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Implementing targeted therapies in the treatment of glioblastoma: Previous shortcomings, future promises, and a multimodal strategy recommendation
Fougner, V., Hasselbalch, B., Lassen, Ulrik Niels, Weischenfeldt, Joachim Lütken, Poulsen, H. S. & Urup, T., 2022, In: Neuro-Oncology Advances. 4, 1, vdac157.Research output: Contribution to journal › Review › Research › peer-review
- Published
Level of unique T cell clonotypes is associated with clonal hematopoiesis and survival in patients with lymphoma undergoing ASCT
Husby, Simon, Jørgensen, G. Ø., Favero, Francesco, Jespersen, Jakob Schmidt, Rodriguez Gonzalez, Francisco G, Nielsen, C., Sorensen, B., Ebbesen, L. H., Bæch, J., Haastrup, E. K., Josefsson, P., Thorsgaard, M., Brown, Peter de Nully, El-Galaly, T. C., Larsen, T. S., Weischenfeldt, Joachim Lütken & Grønbæk, Kirsten, 2022, In: Bone Marrow Transplantation. 57, p. 674-677Research output: Contribution to journal › Letter › Research › peer-review
- Published
Rare Germline Variants Are Associated with Rapid Biochemical Recurrence After Radical Prostate Cancer Treatment: A Pan Prostate Cancer Group Study
Burns, D., Anokian, E., Saunders, E. J., Bristow, R. G., Fraser, M., Reimand, J., Schlomm, T., Sauter, G., Brors, B., Korbel, J., Weischenfeldt, J., Waszak, S. M., Corcoran, N. M., Jung, C. H., Pope, B. J., Hovens, C. M., Cancel-Tassin, G., Cussenot, O., Loda, M., Sander, C. & 16 others, , 2022, In: European Urology. 82, 2, p. 201-211 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Somatic structural variant formation is guided by and influences genome architecture
Sidiropoulos, N., Mardin, B. R., Rodriguez Gonzalez, Francisco G, Bochkov, I. D., Garg, S., Stuetz, A. M., Korbel, J. O., Aiden, E. L. & Weischenfeldt, Joachim Lütken, 2022, In: Genome Research. 32, 4, p. 643-655Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural variations in cancer and the 3D genome
Dubois, F., Sidiropoulos, N., Weischenfeldt, Joachim Lütken & Beroukhim, R., 2022, In: Nature Reviews Cancer. 22, p. 533-546Research output: Contribution to journal › Review › Research › peer-review
- Published
Tumor mutational burden and purity adjustment before and after treatment with temozolomide in 27 paired samples of glioblastoma: a prospective study
Nørøxe, D. S., Flynn, A., Yde, C. W., Østrup, O., Nielsen, Finn Cilius, Skjøth, Jane, Brennum, J., Hamerlik, P., Weischenfeldt, Joachim Lütken, Skovgaard Poulsen, H. & Lassen, Ulrik Niels, 2022, In: Molecular Oncology. 16, 1, p. 206-218Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Mutations known from B-cell lymphoid malignancies are not found in CD34+ stem cells from patients with lymphoma
Husby, Simon, Favero, Francesco, Rodriguez Gonzalez, Francisco G, Sutton, L. A., Haastrup, E. K., mxz703, mxz703, Hansen, Jakob Werner, Arboe, B., Aslan, D., Clasen-Linde, E., Gjerdrum, Lise Mette Rahbek, Gørlev, J. S., Brown, Peter de Nully, Fischer-Nielsen, A., Rosenquist, R., Weischenfeldt, Joachim Lütken & Grønbæk, Kirsten, 2021, In: Leukemia and Lymphoma. 62, 11, p. 2808-2811Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Systematic dissection of transcriptional regulatory networks by genome-scale and single-cell CRISPR screens
Lopes, R., Sprouffske, K., Sheng, C., Uijttewaal, E. C. H., Wesdorp, A. E., Dahinden, J., Wengert, S., Diaz-Miyar, J., Yildiz, U., Bleu, M., Apfel, V., Mermet-Meillon, F., Krese, R., Eder, M., Olsen, A. V., Hoppe, P., Knehr, J., Carbone, W., Cuttat, R., Waldt, A. & 8 others, , 2021, In: Science Advances. 7, 27, eabf5733.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis
Tulstrup, Morten Rytter, Soerensen, M., Hansen, Jakob Werner, Gillberg, Linn, Needhamsen, M., Kaastrup, K., Helin, K., Christensen, K., Weischenfeldt, Joachim Lütken & Grønbæk, Kirsten, 2021, In: Nature Communications. 12, 1, 10 p., 6061.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
Cortés-Ciriano, I., Lee, J. J. K., Xi, R., Jain, D., Jung, Y. L., Yang, L., Gordenin, D., Klimczak, L. J., Zhang, C. Z., Pellman, D. S., Akdemir, K. C., Alvarez, E. G., Baez-Ortega, A., Beroukhim, R., Boutros, P. C., Bowtell, D. D. L., Brors, B., Burns, K. H., Campbell, P. J., Chan, K. & 32 others, , 6 Feb 2020, In: Nature Genetics.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrative pathway enrichment analysis of multivariate omics data
Paczkowska, M., Barenboim, J., Sintupisut, N., Fox, N. S., Zhu, H., Abd-Rabbo, D., Mee, M. W., Boutros, P. C., Abascal, F., Amin, S. B., Bader, G. D., Beroukhim, R., Bertl, J., Boroevich, K. A., Brunak, S., Campbell, P. J., Carlevaro-Fita, J., Chakravarty, D., Chan, C. W. Y., Chen, K. & 30 others, , 5 Feb 2020, In: Nature Communications. 11, 1, 735.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
Rheinbay, E., Nielsen, M. M., Abascal, F., Wala, J. A., Shapira, O., Tiao, G., Hornshøj, H., Hess, J. M., Juul, R. I., Lin, Z., Feuerbach, L., Sabarinathan, R., Madsen, T., Kim, J., Mularoni, L., Shuai, S., Lanzós, A., Herrmann, C., Maruvka, Y. E., Shen, C. & 31 others, , Feb 2020, In: Nature. 578, 7793, p. 102-111 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Novel Gene Signature-Based Model Predicts Biochemical Recurrence-Free Survival in Prostate Cancer Patients after Radical Prostatectomy
Shi, R., Bao, X., Weischenfeldt, Joachim Lütken, Schaefer, C., Rogowski, P., Schmidt-Hegemann, N., Unger, K., Lauber, K., Wang, X., Buchner, A., Stief, C., Schlomm, T., Belka, C. & Li, M., 2020, In: Cancers. 12, 1, p. 1-12 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Butler enables rapid cloud-based analysis of thousands of human genomes
Weischenfeldt, Joachim Lütken, PCAWG Technical Working Group, P. T. W. G. & PCAWG Consortium, P. C., 2020, In: Nature Biotechnology. 38, 3, p. 288-292 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
Carlevaro-Fita, J., Lanzós, A., Feuerbach, L., Hong, C., Mas-Ponte, D., Pedersen, J. S., Johnson, R., Sidiropoulos, N., Weischenfeldt, Joachim Lütken & Brunak, Søren, 2020, In: Communications Biology. 3, 1, p. 1-16 56.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clinical impact of clonal hematopoiesis in patients with lymphoma undergoing ASCT: a national population-based cohort study
Husby, S., Favero, F., Nielsen, C., Sørensen, B. S., Bæch, J., Grell, K., Hansen, J. W., Rodriguez-Gonzalez, F. G., Haastrup, E. K., Fischer-Nielsen, A., Andersen, P., Arboe, B., Sækmose, S. G., Hansen, P. B., Christiansen, I., Clasen-Linde, E., Meldgaard, L., Ebbesen, L. H., Segel, E. K., Josefsson, P. & 6 others, , 2020, In: Leukemia. 34, p. 3256-3268 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clonal hematopoiesis evolves from pretreatment clones and stabilizes after end of chemotherapy in patients with MCL
Eskelund, C. W., Husby, Simon, Favero, Francesco, Klausen, T. W., Rodriguez Gonzalez, Francisco G, Kolstad, A., Pedersen, L. B., Räty, R. K., Geisler, C. H., Jerkeman, M., Weischenfeldt, Joachim Lütken & Grønbæk, Kirsten, 2020, In: Blood. 135, 22, p. 2000-2004Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Clonal hematopoiesis in elderly twins: concordance, discordance, and mortality
Hansen, Jakob Werner, Pedersen, D. A., Larsen, L. A., Husby, Simon, Clemmensen, S. B., Hjelmborg, J., Favero, Francesco, Weischenfeldt, Joachim Lütken, Christensen, K. & Grønbæk, Kirsten, 2020, In: Blood. 135, 4, p. 261-268Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combined burden and functional impact tests for cancer driver discovery using DriverPower
Shuai, S., Abascal, F., Amin, S. B., Bader, G. D., Bandopadhayay, P., Barenboim, J., Beroukhim, R., Bertl, J., Boroevich, K. A., Brunak, S., Campbell, P. J., Carlevaro-Fita, J., Chakravarty, D., Chan, C. W. Y., Chen, K., Choi, J. K., Deu-Pons, J., Dhingra, P., Diamanti, K., Feuerbach, L. & 32 others, , 2020, In: Nature Communications. 11, 1, 12 p., 734.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
Akdemir, K. C., Le, V. T., Chandran, S., Li, Y., Verhaak, R. G., Beroukhim, R., Campbell, P. J., Chin, L., Dixon, J. R., Futreal, P. A., Akdemir, K. C., Alvarez, E. G., Baez-Ortega, A., Beroukhim, R., Boutros, P. C., Bowtell, D. D. L., Brors, B., Burns, K. H., Campbell, P. J., Chan, K. & 32 others, , 2020, In: Nature Genetics. p. 294-305Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomic footprints of activated telomere maintenance mechanisms in cancer
Sieverling, L., Hong, C., Koser, S. D., Ginsbach, P., Kleinheinz, K., Hutter, B., Braun, D. M., Cortés-Ciriano, I., Xi, R., Kabbe, R., Park, P. J., Eils, R., Schlesner, M., Akdemir, K. C., Alvarez, E. G., Baez-Ortega, A., Beroukhim, R., Boutros, P. C., Bowtell, D. D. L., Brors, B. & 32 others, , 2020, In: Nature Communications. 11, 1, 733.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
Zhang, Y., Chen, F., Fonseca, N. A., He, Y., Fujita, M., Nakagawa, H., Zhang, Z., Brazma, A., Amin, S. B., Awadalla, P., Bailey, P. J., Brazma, A., Brooks, A. N., Calabrese, C., Chateigner, A., Cortés-Ciriano, I., Craft, B., Craft, D., Creighton, C. J., Davidson, N. R. & 33 others, , 2020, In: Nature Communications. 11, 1, p. 1-14 736.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of unique and shared mitochondrial DNA mutations in neurodegeneration and cancer by single-cell mitochondrial DNA structural variation sequencing (MitoSV-seq)
Jaberi, E., Tresse-Gommeaux, Emilie, Grønbæk, Kirsten, Weischenfeldt, Joachim Lütken & Issazadeh-Navikas, Shohreh, 2020, In: EBioMedicine. 57, p. 1-17 102868.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pan-cancer analysis of whole genomes
ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, I. P. A. O. W. G. C., Weischenfeldt, Joachim Lütken, Sidiropoulos, N., Brunak, Søren & Rodriguez Gonzalez, Francisco G, 2020, In: Nature. 578, 7793, p. 82-93 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
Rodriguez-Martin, B., Alvarez, E. G., Baez-Ortega, A., Zamora, J., Supek, F., Demeulemeester, J., Santamarina, M., Ju, Y. S., Temes, J., Garcia-Souto, D., Detering, H., Li, Y., Rodriguez-Castro, J., Dueso-Barroso, A., Bruzos, A. L., Dentro, S. C., Blanco, M. G., Contino, G., Ardeljan, D., Tojo, M. & 32 others, , 2020, In: Nature Genetics. 52, 3, p. 306-319 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pathway and network analysis of more than 2500 whole cancer genomes
Reyna, M. A., Haan, D., Paczkowska, M., Verbeke, L. P. C., Vazquez, M., Kahraman, A., Pulido-Tamayo, S., Barenboim, J., Wadi, L., Dhingra, P., Shrestha, R., Getz, G., Lawrence, M. S., Pedersen, J. S., Rubin, M. A., Wheeler, D. A., Brunak, S., Izarzugaza, J. M. G., Khurana, E., Marchal, K. & 32 others, , 2020, In: Nature Communications. 11, 1, p. 1-17 729.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Patterns of somatic structural variation in human cancer genomes
Li, Y., Roberts, N. D., Wala, J. A., Shapira, O., Schumacher, S. E., Kumar, K., Khurana, E., Waszak, S., Korbel, J. O., Haber, J. E., Imielinski, M., Akdemir, K. C., Alvarez, E. G., Baez-Ortega, A., Beroukhim, R., Boutros, P. C., Bowtell, D. D. L., Brors, B., Burns, K. H., Campbell, P. J. & 29 others, , 2020, In: Nature. 578, 7793, p. 112-121 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
Bailey, M. H., Meyerson, W. U., Dursi, L. J., Wang, L. B., Dong, G., Liang, W. W., Weerasinghe, A., Li, S., Kelso, S., Akbani, R., Anur, P., Bailey, M. H., Buchanan, A., Chiotti, K., Covington, K., Creason, A., Ding, L., Weischenfeldt, J., Brunak, S., Ding, L. & 4 others, , 2020, In: Nature Communications. 11, 1, 4748.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability
Achuthankutty, D., Thakur, R. S., Haahr, Peter Thorlund, Hoffmann, Saskia, Drainas, A. P., Bizard, A. H., Weischenfeldt, Joachim Lütken, Hickson, Ian David & Mailand, Niels, 2019, In: The Journal of Cell Biology. 218, 12, 11 p., 3943.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Response to olaparib in a PALB2 germline mutated prostate cancer and genetic events associated with resistance
Horak, P., Weischenfeldt, J., von Amsberg, G., Beyer, B., Schütte, A., Uhrig, S., Gieldon, L., Klink, B., Feuerbach, L., Hübschmann, D., Kreutzfeldt, S., Heining, C., Maier, S., Hutter, B., Penzel, R., Schlesner, M., Eils, R., Sauter, G., Stenzinger, A., Brors, B. & 4 others, , 2019, In: Cold Spring Harbor molecular case studies. 5, 2, p. 1-9 a003657.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories
Gerhauser, C., Favero, F., Risch, T., Simon, R., Feuerbach, L., Assenov, Y., Heckmann, D., Sidiropoulos, N., Waszak, S. M., Hübschmann, D., Urbanucci, A., Girma, E. G., Kuryshev, V., Klimczak, L. J., Saini, N., Stütz, A. M., Weichenhan, D., Böttcher, L. M., Toth, R., Hendriksen, J. D. & 35 others, , 2018, In: Cancer Cell. 34, 6, p. 996-1011.e8 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort
Waszak, S. M., Northcott, P. A., Buchhalter, I., Robinson, G. W., Sutter, C., Groebner, S., Grund, K. B., Brugières, L., Jones, D. T. W., Pajtler, K. W., Morrissy, A. S., Kool, M., Sturm, D., Chavez, L., Ernst, A., Brabetz, S., Hain, M., Zichner, T., Segura-Wang, M., Weischenfeldt, J. & 67 others, , 2018, In: The Lancet Oncology. 19, 6, p. 785-798 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SvABA: genome-wide detection of structural variants and indels by local assembly
Wala, J. A., Bandopadhayay, P., Greenwald, N. F., O'Rourke, R., Sharpe, T., Stewart, C., Schumacher, S., Li, Y., Weischenfeldt, Joachim Lütken, Yao, X., Nusbaum, C., Campbell, P., Getz, G., Meyerson, M., Zhang, C., Imielinski, M. & Beroukhim, R., 2018, In: Genome Research. 28, 4, p. 581-591 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The landscape of genomic alterations across childhood cancers
ICGC PedBrain-Seq Project, I. P. P., 2018, In: Nature. 555, 7696, p. 321-327 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
Deletion lengthening at chromosomes 6q and 16q targets multiple tumor suppressor genes and is associated with an increasingly poor prognosis in prostate cancer
Kluth, M., Jung, S., Habib, O., Eshagzaiy, M., Heinl, A., Amschler, N., Masser, S., Mader, M., Runte, F., Barow, P., Frogh, S., Omari, J., Möller-Koop, C., Hube-Magg, C., Weischenfeldt, J., Korbel, J., Steurer, S., Krech, T., Huland, H., Graefen, M. & 4 others, , 12 Dec 2017, In: OncoTarget. 8, 65, p. 108923-108935 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mitochondrial mutations drive prostate cancer aggression
Hopkins, J. F., Sabelnykova, V. Y., Weischenfeldt, J., Simon, R., Aguiar, J. A., Alkallas, R., Heisler, L. E., Zhang, J., Watson, J. D., Chua, M. L. K., Fraser, M., Favero, F., Lawerenz, C., Plass, C., Sauter, G., McPherson, J. D., Van Der Kwast, T., Korbel, J., Schlomm, T., Bristow, R. G. & 1 others, , 1 Dec 2017, In: Nature Communications. 8, 1, 8 p., 656.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomes of early onset prostate cancer
Weischenfeldt, Joachim Lütken & Korbel, J. O., 1 Sep 2017, In: Current Opinion in Urology. 27, 5, p. 481-487 7 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The whole-genome landscape of medulloblastoma subtypes
Northcott, P. A., Buchhalter, I., Morrissy, A. S., Hovestadt, V., Weischenfeldt, J., Ehrenberger, T., Gröbner, S., Segura-Wang, M., Zichner, T., Rudneva, V. A., Warnatz, H. J., Sidiropoulos, N., Phillips, A. H., Schumacher, S., Kleinheinz, K., Waszak, S. M., Erkek, S., Jones, D. T. W., Worst, B. C., Kool, M. & 67 others, , 19 Jul 2017, In: Nature. 547, 7663, p. 311-317 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking
Weischenfeldt, J. L., Dubash, T., Drainas, A. P., Mardin, B. R., Chen, Y., Stütz, A. M., Waszak, S. M., Bosco, G., Halvorsen, A. R., Raeder, B., Efthymiopoulos, T., Erkek, S., Siegl, C., Brenner, H., Brustugun, O. T., Dieter, S. M., Northcott, P. A., Petersen, I., Pfister, S. M., Schneider, M. & 12 others, , 2017, In: Nature Genetics. 49, 1, p. 65-74 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
Heterogeneity of ERG expression in prostate cancer: a large section mapping study of entire prostatectomy specimens from 125 patients
Tsourlakis, M., Stender, A., Quaas, A., Kluth, M., Wittmer, C., Haese, A., Graefen, M., Steurer, S., Simon, R., Korbel, J., Weischenfeldt, Joachim Lütken, Huland, H., Sauter, G., Schlomm, T. & Minner, S., 17 Aug 2016, In: B M C Cancer. 16, p. 641Research output: Contribution to journal › Journal article › Research › peer-review
Immortalization capacity of HPV types is inversely related to chromosomal instability
Schütze, D. M., Krijgsman, O., Snijders, P. J. F., Ylstra, B., Weischenfeldt, Joachim Lütken, Mardin, B. R., Stütz, A. M., Korbel, J. O., de Winter, J. P., Meijer, C. J. L. M., Quint, W. G. V., Bosch, L., Wilting, S. M. & Steenbergen, R. D. M., 14 Mar 2016, In: OncoTarget. 7, 25, p. 37608-37621 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
The Aging Prostate Is Never "Normal": Implications from the Genomic Characterization of Multifocal Prostate Cancers
Schlomm, T., Weischenfeldt, Joachim Lütken, Korbel, J. & Sauter, G., Sep 2015, In: European Urology (Italian Edition). 68, 3, p. 348-50 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
Pediatric T-lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation
Kunz, J. B., Rausch, T., Bandapalli, O. R., Eilers, J., Pechanska, P., Schuessele, S., Assenov, Y., Stütz, A. M., Kirschner-Schwabe, R., Hof, J., Eckert, C., von Stackelberg, A., Schrappe, M., Stanulla, M., Koehler, R., Avigad, S., Elitzur, S., Handgretinger, R., Benes, V., Weischenfeldt, J. & 3 others, , 20 Aug 2015, In: Haematologica. p. 1442-1450 8 p., 100.Research output: Contribution to journal › Journal article › Research › peer-review
Prevalence of chromosomal rearrangements involving non-ETS genes in prostate cancer
Kluth, M., Galal, R., Krohn, A., Weischenfeldt, Joachim Lütken, Tsourlakis, C., Paustian, L., Ahrary, R., Ahmed, M., Scherzai, S., Meyer, A., Sirma, H., Korbel, J., Sauter, G., Schlomm, T., Simon, R. & Minner, S., Apr 2015, In: International Journal of Oncology. 46, 4, p. 1637-42 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
A cell-based model system links chromothripsis with hyperploidy
Mardin, B. R., Drainas, A. P., Waszak, S. M., Weischenfeldt, Joachim Lütken, Isokane, M., Stütz, A. M., Raeder, B., Efthymiopoulos, T., Buccitelli, C., Segura-Wang, M., Northcott, P., Pfister, S. M., Lichter, P., Ellenberg, J. & Korbel, J. O., 2015, In: Molecular Systems Biology. 11, 9, p. 828Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
TMPRSS2-ERG fusions are strongly linked to young patient age in low-grade prostate cancer
Steurer, S., Mayer, P. S., Adam, M., Krohn, A., Koop, C., Ospina-Klinck, D., Tehrani, A. A., Simon, R., Tennstedt, P., Graefen, M., Wittmer, C., Brors, B., Plass, C., Korbel, J., Weischenfeldt, Joachim Lütken, Sauter, G., Huland, H., Tsourlakis, M. C., Minner, S. & Schlomm, T., Dec 2014, In: European Urology (Italian Edition). 66, 6, p. 978-81 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer
Brocks, D., Assenov, Y., Minner, S., Bogatyrova, O., Simon, R., Koop, C., Oakes, C., Zucknick, M., Lipka, D. B., Weischenfeldt, J., Feuerbach, L., Cowper-Sal Lari, R., Lupien, M., Brors, B., Korbel, J., Schlomm, T., Tanay, A., Sauter, G., Gerhäuser, C., Plass, C. & 1 others, , 7 Aug 2014, In: Cell Reports. 8, 3, p. 798-806 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer
Weischenfeldt, J., Simon, R., Feuerbach, L., Schlangen, K., Weichenhan, D., Minner, S., Wuttig, D., Warnatz, H-J., Stehr, H., Rausch, T., Jäger, N., Gu, L., Bogatyrova, O., Stütz, A. M., Claus, R., Eils, J., Eils, R., Gerhäuser, C., Huang, P-H., Hutter, B. & 40 others, , 11 Feb 2013, In: Cancer Cell. 23, 2, p. 159-70 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Phenotypic impact of genomic structural variation: insights from and for human disease
Weischenfeldt, Joachim Lütken, Symmons, O., Spitz, F. & Korbel, J. O., Feb 2013, In: Nature Reviews. Genetics. 14, 2, p. 125-38 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
Dissecting the genomic complexity underlying medulloblastoma
Jones, D. T. W., Jäger, N., Kool, M., Zichner, T., Hutter, B., Sultan, M., Cho, Y-J., Pugh, T. J., Hovestadt, V., Stütz, A. M., Rausch, T., Warnatz, H-J., Ryzhova, M., Bender, S., Sturm, D., Pleier, S., Cin, H., Pfaff, E., Sieber, L., Wittmann, A. & 70 others, , 2 Aug 2012, In: Nature. 488, 7409, p. 100-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
Rausch, T., Jones, D. T. W., Zapatka, M., Stütz, A. M., Zichner, T., Weischenfeldt, J., Jäger, N., Remke, M., Shih, D., Northcott, P. A., Pfaff, E., Tica, J., Wang, Q., Massimi, L., Witt, H., Bender, S., Pleier, S., Cin, H., Hawkins, C., Beck, C. & 31 others, , 20 Jan 2012, In: Cell. 148, 1-2, p. 59-71 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns
Weischenfeldt, Joachim Lütken, Waage, J. E., Tian, G., Zhao, J., Damgaard, I., Jakobsen, J. S., Kristiansen, Karsten, Krogh, Anders, Wang, J. & Porse, Bo Torben, 2012, In: Genome Biology (Online Edition). 13, 5, 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
UPF2 is a critical regulator of liver development, function and regeneration
Thoren, L. A., Nørgaard, G. A., Weischenfeldt, Joachim Lütken, Waage, J., Jakobsen, J. S., Damgaard, I., Bergström, F. C., Blom, A. M., Borup, R., Bisgaard, Hanne Cathrine & Porse, Bo Torben, 2010, In: PLoS ONE. 5, 7, p. e11650Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Bone Marrow-derived Macrophages (BMMs): Isolation and applications.
Weischenfeldt, Joachim Lütken & Porse, Bo Torben, 2008, In: Cold Spring Harbor Protocols.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.
Weischenfeldt, Joachim Lütken, Damgaard, I., Bryder, D., Theilgaard-Mønch, Kim, Thoren, L. A., Nielsen, F. C., Jacobsen, S. E. W., Nerlov, C. & Porse, Bo Torben, 2008, In: Genes & Development. 22, 10, p. 1381-96 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- 2005
- Published
Messenger RNA surveillance: neutralizing natural nonsense.
Weischenfeldt, Joachim Lütken, Lykke-Andersen, J. & Porse, Bo Torben, 2005, In: Current Biology. 15, 14, p. R559-62Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
Comparative analysis of different vaccine constructs expressing defined antigens from Mycobacterium tuberculosis.
Doherty, T. M., Olsen, A. W., Weischenfeldt, Joachim Lütken, Huygen, K., D'Souza, S., Kondratieva, T. K., Yeremeev, V. V., Apt, A. S., Raupach, B., Grode, L., Kaufmann, S. & Andersen, P., 2004, In: Journal of Infectious Diseases. 190, 12, p. 2146-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 3997200
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Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns
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The landscape of genomic alterations across childhood cancers
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The whole-genome landscape of medulloblastoma subtypes
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